89
Views
0
CrossRef citations to date
0
Altmetric
Review

Stem cells and regenerative therapies for Parkinson’s disease

&
Pages 79-92 | Published online: 19 Jul 2012

References

  • WirdefeldtKAdamiHOColePTrichopoulosDMandelJEpidemiology and etiology of Parkinson’s disease: a review of the evidenceEur J Epidemiol26Suppl 1S1S5821626386
  • de RijkMCLaunerLJBergerKPrevalence of Parkinson’s disease in Europe: a collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research GroupNeurology20005411 Suppl 5S21S23
  • Williams-GrayCHFoltynieTBrayneCERobbinsTWBarkerRAEvolution of cognitive dysfunction in an incident Parkinson’s disease cohortBrain2007130Pt 71787179817535834
  • EvansJRMasonSLWilliams-GrayCHThe natural history of treated Parkinson’s disease in an incident, community based cohortJ Neurol Neurosurg Psychiatry201182101112111821593513
  • BraakHGhebremedhinERübUBratzkeHDel TrediciKStages in the development of Parkinson’s disease-related pathologyCell Tissue Res2004318112113415338272
  • KordowerJHSikorszkyVBodnarRJCentral antinociceptive effects of lysine-vasopressin and an analoguePeptides1982346136177134029
  • MeissnerWGFrasierMGasserTPriorities in Parkinson’s disease researchNat Rev Drug Discov201110537739321532567
  • FreedCRGreenePEBreezeRETransplantation of embryonic dopamine neurons for severe Parkinson’s diseaseN Engl J Med20013441071071911236774
  • OlanowCWGoetzCGKordowerJHA double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson’s diseaseAnn Neurol200354340341412953276
  • LindvallORehncronaSBrundinPHuman fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson’s disease. A detailed account of methodology and a 6-month follow-upArch Neurol19894666156312786405
  • PangZPYangNVierbuchenTInduction of human neuronal cells by defined transcription factorsNature2011476735922022321617644
  • WakemanDRDodiyaHBKordowerJHCell transplantation and gene therapy in Parkinson’s diseaseMt Sinai J Med201178112615821259269
  • PerlowMJFreedWJHofferBJSeigerAOlsonLWyattRJBrain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine systemScience19792044393643647571147
  • FreundTFBolamJPBjörklundAEfferent synaptic connections of grafted dopaminergic neurons reinnervating the host neostriatum: a tyrosine hydroxylase immunocytochemical studyJ Neurosci1985536036162857778
  • DunnettSBBjörklundASchmidtRHSteneviUIversenSDIntracerebral grafting of neuronal cell suspensions. V. Behavioural recovery in rats with bilateral 6-OHDA lesions following implantation of nigral cell suspensionsActa Physiol Scand Suppl198352239476426251
  • BjörklundASteneviUReconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplantsBrain Res19791773555560574053
  • AnnettLETorresEMClarkeDJSurvival of nigral grafts within the striatum of marmosets with 6-OHDA lesions depends critically on donor embryo ageCell Transplant1997665575699440865
  • AnnettLEDunnettSBMartelFLA functional assessment of embryonic dopaminergic grafts in the marmosetProg Brain Res1990825355422127119
  • MadrazoILeónVTorresCTransplantation of fetal substantia nigra and adrenal medulla to the caudate nucleus in two patients with Parkinson’s diseaseN Engl J Med1988318151
  • LindvallOBrundinPWidnerHGrafts of fetal dopamine neurons survive and improve motor function in Parkinson’s diseaseScience199024749425745772105529
  • LindvallOSawleGWidnerHEvidence for long-term survival and function of dopaminergic grafts in progressive Parkinson’s diseaseAnn Neurol19943521721808109898
  • FreedCRBreezeRERosenbergNLSurvival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson’s diseaseN Engl J Med199232722154915551435881
  • SpencerDDRobbinsRJNaftolinFUnilateral transplantation of human fetal mesencephalic tissue into the caudate nucleus of patients with Parkinson’s diseaseN Engl J Med199232722154115481435880
  • PeschanskiMDeferGN’GuyenJPBilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson’s disease following intrastriatal transplantation of foetal ventral mesencephalonBrain1994117Pt 34874998032859
  • MaYTangCChalyTDopamine cell implantation in Parkinson’s disease: long-term clinical and (18)F-FDOPA PET outcomesJ Nucl Med201051171520008998
  • OlanowCWGraciesJMGoetzCGClinical pattern and risk factors for dyskinesias following fetal nigral transplantation in Parkinson’s disease: a double blind video-based analysisMov Disord200924333634319006186
  • PolitisMDyskinesias after neural transplantation in Parkinson’s disease: what do we know and what is next?BMC Med201088021126348
  • OlanowCWFahnSFetal nigral transplantation as a therapy for Parkinson’s diseaseBrundinPOlanowCWRestorative Therapies in Parkinson’s DiseaseNew YorkSpringer1996
  • Toledo-AralJJMéndez-FerrerSPardalRLópez-BarneoJDopaminergic cells of the carotid body: physiological significance and possible therapeutic applications in Parkinson’s diseaseBrain Res Bull200257684785312031283
  • EspejoEFMontoroRJArmengolJALópez-BarneoJCellular and functional recovery of Parkinsonian rats after intrastriatal transplantation of carotid body cell aggregatesNeuron19982021972069491982
  • LuquinMRMontoroRJGuillénJRecovery of chronic parkinsonian monkeys by autotransplants of carotid body cell aggregates into putamenNeuron199922474375010230794
  • ArjonaVMínguez-CastellanosAMontoroRJAutotrans-plantation of human carotid body cell aggregates for treatment of Parkinson’s diseaseNeurosurgery2003532321328 discussion 328–33012925247
  • Mínguez-CastellanosAEscamilla-SevillaFHottonGRCarotid body autotransplantation in Parkinson disease: a clinical and positron emission tomography studyJ Neurol Neurosurg Psychiatry200778882583117220289
  • GillSSPatelNKHottonGRDirect brain infusion of glial cell line-derived neurotrophic factor in Parkinson diseaseNat Med20039558959512669033
  • McKayBSGoodmanBFalkTShermanSJRetinal pigment epithelial cell transplantation could provide trophic support in Parkinson’s disease: results from an in vitro model systemExp Neurol2006201123424316764861
  • MingMLiXFanXRetinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson’s diseaseJ Transl Med200975319558709
  • FalkTZhangSShermanSJPigment epithelium derived factor (PEDF) is neuroprotective in two in vitro models of Parkinson’s diseaseNeurosci Lett20094582495219442875
  • BakayRARaiserCDStoverNPImplantation of Spheramine in advanced Parkinson’s disease (PD)Front Biosci2004959260214766394
  • GrossREWattsRLHauserRAIntrastriatal transplantation of microcarrier-bound human retinal pigment epithelial cells versus sham surgery in patients with advanced Parkinson’s disease: a double-blind, randomised, controlled trialLancet Neurol201110650951921565557
  • FaragESVintersHVBronsteinJPathologic findings in retinal pigment epithelial cell implantation for Parkinson diseaseNeurology200973141095110219726750
  • LinLFDohertyDHLileJDBekteshSCollinsFGDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neuronsScience19932605111113011328493557
  • KirikDGeorgievskaBRosenbladCBjörklundADelayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson’s diseaseEur J Neurosci20011381589159911328352
  • GashDMZhangZOvadiaAFunctional recovery in parkinsonian monkeys treated with GDNFNature199638065712522558637574
  • AronLKleinRRepairing the parkinsonian brain with neurotrophic factorsTrends Neurosci20113428810021144600
  • GrondinRZhangZAiYGashDMGerhardtGAIntracranial delivery of proteins and peptides as a therapy for neurodegenerative diseasesProg Drug Res20036110112314674610
  • NuttJGBurchielKJComellaCLRandomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PDNeurology2003601697312525720
  • LoveSPlahaPPatelNKHottonGRBrooksDJGillSSGlial cell line-derived neurotrophic factor induces neuronal sprouting in human brainNat Med200511770370416015352
  • SlevinJTGerhardtGASmithCDGashDMKryscioRYoungBImprovement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factorJ Neurosurg2005102221622215739547
  • LangAEGillSPatelNKRandomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson diseaseAnn Neurol200659345946616429411
  • BarkerRAParkinson’s disease and growth factors – are they the answer?Parkinsonism Relat Disord200915Suppl 3S181S18420082986
  • San SebastianWRichardsonRMKellsAPSafety and tolerability of MRI-guided convection-enhanced delivery of AAV2-hAADC with a novel delivery platform in non-human primate striatumHum Gene Ther201223221021722017504
  • HovlandDNJrBoydRBButtMTSix-month continuous intraputamenal infusion toxicity study of recombinant methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF) in rhesus monkeysToxicol Pathol20073571013102918098052
  • SlevinJTGashDMSmithCDUnilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawalJ Neurosurg2007106461462017432712
  • LeibrockJLottspeichFHohnAMolecular cloning and expression of brain-derived neurotrophic factorNature198934162381491522779653
  • MogiMTogariAKondoTBrain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson’s diseaseNeurosci Lett19992701454810454142
  • ParainKMurerMGYanQReduced expression of brain-derived neurotrophic factor protein in Parkinson’s disease substantia nigraNeuroreport199910355756110208589
  • ChioccoMJHarveyBKWangYHofferBJNeurotrophic factors for the treatment of Parkinson’s diseaseParkinsonism Relat Disord200713Suppl 3S321S32818267258
  • KleinRLLewisMHMuzyczkaNMeyerEMPrevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transferBrain Res1999847231432010575102
  • SunMKongLWangXLuXGGaoQGellerAIComparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson’s diseaseBrain Res20051052211912916018990
  • WestermarkBHeldinCHPlatelet-derived growth factor. Structure, function and implications in normal and malignant cell growthActa Oncol19933221011058323751
  • ErlandssonAEnarssonMForsberg-NilssonKImmature neurons from CNS stem cells proliferate in response to platelet-derived growth factorJ Neurosci200121103483349111331377
  • FunaKYamadaNBrodinGEnhanced synthesis of platelet-derived growth factor following injury induced by 6-hydroxydopamine in rat brainNeuroscience19967438258338884778
  • PietzKOdinPFunaKLindvallOProtective effect of platelet-derived growth factor against 6-hydroxydopamine-induced lesion of rat dopaminergic neurons in cultureNeurosci Lett19962041–21011048929988
  • MohapelPFrielingsdorfHHäggbladJZachrissonOBrundinPPlatelet-derived growth factor (PDGF-BB) and brain-derived neurotrophic factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesionsNeuroscience2005132376777615837137
  • KayMAState-of-the-art gene-based therapies: the road aheadNat Rev Genet201112531632821468099
  • ZaissAKMuruveDAImmune responses to adeno-associated virus vectorsCurr Gene Ther20055332333115975009
  • SheridanCGene therapy finds its nicheNat Biotechnol201129212112821301435
  • EberlingJLJagustWJChristineCWResults from a Phase I safety trial of hAADC gene therapy for Parkinson diseaseNeurology200870211980198318401019
  • KaplittMGFeiginATangCSafety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson’s disease: an open label, Phase I trialLancet200736995792097210517586305
  • LeWittPARezaiARLeeheyMAAAV2-GAD gene therapy for advanced Parkinson’s disease: a double-blind, sham-surgery controlled, randomised trialLancet Neurol201110430931921419704
  • MarksWJJrBartusRTSiffertJGene delivery of AAV2-neurturin for Parkinson’s disease: a double-blind, randomised, controlled trialLancet Neurol20109121164117220970382
  • HorgerBANishimuraMCArmaniniMPNeurturin exerts potent actions on survival and function of midbrain dopaminergic neuronsJ Neurosci19981813492914379634558
  • KordowerJHHerzogCDDassBDelivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeysAnn Neurol200660670671517192932
  • MarksWJJrOstremJLVerhagenLSafety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson’s disease: an open-label, Phase I trialLancet Neurol20087540040818387850
  • VisanjiNPOrsiAJohnstonTHPYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson’s diseaseFASEB J20082272488249718364399
  • IllesJSahakianBJThe Oxford Handbook of NeuroethicsNew YorkOxford University Pressxxxix935
  • PolitisMDyskinesias after neural transplantation in Parkinson’s disease: what do we know and what is next?BMC Med201088021126348
  • PolitisMOertelWHWuKGraft-induced dyskinesias in Parkinson’s disease: high striatal serotonin/dopamine transporter ratioMov Disord201126111997200321611977
  • MaYFeiginADhawanVDyskinesia after fetal cell transplantation for parkinsonism: a PET studyAnn Neurol200252562863412402261
  • KordowerJHChuYHauserRAFreemanTBOlanowCWLewy body-like pathology in long-term embryonic nigral transplants in P arkinson’s diseaseNat Med200814550450618391962
  • KordowerJHBrundinPLewy body pathology in long-term fetal nigral transplants: is Parkinson’s disease transmitted from one neural system to another?Neuropsychopharmacology200934125419079079
  • LentzTBGraySJSamulskiRJViral vectors for gene delivery to the central nervous systemNeurobiol Dis Epub10 7, 2011
  • MingozziFHighKATherapeutic in vivo gene transfer for genetic disease using AAV: progress and challengesNat Rev Genet201112534135521499295
  • KellsAPHadaczekPYinDEfficient gene therapy-based method for the delivery of therapeutics to primate cortexProc Natl Acad Sci U S A200910672407241119193857
  • KordowerJHOlanowCWRegulatable promoters and gene therapy for Parkinson’s disease: is the only thing to fear, fear itself?Exp Neurol20082091344017888424
  • SpencerDMDevelopments in suicide genes for preclinical and clinical applicationsCurr Opin Mol Ther20002443344011249774
  • CressDEThe need for regulatable vectors for gene therapy for Parkinson’s diseaseExp Neurol20082091303317942096
  • LangAEObesoJATime to move beyond nigrostriatal dopamine deficiency in Parkinson’s diseaseAnn Neurol200455676176515174009
  • Ke KehagiaAABarkerRARobbinsTWNeuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson’s diseaseLancet Neurol20109121200121320880750
  • ThomsonJAItskovitz-EldorJShapiroSSEmbryonic stem cell lines derived from human blastocystsScience19982825391114511479804556
  • MasterZMcLeodMMendezIBenefits, risks and ethical considerations in translation of stem cell research to clinical applications in Parkinson’s diseaseJ Med Ethics200733316917317329391
  • Ben-HurTIdelsonMKhanerHTransplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian ratsStem Cells20042271246125515579643
  • BjorklundLMSánchez-PernauteRChungSEmbryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat modelProc Natl Acad Sci U S A20029942344244911782534
  • HiyamaEHiyamaKTelomere and telomerase in stem cellsBr J Cancer20079671020102417353922
  • BakerDEHarrisonNJMaltbyEAdaptation to culture of human embryonic stem cells and oncogenesis in vivoNat Biotechnol200725220721517287758
  • NussbaumJMinamiELaflammeMATransplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune responseFASEB J20072171345135717284483
  • Ben-DavidUBenvenistyNThe tumorigenicity of human embryonic and induced pluripotent stem cellsNat Rev Cancer201111426827721390058
  • PruszakJSonntagKCAungMHSanchez-PernauteRIsacsonOMarkers and methods for cell sorting of human embryonic stem cell-derived neural cell populationsStem Cells20072592257226817588935
  • FongCYPehGSGauthamanKBongsoASeparation of SSEA-4 and TRA-1-60 labelled undifferentiated human embryonic stem cells from a heterogeneous cell population using magnetic-activated cell sorting (MACS) and fluorescence-activated cell sorting (FACS)Stem Cell Rev200951728019184635
  • ReubinoffBEItsyksonPTuretskyTNeural progenitors from human embryonic stem cellsNat Biotechnol200119121134114011731782
  • Sánchez-DanésAConsiglioARichaudYEfficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and iPS cellsHum Gene Ther2012231566921877920
  • CaiJDonaldsonAYangMGermanMSEnikolopovGIacovittiLThe role of Lmx1a in the differentiation of human embryonic stem cells into midbrain dopamine neurons in culture and after transplantation into a Parkinson’s disease modelStem Cells200927122022918832589
  • KimHLeeGGanatYmiR-371-3 expression predicts neural differentiation propensity in human pluripotent stem cellsCell Stem Cell20118669570621624813
  • MorizaneADarsaliaVGulogluMOA simple method for large-scale generation of dopamine neurons from human embryonic stem cellsJ Neurosci Res201088163467347820981866
  • LiJYChristophersenNSHallVSouletDBrundinPCritical issues of clinical human embryonic stem cell therapy for brain repairTrends Neurosci200831314615318255164
  • KriksSShimJWPiaoJDopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s diseaseNature2011480737854755122056989
  • HoriguchiSTakahashiJKishiYNeural precursor cells derived from human embryonic brain retain regional specificityJ Neurosci Res200475681782414994342
  • J JoAYKimMYLeeHSGeneration of dopamine neurons with improved cell survival and phenotype maintenance using a degradation-resistant nurr1 mutantStem Cells20092792238224619522012
  • JoannidesAGaughwinPSchwieningCEfficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cellsLancet2004364942917217815246730
  • RoyNSWangSJiangLIn vitro neurogenesis by progenitor cells isolated from the adult human hippocampusNat Med20006327127710700228
  • DoetschFGarcía-VerdugoJMAlvarez-BuyllaACellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brainJ Neurosci19971713504650619185542
  • DoetschFAlvarez-BuyllaANetwork of tangential pathways for neuronal migration in adult mammalian brainProc Natl Acad Sci U S A1996932514895149008962152
  • DoetschFPetreanuLCailleIGarcia-VerdugoJMAlvarez-BuyllaAEGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cellsNeuron20023661021103412495619
  • MorsheadCMCraigCGvan der KooyDIn vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrainDevelopment199812512225122619584124
  • O’KeeffeGCTyersPAarslandDDalleyJWBarkerRACaldwellMADopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGFProc Natl Acad Sci U S A2009106218754875919433789
  • DeleidiMCooperOHargusGLevyAIsacsonOOct4-induced reprogramming is required for adult brain neural stem cell differentiation into midbrain dopaminergic neuronsPLoS One201165e1992621655272
  • SanaiNNguyenTIhrieRACorridors of migrating neurons in the human brain and their decline during infancyNature2011478736938238621964341
  • TakahashiKYamanakaSInduction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsCell2006126466367616904174
  • TakahashiKTanabeKOhnukiMInduction of pluripotent stem cells from adult human fibroblasts by defined factorsCell2007131586187218035408
  • OkitaKMatsumuraYSatoYA more efficient method to generate integration-free human iPS cellsNat Methods20118540941221460823
  • GasserTHardyJMizunoYMilestones in PD geneticsMov Disord20112661042104821626549
  • NguyenHNByersBCordBLRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stressCell Stem Cell20118326728021362567
  • DevineMJRytenMVodickaPParkinson’s disease induced pluripotent stem cells with triplication of the alpha-synuclein locusNat Commun2011244021863007
  • SoldnerFHockemeyerDBeardCParkinson’s disease patient-derived induced pluripotent stem cells free of viral reprogramming factorsCell2009136596497719269371
  • KastenbergZJOdoricoJSAlternative sources of pluripotency: science, ethics, and stem cellsTransplant Rev (Orlando)200822321522218631882
  • WernigMZhaoJPPruszakJNeurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson’s diseaseProc Natl Acad Sci U S A2008105155856586118391196
  • CaiJYangMPoremskyEKiddSSchneiderJSIacovittiLDopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned ratsStem Cells Dev20101971017102319824823
  • HargusGCooperODeleidiMDifferentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian ratsProc Natl Acad Sci U S A201010736159211592620798034
  • JaegerIArberCRisner-JaniczekJRTemporally controlled modulation of FGF/ERK signaling directs midbrain dopaminergic neural progenitor fate in mouse and human pluripotent stem cellsDevelopment2011138204363437421880784
  • ChangYLChenSJKaoCLDocosahexaenoic acid promotes dopaminergic differentiation in induced pluripotent stem cells and inhibits teratoma formation in rats with Parkinson-like pathologyCell Transplant201221131333221669041
  • PlathKLowryWEProgress in understanding reprogramming to the induced pluripotent stateNat Rev Genet201112425326521415849
  • YangCSLopezCGRanaTMDiscovery of NSAID and Anticancer Drugs Enhancing Reprogramming and IPS Cell GenerationStem Cells201129101528153621898684
  • HannaJSahaKPandoBDirect cell reprogramming is a stochastic process amenable to accelerationNature2009462727359560119898493
  • BanHNishishitaNFusakiNEfficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectorsProc Natl Acad Sci U S A201110834142341423921821793
  • AasenTIzpisúa BelmonteJCBelmonte, Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cellsNat Protoc20105237138220134422
  • AasenTRayaABarreroMJEfficient and rapid generation of induced pluripotent stem cells from human keratinocytesNat Biotechnol200826111276128418931654
  • KimKDoiAWenBEpigenetic memory in induced pluripotent stem cellsNature2010467731328529020644535
  • ChinMHMasonMJXieWInduced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signaturesCell Stem Cell20095111112319570518
  • PickMStelzerYBar-NurOMaysharYEdenABenvenistyNClone- and gene-specific aberrations of parental imprinting in human induced pluripotent stem cellsStem Cells200927112686269019711451
  • WuSMHochedlingerKHarnessing the potential of induced pluripotent stem cells for regenerative medicineNat Cell Biol201113549750521540845
  • SchoenhalsMKassambaraADe VosJHoseDMoreauxJKleinBEmbryonic stem cell markers expression in cancersBiochem Biophys Res Commun2009383215716219268426
  • StadtfeldMNagayaMUtikalJWeirGHochedlingerKInduced pluripotent stem cells generated without viral integrationScience2008322590394594918818365
  • OkitaKNakagawaMHyenjongHIchisakaTYamanakaSGeneration of mouse induced pluripotent stem cells without viral vectorsScience2008322590394995318845712
  • YuJHuKSmuga-OttoKHuman induced pluripotent stem cells free of vector and transgene sequencesScience2009324592879780119325077
  • ShaoLFengWSunYGeneration of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frameCell Res200919329630619238173
  • ZhouHWuSJooJYGeneration of induced pluripotent stem cells using recombinant proteinsCell Stem Cell20094538138419398399
  • LaurentLCUlitskyISlavinIDynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in cultureCell Stem Cell20118110611821211785
  • SpitsCMateizelIGeensMRecurrent chromosomal abnormalities in human embryonic stem cellsNat Biotechnol200826121361136319029912
  • MaysharYBen-DavidULavonNIdentification and classification of chromosomal aberrations in human induced pluripotent stem cellsCell Stem Cell20107452153120887957
  • OhmJEMaliPVan NesteLCancer-related epigenome changes associated with reprogramming to induced pluripotent stem cellsCancer Res201070197662767320841480
  • BlumBBar-NurOGolan-LevTBenvenistyNThe anti-apoptotic gene survivin contributes to teratoma formation by human embryonic stem cellsNat Biotechnol200927328128719252483
  • FairchildPJThe challenge of immunogenicity in the quest for induced pluripotencyNat Rev Immunol2010101286887521107347
  • ZhaoTZhangZNRongZXuYImmunogenicity of induced pluripotent stem cellsNature2011474735021221521572395
  • VierbuchenTOstermeierAPangZPKokubuYSüdhofTCWernigMDirect conversion of fibroblasts to functional neurons by defined factorsNature201046372841035104120107439
  • PfistererUKirkebyATorperODirect conversion of human fibroblasts to dopaminergic neuronsProc Natl Acad Sci U S A201110825103431034821646515
  • CaiazzoMDell’AnnoMTDvoretskovaEDirect generation of functional dopaminergic neurons from mouse and human fibroblastsNature2011476735922422721725324
  • KimJSuSCWangHFunctional integration of dopaminergic neurons directly converted from mouse fibroblastsCell Stem Cell20119541341922019014
  • LangAEA critical appraisal of the premotor symptoms of Parkinson’s disease: potential usefulness in early diagnosis and design of neuroprotective trialsMov Disord201126577578321484865
  • EvansJRBarkerRADefining meaningful outcome measures in trials of disease-modifying therapies in Parkinson’s diseaseExpert Opin Pharmacother20111281249125821345151
  • EvansJRMasonSLWilliams-GrayCHThe natural history of treated Parkinson’s disease in an incident, community based cohortJ Neurol Neurosurg Psychiatry201182101112111821593513
  • HallidayGMMcCannHThe progression of pathology in Parkinson’s diseaseAnn N Y Acad Sci2010118418819520146698