Pathophysiological Mechanisms and Clinical Associations of Non-Alcoholic Fatty Pancreas Disease

References

• Mathur A, Marine M, Lu D, et al. Nonalcoholic fatty pancreas disease. HPB. 2007;9(4):312–318. doi:10.1080/13651820701504157
   PubMedGoogle Scholar
• Filippatos TD. Non-Alcoholic Fatty Pancreas Disease: a Diagnosis of Increasing Importance. Angiology. 2022;73(6):495–496. doi:10.1177/00033197211053902
   PubMed Web of Science ®Google Scholar
• Pinnick KE, Collins SC, Londos C, Gauguier D, Clark A, Fielding BA. Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. Obesity (Silver Spring). 2008;16(3):522–530. doi:10.1038/oby.2007.110
   PubMed Web of Science ®Google Scholar
• Kovanlikaya A, Mittelman SD, Ward A, Geffner ME, Dorey F, Gilsanz V. Obesity and fat quantification in lean tissues using three-point Dixon MR imaging. Pediatr Radiol. 2005;35(6):601–607. doi:10.1007/s00247-005-1413-y
   PubMed Web of Science ®Google Scholar
• Ogilvie RF. The islands of Langerhans in 19 cases of obesity. J Pathol Bacteriol. 1933;37(3):473–481. doi:10.1002/path.1700370314
   Google Scholar
• Paul J, Shihaz AVH. Pancreatic Steatosis: a New Diagnosis and Therapeutic Challenge in Gastroenterology. Arq Gastroenterol. 2020;57(2):216–220. doi:10.1590/s0004-2803.202000000-27
   PubMedGoogle Scholar
• Smits MM, van Geenen EJ. The clinical significance of pancreatic steatosis. Nat Rev Gastroenterol Hepatol. 2011;8(3):169–177. doi:10.1038/nrgastro.2011.4
   PubMed Web of Science ®Google Scholar
• Wang CY, Ou HY, Chen MF, Chang TC, Chang CJ. Enigmatic ectopic fat: prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese population. J Am Heart Assoc. 2014;3(1):e000297. doi:10.1161/JAHA.113.000297
   PubMed Web of Science ®Google Scholar
• Wong VW, Wong GL, Yeung DK, et al. Fatty pancreas, insulin resistance, and beta-cell function: a population study using fat-water magnetic resonance imaging. Am J Gastroenterol. 2014;109(4):589–597. doi:10.1038/ajg.2014.1
   PubMed Web of Science ®Google Scholar
• Sepe PS, Ohri A, Sanaka S, et al. A prospective evaluation of fatty pancreas by using EUS. Gastrointest Endosc. 2011;73(5):987–993. doi:10.1016/j.gie.2011.01.015
   PubMed Web of Science ®Google Scholar
• Lesmana CR, Pakasi LS, Inggriani S, Aidawati ML, Lesmana LA. Prevalence of Non-Alcoholic Fatty Pancreas Disease (NAFPD) and its risk factors among adult medical check-up patients in a private hospital: a large cross sectional study. BMC Gastroenterol. 2015;15:174. doi:10.1186/s12876-015-0404-1
   PubMed Web of Science ®Google Scholar
• Al-Haddad M, Khashab M, Zyromski N, et al. Risk factors for hyperechogenic pancreas on endoscopic ultrasound: a case-control study. Pancreas. 2009;38(6):672–675. doi:10.1097/MPA.0b013e3181a9d5af
   PubMed Web of Science ®Google Scholar
• Muftah AA, Pecha RL, Riojas Barrett M, et al. Pancreatic parenchymal changes seen on endoscopic ultrasound are dynamic in the setting of fatty pancreas: a short-term follow-up study. Pancreatology. 2022;22(8):1187–1194. doi:10.1016/j.pan.2022.10.006
   PubMed Web of Science ®Google Scholar
• Ahbab S, Ünsal A, Ataoğlu HE, Can TS, Kayaş D, Savaş Y. Prediabetes and Type 2 Diabetes are Independent Risk Factors for Computed Tomography-Estimated Nonalcoholic Fatty Pancreas Disease. Clinics. 2019;74:e1337. doi:10.6061/clinics/2019/e1337
   PubMed Web of Science ®Google Scholar
• Li J, Xie Y, Yuan F, Song B, Tang C. Noninvasive quantification of pancreatic fat in healthy male population using chemical shift magnetic resonance imaging: effect of aging on pancreatic fat content. Pancreas. 2011;40(2):295–299. doi:10.1097/MPA.0b013e318201669f
   PubMed Web of Science ®Google Scholar
• Patel NS, Peterson MR, Brenner DA, Heba E, Sirlin C, Loomba R. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2013;37(6):630–639. doi:10.1111/apt.12237
   PubMed Web of Science ®Google Scholar
• Tushuizen ME, Bunck MC, Pouwels PJ, et al. Pancreatic fat content and beta-cell function in men with and without type 2 diabetes. Diabetes Care. 2007;30(11):2916–2921. doi:10.2337/dc07-0326
   PubMed Web of Science ®Google Scholar
• Ma J. Dixon techniques for water and fat imaging. J Magn Reson Imaging. 2008;28(3):543–558. doi:10.1002/jmri.21492
   PubMed Web of Science ®Google Scholar
• Reeder SB, Pineda AR, Wen Z, et al. Iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL): application with fast spin-echo imaging. Magn Reson Med. 2005;54(3):636–644. doi:10.1002/mrm.20624
   PubMed Web of Science ®Google Scholar
• Singh RG, Yoon HD, Wu LM, Lu J, Plank LD, Petrov MS. Ectopic fat accumulation in the pancreas and its clinical relevance: a systematic review, meta-analysis, and meta-regression. Metabolism. 2017;69:1–13. doi:10.1016/j.metabol.2016.12.012
   PubMed Web of Science ®Google Scholar
• Catanzaro R, Cuffari B, Italia A, Marotta F. Exploring the metabolic syndrome: nonalcoholic fatty pancreas disease. World J Gastroenterol. 2016;22(34):7660–7675. doi:10.3748/wjg.v22.i34.7660
   PubMed Web of Science ®Google Scholar
• Rugivarodom M, Geeratragool T, Pausawasdi N, Charatcharoenwitthaya P. Fatty Pancreas: linking Pancreas Pathophysiology to Nonalcoholic Fatty Liver Exploring the metabolic syndrome: nonalcoholic fatty pancreas disease Disease. J Clin Transl Hepatol. 2022;10(6):1229–1239. doi:10.14218/JCTH.2022.00085
   PubMed Web of Science ®Google Scholar
• Guglielmi V, Sbraccia P. Type 2 diabetes: does pancreatic fat really matter? Diabetes Metab Res Rev. 2018;34(2). doi:10.1002/dmrr.2955
   PubMed Web of Science ®Google Scholar
• Tannenbaum BM, Brindley DN, Tannenbaum GS, Dallman MF, McArthur MD, Meaney MJ. High-fat feeding alters both basal and stress-induced hypothalamic-pituitary-adrenal activity in the rat. Am J Physiol. 1997;273(6):E1168–1177. doi:10.1152/ajpendo.1997.273.6.E1168
   PubMedGoogle Scholar
• Kyrou I, Tsigos C. Stress mechanisms and metabolic complications. Horm Metab Res. 2007;39(6):430–438. doi:10.1055/s-2007-981462
   PubMed Web of Science ®Google Scholar
• Fraulob JC, Ogg-Diamantino R, Fernandes-Santos C, Aguila MB, Mandarim-de-Lacerda CA. A Mouse Model of Metabolic Syndrome: insulin Resistance, Fatty Liver and Non-Alcoholic Fatty Pancreas Disease (NAFPD) in C57BL/6 Mice Fed a High Fat Diet. J Clin Biochem Nutr. 2010;46(3):212–223. doi:10.3164/jcbn.09-83
   PubMed Web of Science ®Google Scholar
• Zhang X, Cui Y, Fang L, Li F. Chronic high-fat diets induce oxide injuries and fibrogenesis of pancreatic cells in rats. Pancreas. 2008;37(3):e31–38. doi:10.1097/MPA.0b013e3181744b50
   PubMed Web of Science ®Google Scholar
• Filippatos TD, Alexakis K, Mavrikaki V, Mikhailidis DP. Nonalcoholic Fatty Pancreas Disease: role in Metabolic Syndrome, “Prediabetes”, Diabetes and Atherosclerosis. Dig Dis Sci. 2022;67(1):26–41. doi:10.1007/s10620-021-06824-7
   PubMed Web of Science ®Google Scholar
• Yoshikawa H, Tajiri Y, Sako Y, Hashimoto T, Umeda F, Nawata H. Effects of free fatty acids on beta-cell functions: a possible involvement of peroxisome proliferator-activated receptors alpha or pancreatic/duodenal homeobox. Metabolism. 2001;50(5):613–618. doi:10.1053/meta.2001.22565
   PubMed Web of Science ®Google Scholar
• Walz HA, Harndahl L, Wierup N, et al. Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B. J Endocrinol. 2006;189(3):629–641. doi:10.1677/joe.1.06522
   PubMed Web of Science ®Google Scholar
• Houten SM, Wanders RJ. A general introduction to the biochemistry of mitochondrial fatty acid beta-oxidation. J Inherit Metab Dis. 2010;33(5):469–477. doi:10.1007/s10545-010-9061-2
   PubMed Web of Science ®Google Scholar
• Juge-Aubry CE, Henrichot E, Meier CA. Adipose tissue: a regulator of inflammation. Best Pract Res Clin Endocrinol Metab. 2005;19(4):547–566. doi:10.1016/j.beem.2005.07.009
   PubMed Web of Science ®Google Scholar
• Greenberg AS, Obin MS. Obesity and the role of adipose tissue in inflammation and metabolism. Am J Clin Nutr. 2006;83(2):461S–465S. doi:10.1093/ajcn/83.2.461S
   PubMed Web of Science ®Google Scholar
• Matsuda A, Makino N, Tozawa T, et al. Pancreatic fat accumulation, fibrosis, and acinar cell injury in the Zucker diabetic fatty rat fed a chronic high-fat diet. Pancreas. 2014;43(5):735–743. doi:10.1097/MPA.0000000000000129
   PubMed Web of Science ®Google Scholar
• Horii T, Kozawa J, Fujita Y, et al. Lipid droplet accumulation in beta cells in patients with type 2 diabetes is associated with insulin resistance, hyperglycemia and beta cell dysfunction involving decreased insulin granules. Front Endocrinol. 2022;13:996716. doi:10.3389/fendo.2022.996716
   PubMed Web of Science ®Google Scholar
• Petrov MS, Taylor R. Intra-pancreatic fat deposition: bringing hidden fat to the fore. Nat Rev Gastroenterol Hepatol. 2022;19(3):153–168. doi:10.1038/s41575-021-00551-0
   PubMed Web of Science ®Google Scholar
• Altinel D, Basturk O, Sarmiento JM, et al. Lipomatous pseudohypertrophy of the pancreas: a clinicopathologically distinct entity. Pancreas. 2010;39(3):392–397. doi:10.1097/MPA.0b013e3181bd2923
   PubMed Web of Science ®Google Scholar
• Yan MX, Li YQ, Meng M, Ren HB, Kou Y. Long-term high-fat diet induces pancreatic injuries via pancreatic microcirculatory disturbances and oxidative stress in rats with hyperlipidemia. Biochem Biophys Res Commun. 2006;347(1):192–199. doi:10.1016/j.bbrc.2006.06.063
   PubMed Web of Science ®Google Scholar
• Lee Y, Lingvay I, Szczepaniak LS, Ravazzola M, Orci L, Unger RH. Pancreatic steatosis: harbinger of type 2 diabetes in obese rodents. Int J Obes Lond. 2010;34(2):396–400. doi:10.1038/ijo.2009.245
   PubMed Web of Science ®Google Scholar
• Lopez JM, Bombi JA, Valderrama R, et al. Effects of prolonged ethanol intake and malnutrition on rat pancreas. Gut. 1996;38(2):285–292. doi:10.1136/gut.38.2.285
   PubMed Web of Science ®Google Scholar
• Chang ML. Fatty Pancreas-Centered Metabolic Basis of Pancreatic Adenocarcinoma: from Obesity, Diabetes and Pancreatitis to Oncogenesis. Biomedicines. 2022;10(3). doi:10.3390/biomedicines10030692
   Web of Science ®Google Scholar
• Silva L, Fernandes MSS, Lima EA, Stefano JT, Oliveira CP, Jukemura J. Fatty Pancreas: disease or Finding? Clinics (Sao Paulo). 2021;76:e2439. doi:10.6061/clinics/2021/e2439
   PubMed Web of Science ®Google Scholar
• Patel S, Bellon EM, Haaga J, Park CH. Fat replacement of the exocrine pancreas. AJR Am J Roentgenol. 1980;135(4):843–845. doi:10.2214/ajr.135.4.843
   PubMed Web of Science ®Google Scholar
• den Boer M, Voshol PJ, Kuipers F, Havekes LM, Romijn JA. Hepatic steatosis: a mediator of the metabolic syndrome. Lessons from animal models. Arterioscler Thromb Vasc Biol. 2004;24(4):644–649. doi:10.1161/01.ATV.0000116217.57583.6e
   PubMed Web of Science ®Google Scholar
• Nunez-Duran E, Chanclon B, Sutt S, et al. Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in mice. J Endocrinol. 2017;234(1):15–27. doi:10.1530/JOE-17-0018
   PubMed Web of Science ®Google Scholar
• Pinte L, Balaban DV, Baicus C, Jinga M. Non-alcoholic fatty pancreas disease - practices for clinicians. Rom J Intern Med. 2019;57(3):209–219. doi:10.2478/rjim-2019-0005
   PubMed Web of Science ®Google Scholar
• Nascimento FA, Barbosa-da-silva S, Fernandes-Santos C, Mandarim-de-Lacerda CA, Aguila MB. Adipose tissue, liver and pancreas structural alterations in C57BL/6 mice fed high-fat-high-sucrose diet supplemented with fish oil (n-3 fatty acid rich oil). Exp Toxicol Pathol. 2010;62(1):17–25. doi:10.1016/j.etp.2008.12.008
   PubMedGoogle Scholar
• Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci U S A. 1994;91(23):10878–10882. doi:10.1073/pnas.91.23.10878
   PubMed Web of Science ®Google Scholar
• Chitturi S, Abeygunasekera S, Farrell GC, et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology. 2002;35(2):373–379. doi:10.1053/jhep.2002.30692
   PubMed Web of Science ®Google Scholar
• Bollheimer LC, Skelly RH, Chester MW, McGarry JD, Rhodes CJ. Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin Invest. 1998;101(5):1094–1101. doi:10.1172/JCI420
   PubMed Web of Science ®Google Scholar
• Lin M, Weng SY, Chai KF, Mao ZJ. Lipidomics as a tool of predicting progression from non-alcoholic fatty pancreas disease to type 2 diabetes mellitus. RSC Adv. 2019;9(71):41419–41430. doi:10.1039/c9ra07071k
   PubMed Web of Science ®Google Scholar
• Bonora E. The metabolic syndrome and cardiovascular disease. Ann Med. 2006;38(1):64–80. doi:10.1080/07853890500401234
   PubMed Web of Science ®Google Scholar
• Yu TY, Wang CY. Impact of non-alcoholic fatty pancreas disease on glucose metabolism. J Diabetes Investig. 2017;8(6):735–747. doi:10.1111/jdi.12665
   PubMed Web of Science ®Google Scholar
• Fernandes-Santos C, Evangelista Carneiro R, de Souza Mendonca L, Barbosa Aguila M, Mandarim-de-Lacerda CA. Rosiglitazone aggravates nonalcoholic Fatty pancreatic disease in C57BL/6 mice fed high-fat and high-sucrose diet. Pancreas. 2009;38(3):e80–86. doi:10.1097/MPA.0b013e3181987d9d
   PubMed Web of Science ®Google Scholar
• Fields M, Lewis CG. Impaired endocrine and exocrine pancreatic functions in copper-deficient rats: the effect of gender. J Am Coll Nutr. 1997;16(4):346–351. doi:10.1080/07315724.1997.10718696
   PubMed Web of Science ®Google Scholar
• Tarantino G, Porcu C, Arciello M, Andreozzi P, Balsano C. Prediction of carotid intima-media thickness in obese patients with low prevalence of comorbidities by serum copper bioavailability. J Gastroenterol Hepatol. 2018;33(8):1511–1517. doi:10.1111/jgh.14104
   PubMed Web of Science ®Google Scholar
• Walters MN. Adipose atrophy of the exocrine pancreas. J Pathol Bacteriol. 1966;92(2):547–557. doi:10.1002/path.1700920232
   PubMedGoogle Scholar
• de Wilde J, Mohren R, van den Berg S, et al. Short-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice. Physiol Genomics. 2008;32(3):360–369. doi:10.1152/physiolgenomics.00219.2007
   PubMed Web of Science ®Google Scholar
• Emery MG, Fisher JM, Chien JY, et al. CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease. Hepatology. 2003;38(2):428–435. doi:10.1053/jhep.2003.50342
   PubMed Web of Science ®Google Scholar
• Chtioui H, Semela D, Ledermann M, Zimmermann A, Dufour JF. Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis. Liver Int. 2007;27(6):764–771. doi:10.1111/j.1478-3231.2007.01524.x
   PubMed Web of Science ®Google Scholar
• Ikejima K, Okumura K, Kon K, Takei Y, Sato N. Role of adipocytokines in hepatic fibrogenesis. J Gastroenterol Hepatol. 2007;22(Suppl 1):S87–92. doi:10.1111/j.1440-1746.2007.04961.x
   PubMedGoogle Scholar
• Nerstedt A, Cansby E, Andersson CX, et al. Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal muscle. Diabetologia. 2012;55(6):1797–1807. doi:10.1007/s00125-012-2511-7
   PubMed Web of Science ®Google Scholar
• Chursa U, Nunez-Duran E, Cansby E, et al. Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle. Diabetologia. 2017;60(3):553–567. doi:10.1007/s00125-016-4171-5
   PubMed Web of Science ®Google Scholar
• Amrutkar M, Cansby E, Chursa U, et al. Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model. Diabetes. 2015;64(8):2791–2804. doi:10.2337/db15-0060
   PubMed Web of Science ®Google Scholar
• Amrutkar M, Cansby E, Nunez-Duran E, et al. Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH. FASEB J. 2015;29(4):1564–1576. doi:10.1096/fj.14-264937
   PubMed Web of Science ®Google Scholar
• Amrutkar M, Chursa U, Kern M, et al. STK25 is a critical determinant in nonalcoholic steatohepatitis. FASEB J. 2016;30(10):3628–3643. doi:10.1096/fj.201600562R
   PubMed Web of Science ®Google Scholar
• Munzberg H, Flier JS, Bjorbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology. 2004;145(11):4880–4889. doi:10.1210/en.2004-0726
   PubMed Web of Science ®Google Scholar
• Akagiri S, Naito Y, Ichikawa H, et al. A Mouse Model of Metabolic Syndrome; Increase in Visceral Adipose Tissue Precedes the Development of Fatty Liver and Insulin Resistance in High-Fat Diet-Fed Male KK/Ta Mice. J Clin Biochem Nutr. 2008;42(2):150–157. doi:10.3164/jcbn.2008022
   PubMed Web of Science ®Google Scholar
• Al-Ani Z, Ko J, Petrov MS. Intra-pancreatic fat deposition across the pancreatitis spectrum and the influence of gut hormones. Dig Liver Dis. 2023;55(8):1081–1090. doi:10.1016/j.dld.2023.02.013
   PubMedGoogle Scholar
• Finelli C, Padula MC, Martelli G, Tarantino G. Could the improvement of obesity-related co-morbidities depend on modified gut hormones secretion? World J Gastroenterol. 2014;20(44):16649–16664. doi:10.3748/wjg.v20.i44.16649
   PubMed Web of Science ®Google Scholar
• Begovatz P, Koliaki C, Weber K, et al. Pancreatic adipose tissue infiltration, parenchymal steatosis and beta cell function in humans. Diabetologia. 2015;58(7):1646–1655. doi:10.1007/s00125-015-3544-5
   PubMed Web of Science ®Google Scholar
• Heni M, Machann J, Staiger H, et al. Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study. Diabetes Metab Res Rev. 2010;26(3):200–205. doi:10.1002/dmrr.1073
   PubMed Web of Science ®Google Scholar
• Ozturk K, Uygun A, Guler AK, et al. Nonalcoholic fatty liver disease is an independent risk factor for atherosclerosis in young adult men. Atherosclerosis. 2015;240(2):380–386. doi:10.1016/j.atherosclerosis.2015.04.009
   PubMed Web of Science ®Google Scholar
• Li YX, Sang YQ, Sun Y, et al. Pancreatic Fat is not significantly correlated with beta-cell Dysfunction in Patients with new-onset Type 2 Diabetes Mellitus using quantitative Computed Tomography. Int J Med Sci. 2020;17(12):1673–1682. doi:10.7150/ijms.46395
   PubMed Web of Science ®Google Scholar
• van Geenen EJ, Smits MM, Schreuder TC, van der Peet DL, Bloemena E, Mulder CJ. Nonalcoholic fatty liver disease is related to nonalcoholic fatty pancreas disease. Pancreas. 2010;39(8):1185–1190. doi:10.1097/MPA.0b013e3181f6fce2
   PubMed Web of Science ®Google Scholar
• Wu S, Wu F, Ding Y, Hou J, Bi J, Zhang Z. Association of non-alcoholic fatty liver disease with major adverse cardiovascular events: a systematic review and meta-analysis. Sci Rep. 2016;6:33386. doi:10.1038/srep33386
   PubMed Web of Science ®Google Scholar
• Sijens PE, Edens MA, Bakker SJ, Stolk RP. MRI-determined fat content of human liver, pancreas and kidney. World J Gastroenterol. 2010;16(16):1993–1998. doi:10.3748/wjg.v16.i16.1993
   PubMed Web of Science ®Google Scholar
• Della Corte C, Mosca A, Majo F, et al. Nonalcoholic fatty pancreas disease and Nonalcoholic fatty liver disease: more than ectopic fat. Clin Endocrinol (Oxf). 2015;83(5):656–662. doi:10.1111/cen.12862
   PubMed Web of Science ®Google Scholar
• Patel NS, Peterson MR, Lin GY, et al. Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls. Gastroenterol Res Pract. 2013;2013:498296. doi:10.1155/2013/498296
   PubMed Web of Science ®Google Scholar
• Schwenzer NF, Machann J, Martirosian P, et al. Quantification of pancreatic lipomatosis and liver steatosis by MRI: comparison of in/opposed-phase and spectral-spatial excitation techniques. Invest Radiol. 2008;43(5):330–337. doi:10.1097/RLI.0b013e31816a88c6
   PubMed Web of Science ®Google Scholar
• Rathod A, Neema S, Radhakrishnan S, Vendhan S, Tripathy DM, Vasudevan B. Palmoplantar Plaque Psoriasis is Associated with Diabetes, Hypertension, Obesity, and Metabolic Syndrome-A Case-Control Study. Indian Dermatol Online J. 2022;13(5):606–610. doi:10.4103/idoj.idoj_59_22
   PubMedGoogle Scholar
• Jensen P, Skov L. Psoriasis and Obesity. Dermatology. 2016;232(6):633–639. doi:10.1159/000455840
   PubMed Web of Science ®Google Scholar
• Hao Y, Zhu YJ, Zou S, et al. Metabolic Syndrome and Psoriasis: mechanisms and Future Directions. Front Immunol. 2021;12:711060. doi:10.3389/fimmu.2021.711060
   PubMed Web of Science ®Google Scholar
• Balato N, Napolitano M, Ayala F, Patruno C, Megna M, Tarantino G. Nonalcoholic fatty liver disease, spleen and psoriasis: new aspects of low-grade chronic inflammation. World J Gastroenterol. 2015;21(22):6892–6897. doi:10.3748/wjg.v21.i22.6892
   PubMed Web of Science ®Google Scholar
• Białecka A. Evaluation of pancreatic function in patients with plaque psoriasis. Postepy Dermatol Alergol. 2023;40(3):372–376. doi:10.5114/ada.2023.129400
   PubMed Web of Science ®Google Scholar
• Haslam DW, James WP. Obesity. Lancet. 2005;366(9492):1197–1209. doi:10.1016/S0140-6736(05)67483-1
   PubMed Web of Science ®Google Scholar
• Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature. 2006;444(7121):875–880. doi:10.1038/nature05487
   PubMed Web of Science ®Google Scholar
• Panuganti KK, Nguyen M, Kshirsagar RK. Obesity. Statpearls, Treasure Island. 2022.
   Google Scholar
• Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112(17):2735–2752. doi:10.1161/CIRCULATIONAHA.105.169404
   PubMed Web of Science ®Google Scholar
• Lee JS, Kim SH, Jun DW, et al. Clinical implications of fatty pancreas: correlations between fatty pancreas and metabolic syndrome. World J Gastroenterol. 2009;15(15):1869–1875. doi:10.3748/wjg.15.1869
   PubMed Web of Science ®Google Scholar
• Wu WC, Wang CY. Association between non-alcoholic fatty pancreatic disease (NAFPD) and the metabolic syndrome: case-control retrospective study. Cardiovasc Diabetol. 2013;12:77. doi:10.1186/1475-2840-12-77
   PubMed Web of Science ®Google Scholar
• Ozturk K, Dogan T, Celikkanat S, et al. The association of fatty pancreas with subclinical atherosclerosis in nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol. 2018;30(4):411–417. doi:10.1097/MEG.0000000000001059
   PubMed Web of Science ®Google Scholar
• Seppala-Lindroos A, Vehkavaara S, Hakkinen AM, et al. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab. 2002;87(7):3023–3028. doi:10.1210/jcem.87.7.8638
   PubMed Web of Science ®Google Scholar
• Gabriely I, Ma XH, Yang XM, et al. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes. 2002;51(10):2951–2958. doi:10.2337/diabetes.51.10.2951
   PubMed Web of Science ®Google Scholar
• Kotronen A, Seppala-Lindroos A, Bergholm R, Yki-Jarvinen H. Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome. Diabetologia. 2008;51(1):130–138. doi:10.1007/s00125-007-0867-x
   PubMed Web of Science ®Google Scholar
• Milburn JL Jr, Hirose H, Lee YH, et al. Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids. J Biol Chem. 1995;270(3):1295–1299. doi:10.1074/jbc.270.3.1295
   PubMed Web of Science ®Google Scholar
• Lingvay I, Esser V, Legendre JL, et al. Noninvasive quantification of pancreatic fat in humans. J Clin Endocrinol Metab. 2009;94(10):4070–4076. doi:10.1210/jc.2009-0584
   PubMed Web of Science ®Google Scholar
• Yamazaki H, Tsuboya T, Katanuma A, et al. Lack of Independent Association Between Fatty Pancreas and Incidence of Type 2 Diabetes: 5-Year Japanese Cohort Study. Diabetes Care. 2016;39(10):1677–1683. doi:10.2337/dc16-0074
   PubMed Web of Science ®Google Scholar
• Raeder H, Haldorsen IS, Ersland L, et al. Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase. Diabetes. 2007;56(2):444–449. doi:10.2337/db06-0859
   PubMed Web of Science ®Google Scholar
• Lim S, Meigs JB. Links between ectopic fat and vascular disease in humans. Arterioscler Thromb Vasc Biol. 2014;34(9):1820–1826. doi:10.1161/ATVBAHA.114.303035
   PubMed Web of Science ®Google Scholar
• Chung GE, Choi SY, Kim D, et al. Nonalcoholic fatty liver disease as a risk factor of arterial stiffness measured by the cardioankle vascular index. Medicine (Baltimore). 2015;94(12):e654. doi:10.1097/MD.0000000000000654
   PubMed Web of Science ®Google Scholar
• Ozturk K, Guler AK, Cakir M, et al. Pulse Wave Velocity, Intima Media Thickness, and Flow-mediated Dilatation in Patients with Normotensive Normoglycemic Inflammatory Bowel Disease. Inflamm Bowel Dis. 2015;21(6):1314–1320. doi:10.1097/MIB.0000000000000355
   PubMed Web of Science ®Google Scholar
• Rasool A, Dar W, Latief M, Dar I, Sofi N, Khan MA. Nonalcoholic fatty liver disease as an independent risk factor for carotid atherosclerosis. Brain Circ. 2017;3(1):35–40. doi:10.4103/bc.bc_28_16
   PubMedGoogle Scholar
• Fracanzani AL, Tiraboschi S, Pisano G, et al. Progression of carotid vascular damage and cardiovascular events in non-alcoholic fatty liver disease patients compared to the general population during 10 years of follow-up. Atherosclerosis. 2016;246:208–213. doi:10.1016/j.atherosclerosis.2016.01.016
   PubMed Web of Science ®Google Scholar
• Li N, Zhang GW, Zhang JR, et al. Non-alcoholic fatty liver disease is associated with progression of arterial stiffness. Nutr, Metab Cardiovasc Dis. 2015;25(2):218–223. doi:10.1016/j.numecd.2014.10.002
   PubMed Web of Science ®Google Scholar
• Zheng J, Zhou Y, Zhang K, et al. Association between nonalcoholic fatty liver disease and subclinical atherosclerosis: a cross-sectional study on population over 40 years old. BMC Cardiovasc Disord. 2018;18(1):147. doi:10.1186/s12872-018-0877-2
   PubMedGoogle Scholar
• Sahin S, Yerlikaya MG, Ozderya A, et al. Non-Alcoholic Fatty Pancreas Disease is Associated with SYNTAX Score in Acute Coronary Syndrome. Acta Cardiol Sin. 2022;38(6):683–690. doi:10.6515/ACS.202211_38(6).20220424A
   PubMed Web of Science ®Google Scholar
• Kul S, Karadeniz A, Dursun I, et al. Non-Alcoholic Fatty Pancreas Disease is Associated with Increased Epicardial Adipose Tissue and Aortic Intima-Media Thickness. Acta Cardiol Sin. 2019;35(2):118–125. doi:10.6515/ACS.201903_35(2).20181009A
   PubMed Web of Science ®Google Scholar
• Pitt HA. Hepato-pancreato-biliary fat: the good, the bad and the ugly. HPB. 2007;9(2):92–97. doi:10.1080/13651820701286177
   PubMedGoogle Scholar
• Zyromski NJ, Mathur A, Pitt HA, et al. A murine model of obesity implicates the adipokine milieu in the pathogenesis of severe acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2008;295(3):G552–558. doi:10.1152/ajpgi.90278.2008
   PubMed Web of Science ®Google Scholar
• Sbeit W, Khoury T. Fatty Pancreas Represents a Risk Factor for Acute Pancreatitis: a Pilot Study. Pancreas. 2021;50(7):990–993. doi:10.1097/MPA.0000000000001867
   PubMed Web of Science ®Google Scholar
• Arslan AA, Helzlsouer KJ, Kooperberg C, et al. Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). Arch Intern Med. 2010;170(9):791–802. doi:10.1001/archinternmed.2010.63
   PubMedGoogle Scholar
• Lesmana CRA, Gani RA, Lesmana LA. Non-alcoholic fatty pancreas disease as a risk factor for pancreatic cancer based on endoscopic ultrasound examination among pancreatic cancer patients: a single-center experience. JGH Open. 2018;2(1):4–7. doi:10.1002/jgh3.12032
   PubMedGoogle Scholar
• Hori M, Takahashi M, Hiraoka N, et al. Association of pancreatic Fatty infiltration with pancreatic ductal adenocarcinoma. Clin Transl Gastroenterol. 2014;5(3):e53. doi:10.1038/ctg.2014.5
   PubMed Web of Science ®Google Scholar
• Khoury T, Sbeit W. Fatty Pancreas and Pancreatic Cancer: an Overlooked Association? J Clin Med. 2022;11(3). doi:10.3390/jcm11030763
   Web of Science ®Google Scholar
• Mathur A, Zyromski NJ, Pitt HA, et al. Pancreatic steatosis promotes dissemination and lethality of pancreatic cancer. J Am Coll Surg. 2009;208(5):989–994. doi:10.1016/j.jamcollsurg.2008.12.026
   PubMed Web of Science ®Google Scholar
• Zhang CL, Wang JJ, Li JN, Yang Y. Nonalcoholic fatty pancreas disease: an emerging clinical challenge. World J Clin Cases. 2021;9(23):6624–6638. doi:10.12998/wjcc.v9.i23.6624
   PubMed Web of Science ®Google Scholar
• Rizos CV, Liberopoulos EN, Mikhailidis DP, Elisaf MS. Pleiotropic effects of thiazolidinediones. Expert Opin Pharmacother. 2008;9(7):1087–1108. doi:10.1517/14656566.9.7.1087
   PubMed Web of Science ®Google Scholar
• Gottlieb S. Company played down drug’s risks, report says. BMJ. 2001;322(7288).
   Google Scholar
• Jia DM, Fukumitsu KI, Tabaru A, Akiyama T, Otsuki M. Troglitazone stimulates pancreatic growth in congenitally CCK-A receptor-deficient OLETF rats. Am J Physiol Regul Integr Comp Physiol. 2001;280(5):R1332–1340. doi:10.1152/ajpregu.2001.280.5.R1332
   PubMed Web of Science ®Google Scholar
• Fang T, Huang S, Chen Y, Chen Z, Chen J, Hu W. Glucagon Like Peptide-1 Receptor Agonists Alter Pancreatic and Hepatic Histology and Regulation of Endoplasmic Reticulum Stress in High-fat Diet Mouse Model. Exp Clin Endocrinol Diabetes. 2021;129(9):625–633. doi:10.1055/a-1240-4936
   PubMed Web of Science ®Google Scholar
• Akoumianakis I, Zagaliotis A, Konstantaraki M, Filippatos TD. GLP-1 analogs and regional adiposity: a systematic review and meta-analysis. Obes Rev. 2023;e13574. doi:10.1111/obr.13574
   PubMed Web of Science ®Google Scholar
• Souza-Mello V, Gregório BM, Relvas-Lucas B, da Silva Faria T, Aguila MB, Mandarim-de-Lacerda CA. Pancreatic ultrastructural enhancement due to telmisartan plus sitagliptin treatment in diet-induced obese C57BL/6 mice. Pancreas. 2011;40(5):715–722. doi:10.1097/MPA.0b013e3182153922
   PubMed Web of Science ®Google Scholar
• Salman AA, Salman MA, Said M, et al. Improvement of Pancreatic Steatosis and Indices of Insulin Resistance After Metabolic Surgery. Front Med Lausanne. 2022;9:894465. doi:10.3389/fmed.2022.894465
   PubMed Web of Science ®Google Scholar
• Rinella ME, Lazarus JV, Ratziu V, et al. A multi-society Delphi consensus statement on new fatty liver disease nomenclature. Ann Hepatol. 2023:101133. doi:10.1016/j.aohep.2023.101133
   PubMed Web of Science ®Google Scholar
• Rinella ME, Lazarus JV, Ratziu V, et al. A multi-society Delphi consensus statement on new fatty liver disease nomenclature. J Hepatol. 2023. doi:10.1016/j.jhep.2023.06.003
   Google Scholar
• Rinella ME, Lazarus JV, Ratziu V, et al. A multi-society Delphi consensus statement on new fatty liver disease nomenclature. Hepatology. 2023. doi:10.1097/hep.0000000000000520
   Web of Science ®Google Scholar