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REVIEW

Metabolic Syndrome and Tendon Disease: A Comprehensive Review

, , , , , , & show all
Pages 1597-1609 | Received 11 Jan 2024, Accepted 21 Mar 2024, Published online: 08 Apr 2024

References

  • Kylin E. Studien ueber das hypertonie-hyperglykamie-hyperurikamiesyndrom. Zentralblatt Fuer Innere Med. 1923;44:105–127.
  • Vague J. Sexual differentiation, a factor affecting the forms of obesity. Presse Medl. 1947;53:339–340.
  • Reaven GM. Role of insulin resistance in human disease. Diabetes. 1988;37:1595–1607. doi:10.2337/diab.37.12.1595
  • Kaplan NM. The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med. 1989;149(7):1514–1520. doi:10.1001/archinte.1989.00390070054005
  • DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care. 1991;14(3):173–194. doi:10.2337/diacare.14.3.173
  • Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, Stern MP. Prospective analysis of the insulin-resistance syndrome (syndrome X). Diabetes. 1992;41(6):715–722. doi:10.2337/diab.41.6.715
  • Cornier MA, Dabelea D, Hernandez TL, et al. The MS. Endocr Rev. 2008;29(7):777–822. doi:10.1210/er.2008-0024
  • Després JP, Lemieux I. Abdominal obesity and MS. Nature. 2006;444(7121):881–887. doi:10.1038/nature05488
  • Anderson PJ, Critchley JA, Chan JC, et al. Factor analysis of the MS: obesity vs insulin resistance as the central abnormality. Int J Obes Relat Metab Disord. 2001;25(12):1782–1788. doi:10.1038/sj.ijo.0801837
  • Nakamura T, Tokunaga K, Shimomura I, et al. Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men. Atherosclerosis. 1994;107(2):239–246. doi:10.1016/0021-9150(94)90025-6
  • Stern M. Natural history of macrovascular disease in type 2 diabetes. Role of Insulin Resistance. Diabetes Care. 1999;22(3):C2–C5.
  • Huang PL. A comprehensive definition for MS. Dis Model Mech. 2009;2(5–6):231–237. doi:10.1242/dmm.001180
  • Lakka HM, Laaksonen DE, Lakka TA, et al. The MS and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002;288(21):2709–2716. doi:10.1001/jama.288.21.2709
  • Malik S, Wong ND, Franklin SS, et al. Impact of the MS on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation. 2004;110(10):1245–1250. doi:10.1161/01.CIR.0000140677.20606.0E
  • Gami AS, Witt BJ, Howard DE, et al. MS and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol. 2007;49(4):403–414. doi:10.1016/j.jacc.2006.09.032
  • Dekker JM, Girman C, Rhodes T, et al. MS and 10-year cardiovascular disease risk in the Hoorn Study. Circulation. 2005;112(5):666–673. doi:10.1161/CIRCULATIONAHA.104.516948
  • Zhuo Q, Yang W, Chen J, Wang Y. MS meets osteoarthritis. Nat Rev Rheumatol. 2012;8(12):729–737. doi:10.1038/nrrheum.2012.135
  • Yang L, Lv X, Wei D, Yue F, Guo J, Zhang T. MS and the risk of bone fractures: a Meta-analysis of prospective cohort studies. Bone. 2016;84:52–56. doi:10.1016/j.bone.2015.12.008
  • Babagoli M, Soleimani M, Baghdadi S, Vatan MS, Shafiei SH. Does MS increase the risk of fracture? A systematic review and meta-analysis. Arch Osteoporos. 2022;17(1):118. doi:10.1007/s11657-022-01149-y
  • Skovgaard D, Siersma VD, Klausen SB, et al. Chronic hyperglycemia, hypercholesterolemia, and MS are associated with risk of tendon injury. Scand J Med Sci Sports. 2021;31(9):1822–1831. doi:10.1111/sms.13984
  • Alberti KG, Zimmet PZ. Definition, diagnosis and classification of DM and its complications. Part 1: diagnosis and classification of DM provisional report of a WHO consultation. Diabet Med. 1998;15(7):539–553. doi:10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
  • Balkau B, Charles MA. Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR). Diabet Med. 1999;16(5):442–443.
  • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;285(19):2486–2497. doi:10.1001/jama.285.19.2486
  • Bloomgarden ZT. American Association of Clinical Endocrinologists (AACE) consensus conference on the insulin resistance syndrome: 25–26 August 2002, Washington, DC. Diabetes Care. 2003;26(4):1297–1303. doi:10.2337/diacare.26.4.1297
  • Alberti KG, Zimmet P, Shaw J. MS--A new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med. 2006;23(5):469–480. doi:10.1111/j.1464-5491.2006.01858.x
  • Ateschrang A, Eggensperger F, Ahrend MD, Schröter S, Stöckle U, Kraus TM. Obesity causes poorer clinical results and higher re-tear rates in rotator cuff repair. Arch Orthop Trauma Surg. 2018;138(6):835–842. doi:10.1007/s00402-018-2921-1
  • Abate M, Salini V, Andia I. How Obesity Affects Tendons? Adv Exp Med Biol. 2016;920:167–177.
  • Warrender WJ, Brown OL, Abboud JA. Outcomes of arthroscopic rotator cuff repairs in obese patients. J Shoulder Elbow Surg. 2011;20(6):961–967. doi:10.1016/j.jse.2010.11.006
  • Namdari S, Baldwin K, Glaser D, Green A. Does obesity affect early outcome of rotator cuff repair? J Shoulder Elbow Surg. 2010;19(8):1250–1255. doi:10.1016/j.jse.2010.03.003
  • David MA, Jones KH, Inzana JA, Zuscik MJ, Awad HA, Mooney RA. Tendon repair is compromised in a high fat diet-induced mouse model of obesity and type 2 diabetes. PLoS One. 2014;9(3):e91234. doi:10.1371/journal.pone.0091234
  • Oliva F, Marsilio E, Asparago G, et al. Achilles tendon rupture and dysmetabolic diseases: a multicentric, epidemiologic study. J Clin Med. 2022;11(13):3698. doi:10.3390/jcm11133698
  • Collins KH, Herzog W, MacDonald GZ, et al. Obesity, metabolic syndrome, and musculoskeletal disease: common inflammatory pathways suggest a central role for loss of muscle integrity. Front Physiol. 2018;9:112. doi:10.3389/fphys.2018.00112
  • Abate M. How obesity modifies tendons (implications for athletic activities). Muscles Ligaments Tendons J. 2014;4(3):298–302. doi:10.32098/mltj.03.2014.06
  • Battery L, Maffulli N. Inflammation in overuse tendon injuries. Sports Med Arthrosc Rev. 2011;19(3):213–217. doi:10.1097/JSA.0b013e31820e6a92
  • Frey C, Zamora J. The effects of obesity on orthopaedic foot and ankle pathology. Foot Ankle Int. 2007;28(9):996–999. doi:10.3113/FAI.2007.0996
  • Bolam SM, Konar S, Park YE, et al. A high-fat diet has negative effects on tendon resident cells in an in vivo rat model. Int Orthop. 2022;46(5):1181–1190. doi:10.1007/s00264-022-05340-1
  • Abate M, Oliva F, Schiavone C, Salini V. Achilles tendinopathy in amateur runners: role of adiposity (Tendinopathies and obesity). Muscles Ligaments Tendons J. 2012;2(1):44–48.
  • Abate M, Schiavone C, Di Carlo L, Salini V. Achilles tendon and plantar fascia in recently diagnosed type II diabetes: role of body mass index. Clin Rheumatol. 2012;31(7):1109–1113. doi:10.1007/s10067-012-1955-y
  • Wearing SC, Hooper SL, Grigg NL, Nolan G, Smeathers JE. Overweight and obesity alters the cumulative transverse strain in the Achilles tendon immediately following exercise. J Bodyw Mov Ther. 2013;17(3):316–321. doi:10.1016/j.jbmt.2012.11.004
  • Grewal N, Thornton GM, Behzad H, et al. Accumulation of oxidized LDL in the tendon tissues of C57BL/6 or apolipoprotein E knock-out mice that consume a high fat diet: potential impact on tendon health. PLoS One. 2014;9(12):e114214. doi:10.1371/journal.pone.0114214
  • Eriksen C, Svensson RB, Scheijen J, et al. Systemic stiffening of mouse tail tendon is related to dietary advanced glycation end products but not high-fat diet or cholesterol. J Appl Physiol. 2014;117(8):840–847. doi:10.1152/japplphysiol.00584.2014
  • Boivin GP, Platt KM, Corbett J, et al. The effects of high-fat diet, branched-chain amino acids and exercise on female C57BL/6 mouse Achilles tendon biomechanical properties. Bone Joint Res. 2013;2(9):186–192. doi:10.1302/2046-3758.29.2000196
  • Rios JL, Ko L, Joumaa V, et al. The mechanical and biochemical properties of tail tendon in a rat model of obesity: effect of moderate exercise and prebiotic fibre supplementation. J Biomech. 2019;88:148–154. doi:10.1016/j.jbiomech.2019.03.031
  • Batista F, Nery C, Pinzur M, et al. Achilles tendinopathy in DM. Foot Ankle Int. 2008;29(5):498–501. doi:10.3113/FAI.2008.0498
  • Bedi A, Fox AJ, Harris PE, et al. DM impairs tendon-bone healing after rotator cuff repair. J Shoulder Elbow Surg. 2010;19(7):978–988. doi:10.1016/j.jse.2009.11.045
  • Kiortsis DN, Argyropoulou MI, Xydis V, Tsouli SG, Elisaf MS. Correlation of Achilles tendon thickness evaluated by ultrasonography with carotid intima-media thickness in patients with familial hypercholesterolemia. Atherosclerosis. 2006;186(1):228–229. doi:10.1016/j.atherosclerosis.2006.02.002
  • Hast MW, Abboud JA, Soslowsky LJ. Exploring the role of hypercholesterolemia in tendon health and repair. Muscles Ligaments Tendons J. 2014;4(3):275–279. doi:10.32098/mltj.03.2014.02
  • Holmes GB, Mann RA. Possible epidemiological factors associated with rupture of the posterior tibial tendon. Foot Ankle. 1992;13(2):70–79. doi:10.1177/107110079201300204
  • Ahmed AS, Schizas N, Li J, et al. Type 2 diabetes impairs tendon repair after injury in a rat model. J Appl Physiol. 2012;113(11):1784–1791. doi:10.1152/japplphysiol.00767.2012
  • Cho NS, Moon SC, Jeon JW, Rhee YG. The influence of DM on clinical and structural outcomes after arthroscopic rotator cuff repair. Am J Sports Med. 2015;43(4):991–997. doi:10.1177/0363546514565097
  • Thomas SJ, McDougall C, Brown ID, et al. Prevalence of symptoms and signs of shoulder problems in people with DM. J Shoulder Elbow Surg. 2007;16(6):748–751. doi:10.1016/j.jse.2007.02.133
  • Bunker TD, Anthony PP. The pathology of frozen shoulder. A Dupuytren-like disease. J Bone Joint Surg Br. 1995;77(5):677–683. doi:10.1302/0301-620X.77B5.7559688
  • Balci N, Balci MK, Tüzüner S. Shoulder adhesive capsulitis and shoulder range of motion in type II DM: association with diabetic complications. J Diabetes Complications. 1999;13(3):135–140. doi:10.1016/S1056-8727(99)00037-9
  • Bridgman JF. Periarthritis of the shoulder and DM. Ann Rheum Dis. 1972;31(1):69–71. doi:10.1136/ard.31.1.69
  • Soslowsky LJ, Fryhofer GW. Tendon Homeostasis in Hypercholesterolemia. Adv Exp Med Biol. 2016;920:151–165.
  • An L, Gao L, Ning M, et al. [Correlation between decreased plasma miR-29a and vascular endothelial injury induced by hyperlipidemia]. Korrelation zwischen verringertem Plasma-miR-29a-Wert und durch Hyperlipidämie induzierten vaskulären endothelialen Läsionen. Herz. 2023;48(4):301–308. doi:10.1007/s00059-022-05121-x
  • Ridker PM, Bhatt DL, Pradhan AD, et al. Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials. Lancet. 2023;401(10384):1293–1301. doi:10.1016/S0140-6736(23)00215-5
  • Rothman RH, Parke WW. The vascular anatomy of the rotator cuff. Clin Orthop Relat Res. 1965;41:176–186.
  • Sijbrands EJ. Xanthomas and atheromas. Atherosclerosis. 2017;263:315. doi:10.1016/j.atherosclerosis.2017.06.003
  • Tsouli SG, Kiortsis DN, Argyropoulou MI, Mikhailidis DP, Elisaf MS. Pathogenesis, detection and treatment of Achilles tendon xanthomas. Eur J Clin Invest. 2005;35(4):236–244. doi:10.1111/j.1365-2362.2005.01484.x
  • Taylor B, Cheema A, Soslowsky L. Tendon pathology in hypercholesterolemia and familial hypercholesterolemia. Curr Rheumatol Rep. 2017;19(12):76. doi:10.1007/s11926-017-0704-2
  • Ozgurtas T, Yildiz C, Serdar M, Atesalp S, Kutluay T. Is high concentration of serum lipids a risk factor for Achilles tendon rupture? Clin Chim Acta. 2003;331(1–2):25–28. doi:10.1016/S0009-8981(03)00075-5
  • Klemp P, Halland AM, Majoos FL, Steyn K. Musculoskeletal manifestations in hyperlipidaemia: a controlled study. Ann Rheum Dis. 1993;52(1):44–48. doi:10.1136/ard.52.1.44
  • Abboud JA, Kim JS. The effect of hypercholesterolemia on rotator cuff disease. Clin Orthop Relat Res. 2010;468(6):1493–1497. doi:10.1007/s11999-009-1151-9
  • Unger T, Borghi C, Charchar F, et al. 2020 international society of hypertension global hypertension practice guidelines. Hypertension. 2020;75(6):1334–1357. doi:10.1161/HYPERTENSIONAHA.120.15026
  • Giri A, O’Hanlon D, Jain NB. Risk factors for rotator cuff disease: a systematic review and meta-analysis of diabetes, hypertension, and hyperlipidemia. Ann Phys Rehabil Med. 2023;66(1):101631. doi:10.1016/j.rehab.2022.101631
  • Gumina S, Arceri V, Carbone S, et al. The association between arterial hypertension and rotator cuff tear: the influence on rotator cuff tear sizes. J Shoulder Elbow Surg. 2013;22(2):229–232. doi:10.1016/j.jse.2012.05.023
  • Zhao J, Luo M, Liang G, et al. What factors are associated with symptomatic rotator cuff tears: a meta-analysis. Clin Orthop Relat Res. 2022;480(1):96–105. doi:10.1097/CORR.0000000000001949
  • Ranger TA, Wong AM, Cook JL, Gaida JE. Is there an association between tendinopathy and DM? A systematic review with meta-analysis. Br J Sports Med. 2016;50(16):982–989. doi:10.1136/bjsports-2015-094735
  • Otoshi K, Takegami M, Sekiguchi M, et al. Chronic hyperglycemia increases the risk of lateral epicondylitis: the locomotive syndrome and health outcome in aizu cohort study (LOHAS). Springerplus. 2015;4:407. doi:10.1186/s40064-015-1204-3
  • Hansen M, Couppe C, Hansen CS, et al. Impact of oral contraceptive use and menstrual phases on patellar tendon morphology, biochemical composition, and biomechanical properties in female athletes. J Appl Physiol. 2013;114(8):998–1008. doi:10.1152/japplphysiol.01255.2012
  • Shi L, Rui YF, Li G, Wang C. Alterations of tendons in diabetes mellitus: what are the current findings? Int Orthop. 2015;39(8):1465–1473. doi:10.1007/s00264-015-2775-x
  • Kalyanaraman H, Schwaerzer G, Ramdani G, et al. Protein Kinase G activation reverses oxidative stress and restores osteoblast function and bone formation in male mice with type 1 diabetes. Diabetes. 2018;67(4):607–623. doi:10.2337/db17-0965
  • Marin C, Luyten FP, Van der Schueren B, Kerckhofs G, Vandamme K. The impact of type 2 diabetes on bone fracture healing. Front Endocrinol. 2018;9:6. doi:10.3389/fendo.2018.00006
  • Chen Y, Sun Y, Xu Y, et al. Single-Cell Integration Analysis of Heterotopic Ossification and Fibrocartilage Developmental Lineage: endoplasmic Reticulum Stress Effector Xbp1 Transcriptionally Regulates the Notch Signaling Pathway to Mediate Fibrocartilage Differentiation. Oxid Med Cell Longev. 2021;2021:7663366. doi:10.1155/2021/7663366
  • Lin YC, Li YJ, Rui YF, et al. The effects of high glucose on tendon-derived stem cells: implications of the pathogenesis of diabetic tendon disorders. Oncotarget. 2017;8(11):17518–17528. doi:10.18632/oncotarget.15418
  • Cutting GR. Cystic fibrosis genetics: from molecular understanding to clinical application. Nat Rev Genet. 2015;16(1):45–56. doi:10.1038/nrg3849
  • Zhang WK, Wang D, Duan Y, Loy MM, Chan HC, Huang P. Mechanosensitive gating of CFTR. Nat Cell Biol. 2010;12(5):507–512. doi:10.1038/ncb2053
  • Wang HN, Huang YC, Ni GX. Mechanotransduction of stem cells for tendon repair. World J Stem Cells. 2020;12(9):952–965. doi:10.4252/wjsc.v12.i9.952
  • Nourissat G, Berenbaum F, Duprez D. Tendon injury: from biology to tendon repair. Nat Rev Rheumatol. 2015;11(4):223–233. doi:10.1038/nrrheum.2015.26
  • Liu Y, Xu J, Xu L, et al. Cystic fibrosis transmembrane conductance regulator mediates tenogenic differentiation of tendon-derived stem cells and tendon repair: accelerating tendon injury healing by intervening in its downstream signaling. FASEB J. 2017;31(9):3800–3815. doi:10.1096/fj.201601181R
  • Buhrmann C, Mobasheri A, Busch F, et al. Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem. 2011;286(32):28556–28566. doi:10.1074/jbc.M111.256180
  • Jiang D, Gao P, Lin H, Geng H. Curcumin improves tendon healing in rats: a histological, biochemical, and functional evaluation Connect. Tissue Res. 2016;57:20–27. doi:10.3109/03008207.2015.1087517
  • Córdova A, Drobnic F, Noriega-González D, Caballero-García A, Roche E, Alvarez-Mon M. Is curcumine useful in the treatment and prevention of the tendinopathy and myotendinous junction injury? A Scoping Review. Nutrients. 2023;15(2):384. doi:10.3390/nu15020384
  • Hasan S, Soltman S, Wood C, Blackman SM. The role of genetic modifiers, inflammation and CFTR in the pathogenesis of Cystic fibrosis related diabetes. J Clin Transl Endocrinol. 2021;27:100287. doi:10.1016/j.jcte.2021.100287
  • Hart NJ, Aramandla R, Poffenberger G, et al. Cystic fibrosis-related diabetes is caused by islet loss and inflammation. JCI Insight. 2018;3(8):e98240. doi:10.1172/jci.insight.98240
  • Cao T, Hong J, Qi F, et al. A hyperglycemic microenvironment inhibits tendon-to-bone healing through the let-7b-5p/CFTR pathway. Comput Math Methods Med. 2022;2022:8268067. doi:10.1155/2022/8268067
  • Twarda-Clapa A, Olczak A, Białkowska AM, Koziołkiewicz M. Advanced glycation end-products (AGEs): formation, chemistry, classification, receptors, and diseases related to AGEs. Cells. 2022;11(8):1312. doi:10.3390/cells11081312
  • Suzuki A, Yabu A, Nakamura H. Advanced glycation end products in musculoskeletal system and disorders. Methods. 2022;203:179–186. doi:10.1016/j.ymeth.2020.09.012
  • Avery NC, Bailey AJ. The effects of the Maillard reaction on the physical properties and cell interactions of collagen. Pathol Biol. 2006;54(7):387–395. doi:10.1016/j.patbio.2006.07.005
  • Lee JM, Veres SP. Advanced glycation end-product cross-linking inhibits biomechanical plasticity and characteristic failure morphology of native tendon. J Appl Physiol. 2019;126(4):832–841. doi:10.1152/japplphysiol.00430.2018
  • Millar NL, Murrell GA, McInnes IB. Inflammatory mechanisms in tendinopathy - towards translation. Nat Rev Rheumatol. 2017;13(2):110–122. doi:10.1038/nrrheum.2016.213
  • Fessel G, Li Y, Diederich V, et al. Advanced glycation end-products reduce collagen molecular sliding to affect collagen fibril damage mechanisms but not stiffness. PLoS One. 2014;9(11):e110948. doi:10.1371/journal.pone.0110948
  • Gautieri A, Passini FS, Silván U, et al. Advanced glycation end-products: mechanics of aged collagen from molecule to tissue. Matrix Biol. 2017;59:95–108. doi:10.1016/j.matbio.2016.09.001
  • Naresh MD, Brodsky B. X-ray diffraction studies on human tendon show age-related changes in collagen packing. Biochim Biophys Acta. 1992;1122(2):161–166. doi:10.1016/0167-4838(92)90319-9
  • Sell DR, Monnier VM. Age-related association of tail tendon break time with tissue pentosidine in DBA/2 vs C57BL/6 mice: the effect of dietary restriction. J Gerontol a Biol Sci Med Sci. 1997;52(5):B277–84. doi:10.1093/gerona/52a.5.b277
  • Kent MJ, Light ND, Bailey AJ. Evidence for glucose-mediated covalent cross-linking of collagen after glycosylation in vitro. Biochem J. 1985;225(3):745–752. doi:10.1042/bj2250745
  • Schulze-Tanzil G, Al-Sadi O, Wiegand E, et al. The role of pro-inflammatory and immunoregulatory cytokines in tendon healing and rupture: new insights. Scand J Med Sci Sports. 2011;21(3):337–351. doi:10.1111/j.1600-0838.2010.01265.x
  • John T, Lodka D, Kohl B, et al. Effect of pro-inflammatory and immunoregulatory cytokines on human tenocytes. J Orthop Res. 2010;28(8):1071–1077. doi:10.1002/jor.21079
  • Wu YF, Chen CH, Cao Y, Avanessian B, Wang XT, Tang JB. Molecular events of cellular apoptosis and proliferation in the early tendon healing period. J Hand Surg Am. 2010;35(1):2–10. doi:10.1016/j.jhsa.2009.10.021
  • Hosaka Y, Sakamoto Y, Kirisawa R, et al. Distribution of TNF receptors and TNF receptor-associated intracellular signaling factors on equine tendinocytes in vitro. Jpn J Vet Res. 2004;52(3):135–144.
  • Sun L, Yuan Q, Cao N, et al. VEGF genetic polymorphisms may contribute to the risk of diabetic nephropathy in patients with diabetes mellitus: a meta-analysis. Scientif World J. 2014;2014:624573. doi:10.1155/2014/624573
  • Stoll C, John T, Endres M, et al. Extracellular matrix expression of human tenocytes in three-dimensional air-liquid and PLGA cultures compared with tendon tissue: implications for tendon tissue engineering. J Orthop Res. 2010;28(9):1170–1177. doi:10.1002/jor.21109
  • Korntner S, Lehner C, Gehwolf R, et al. Limiting angiogenesis to modulate scar formation. Adv Drug Deliv Rev. 2019;146:170–189. doi:10.1016/j.addr.2018.02.010
  • Doulberis M, Papaefthymiou A, Polyzos SA, et al. Rodent models of obesity. Minerva Endocrinol. 2020;45(3):243–263. doi:10.23736/S0391-1977.19.03058-X
  • Lutz TA, Woods SC. Overview of animal models of obesity. Curr Protoc Pharmacol. 2012;58. doi:10.1002/0471141755.ph0561s58
  • Fuchs T, Loureiro MP, Macedo LE, Nocca D, Nedelcu M, Costa-Casagrande TA. Animal models in metabolic syndrome. Modelos animais na síndrome metabólica. Rev Col Bras Cir. 2018;45(5):e1975. doi:10.1590/0100-6991e-20181975
  • Wang B, Chandrasekera PC, Pippin JJ. Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetes. Curr Diab Rev. 2014;10(2):131–145. doi:10.2174/1573399810666140508121012
  • Wu YF, Wang HK, Chang HW, Sun J, Sun JS, Chao YH. High glucose alters tendon homeostasis through downregulation of the AMPK/Egr1 pathway. Sci Rep. 2017;7:44199. doi:10.1038/srep44199
  • Biancalana A, Veloso LA, Gomes L. Obesity affects collagen fibril diameter and mechanical properties of tendons in Zucker rats. Connect Tissue Res. 2010;51(3):171–178. doi:10.3109/03008200903191312
  • Ahmed AS, Li J, Abdul AM, et al. Compromised neurotrophic and angiogenic regenerative capability during tendon healing in a rat model of type-II diabetes. PLoS One. 2017;12(1):e0170748. doi:10.1371/journal.pone.0170748
  • Xu K, Zhang L, Ren Z, et al. Evaluating the role of type 2 diabetes mellitus in rotator cuff tendinopathy: development and analysis of a novel rat model. Front Endocrinol. 2022;13:1042878. doi:10.3389/fendo.2022.1042878