Neuro-ophthalmic Manifestations of Wernicke Encephalopathy

References

• Wernicke C. Die akute haemorrhagische polioencephalitis superior. Lehrbuch der Gehirnkrankheiten fur Aertze und Studirende. 1881;2:229–242.
   Google Scholar
• Thomson AD, Cook CC, Guerrini I, Sheedy D, Harper C, Marchall EJ. Wernicke’s encephalopathy revisited. Alcohol Alcohol. 2008;43(2):174–179. doi:10.1093/alcalc/agm14418056751
   PubMed Web of Science ®Google Scholar
• Korsakoff SS. Disturbance of psychic function in alcoholic paralysis and its relationship to disturbance in the psychic sphere in multiple neuritis of non-alcoholic origin. Vestn Klin Psichiat Neurol. 1887;4(2):1–102.
   Google Scholar
• Murawieff W. Zwei fälle von polioencephalitis acuta haemorrhagica superior (Wernicke). Neurol Zentralbl. 1897;16:56–61.
   Google Scholar
• Campbell ACP, Russell WR. Wernicke’s encephalopathy: the clinical features and their probable relationship to vitamin B deficiency. Q J Med. 1941;10:41–64. doi:10.1093/oxfordjournals.qjmed.a066371
   Google Scholar
• Sechi G, Serra A. Wernicke’s encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol. 2007;6(5):442–455. doi:10.1016/S1474-4422(07)70104-717434099
   PubMed Web of Science ®Google Scholar
• Manzo G, De Gennaro A, Cozzolino A, Serino A, Fenza G, Manto A. MR imaging findings in alcoholic and nonalcoholic acute wernicke’s encephalopathy: a review. BioMed Res Intl. 2014;2014:1–12. doi:10.1155/2014/503596
   Web of Science ®Google Scholar
• Sinha S, Kataria A, Kolla BP, Thusius N, Loukianova L. Wernicke encephalopathy – clinical pearls. Mayo Clin Proc. 2019;94(6):1065–1072. doi:10.1016/j.mayocp.2019.02.01831171116
   PubMed Web of Science ®Google Scholar
• Kattah JC. Early signs of thiamine deficiency: a case report. Ann Intern Med. 2020. doi:10.7326/L19-0836
   Web of Science ®Google Scholar
• Ogershok PR, Rahman A, Brick J, Nestor S. Wernicke encephalopathy in nonalcoholic patients. Am J Med Sci. 2002;323(2):107–111. doi:10.1097/00000441-200202000-0001011863078
   PubMed Web of Science ®Google Scholar
• Chitra S, Lath KV. Wernicke’s encephalopathy with visual loss in a patient with hyperemesis gravidarum. J Assoc Physicians India. 2012;60:53–56.
   PubMedGoogle Scholar
• Scalzo SJ, Bowden SC, Ambrose ML, Whelan G, Cook MJ. Wernicke-Korsakoff syndrome not related to alcohol use: a systematic review. J Neurol Neurosurg Psychiatry. 2015;86(12):1362–1368. doi:10.1136/jnnp-2014-30959825589780
   PubMed Web of Science ®Google Scholar
• Chandrakumar A, Bhardwaj A, Jong GW. Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis. J Basic Clin Physiol Pharmacol. 2018;30(2):153–162. doi:10.1515/jbcpp-2018-007530281514
   PubMedGoogle Scholar
• Zubaran C, Fernandes JG, Rodnight R. Wernicke-Korsakoff syndrome. Postgrad Med J. 1997;73(855):27–31. doi:10.1136/pgmj.73.855.279039406
   PubMed Web of Science ®Google Scholar
• Kumar N. Neurologic presentations of nutritional deficiencies. Neurol Clin. 2010;28(1):107–170. doi:10.1016/j.ncl.2009.09.00619932379
   PubMed Web of Science ®Google Scholar
• Kulkarni S, Lee AG, Holstein SA, Warner JE. You are what you eat. Surv Ophthalmol. 2005;50(4):389–393. doi:10.1016/j.survophthal.2005.04.00515967192
   PubMed Web of Science ®Google Scholar
• Reuler JB, Girard DE, Cooney TG. Current concepts. Wernicke’s encephalopathy. N Engl J Med. 1985;312(16):1035–1039. doi:10.1056/NEJM1985041831216063885034
   PubMed Web of Science ®Google Scholar
• Deramo VA, Jayamanne DG, Auerbach DB, Danesh-Meyer H. Acute bilateral ophthalmoplegia in a young woman. Surv Ophthalmol. 2000;44(6):513–517. doi:10.1016/s0039-6257(00)00111-910906382
   PubMed Web of Science ®Google Scholar
• Winters J, Niespodzany E, Kini TA, Othman BA, Lee AG. Rapid same-day resolution of internuclear ophthalmoplegia in Wernicke encephalopathy following parental high dose thiamine. Can J Ophthalmol. 2020;55(2):e69–e70. doi:10.1016/j.jcjo.2019.07.00731712022
   PubMed Web of Science ®Google Scholar
• De La Paz MA, Chung SM, McCrary JA. Bilateral internuclear ophthalmoplegia in a patient with Wernicke’s encephalopathy. J Clin Neuroophthalmol. 1992;12(2):116–120.1629372
   PubMedGoogle Scholar
• De Wardener HE, Lennox B. Cerebral beriberi: review of 52 cases in a Singapore prisoner-of-war camp. Lancet. 1947;1:11–17. doi:10.1016/S0140-6736(47)91272-520278697
   PubMed Web of Science ®Google Scholar
• Donnino MW, Vega J, Miller J, Walsh M. Myths and misconceptions of Wernicke’s encephalopathy: what every emergency physician should know. Ann Emerg Med. 2007;50(6):715–721. doi:10.1016/j.annemergmed.2007.02.00717681641
   PubMed Web of Science ®Google Scholar
• Cogan DG, Witt ED, Goldman-Rakic PS. Ocular signs in thiamine-deficient monkeys and in Wernicke’s disease in humans. Arch Ophthalmol. 1960;103(8):1212–1220. doi:10.1001/archopht.1985.01050080124032
   Google Scholar
• Lee SH, Kim SH, Kim JM, Tarnutzer AA. Vestibular dysfunction in Wernicke’s encephalopathy: predominant impairment of the horizontal semicircular canals. Front Neurol. 2018;9:141. doi:10.3389/fneur.2018.0014129593640
   PubMed Web of Science ®Google Scholar
• Choi KD, Oh SY, Kim HJ, Kim JS. The vestibulo-ocular reflexes during head impulse in Wernicke’s encephalopathy. J Neurol Neurosurg Psychiatry. 2007;78(10):1161–1163. doi:10.1136/jnnp.2007.12106117578853
   PubMed Web of Science ®Google Scholar
• Sharma S, Sumich PM, Francis IC, Kiernan MC, Spira PJ. Wernicke’s encephalopathy presenting with upbeat nystagmus. J Clin Neurosci. 2002;9:476–478. doi:10.1054/jocn.2002.112112217687
   PubMed Web of Science ®Google Scholar
• Shin BS, Oh SY, Kim JS, Lee H, Kim EJ, Hwang SB. Upbeat nystagmus changes to downbeat nystagmus with upward gaze in a patient with Wernicke’s encephalopathy. J Neurol Sci. 2010;298(1–2):145–147. doi:10.1016/j.jns.2010.08.01220832081
   PubMed Web of Science ®Google Scholar
• Sakuma A, Kato I, Ogino S, Okada T, Takeyama I. Primary position upbeat nystagmus with special reference to alteration to downbeat nystagmus. Acta Otolaryngol Suppl. 1996;552:43–46.
   Google Scholar
• Abouaf L, Vighetto A, Magnin E, Nove-Josserand A, Mouton S, Tilikete C. Primary position upbeat nystagmus in Wernicke’s encephalopathy. Eur Neurol. 2011;65:160–163. doi:10.1159/00032432921372575
   PubMed Web of Science ®Google Scholar
• Kattah JC. The spectrum of vestibular and ocular motor abnormalities in thiamine deficiency. Curr Neurol Neurosci Rep. 2017;17(5):40. doi:10.1007/s11910-017-0747-928365885
   PubMed Web of Science ®Google Scholar
• Kattah JC, Tehrani AS, Du Lac S, Newman-Toker DE, Zee DS. Conversion of upbeat to downbeat nystagmus in Wernicke encephalopathy. Neurology. 2018;91(17):790–796. doi:10.1212/WNL.000000000000638530348852
   PubMed Web of Science ®Google Scholar
• van Noort BA, Bos PJ, Klopping C, Wilmink JM. Optic neuropathy from thiamine deficiency in a patient with ulcerative colitis. Doc Ophthalmol. 1987;67(1–2):45–51. doi:10.1007/bf001426963123189
   PubMed Web of Science ®Google Scholar
• Vasconcelos MM, Silva KP, Vidal G, Silva AF, Dominigues RC, Berditchevsky CR. Early diagnosis of pediatric Wernicke’s encephalopathy. Pediatr Neurol. 1999;20(4):289–294. doi:10.1016/s0887-8994(98)00153-210328278
   PubMed Web of Science ®Google Scholar
• Sparacia G, Banco A, Lagalla R. Reversible MRI abnormalities in an unusual paediatric presentation of Wernicke’s encephalopathy. Pediatr Radiol. 1999;29(8):581–584. doi:10.1007/s00247005065210415181
   PubMed Web of Science ®Google Scholar
• Li JM, Rucker JC. Irreversible optic neuropathy in wernicke encephalopathy and leber hereditary optic neuropathy. J Neuroophthalmol. 2010;30(1):49–53. doi:10.1097/WNO.0b013e3181ce80c620182208
   PubMed Web of Science ®Google Scholar
• Yeh WY, Lian LM, Chang A, Cheng CK. Thiamine-deficient optic neuropathy associated with Wernicke’s encephalopathy in patients with chronic diarrhea. J Formos Med Assoc. 2013;112(3):165–170. doi:10.1016/j.jfma.2012.10.01023473530
   PubMed Web of Science ®Google Scholar
• Lawton AW, Frisard NE. Visual loss, retinal hemorrhages and optic disc edema resulting from thiamine deficiency following bariatric surgery complicated by prolonged vomiting. Oschner J. 2017;17(1):112–114.
   Google Scholar
• Palakkuzhiyil N, Rehiman S, Manoj PPB, Hameed S, Uvias NA. Visual loss and optic neuropathy associated with Wernicke’s encephalopathy and hyperemesis gravidarum. J Fam Med Prim Care. 2019;8(3):1243–1245. doi:10.4103/jfmpc.jfmpc_121_19
   Google Scholar
• Victor M, Adams RD, Collins GH. The Wernicke-Korsakoff syndrome: a clinical and pathological study of 245 patients, 82 with post-mortem examinations. Contemp Neurol Ser. 1971;7:1–206.5162155
   PubMedGoogle Scholar
• Gratton SM, Lam BL. Visual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency. Clin Ophthalmol. 2014;8:1021–1024. doi:10.2147/OPTH.S6422824899800
   PubMedGoogle Scholar
• Sura AA, Cure JK, Kline LB. Visual loss as a presenting feature of Wernicke encephalopathy. J Neuroophthalmol. 2019;39(3):380–382. doi:10.1097/wno.000000000000077130829946
   PubMed Web of Science ®Google Scholar
• Cox TA, Corbett JJ, Thompson HS, Lennarson L. Upbeat nystagmus changing to downbeat nystagmus with convergence. Neurology. 1981;31(7):891–892. doi:10.1212/wnl.31.7.8917195514
   PubMed Web of Science ®Google Scholar
• Shorey J, Bhardwaj N, Loscalzo J. Acute Wernicke’s encephalopathy after intravenous infusion of high-dose nitroglycerin. Ann Intern Med. 1984;101(4):500. doi:10.7326/0003-4819-101-4-5006433765
   PubMed Web of Science ®Google Scholar
• Halavaara J, Brander A, Lyytinen J, Setälä K, Kallela M. Wernicke’s encephalopathy: is diffusion-weighted MRI useful? Neuroradiology. 2003;45(8):519–523. doi:10.1007/s00234-003-1043-812861431
   PubMed Web of Science ®Google Scholar
• Pacei F, Mullin S, Colombo C, Viganò S, Bet L. A case of Wernicke's encephalopathy due to oesophageal achalasia. Neurol Sci. 2013;34(5):799–800. doi:10.1007/s10072-012-1136-4
   Web of Science ®Google Scholar
• Sia PI, Sia DIT, Crompton JL, Casson RJ. Nerve fiber layer infarcts in thiamine deficiency. J Neuroophthalmol. 2015;35(3):274–276. doi:10.1097/WNO.000000000000024325815858
   PubMed Web of Science ®Google Scholar
• Tan TXZ, Lim KC, Chung CC, Aung T. Starvation-induced diplopia and weakness: a case of beriberi and Wernicke’s encephalopathy. BMJ Case Rep. 2019;12(1):e227412. doi:10.1136/bcr-2018-227412
   Google Scholar
• Thompson RA, Lynde RH. Convergence spasm associated with Wernicke’s encephalopathy. Neurology. 1969;19(7):711–712. doi:10.1212/wnl.19.7.7115815135
   PubMed Web of Science ®Google Scholar
• Shabbir S, Tong O, Gluck L, Robbins M. Convergence spasm in Wernicke encephalopathy. Neurohospitalist. 2018;8(1):NP1–NP2. doi:10.1177/1941874417690668
   Web of Science ®Google Scholar
• Decker MJ, Issacman DJ. A common cause of altered mental status occurring at an uncommon age. Pediatr Emerg Care. 2000;16(2):94–96. doi:10.1097/00006565-200004000-0000710784210
   PubMed Web of Science ®Google Scholar
• Lam BL, Thompson HS, Corbett JJ. The prevalence of simple anisocoria. Am J Ophthalmol. 1987;104(1):69–73. doi:10.1016/0002-9394(87)90296-03605282
   PubMed Web of Science ®Google Scholar
• Thomson AD, Guerrini I, Marshall EJ. The evolution and treatment of Korsakoff’s syndrome: out of sight, out of mind? Neuropsychol Rev. 2012;22(2):81–92. doi:10.1007/s11065-012-9196-z22569770
   PubMed Web of Science ®Google Scholar
• Klooster A, Larkin JR, Wiersema-Buist J, et al. Are brain and heart tissue prone to the development of thiamine deficiency? Alcohol. 2013;47(3):215–221. doi:10.1016/j.alcohol.2012.12.01423357554
   PubMed Web of Science ®Google Scholar
• Sandoval KE, Witt KA. Blood-brain barrier tight junction permeability and ischemic stroke. Neurobiol Dis. 2008;32(2):200–219. doi:10.1016/j.nbd.2008.08.00518790057
   PubMed Web of Science ®Google Scholar
• Thomson AD, Marshall EJ. The natural history and pathophysiology of Wernicke’s encephalopathy and Kosakoff’s psychosis. Alcohol Alcohol. 2006;41(2):151–158. doi:10.1093/alcalc/agh24916384871
   PubMed Web of Science ®Google Scholar
• Thomson AD, Cook CC, Touquet R, Henry JA. The royal college of physician’s report on alcohol: guidelines for managing Wernicke’s encephalopathy in the accident and emergency department. Alcohol Alcohol. 2002;37(6):513–521. doi:10.1093/alcalc/37.6.51312414541
   PubMed Web of Science ®Google Scholar
• Spinazzi M, Angelini C, Patrini C. Subacute sensory ataxia and optic neuropathy with thiamine deficiency. Nat Rev Neurol. 2010;6(5):288–293. doi:10.1038/nrneurol.2010.1620308997
   PubMed Web of Science ®Google Scholar
• Ortigoza-Escobar JD, Melero-Luis M, Arias A, et al. Treatment of genetic defects of thiamine transport and metabolism. Expert Rev Neurother. 2016;16(7):755–763. doi:10.1080/14737175.2016.118756227191787
   PubMed Web of Science ®Google Scholar
• Thomson AD. Mechanisms of vitamin deficiency in chronic alcohol misusers and the development of the Wernicke-Korsakoff syndrome. Alcohol Alcohol Suppl. 2000;35(1):2–7. doi:10.1093/alcalc/35.supplement_1.211304071
   PubMedGoogle Scholar
• Moss HE. Bariatric surgery and the neuro-ophthalmologist. J Neuroophthalmol. 2016;36(1):78–84. doi:10.1097/WNO.000000000000033226764529
   PubMed Web of Science ®Google Scholar
• Kasmaei HD, Baratloo A, Soleymani M, Nasiri Z. Imaging-based diagnosis of wernicke encephalopathy: a case report. Trauma Mon. 2014;19(4):e17403.25717447
   PubMedGoogle Scholar
• Jenkins PF. Wernicke encephalopathy. Am Orthop J. 2015;65:104–108. doi:10.3368/aoj.65.1.104
   Google Scholar
• Porfido D, Guerriero S, Giancipoli G, Vertrugno M, Lefons V, Dicuonzo F. Bilateral sixth nerve palsies as manifestation of Wernicke’s encephalopathy in a patient with refractory vomiting. Eye Brain. 2010;2:95–98. doi:10.2147/EB.S1089928539769
   PubMedGoogle Scholar
• Kim K, Shin DH, Lee YB, et al. Evolution of abnormal eye movements in Wernicke’s encephalopathy: correlation with serial MRI findings. J Neurol Sci. 2012;323(1–2):77–79. doi:10.1016/j.jns.2012.08.01422940074
   PubMed Web of Science ®Google Scholar
• Kattah JC, Guede C, Hassanzadeh B. The medial vestibular nuclei, a vulnerable target in thiamine deficiency. J Neurol. 2018;265(1):213–215. doi:10.1007/s00415-017-8670-129143209
   PubMed Web of Science ®Google Scholar
• Cogan DG, Victor M. Ocular signs of Wernicke’s disease. Arch Ophthalmol. 1954;51(2):204–211. doi:10.1001/archopht.1954.00920040206007
   Google Scholar
• Bohnsack BL, Patel SS. Peripapillary nerve fiber layer thickening, telangiectasia, and retinal hemorrhages in wernicke encephalopathy. J Neuroophthalmol. 2010;30(1):54–58. doi:10.1097/WNO.0b013e3181ceb4d020182209
   PubMed Web of Science ®Google Scholar
• Mumford CJ. Papilloedema delaying diagnosis of Wernicke’s encephalopathy in a comatose patient. Postgrad Med J. 1989;65(764):371–373. doi:10.1136/pgmj.65.764.3712608577
   PubMed Web of Science ®Google Scholar
• Serlin T, Moisseiev E. Fundus findings in wernicke encephalopathy. Case Rep Ophthalmol. 2017;8(2):406–409. doi:10.1159/00047892428924437
   PubMed Web of Science ®Google Scholar
• Caine D, Halliday GM, Krill JJ, Harper CG. Operational criteria for the classification of chronic alcoholics: identification of Wernicke’s encephalopathy. J Neurol Neurosurg Psychiatry. 1997;62(1):51–60. doi:10.1136/jnnp.62.1.519010400
   PubMed Web of Science ®Google Scholar
• Talwar D, Davidson H, Cooney J, St JO’Reilly D. Vitamin B(1) status assessed by direct measurement of thiamin pyrophosphate in erythrocytes or whole blood by HPLC: comparison with erythrocyte transketolase activity assay. Clin Chem. 2000;46(5):704–710. doi:10.1093/clinchem/46.5.70410794754
   PubMed Web of Science ®Google Scholar
• Kim WJ, Kim MM. Wernicke’s encephalopathy presenting with bilateral complete horizontal and downward gaze palsy in a malnourished patient. Korean J Ophthalmol. 2017;31(4):372–374. doi:10.3341/kjo.2017.001428682019
   PubMedGoogle Scholar
• Shogry ME, Curnes JT. Mamillary body enhancement on MR as the only sign of acute Wernicke encephalopathy. AJNR Am J Neuroradiol. 1994;15(1):172–174.8141051
   PubMed Web of Science ®Google Scholar
• Kavuk I, Agelink MW, Gaertner T, et al. Wernicke’s encephalopathy: unusual contrast enhancement revealed by magnetic resonance imaging. Eur J Med Res. 2003;8(11):492–494.14644703
   PubMed Web of Science ®Google Scholar
• Murata T, Fujito T, Kimura H, Omori M, Itoh H, Wada Y. Serial MRI and (1)H-MRS of Wernicke’s encephalopathy: report of a case with remarkable cerebellar lesions on MRI. Psychiatry Res. 2001;108(1):49–55. doi:10.1016/s0925-4927(01)00304-311677067
   PubMed Web of Science ®Google Scholar
• Maschalchi M, Belli G, Guerrini L, Nistri M, Del Seppia I, Villari N. Proton MR spectroscopy of Wernicke encephalopathy. AJNR Am J Neuroradiol. 2002;23(10):1803–1806.12427642
   PubMed Web of Science ®Google Scholar
• Rugilo CA, Uribe Roca MC, Zurru MC, Capizzano AA, Pontello GA, Gatto EM. Proton MR spectroscopy in Wernicke encephalopathy. AJNR Am J Neuroradiol. 2003;24(5):952–955.12748100
   PubMed Web of Science ®Google Scholar
• Subramanian R, Khardori R. Severe hypophosphatemia. Pathophysiologic implications, clinical presentations, and treatment. Medicine (Baltimore). 2000;79(1):1–8. doi:10.1097/00005792-200001000-0000110670405
   PubMed Web of Science ®Google Scholar
• Galvin R, Bråthen G, Ivashynka A, Hillbom M, Tanasescu R, Leone MA; EFNS. EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy. Eur J Neurol. 2010;17(12):1408–1418. doi:10.1111/j.1468-1331.2010.03153.x20642790
   PubMed Web of Science ®Google Scholar
• Ambrose ML, Bowden SC, Whelan G. Thiamin treatment and working memory function of alcohol-dependent people: preliminary findings. Alcohol Clin Exp Res. 2001;25(1):112–116. doi:10.1111/j.1530-0277.2001.tb02134.x11198705
   PubMed Web of Science ®Google Scholar
• Day E, Bentham P, Callaghan R, Kuruvilla T, George S. Thiamine for Wernicke-Korsakoff syndrome in people at risk from alcohol abuse. Cochrane Database Syst Rev. 2004;1:CD004033. doi:10.1002/14651858.CD004033.pub2
   Google Scholar
• Day E, Bentham P, Callaghan R, Kuruvilla T, George S. Thiamine for Wernicke-Korsakoff syndrome in people at risk from alcohol abuse. Cochrane Database Syst Rev. 2013;7:CD004033. doi:10.1002/14651858.CD004033.pub3
   Web of Science ®Google Scholar
• Mehanna HM, Moledina J, Travis J. Refeeding syndrome: what it is, and how to prevent and treat it. BMJ. 2008;336(7659):1495–1498. doi:10.1136/bmj.a30118583681
   PubMed Web of Science ®Google Scholar