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Review

HIV-Associated Histoplasmosis: Current Perspectives

, , & ORCID Icon
Pages 113-125 | Published online: 19 Mar 2020

References

  • McKinsey DS, Spiegel RA, Hutwagner L, et al. Prospective study of histoplasmosis in patients infected with human immunodeficiency virus: incidence, risk factors, and pathophysiology. Clin Infect Dis. 1997;24(6):1195–1203. doi:10.1086/cid.1997.24.issue-69195082
  • Marukutira T, Huprikar S, Azie N, Quan SP, Meier-kriesche HU, Horn DL. Clinical characteristics and outcomes in 303 HIV-infected patients with invasive fungal infections: data from the Prospective Antifungal Therapy Alliance registry, a multicenter, observational study. HIV/AIDS (Auckland, N.z.). 2014;6:39–47. doi:10.2147/HIV.S53910
  • Zerbe CS, Holland SM. Disseminated histoplasmosis in persons with interferon-gamma receptor 1 deficiency. Clin Infect Dis. 2005;41(4):e38–e41. doi:10.1086/43212016028145
  • Wheat LJ, Slama TG, Norton JA, et al. Risk factors for disseminated or fatal histoplasmosis. Analysis of a large urban outbreak. Ann Intern Med. 1982;96(2):159–163. doi:10.7326/0003-4819-96-2-1597059062
  • Smith JA, Kauffman CA. Endemic fungal infections in patients receiving tumour necrosis factor-alpha inhibitor therapy. Drugs. 2009;69(11):1403–1415. doi:10.2165/00003495-200969110-0000219634920
  • Cuellar-rodriguez J, Avery RK, Lard M, et al. Histoplasmosis in solid organ transplant recipients: 10 years of experience at a large transplant center in an endemic area. Clin Infect Dis. 2009;49(5):710–716. doi:10.1086/60471219635026
  • Odio CM, Navarrete M, Carrillo JM, Mora L, Carranza A. Disseminated histoplasmosis in infants. Pediatr Infect Dis J. 1999;18(12):1065–1068. doi:10.1097/00006454-199912000-0000710608625
  • Randhawa HS. Occurrence of histoplasmosis in Asia. Mycopathol Mycol Appl. 1970;41(1):75–89. doi:10.1007/BF020514854938836
  • Baker J, Setianingrum F, Wahyuningsih R, Denning DW. Mapping histoplasmosis in South East Asia - implications for diagnosis in AIDS. Emerg Microbes Infect. 2019;8(1):1139–1145. doi:10.1080/22221751.2019.164453931364950
  • Oladele RO, Toriello C, Ogunsola FT, et al. Prior subclinical histoplasmosis revealed in Nigeria using histoplasmin skin testing. PLoS One. 2018;13(5):e0196224. doi:10.1371/journal.pone.019622429742119
  • Peigne V, Dromer F, Elie C, Lidove O, Lortholary O. Imported acquired immunodeficiency syndrome-related histoplasmosis in metropolitan France: a comparison of pre-highly active anti-retroviral therapy and highly active anti-retroviral therapy eras. Am J Trop Med Hyg. 2011;85(5):934–941. doi:10.4269/ajtmh.2011.11-022422049053
  • Chu JH, Feudtner C, Heydon K, Walsh TJ, Zaoutis TE. Hospitalizations for endemic mycoses: a population-based national study. Clin Infect Dis. 2006;42(6):822–825. doi:10.1086/50040516477560
  • Loulergue P, Bastides F, Baudouin V, et al. Literature review and case histories of Histoplasma capsulatum var. duboisii infections in HIV-infected patients. Emerg Infect Dis. 2007;13(11):1647–1652. doi:10.3201/eid1311.07066518217546
  • Darre T, Saka B, Mouhari-toure A, et al. Histoplasmosis by Histoplasma capsulatum var. duboisii Observed at the Laboratory of Pathological Anatomy of Lome in Togo. J Pathog. 2017;2017:2323412. doi:10.1155/2017/232341228804654
  • Bongomin F, Gago S, Oladele RO, Denning DW. Global and Multi-National prevalence of fungal diseases-estimate precision. J Fungi (Basel). 2017;3(4):57.
  • Adenis AA, Valdes A, Cropet C, et al. Burden of HIV-associated histoplasmosis compared with tuberculosis in Latin America: a modelling study. Lancet Infect Dis. 2018;18(10):1150–1159. doi:10.1016/S1473-3099(18)30354-230146320
  • Nacher M, Adenis A, Adriouch L, et al. What is AIDS in the Amazon and the Guianas? Establishing the burden of disseminated histoplasmosis. Am J Trop Med Hyg. 2011;84(2):239–240. doi:10.4269/ajtmh.2011.10-025121292891
  • Oladele RO, Ayanlowo OO, Richardson MD, Denning DW. Histoplasmosis in Africa: an emerging or a neglected disease? PLoS Negl Trop Dis. 2018;12(1):e0006046. doi:10.1371/journal.pntd.000604629346384
  • Jones PG, Cohen RL, Batts DH, Silva J Jr. Disseminated histoplasmosis, invasive pulmonary aspergillosis, and other opportunistic infections in a homosexual patient with acquired immune deficiency syndrome. Sex Transm Dis. 1983;10(4):202–204. doi:10.1097/00007435-198311000-000106665665
  • Wheat LJ, Connolly-stringfield PA, Baker RL, et al. Disseminated histoplasmosis in the acquired immune deficiency syndrome: clinical findings, diagnosis and treatment, and review of the literature. Medicine (Baltimore). 1990;69(6):361–374. doi:10.1097/00005792-199011000-000042233233
  • Hajjeh RA, Pappas PG, Henderson H, et al. Multicenter case-control study of risk factors for histoplasmosis in human immunodeficiency virus-infected persons. Clin Infect Dis. 2001;32(8):1215–1220. doi:10.1086/31975611283812
  • Wheat LJ, Chetchotisakd P, Williams B, Connolly P, Shutt K, Hajjeh R. Factors associated with severe manifestations of histoplasmosis in AIDS. Clin Infect Dis. 2000;30(6):877–881. doi:10.1086/31382410854363
  • Procknow JJ, Page MI, Loosli CG. Early pathogenesis of experimental histoplasmosis. Arch Pathol. 1960;69:413–426.14434993
  • Newman SL. Macrophages in host defense against Histoplasma capsulatum. Trends Microbiol. 1999;7(2):67–71. doi:10.1016/S0966-842X(98)01431-010081083
  • Woods JP, Heinecke EL, Luecke JW, et al. Pathogenesis of Histoplasma capsulatum. Semin Respir Infect. 2001;16(2):91–101. doi:10.1053/srin.2001.2423911521241
  • Baughman RP, Kim CK, Vinegar A, Hendricks DE, Schmidt DJ, Bullock WE. The pathogenesis of experimental pulmonary histoplasmosis. Correlative studies of histopathology, bronchoalveolar lavage, and respiratory function. Am Rev Respir Dis. 1986;134(4):771–776. doi:10.1164/arrd.1986.134.4.7713767131
  • Horwath MC, Fecher RA, Deepe GS Jr. Histoplasma capsulatum, lung infection and immunity. Future Microbiol. 2015;10(6):967–975. doi:10.2217/fmb.15.2526059620
  • Deepe GS Jr. Modulation of infection with Histoplasma capsulatum by inhibition of tumor necrosis factor-alpha activity. Clin Infect Dis. 2005;41(Suppl 3):S204–S207. doi:10.1086/42999915983901
  • Deepe GS Jr., Seder RA. Molecular and cellular determinants of immunity to Histoplasma capsulatum. Res Immunol. 1998;149(4–5):397–406; discussion 509–310. doi:10.1016/S0923-2494(98)80763-3
  • Vanek J, Schwarz J. The gamut of histoplasmosis. Am J Med. 1971;50(1):89–104. doi:10.1016/0002-9343(71)90208-74924093
  • Kauffman CA. Histoplasmosis: a clinical and laboratory update. Clin Microbiol Rev. 2007;20(1):115–132. doi:10.1128/CMR.00027-0617223625
  • Mandell W, Goldberg DM, Neu HC. Histoplasmosis in patients with the acquired immune deficiency syndrome. Am J Med. 1986;81(6):974–978. doi:10.1016/0002-9343(86)90390-63799657
  • Edwards LB, Acquaviva FA, Livesay VT, Cross FW, Palmer CE. An atlas of sensitivity to tuberculin, PPD-B, and histoplasmin in the United States. Am Rev Respir Dis. 1969;99(4):1–132.4973586
  • Benedict K, Thompson GR 3rd, Deresinski S, Chiller T. Mycotic infections acquired outside areas of known endemicity, United States. Emerg Infect Dis. 2015;21(11):1935–1941. doi:10.3201/eid2111.14195026485441
  • Vail GM, Young RS, Wheat LJ, Filo RS, Cornetta K, Goldman M. Incidence of histoplasmosis following allogeneic bone marrow transplant or solid organ transplant in a hyperendemic area. Transpl Infect Dis. 2002;4(3):148–151. doi:10.1034/j.1399-3062.2002.01016.x12421460
  • Assi M, Martin S, Wheat LJ, et al. Histoplasmosis after solid organ transplant. Clin Infect Dis. 2013;57(11):1542–1549. doi:10.1093/cid/cit59324046304
  • Straub M, Schwarz J. The healed primary complex in histoplasmosis. Am J Clin Pathol. 1955;25(7):727–741. doi:10.1093/ajcp/25.7.72714387973
  • Mashburn JD, Dawson DF, Young JM. Pulmonary calcifications and histoplasmosis. Am Rev Respir Dis. 1961;84:208–216. doi:10.1164/arrd.1961.84.2.20813767747
  • Hage CA, Wheat LJ, Loyd J, Allen SD, Blue D, Knox KS. Pulmonary histoplasmosis. Semin Respir Crit Care Med. 2008;29(2):151–165. doi:10.1055/s-2008-106385418365997
  • Baddley JW, Sankara IR, Rodriquez JM, Pappas PG, Many WJ Jr. Histoplasmosis in HIV-infected patients in a southern regional medical center: poor prognosis in the era of highly active antiretroviral therapy. Diagn Microbiol Infect Dis. 2008;62(2):151–156. doi:10.1016/j.diagmicrobio.2008.05.00618597967
  • Couppie P, Aznar C, Carme B, Nacher M. American histoplasmosis in developing countries with a special focus on patients with HIV: diagnosis, treatment, and prognosis. Curr Opin Infect Dis. 2006;19(5):443–449. doi:10.1097/01.qco.0000244049.15888.b916940867
  • Karimi K, Wheat LJ, Connolly P, et al. Differences in histoplasmosis in patients with acquired immunodeficiency syndrome in the United States and Brazil. J Infect Dis. 2002;186(11):1655–1660. doi:10.1086/jid.2002.186.issue-1112447743
  • Corcoran GR, Al-abdely H, Flanders CD, Geimer J, Patterson TF. Markedly elevated serum lactate dehydrogenase levels are a clue to the diagnosis of disseminated histoplasmosis in patients with AIDS. Clin Infect Dis. 1997;24(5):942–944. doi:10.1093/clinids/24.5.9429142797
  • Kirn DH, Fredericks D, McCutchan JA, Stites D, Shuman M. Serum ferritin levels correlate with disease activity in patients with AIDS and disseminated histoplasmosis. Clin Infect Dis. 1995;21(4):1048–1049. doi:10.1093/clinids/21.4.10488645808
  • Khasawneh FA, Ahmed S, Halloush RA. Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia. Int J Gen Med. 2013;6:79–83. doi:10.2147/IJGM.S4152023467543
  • Assi MA, Sandid MS, Baddour LM, Roberts GD, Walker RC. Systemic histoplasmosis: a 15-year retrospective institutional review of 111 patients. Medicine (Baltimore). 2007;86(3):162–169. doi:10.1097/md.0b013e318067913017505255
  • Riddell J, Kauffman CA, Smith JA, et al. Histoplasma capsulatum endocarditis: multicenter case series with review of current diagnostic techniques and treatment. Medicine (Baltimore). 2014;93(5):186–193. doi:10.1097/MD.000000000000003425181311
  • Wheat LJ, Batteiger BE, Sathapatayavongs B. Histoplasma capsulatum infections of the central nervous system. A clinical review. Medicine (Baltimore). 1990;69(4):244–260. doi:10.1097/00005792-199007000-000062197524
  • Conces DJ Jr., Stockberger SM, Tarver RD, Wheat LJ. Disseminated histoplasmosis in AIDS: findings on chest radiographs. AJR Am J Roentgenol. 1993;160(1):15–19. doi:10.2214/ajr.160.1.84166148416614
  • Chan KS, Looi LM, Chan SP. Disseminated histoplasmosis mimicking miliary tuberculosis: a case report. Malays J Pathol. 1993;15(2):155–158.8065179
  • Agudelo CA, Restrepo CA, Molina DA, et al. Tuberculosis and histoplasmosis co-infection in AIDS patients. Am J Trop Med Hyg. 2012;87(6):1094–1098. doi:10.4269/ajtmh.2012.12-029223128292
  • Carreto-binaghi LE, Morales-villarreal FR, Garcia-de la Torre G, et al. Histoplasma capsulatum and Pneumocystis jirovecii coinfection in hospitalized HIV and non-HIV patients from a tertiary care hospital in Mexico. Int J Infect Dis. 2019;86:65–72. doi:10.1016/j.ijid.2019.06.01031207386
  • Nunes JO, Pillon KR, Bizerra PL, Paniago AM, Mendes RP, Chang MR. The simultaneous occurrence of histoplasmosis and cryptococcal fungemia: a case report and review of the literature. Mycopathologia. 2016;181(11–12):891–897. doi:10.1007/s11046-016-0036-127423433
  • Caceres DH, Tobon AM, Restrepo A, Chiller T, Gomez BL. The important role of co-infections in patients with AIDS and progressive disseminated histoplasmosis (PDH): A cohort from Colombia. Med Mycol Case Rep. 2018;19:41–44. doi:10.1016/j.mmcr.2017.07.00429379705
  • Huber F, Nacher M, Aznar C, et al. AIDS-related Histoplasma capsulatum var. capsulatum infection: 25 years experience of French Guiana. AIDS. 2008;22(9):1047–1053. doi:10.1097/QAD.0b013e3282ffde6718520348
  • Adenis A, Nacher M, Hanf M, et al. HIV-associated histoplasmosis early mortality and incidence trends: from neglect to priority. PLoS Negl Trop Dis. 2014;8(8):e3100. doi:10.1371/journal.pntd.000310025144374
  • Hage CA, Ribes JA, Wengenack NL, et al. A multicenter evaluation of tests for diagnosis of histoplasmosis. Clin Infect Dis. 2011;53(5):448–454. doi:10.1093/cid/cir43521810734
  • Myint T, Anderson AM, Sanchez A, et al. Histoplasmosis in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS): multicenter study of outcomes and factors associated with relapse. Medicine (Baltimore). 2014;93(1):11–18. doi:10.1097/MD.000000000000001624378739
  • Johnson PC, Wheat LJ, Cloud GA, et al. Safety and efficacy of liposomal amphotericin B compared with conventional amphotericin B for induction therapy of histoplasmosis in patients with AIDS. Ann Intern Med. 2002;137(2):105–109. doi:10.7326/0003-4819-137-2-200207160-0000812118965
  • Caceres DH, Knuth M, Derado G, Lindsley MD. Diagnosis of progressive disseminated histoplasmosis in advanced HIV: a meta-analysis of assay analytical performance. J Fungi (Basel). 2019;5(3):76.
  • Wheat LJ, Kohler RB, Tewari RP. Diagnosis of disseminated histoplasmosis by detection of Histoplasma capsulatum antigen in serum and urine specimens. N Engl J Med. 1986;314(2):83–88. doi:10.1056/NEJM1986010931402053941695
  • Durkin MM, Connolly PA, Wheat LJ. Comparison of radioimmunoassay and enzyme-linked immunoassay methods for detection of Histoplasma capsulatum var. capsulatum antigen. J Clin Microbiol. 1997;35(9):2252–2255. doi:10.1128/JCM.35.9.2252-2255.19979276396
  • Swartzentruber S, LeMonte A, Witt J, et al. Improved detection of Histoplasma antigenemia following dissociation of immune complexes. Clin Vaccine Immunol. 2009;16(3):320–322. doi:10.1128/CVI.00409-0819144790
  • Connolly PA, Durkin MM, Lemonte AM, Hackett EJ, Wheat LJ. Detection of histoplasma antigen by a quantitative enzyme immunoassay. Clin Vaccine Immunol. 2007;14(12):1587–1591. doi:10.1128/CVI.00071-0717913863
  • Hage CA, Davis TE, Fuller D, et al. Diagnosis of histoplasmosis by antigen detection in BAL fluid. Chest. 2010;137(3):623–628. doi:10.1378/chest.09-170219837826
  • Bloch KC, Myint T, Raymond-guillen L, et al. Improvement in diagnosis of histoplasma meningitis by combined testing for histoplasma antigen and immunoglobulin G and immunoglobulin M anti-histoplasma antibody in cerebrospinal fluid. Clin Infect Dis. 2018;66(1):89–94. doi:10.1093/cid/cix70629020213
  • Azuma I, Kanetsuna F, Tanaka Y, Yamamura Y, Carbonell LM. Chemical and immunological properties of galactomannans obtained from Histoplasma duboisii, Histoplasma capsulatum, Paracoccidioides brasiliensis and Blasomyces dermatitidis. Mycopathol Mycol Appl. 1974;54(1):111–125. doi:10.1007/BF020559794279334
  • Durkin M, Connolly P, Kuberski T, et al. Diagnosis of coccidioidomycosis with use of the Coccidioides antigen enzyme immunoassay. Clin Infect Dis. 2008;47(8):e69–e73. doi:10.1086/59329918781884
  • Durkin M, Estok L, Hospenthal D, et al. Detection of Coccidioides antigenemia following dissociation of immune complexes. Clin Vaccine Immunol. 2009;16(10):1453–1456. doi:10.1128/CVI.00227-0919675225
  • Bahr NC, Sarosi GA, Meya DB, et al. Seroprevalence of histoplasmosis in Kampala, Uganda. Med Mycol. 2016;54(3):295–300. doi:10.1093/mmy/myv08126527637
  • Theel ES, Jespersen DJ, Harring J, Mandrekar J, Binnicker MJ. Evaluation of an enzyme immunoassay for detection of Histoplasma capsulatum antigen from urine specimens. J Clin Microbiol. 2013;51(11):3555–3559. doi:10.1128/JCM.01868-1323966508
  • Zhang C, Lei GS, Lee CH, Hage CA. Evaluation of two new enzyme immunoassay reagents for diagnosis of histoplasmosis in a cohort of clinically characterized patients. Med Mycol. 2015;53(8):868–873. doi:10.1093/mmy/myv06226337088
  • Gutierrez ME, Canton A, Connolly P, Zarnowski R, Wheat LJ. Detection of Histoplasma capsulatum antigen in Panamanian patients with disseminated histoplasmosis and AIDS. Clin Vaccine Immunol. 2008;15(4):681–683. doi:10.1128/CVI.00358-0718287576
  • Caceres DH, Samayoa BE, Medina NG, et al. Multicenter validation of commercial antigenuria reagents to diagnose progressive disseminated histoplasmosis in people living with HIV/AIDS in two Latin American countries. J Clin Microbiol. 2018;56:6. doi:10.1128/JCM.01959-17
  • Falci DR, Monteiro AA, Braz Caurio CF, et al. Histoplasmosis, an underdiagnosed disease affecting people living with HIV/AIDS in Brazil: results of a Multicenter Prospective Cohort Study Using both classical mycology tests and histoplasma urine antigen detection. Open Forum Infect Dis. 2019;6(4):ofz073. doi:10.1093/ofid/ofz07330997365
  • Hage CA, Kirsch EJ, Stump TE, et al. Histoplasma antigen clearance during treatment of histoplasmosis in patients with AIDS determined by a quantitative antigen enzyme immunoassay. Clin Vaccine Immunol. 2011;18(4):661–666. doi:10.1128/CVI.00389-1021307278
  • Caceres DH, Gomez BL, Tobon AM, Chiller TM, Lindsley MD. Evaluation of a Histoplasma antigen Lateral Flow Assay for the rapid diagnosis of progressive disseminated histoplasmosis in Colombian patients with AIDS. Mycoses. 2019.
  • Wheat J, French ML, Kohler RB, et al. The diagnostic laboratory tests for histoplasmosis: analysis of experience in a large urban outbreak. Ann Intern Med. 1982;97(5):680–685. doi:10.7326/0003-4819-97-5-6806814316
  • Richer SM, Smedema ML, Durkin MM, et al. Improved diagnosis of acute pulmonary histoplasmosis by combining antigen and antibody detection. Clin Infect Dis. 2016;62(7):896–902. doi:10.1093/cid/ciw00726797210
  • Almeida MA, Damasceno LS, Pizzini CV, Muniz MM, Almeida-paes R, Zancope-oliveira RM. Role of Western blot assay for the diagnosis of histoplasmosis in AIDS patients from a National Institute of Infectious Diseases in Rio de Janeiro, Brazil. Mycoses. 2019;62(3):261–267. doi:10.1111/myc.1287730561870
  • Tang YW, Li H, Durkin MM, et al. Urine polymerase chain reaction is not as sensitive as urine antigen for the diagnosis of disseminated histoplasmosis. Diagn Microbiol Infect Dis. 2006;54(4):283–287. doi:10.1016/j.diagmicrobio.2005.10.00816466889
  • Azar MM, Hage CA. Laboratory diagnostics for histoplasmosis. J Clin Microbiol. 2017;55(6):1612–1620. doi:10.1128/JCM.02430-1628275076
  • Bongomin F, Kwizera R, Denning DW. Getting histoplasmosis on the map of international recommendations for patients with advanced HIV disease. J Fungi (Basel). 2019;5(3):80.
  • Wheat J, Myint T, Guo Y, et al. Central nervous system histoplasmosis: multicenter retrospective study on clinical features, diagnostic approach and outcome of treatment. Medicine (Baltimore). 2018;97(13):e0245. doi:10.1097/MD.000000000001024529595679
  • Myint T, Chow FC, Bloch KC, et al. Detection of (1,3)-beta-d-Glucan in Cerebrospinal Fluid in Histoplasma Meningitis. J Clin Microbiol. 2018;56:10. doi:10.1128/JCM.00663-18
  • Wheat LJ, Freifeld AG, Kleiman MB, et al. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis. 2007;45(7):807–825. doi:10.1086/52125917806045
  • Reddy P, Gorelick DF, Brasher CA, Larsh H. Progressive disseminated histoplasmosis as seen in adults. Am J Med. 1970;48(5):629–636. doi:10.1016/0002-9343(70)90014-85425240
  • Wheat J, Hafner R, Korzun AH, et al. Itraconazole treatment of disseminated histoplasmosis in patients with the acquired immunodeficiency syndrome. AIDS Clinical Trial Group. Am J Med. 1995;98(4):336–342. doi:10.1016/S0002-9343(99)80311-87709945
  • Wheat J, Hafner R, Wulfsohn M, et al. Prevention of relapse of histoplasmosis with itraconazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1993;118(8):610–616. doi:10.7326/0003-4819-118-8-199304150-000068383934
  • Ashbee HR, Barnes RA, Johnson EM, Richardson MD, Gorton R, Hope WW. Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology. J Antimicrob Chemother. 2014;69(5):1162–1176. doi:10.1093/jac/dkt50824379304
  • Andes D, Pascual A, Marchetti O. Antifungal therapeutic drug monitoring: established and emerging indications. Antimicrob Agents Chemother. 2009;53(1):24–34. doi:10.1128/AAC.00705-0818955533
  • Lestner JM, Roberts SA, Moore CB, Howard SJ, Denning DW, Hope WW. Toxicodynamics of itraconazole: implications for therapeutic drug monitoring. Clin Infect Dis. 2009;49(6):928–930. doi:10.1086/60549919681707
  • Li RK, Ciblak MA, Nordoff N, Pasarell L, Warnock DW, McGinnis MR. In vitro activities of voriconazole, itraconazole, and amphotericin B against Blastomyces dermatitidis, Coccidioides immitis, and Histoplasma capsulatum. Antimicrob Agents Chemother. 2000;44(6):1734–1736. doi:10.1128/AAC.44.6.1734-1736.200010817743
  • Law D, Moore CB, Denning DW. Bioassay for serum itraconazole concentrations using hydroxyitraconazole standards. Antimicrob Agents Chemother. 1994;38(7):1561–1566. doi:10.1128/AAC.38.7.15617979289
  • Nivoix Y, Leveque D, Herbrecht R, Koffel JC, Beretz L, Ubeaud-sequier G. The enzymatic basis of drug-drug interactions with systemic triazole antifungals. Clin Pharmacokinet. 2008;47(12):779–792. doi:10.2165/0003088-200847120-0000319026034
  • Wheat LJ, Connolly P, Smedema M, et al. Activity of newer triazoles against Histoplasma capsulatum from patients with AIDS who failed fluconazole. J Antimicrob Chemother. 2006;57(6):1235–1239.16627592
  • Connolly P, Wheat LJ, Schnizlein-bick C, et al. Comparison of a new triazole, posaconazole, with itraconazole and amphotericin B for treatment of histoplasmosis following pulmonary challenge in immunocompromised mice. Antimicrob Agents Chemother. 2000;44(10):2604–2608. doi:10.1128/AAC.44.10.2604-2608.200010991831
  • Restrepo A, Tobon A, Clark B, et al. Salvage treatment of histoplasmosis with posaconazole. J Infect. 2007;54(4):319–327. doi:10.1016/j.jinf.2006.05.00616824608
  • Wheat LJ, Connolly P, Smedema M, Brizendine E, Hafner R. Emergence of resistance to fluconazole as a cause of failure during treatment of histoplasmosis in patients with acquired immunodeficiency disease syndrome. Clin Infect Dis. 2001;33(11):1910–1913. doi:10.1086/cid.2001.33.issue-1111692303
  • Wheat J, MaWhinney S, Hafner R, et al. Treatment of histoplasmosis with fluconazole in patients with acquired immunodeficiency syndrome. National Institute of Allergy and Infectious Diseases Acquired Immunodeficiency Syndrome Clinical Trials Group and Mycoses Study Group. Am J Med. 1997;103(3):223–232. doi:10.1016/S0002-9343(97)00151-49316555
  • McKinsey DS, Kauffman CA, Pappas PG, et al. Fluconazole therapy for histoplasmosis. The National Institute of Allergy and Infectious Diseases Mycoses Study Group. Clin Infect Dis. 1996;23(5):996–1001. doi:10.1093/clinids/23.5.9968922792
  • Spec A, Connolly P, Montejano R, Wheat LJ. In vitro activity of isavuconazole against fluconazole-resistant isolates of Histoplasma capsulatum. Med Mycol. 2018;56(7):834–837. doi:10.1093/mmy/myx13029253204
  • Thompson GR 3rd, Rendon A, Ribeiro Dos Santos R, et al. Isavuconazole treatment of cryptococcosis and dimorphic mycoses. Clin Infect Dis. 2016;63(3):356–362. doi:10.1093/cid/ciw30527169478
  • Goldman M, Zackin R, Fichtenbaum CJ, et al. Safety of discontinuation of maintenance therapy for disseminated histoplasmosis after immunologic response to antiretroviral therapy. Clin Infect Dis. 2004;38(10):1485–1489. doi:10.1086/42074915156489
  • Haynes RR, Connolly PA, Durkin MM, et al. Antifungal therapy for central nervous system histoplasmosis, using a newly developed intracranial model of infection. J Infect Dis. 2002;185(12):1830–1832. doi:10.1086/jid.2002.185.issue-1212085335
  • Wheat LJ, Cloud G, Johnson PC, et al. Clearance of fungal burden during treatment of disseminated histoplasmosis with liposomal amphotericin B versus itraconazole. Antimicrob Agents Chemother. 2001;45(8):2354–2357. doi:10.1128/AAC.45.8.2354-2357.200111451696
  • Hage CA, Azar MM, Bahr N, Loyd J, Wheat LJ. Histoplasmosis: up-to-date evidence-based approach to diagnosis and management. Semin Respir Crit Care Med. 2015;36(5):729–745. doi:10.1055/s-0000007526398539
  • AIDS info, Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV. Available from: https://aidsinfo.nih.gov/contentfiles/lvguidelines/adult_oi.pdf. Accessed March 11, 2020.
  • Shelburne SA 3rd, Darcourt J, White, AC Jr., et al. The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy. Clin Infect Dis. 2005;40(7):1049–1052. doi:10.1086/cid.2005.40.issue-715825000
  • Melzani A, De Reynal De Saint Michel R, Ntab B, et al. Incidence and trends in immune reconstitution inflammatory syndrome associated with Histoplasma capsulatum among people living with HIV: a 20-year case series and literature review. Clin Infect Dis. 2019. doi:10.1093/cid/ciz247
  • Novak RM, Richardson JT, Buchacz K, et al. Immune reconstitution inflammatory syndrome: incidence and implications for mortality. AIDS. 2012;26(6):721–730. doi:10.1097/QAD.0b013e3283511e9122233655
  • Ratnam I, Chiu C, Kandala NB, Easterbrook PJ. Incidence and risk factors for immune reconstitution inflammatory syndrome in an ethnically diverse HIV type 1-infected cohort. Clin Infect Dis. 2006;42(3):418–427. doi:10.1086/49935616392092
  • Manabe YC, Campbell JD, Sydnor E, Moore RD. Immune reconstitution inflammatory syndrome: risk factors and treatment implications. J Acquir Immune Defic Syndr. 2007;46(4):456–462. doi:10.1097/QAI.0b013e3181594c8c18077835
  • Breton G, Duval X, Estellat C, et al. Determinants of immune reconstitution inflammatory syndrome in HIV type 1-infected patients with tuberculosis after initiation of antiretroviral therapy. Clin Infect Dis. 2004;39(11):1709–1712. doi:10.1086/cid.2004.39.issue-1115578375
  • Shelburne SA, Montes M, Hamill RJ. Immune reconstitution inflammatory syndrome: more answers, more questions. J Antimicrob Chemother. 2006;57(2):167–170. doi:10.1093/jac/dki44416354748
  • Meintjes G, Scriven J, Marais S. Management of the immune reconstitution inflammatory syndrome. Curr HIV/AIDS Rep. 2012;9(3):238–250. doi:10.1007/s11904-012-0129-522752438
  • McKinsey DS, Wheat LJ, Cloud GA, et al. Itraconazole prophylaxis for fungal infections in patients with advanced human immunodeficiency virus infection: randomized, placebo-controlled, double-blind study. National Institute of Allergy and Infectious Diseases Mycoses Study Group. Clin Infect Dis. 1999;28(5):1049–1056. doi:10.1086/cid.1999.28.issue-510452633