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Review

Diabetes and sexual dysfunction: current perspectives

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Pages 95-105 | Published online: 06 Mar 2014

References

  • International Diabetes Federation IDF Diabetes Atlas 5th edition Update Brussels, Belgium International Diabetes Federation 2012
  • Wild S Roglic G Green A Sicree R King H Global prevalence of diabetes: estimates for the year 2000 and projections for 2030 Diabetes Care 2004 27 5 1047 1053 15111519
  • Kopelman PG Obesity as a medical problem Nature 2000 404 6778 635 643 10766250
  • Go AS Mozaffarian D Roger VL American Heart Association Statistics Committee and Stroke Statistics Subcommittee Heart disease and stroke statistics – 2013 update: a report from the American Heart Association Circulation 2013 127 1 e6 e245 23239837
  • International Diabetes Federation Diabetes Atlas 5th ed Brussels, Belgium International Diabetes Federation 2011
  • Campos C Chronic hyperglycemia and glucose toxicity: pathology and clinical sequelae Postgrad Med 2012 124 6 90 97 23322142
  • Rahman S Rahman T Ismail AA Rashid AR Diabetes-associated macrovasculopathy: pathophysiology and pathogenesis Diabetes Obes Metab 2007 9 6 767 780 17924861
  • Fox CS Coady S Sorlie PD Increasing cardiovascular disease burden due to diabetes mellitus: the Framingham Heart Study Circulation 2007 115 12 1544 1550 17353438
  • Preis SR Pencina MJ Hwang SJ Trends in cardiovascular disease risk factors in individuals with and without diabetes mellitus in the Framingham Heart Study Circulation 2009 120 3 212 220 19581493
  • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group N Engl J Med 1993 329 14 977 986 8366922
  • Stratton IM Adler AI Neil HA Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study BMJ 2000 321 7258 405 412 10938048
  • Feldman HA Goldstein I Hatzichristou DG Krane RJ McKinlay JB Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study J Urol 1994 151 1 54 61 8254833
  • Penson DF Latini DM Lubeck DP Wallace KL Henning JM Lue TF Comprehensive Evaluation of Erectile Dysfunction (ExCEED) database Do impotent men with diabetes have more severe erectile dysfunction and worse quality of life than the general population of impotent patients? Results from the Exploratory Comprehensive Evaluation of Erectile Dysfunction (ExCEED) database Diabetes Care 2003 26 4 1093 1099 12663579
  • Lu CC Jiann BP Sun CC Lam HC Chu CH Lee JK Association of glycemic control with risk of erectile dysfunction in men with type 2 diabetes J Sex Med 2009 6 6 1719 1728 19473477
  • Enzlin P Rosen R Wiegel M DCCT/EDIC Research Group Sexual dysfunction in women with type 1 diabetes: long-term findings from the DCCT/EDIC study cohort Diabetes Care 2009 32 5 780 785 19407075
  • Abu Ali RM Al Hajeri RM Khader YS Shegem NS Ajlouni KM Sexual dysfunction in Jordanian diabetic women Diabetes Care 2008 31 8 1580 1581 18458140
  • Olarinoye J Olarinoye A Determinants of sexual function among women with type 2 diabetes in a Nigerian population J Sex Med 2008 5 4 878 886 18069996
  • Giugliano F Maiorino M Bellastella G Gicchino M Giugliano D Esposito K Determinants of erectile dysfunction in type 2 diabetes Int J Impot Res 2010 22 3 204 209 20147958
  • Enzlin P Mathieu C Van Den Bruel A Vanderschueren D Demyttenaere K Prevalence and predictors of sexual dysfunction in patients with type 1 diabetes Diabetes Care 2003 26 2 409 414 12547871
  • Salonia A Lanzi R Scavini M Sexual function and endocrine profile in fertile women with type 1 diabetes Diabetes Care 2006 29 2 312 316 16443879
  • Esposito K Maiorino MI Bellastella G Giugliano F Romano M Giugliano D Determinants of female sexual dysfunction in type 2 diabetes Int J Impot Res 2010 22 3 179 184 20376056
  • Seftel AD Sun P Swindle R The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction J Urol 2004 171 6 Pt 1 2341 2345 15126817
  • Esposito K Giugliano F Martedì E High proportions of erectile dysfunction in men with the metabolic syndrome Diabetes Care 2005 28 5 1201 1203 15855589
  • Lewis RW Fugl-Meyer KS Corona G Definitions/epidemiology/risk factors for sexual dysfunction J Sex Med 2010 7 4 Pt 2 1598 1607 20388160
  • Miner M Esposito K Guay A Montorsi P Goldstein I Cardiometabolic risk and female sexual health: the Princeton III summary J Sex Med 2012 9 3 641 651 quiz 652 22372651
  • Esposito K Ciotola M Maiorino MI Hyperlipidemia and sexual function in premenopausal women J Sex Med 2009 6 6 1696 1703 19453904
  • Esposito K Ciotola M Marfella R Di Tommaso D Cobellis L Giugliano D Sexual dysfunction in women with the metabolic syndrome Diabetes Care 2005 28 3 756 15735227
  • NIH Consensus Conference Impotence. NIH Consensus Development Panel on Impotence JAMA 1993 270 1 83 90 8510302
  • Laumann EO Paik A Rosen RC Sexual dysfunction in the United States: prevalence and predictors JAMA 1999 281 6 537 544 10022110
  • De Berardis G Franciosi M Belfiglio M Quality of Care and Outcomes in Type 2 Diabetes (QuED) Study Group Erectile dysfunction and quality of life in type 2 diabetic patients: a serious problem too often overlooked Diabetes Care 2002 25 2 284 291 11815497
  • Johannes CB Araujo AB Feldman HA Derby CA Kleinman KP McKinlay JB Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts male aging study J Urol 2000 163 2 460 463 10647654
  • Bacon CG Mittleman MA Kawachi I Giovannucci E Glasser DB Rimm EB Sexual function in men older than 50 years of age: results from the health professionals follow-up study Ann Intern Med 2003 139 3 161 168 12899583
  • Ayta IA McKinlay JB Krane RJ The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences BJU Int 1999 84 1 50 56 10444124
  • Ponholzer A Temml C Mock K Marszalek M Obermayr R Madersbacher S Prevalence and risk factors for erectile dysfunction in 2869 men using a validated questionnaire Eur Urol 2005 47 1 80 85 discussion 85–86 15582253
  • Bortolotti A Fedele D Chatenoud L Cigarette smoking: a risk factor for erectile dysfunction in diabetics Eur Urol 2001 40 4 392 396 discussion 397 11713392
  • Giuliano FA Leriche A Jaudinot EO de Gendre AS Prevalence of erectile dysfunction among 7689 patients with diabetes or hypertension, or both Urology 2004 64 6 1196 1201 15596196
  • Nicolosi A Moreira ED Shirai M Bin Mohd Tambi MI Glasser DB Epidemiology of erectile dysfunction in four countries: cross-national study of the prevalence and correlates of erectile dysfunction Urology 2003 61 1 201 206 12559296
  • De Berardis G Pellegrini F Franciosi M QuED Study Group Clinical and psychological predictors of incidence of self-reported erectile dysfunction in patients with type 2 diabetes J Urol 2007 177 1 252 257 17162057
  • Demir O Akgul K Akar Z Association between severity of lower urinary tract symptoms, erectile dysfunction and metabolic syndrome Aging Male 2009 12 1 29 34 19326294
  • Turek SJ Hastings SM Sun JK King GL Keenan HA Sexual dysfunction as a marker of cardiovascular disease in males with 50 or more years of type 1 diabetes Diabetes Care 2013 36 10 3222 3226 23780949
  • Dong JY Zhang YH Qin LQ Erectile dysfunction and risk of cardiovascular disease: meta-analysis of prospective cohort studies J Am Coll Cardiol 2011 58 13 1378 1385 21920268
  • Ponholzer A Temml C Obermayr R Wehrberger C Madersbacher S Is erectile dysfunction an indicator for increased risk of coronary heart disease and stroke? Eur Urol 2005 48 3 512 518 discussion 517–518 15998563
  • Araujo AB Travison TG Ganz P Erectile dysfunction and mortality J Sex Med 2009 6 9 2445 2454 19538544
  • Rosen RC Cappelleri JC Smith MD Lipsky J Peña BM Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction Int J Impot Res 1999 11 6 319 326 10637462
  • Thorve VS Kshirsagar AD Vyawahare NS Joshi VS Ingale KG Mohite RJ Diabetes-induced erectile dysfunction: epidemiology, pathophysiology and management J Diabetes Complications 2011 25 2 129 136 20462773
  • Bacon CG Hu FB Giovannucci E Glasser DB Mittleman MA Rimm EB Association of type and duration of diabetes with erectile dysfunction in a large cohort of men Diabetes Care 2002 25 8 1458 1463 12145250
  • Kalter-Leibovici O Wainstein J Ziv A Harman-Bohem I Murad H Raz I Israel Diabetes Research Group (IDRG) Investigators Clinical, socioeconomic, and lifestyle parameters associated with erectile dysfunction among diabetic men Diabetes Care 2005 28 7 1739 1744 15983328
  • Fedele D Coscelli C Santeusanio F Erectile dysfunction in diabetic subjects in Italy. Gruppo Italiano Studio Deficit Erettile nei Diabetici Diabetes Care 1998 21 11 1973 1977 9802753
  • Goldstein I Lue TF Padma-Nathan H Rosen RC Steers WD Wicker PA Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group N Engl J Med 1998 338 20 1397 1404 9580646
  • Corona G Giorda CB Cucinotta D Guida P Nada E Gruppo di studio SUBITO-DE The SUBITO-DE study: sexual dysfunction in newly diagnosed type 2 diabetes male patients J Endocrinol Invest 2013 36 10 864 868 23686080
  • Siu SC Lo SK Wong KW Ip KM Wong YS Prevalence of and risk factors for erectile dysfunction in Hong Kong diabetic patients Diabet Med 2001 18 9 732 738 11606171
  • Al-Hunayan A Al-Mutar M Kehinde EO Thalib L Al-Ghorory M The prevalence and predictors of erectile dysfunction in men with newly diagnosed with type 2 diabetes mellitus BJU Int 2007 99 1 130 134 17026597
  • Rosen RC Wing RR Schneider S Erectile dysfunction in type 2 diabetic men: relationship to exercise fitness and cardiovascular risk factors in the Look AHEAD trial J Sex Med 2009 6 5 1414 1422 19192106
  • Vinik AI Maser RE Mitchell BD Freeman R Diabetic autonomic neuropathy Diabetes Care 2003 26 5 1553 1579 12716821
  • Chew SKh Taouk Y Xie J Relationship between diabetic retinopathy, diabetic macular oedema and erectile dysfunction in type 2 diabetics Clin Experiment Ophthalmol 2013 41 7 683 689 23448500
  • Heruti RJ Uri I Arbel Y Swartzon M Galor S Justo D Erectile dysfunction severity might be associated with poor cardiovascular prognosis in diabetic men J Sex Med 2007 4 2 465 471 17367441
  • Chew KK Bremner A Jamrozik K Earle C Stuckey B Male erectile dysfunction and cardiovascular disease: is there an intimate nexus? J Sex Med 2008 5 4 928 934 18194189
  • Rosen RC Sexual dysfunction as an obstacle to compliance with antihypertensive therapy Blood Press Suppl 1997 1 47 51 9285109
  • Foresta C Caretta N Corona G Clinical and metabolic evaluation of subjects with erectile dysfunction: a review with a proposal flowchart Int J Androl 2009 32 3 198 211 19076256
  • Guay AT ED2: erectile dysfunction = endothelial dysfunction Endocrinol Metab Clin North Am 2007 36 2 453 463 17543729
  • Cheitlin MD Erectile dysfunction: the earliest sign of generalized vascular disease? J Am Coll Cardiol 2004 43 2 185 186 14736435
  • Malavige LS Levy JC Erectile dysfunction in diabetes mellitus J Sex Med 2009 6 5 1232 1247 19210706
  • Esposito K Ciotola M Giugliano F Endothelial microparticles correlate with erectile dysfunction in diabetic men Int J Impot Res 2007 19 2 161 166 16900206
  • Nehra A Moreland RB Neurologic erectile dysfunction Urol Clin North Am 2001 28 2 289 308 11402582
  • Sáenz de Tejada I Angulo J Cellek S Pathophysiology of erectile dysfunction J Sex Med 2005 2 1 26 39 16422902
  • Esposito K Giugliano D Obesity, the metabolic syndrome, and sexual dysfunction in men Clin Pharmacol Ther 2011 90 1 169 173 21613988
  • Dhindsa S Prabhakar S Sethi M Bandyopadhyay A Chaudhuri A Dandona P Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes J Clin Endocrinol Metab 2004 89 11 5462 5468 15531498
  • Kapoor D Aldred H Clark S Channer KS Jones TH Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: correlations with bioavailable testosterone and visceral adiposity Diabetes Care 2007 30 4 911 917 17392552
  • Shabsigh R Rajfer J Aversa A The evolving role of testosterone in the treatment of erectile dysfunction Int J Clin Pract 2006 60 9 1087 1092 16939550
  • Isidori AM Buvat J Corona G A critical analysis of the role of testosterone in erectile function: from pathophysiology to treatment – a systematic review Eur Urol 2014 65 1 99 112 24050791
  • Dandona P Dhindsa S Update: Hypogonadotropic hypogonadism in type 2 diabetes and obesity J Clin Endocrinol Metab 2011 96 9 2643 2651 21896895
  • Bellastella G Maiorino MI Olita L De Bellis A Giugliano D Esposito K Anti-pituitary antibodies and hypogonadotropic hypogonadism in type 2 diabetes: in search of a role Diabetes Care 2013 36 8 e116 e117 23881971
  • Skyler JS Bergenstal R Bonow RO American Diabetes Association American College of Cardiology Foundation American Heart Association Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA diabetes trials: a position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association Diabetes Care 2009 32 1 187 192 19092168
  • Roth A Kalter-Leibovici O Kerbis Y Prevalence and risk factors for erectile dysfunction in men with diabetes, hypertension, or both diseases: a community survey among 1,412 Israeli men Clin Cardiol 2003 26 1 25 30 12539809
  • Romeo JH Seftel AD Madhun ZT Aron DC Sexual function in men with diabetes type 2: association with glycemic control J Urol 2000 163 3 788 791 10687978
  • Wessells H Penson DF Cleary P Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group Effect of intensive glycemic therapy on erectile function in men with type 1 diabetes J Urol 2011 185 5 1828 1834 21420129
  • Khatana SA Taveira TH Miner MM Eaton CB Wu WC Does cardiovascular risk reduction alleviate erectile dysfunction in men with type II diabetes mellitus? Int J Impot Res 2008 20 5 501 506 18668114
  • Yaman O Akand M Gursoy A Erdogan MF Anafarta K The effect of diabetes mellitus treatment and good glycemic control on the erectile function in men with diabetes mellitus-induced erectile dysfunction: a pilot study J Sex Med 2006 3 2 344 348 16490030
  • Esposito K Ciotola M Giugliano F Effects of intensive lifestyle changes on erectile dysfunction in men J Sex Med 2009 6 1 243 250 19170853
  • Wing RR Rosen RC Fava JL Effects of weight loss intervention on erectile function in older men with type 2 diabetes in the Look AHEAD trial J Sex Med 2010 7 1 Pt 1 156 165 19694925
  • Esposito K Giugliano D Lifestyle/dietary recommendations for erectile dysfunction and female sexual dysfunction Urol Clin North Am 2011 38 3 293 301 21798391
  • Konstantinos G Petros P Phosphodiesterase-5 inhibitors: future perspectives Curr Pharm Des 2009 15 30 3540 3551 19860699
  • Brant WO Bella AJ Lue TF Treatment options for erectile dysfunction Endocrinol Metab Clin North Am 2007 36 2 465 479 17543730
  • Vardi M Nini A Phosphodiesterase inhibitors for erectile dysfunction in patients with diabetes mellitus Cochrane Database Syst Rev 2007 CD002187 17253475
  • Francis SH Corbin JD PDE5 inhibitors: targeting erectile dysfunction in diabetics Curr Opin Pharmacol 2011 11 6 683 688 21924956
  • Rendell MS Rajfer J Wicker PA Smith MD Sildenafil for treatment of erectile dysfunction in men with diabetes: a randomized controlled trial. Sildenafil Diabetes Study Group JAMA 1999 281 5 421 426 9952201
  • Goldstein I Young JM Fischer J Bangerter K Segerson T Taylor T Vardenafil Diabetes Study Group Vardenafil, new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study Diabetes Care 2003 26 3 777 783 12610037
  • Sáenz de Tejada I Anglin G Knight JR Emmick JT Effects of tadalafil on erectile dysfunction in men with diabetes Diabetes Care 2002 25 12 2159 2164 12453954
  • Ferrini MG Kovanecz I Sanchez S Long-term continuous treatment with sildenafil ameliorates aging-related erectile dysfunction and the underlying corporal fibrosis in the rat Biol Reprod 2007 76 5 915 923 17287493
  • Porst H Giuliano F Glina S Evaluation of the efficacy and safety of once-a-day dosing of tadalafil 5 mg and 10 mg in the treatment of erectile dysfunction: results of a multicenter, randomized, double-blind, placebo-controlled trial Eur Urol 2006 50 2 351 359 16766116
  • Bella AJ Deyoung LX Al-Numi M Brock GB Daily administration of phosphodiesterase type 5 inhibitors for urological and nonurological indications Eur Urol 2007 52 4 990 1005 17646047
  • Nehra A Jackson G Miner M The Princeton III Consensus recommendations for the management of erectile dysfunction and cardiovascular disease Mayo Clin Proc 2012 87 8 766 788 22862865
  • Williams G Abbou CC Amar ET Efficacy and safety of transurethral alprostadil therapy in men with erectile dysfunction. MUSE Study Group Br J Urol 1998 81 6 889 894 9666777
  • Padma-Nathan H Hellstrom WJ Kaiser FE Treatment of men with erectile dysfunction with transurethral alprostadil. Medicated Urethral System for Erection (MUSE) Study Group N Engl J Med 1997 336 1 1 7 8970933
  • Wang C Nieschlag E Swerdloff R Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations Eur J Endocrinol 2008 159 5 507 514 18955511
  • Jones TH Arver S Behre HM TIMES2 Investigators Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study) Diabetes Care 2011 34 4 828 837 21386088
  • Basson R Berman J Burnett A Report of the international consensus development conference on female sexual dysfunction: definitions and classifications J Urol 2000 163 3 888 893 10688001
  • Basson R Wierman ME van Lankveld J Brotto L Summary of the recommendations on sexual dysfunction in women J Sex Med 2010 7 1 Pt 2 314 326 20092441
  • American Psychiatric Association Appendix. Highlights of changes from DSM-IV to DSM-5 Diagnostic and Statistical Manual of Mental Disorders 5th ed Arlington, VA American Psychiatric Association 2013
  • Shifren JL Monz BU Russo PA Segreti A Johannes CB Sexual problems and distress in United States women: prevalence and correlates Obstet Gynecol 2008 112 5 970 978 18978095
  • Dennerstein L Randolph J Taffe J Dudley E Burger H Hormones, mood, sexuality, and the menopausal transition Fertil Steril 2002 77 Suppl 4 S42 S48 12007901
  • Lindau ST Schumm LP Laumann EO Levinson W O’Muircheartaigh CA Waite LJ A study of sexuality and health among older adults in the United States N Engl J Med 2007 357 8 762 774 17715410
  • Eyada M Atwa M Sexual function in female patients with unstable angina or non-ST-elevation myocardial infarction J Sex Med 2007 4 5 1373 1380 17451489
  • Doumas M Tsiodras S Tsakiris A Female sexual dysfunction in essential hypertension: a common problem being uncovered J Hypertens 2006 24 12 2387 2392 17082720
  • Krychman M Millheiser LS Sexual health issues in women with cancer J Sex Med 2013 10 Suppl 1 5 15 23387907
  • Peng YS Chiang CK Kao TW Sexual dysfunction in female hemodialysis patients: a multicenter study Kidney Int 2005 68 2 760 765 16014053
  • Bhasin S Enzlin P Coviello A Basson R Sexual dysfunction in men and women with endocrine disorders Lancet 2007 369 9561 597 611 17307107
  • Tyrer G Steel JM Ewing DJ Bancroft J Warner P Clarke BF Sexual responsiveness in diabetic women Diabetologia 1983 24 3 166 171 6840426
  • Enzlin P Mathieu C Vanderschueren D Demyttenaere K Diabetes mellitus and female sexuality: a review of 25 years’ research Diabet Med 1998 15 10 809 815 9796879
  • Pontiroli AE Cortelazzi D Morabito A Female sexual dysfunction and diabetes: a systematic review and meta-analysis J Sex Med 2013 10 4 1044 1051 23347454
  • Veronelli A Mauri C Zecchini B Sexual dysfunction is frequent in premenopausal women with diabetes, obesity, and hypothyroidism, and correlates with markers of increased cardiovascular risk. A preliminary report J Sex Med 2009 6 6 1561 1568 19453923
  • Esposito K Ciotola M Giugliano F Association of body weight with sexual function in women Int J Impot Res 2007 19 4 353 357 17287832
  • Castellini G Mannucci E Mazzei C Sexual function in obese women with and without binge eating disorder J Sex Med 2010 7 12 3969 3978 20722790
  • Martelli V Valisella S Moscatiello S Prevalence of sexual dysfunction among postmenopausal women with and without metabolic syndrome J Sex Med 2012 9 2 434 441 22023878
  • Berman JR Berman LA Toler SM Gill J Haughie S Sildenafil Study Group Safety and efficacy of sildenafil citrate for the treatment of female sexual arousal disorder: a double-blind, placebo controlled study J Urol 2003 170 6 Pt 1 2333 2338 14634409
  • Min K Munarriz R Kim NN Goldstein I Traish A Effects of ovariectomy and estrogen and androgen treatment on sildenafil-mediated changes in female genital blood flow and vaginal lubrication in the animal model Am J Obstet Gynecol 2002 187 5 1370 1376 12439533
  • Bargiota A Dimitropoulos K Tzortzis V Koukoulis GN Sexual dysfunction in diabetic women Hormones (Athens) 2011 10 3 196 206 22001130
  • Meeking DR Fosbury JA Cummings MH Sexual dysfunction and sexual health concerns in women with diabetes Practical Diabetes 2013 30 8 327 331
  • Muniyappa R Norton M Dunn ME Banerji MA Diabetes and female sexual dysfunction: moving beyond “benign neglect” Curr Diab Rep 2005 5 3 230 236 15929871
  • Giraldi A Persson K Werkström V Alm P Wagner G Andersson KE Effects of diabetes on neurotransmission in rat vaginal smooth muscle Int J Impot Res 2001 13 2 58 66 11426340
  • Park K Ahn K Chang JS Lee SE Ryu SB Park YI Diabetes induced alteration of clitoral hemodynamics and structure in the rabbit J Urol 2002 168 3 1269 1272 12187280
  • Park K Ryu SB Park YI Ahn K Lee SN Nam JH Diabetes mellitus induces vaginal tissue fibrosis by TGF-beta 1 expression in the rat model J Sex Marital Ther 2001 27 5 577 587 11554221
  • Kim NN Stankovic M Cushman TT Goldstein I Munarriz R Traish AM Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers BMC Physiol 2006 6 4 16734901
  • Duby JJ Campbell RK Setter SM White JR Rasmussen KA Diabetic neuropathy: an intensive review Am J Health Syst Pharm 2004 61 2 160 173 quiz 175 14750401
  • Brown JS Wessells H Chancellor MB Urologic complications of diabetes Diabetes Care 2005 28 1 177 185 15616253
  • Feldhaus-Dahir M The causes and prevalence of hypoactive sexual desire disorder: part I Urol Nurs 2009 29 4 259 260 263 19718942
  • Schram MT Baan CA Pouwer F Depression and quality of life in patients with diabetes: a systematic review from the European depression in diabetes (EDID) research consortium Curr Diabetes Rev 2009 5 2 112 119 19442096
  • Rockliffe-Fidler C Kiemle G Sexual function in diabetic women: a psychological perspective Sex Relation Ther 2003 18 2 143 159
  • Ogbera AO Chinenye S Akinlade A Eregie A Awobusuyi J Frequency and correlates of sexual dysfunction in women with diabetes mellitus J Sex Med 2009 6 12 3401 3406 19627467
  • Giugliano F Maiorino MI Di Palo C Adherence to Mediterranean diet and sexual function in women with type 2 diabetes J Sex Med 2010 7 5 1883 1890 20214715
  • Esposito K Ciotola M Giugliano F Mediterranean diet improves sexual function in women with the metabolic syndrome Int J Impot Res 2007 19 5 486 491 17673936
  • Wing RR Bond DS Gendrano IN Sexual Dysfunction Subgroup of the Look AHEAD Research Group Effect of intensive lifestyle intervention on sexual dysfunction in women with type 2 diabetes: results from an ancillary Look AHEAD study Diabetes Care 2013 36 10 2937 2944 23757437
  • Chivers ML Rosen RC Phosphodiesterase type 5 inhibitors and female sexual response: faulty protocols or paradigms? J Sex Med 2010 7 2 Pt 2 858 872 19929916
  • Uckert S Ellinghaus P Albrecht K Jonas U Oelke M Expression of messenger ribonucleic acid encoding for phosphodiesterase isoenzymes in human female genital tissues J Sex Med 2007 4 6 1604 1609 17888073