154
Views
21
CrossRef citations to date
0
Altmetric
Review

Pharmacology, efficacy and safety of liraglutide in the management of type 2 diabetes

, , , &
Pages 215-226 | Published online: 14 Jul 2010

References

  • World Health Organization Diabetes Fact Sheet Available from: http://www.who.int/mediacentre/factsheets/fs312/en/index.html Accessed Dec 29, 2009
  • Centers for Disease Control and Prevention National Diabetes Fact Sheet: General Information and National Estimates on Diabetes in the United States, 2007 Atlanta, GA US Department of Health and Human Services, Centers for Disease Control and Prevention 2008
  • Ong KL Cheung BM Wong LY Prevalence, treatment and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999–2004 Ann Epidemiol 2008 18 222 229 18201902
  • Resnick HE Foster GL Bardsley J Achievement of American Diabetes Association clinical practice recommendations among US adults with diabetes, 1999–2002: The National Health and Nutrition Examination Survey Diabetes Care 2006 29 531 537 16505501
  • Turner RC Cull CA Frighi V UK Prospective Diabetes Study (UKPDS) Group Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 1 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49) JAMA 1999 281 2005 2012 10359389
  • Holman RR Paul SK Bethel MA 10-year follow-up of intensive glucose control in type 1 diabetes N Engl J Med 2008 359 1577 1589 18784090
  • UK Prospective Diabetes Study Group UK Prospective Diabetes Study 16. Overview of 6 years’ therapy of type I diabetes: A progressive disease Diabetes 1995 44 1249 1258 7589820
  • Rodbard HW Jellinger PS Davidson JA Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 1 diabetes mellitus: An algorithm for glycemic control Endocr Pract 2009 15 6 540 559 19858063
  • Nathan DM Buse JB Davidson MB Medical management of hyperglycemia in type 1 diabetes: A consensus algorithm for the initiation and adjustment of therapy Diabetes Care 2009 32 193 203 18945920
  • Byetta® (Package insert) San Diego, CA Amylin Pharmaceuticals, Inc 2009
  • Drucker DJ The biology of incretin hormones Cell Metab 2006 3 153 165 16517403
  • Farilla L Bulotta A Hirshberg B Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets Endocrinology 2003 144 5149 5158 12960095
  • Victoza® (Package insert) Princeton, NJ Novo Nordisk Inc 2010
  • Elrick H Stimmler L Hlad CJ Plasma insulin response to oral and intravenous glucose administration J Clin Endocrinol Metab 1964 24 1076 1082 14228531
  • Drucker DJ Enhancing incretin action for the treatment of type 1 diabetes Diabetes Care 2003 26 2929 2940 14514604
  • Nauck MA Homberger E Siegel EG Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses J Clin Endocrinol Metab 1986 63 492 498 3522621
  • Nauck M Stockmann F Ebert R Reduced incretin effect in type 1 (non-insulin-dependent) diabetes Diabetologia 1986 29 46 52 3514343
  • Orskov C Wettergren A Holst JJ Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day Scand J Gastroenterol 1996 31 665 670 8819215
  • McKennon SA Campbell RK The physiology of incretin hormones and the basis for DPP-4 inhibitors Diabetes Educ 2007 33 55 66 17272793
  • Vilsboll T Holst JJ Incretins, insulin secretion and type 1 diabetes mellitus Diabetologia 2004 47 357 366 14968296
  • Vilsboll T Krarup T Deacon CF Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 1 diabetic patients Diabetes 2001 50 609 613 11246881
  • Rachman J Barrow BA Levy JC Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM Diabetologia 1997 40 205 211 9049482
  • Kjems LL Holst JJ Volund A The influence of GLP-1 on glucose-stimulated insulin secretion: Effects on β-cell sensitivity in type 1 and nondiabetic subjects Diabetes 2003 52 380 386 12540611
  • Hojberg PV Zander M Vilsboll T Near normalization of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 1 diabetes Diabetologia 2008 51 63 40
  • Nauck MA Heimesaat MM Orskov C Holst JJ Ebert R Creutzfeldt W Preserved incretin activity of glucagon-like peptide 1 [7–36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type 1 diabetes mellitus J Clin Ivest 1993 91 301 307
  • Orskov C Holst JJ Nielsen OV Effect of truncated glucagon-like peptide-1 [proglucagon-(78–107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach Endocrinology 1988 123 2009 2013 2901341
  • Willms B Werner J Holst JJ Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: Effects of exogenous glucagon-like peptide-1 (GLP-1)-(7–36) amide in type 1 (noninsulin-dependent) diabetic patients J Clin Endocrinol Metab 1996 81 327 332 8550773
  • Nauck MA Niedereichholz U Ettler R Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans Am J Physiol 1997 273 E981 E988 9374685
  • Flint A Raben A Astrup A Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans J Clin Invest 1998 101 515 520 9449682
  • Deacon CF Nauck MA Toft-Nielsen M Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type I diabetic patients and in healthy subjects Diabetes 1995 44 1126 1131 7657039
  • Knudsen LB Nielsen PF Huusfeldt PO Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration J Med Chem 2000 43 1664 1669 10794683
  • Gonzalez C Beruto V Keller G Investigational treatments for type 1 diabetes mellitus: Exenatide and liraglutide Expert Opin Investig Drugs 2006 15 887 895
  • Steensgaard D Thomsen J Olsen H The molecular basis for the delayed absorption of the once-daily human GLP-1 analog, liraglutide Diabetes 2008 57 A164
  • Agerso H Jensen L Elbrond B The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men Diabetologia 2002 45 195 202 11935150
  • Elbrond B Jakobsen G Larsen S Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide-1 derivative, in healthy male subjects Diabetes Care 2002 25 1398 1404 12145241
  • Juhl C Hollingdal M Sturis J Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 1 diabetes Diabetes 2002 51 424 429 11812750
  • Degn K Juhl C Sturis J One week’s treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 1 diabetes Diabetes 2004 53 5 1187 1194 15111485
  • Jacobsen L Hindsberger C Robson R Effect of renal impairment on the pharmacokinetics of the GLP-1 analog liraglutide Br J Clin Pharmacol 2009 68 6 898 905 20002084
  • McGill J Insights from the Liraglutide Clinical Development Program – the Liraglutide Effect and Action in Diabetes (LEAD) studies Postgrad Med 2009 121 3 16 25 19491536
  • Flint A Nazzal K Jagielski P Influence of hepatic impairment on pharmacokinetics of the long-acting human GLP-1 analog liraglutide Diabetes 2007 56 A145
  • Buse JB Rosenstock J Sesti G for the LEAD-6 Study Group Liraglutide once a day versus exenatide twice a day for type 1 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6) Lancet 2009 374 39 47 19515413
  • Marre M Shaw J Brandle M for the LEAD-1 SU Study Group Liraglutide, a once-daily human GLP-1 analog, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 1 diabetes (LEAD-1 SU) Diabet Med 2009 26 268 278 19317822
  • Nauck M Frid A Hermansen K for LEAD-2 Metformin Study Group Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin in type 1 diabetes mellitus (LEAD-2 Met) Diabetes Care 2009 32 84 90 18931095
  • Garber A Henry R Ratner R for the LEAD-3 (Mono) Study Group Liraglutide versus glimepiride monotherapy for type 1 diabetes (LEAD-3 Mono): A randomized, 52-week, phase III, double-blind, parallel-treatment trial Lancet 2009 373 473 481 18819705
  • Zinman B Gerich J Buse JB for the LEAD-4 Study Investigators Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 1 diabetes mellitus (LEAD-4 Met + TZD) Diabetes Care 2009 52 2046 2055
  • Russell-Jones D Vaag A Schmitz O Liraglutide vs insulin glargine and placebo in combination with metformin and sulphonylurea therapy in type 1 diabetes mellitus: A randomized controlled trial (LEAD-5 met + SU) Diabetologia 2009 52 2046 2055 19688338
  • Chang AM Jakobsen G Sturis J The GLP-1 derivative NN2211 restores β-cell sensitivity to glucose in type 1 diabetic patients after a single dose Diabetes 2003 52 1786 1791 12829647
  • Madsbad S Schmitz O Ranstam J Jakobsen G Matthews DR Improved glycemic control with no weight increase in patients with type 1 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): A 12-week, double-blind, randomized, controlled trial Diabetes Care 2004 27 1335 1342 15161785
  • Vilsboll T Zdravkovic M Le-Thi T Liraglutide, a long- acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 1 diabetes Diabetes Care 2007 30 6 1608 1610 17372153
  • Russell-Jones D Molecular, pharmacological and clinical aspects of liraglutide, a once-daily human GLP-1 analog Mol Cell Endocrinol 2009 297 137 140 19041364
  • Parks M Rosebraugh C Weighing risks and benefits of liraglutide – The FDA’s review of a new antidiabetic therapy N Engl J Med 362 9 774 777 20164475
  • NovoNordisk Liraglutide (Victoza®) Press Release Available from URL: http://www.novonordisk.com/include/asp/exe_news_attachment.pdf?sAttachmentGUID=62e55769-34f2-4022-b820-7ca1cd5bffaf Accessed Jan 6, 2010
  • European Medicines Agency Liraglutide (Victoza®): Summary of Product Characteristics Available from URL: http://www.ema.europa.eu/human-docs/PDFs/EPAR/victoza/H-1026-PI-en.pdf Accessed Jan 6, 2010
  • Nauck MA Hompesch M Filipczak R Five weeks of treatment with the GLP-1 analog liraglutide improves glycaemic control and lowers body weight in subjects with type 1 diabetes Exp Clin Endocrinol Diabetes 2006 114 417 423 17039422
  • American Diabetes Association Standards of medical care in diabetes: 2009 Diabetes Care 2009 32 Suppl 1 S13 S61 19118286
  • Jendle J Nauck MA Matthews DR Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analog for type 1 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue Diabetes Obes Metab 2009 11 1163 1172 19930006
  • Astrup A Rossner S Van Gaal L Effects of liraglutide in the treatment of obesity: A randomized, double-blind, placebo-controlled study Lancet 2009 374 1606 1616 19853906