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Review

Severe alcoholic hepatitis: current perspectives

, , , &
Pages 97-108 | Published online: 08 Aug 2019

References

  • Kerr WC, Stockwell T. Understanding standard drinks and drinking guidelines. Drug Alcohol Rev. 2011;31(2):200–205. doi:10.1111/j.1465-3362.2011.00374.x22050262
  • Lieber CS. Relationships between nutrition, alcohol use, and liver disease. Alcohol Res Health. 2003;27(3):220–231.15535450
  • Frazier TH, Stocker AM, Kershner NA, Marsano LS, McClain CJ. Treatment of alcoholic liver disease. Therap Adv Gastroenterol. 2011;4:63–81. doi:10.1177/1756283X10378925
  • Seitz HK, Bataller R, Cortez-Pinto H, et al. Alcoholic liver disease. Nat Rev Dis Primers. 2018;4(1):16. doi:10.1038/s41572-018-0014-730115921
  • Dugum MF, McCullough AJ. Acute alcoholic hepatitis, the clinical aspects. Clin Liver Dis. 2016;20:499–508. doi:10.1016/j.cld.2016.02.00827373612
  • Crabb DW, Bataller R, Chalasani NP, et al. Standard definitions and common data elements for clinical trials in patients with alcoholic hepatitis: recommendation from the NIAAA alcoholic hepatitis consortia. Gastroenterology. 2016;150(4):785–790. doi:10.1053/j.gastro.2016.02.04226921783
  • Singal AK, Louvet A, Shah VH, Kamath PS. Grand rounds: alcoholic hepatitis. J Hepatol. 2018;69:534–543. doi:10.1016/j.jhep.2018.05.00129753761
  • Roth NC, Saberi B, Macklin J, et al. Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy. Hepatol Commun. 2017;1(10):1070–1084. doi:10.1002/hep4.110329404443
  • Caldwell S, Ikura Y, Dias D, et al. Hepatocellular ballooning in NASH. J Hepatol. 2010;53(4):719–723. doi:10.1016/j.jhep.2010.01.03220624660
  • Sakhuja P. Pathology of alcoholic liver disease, can it be differentiated from nonalcoholic steatohepatitis? World J Gastroenterol. 2014;20(44):16474–16479. doi:10.3748/wjg.v20.i44.1647425469015
  • Theise ND. Histopathology of alcoholic liver disease. Clin Liver Dis. 2013;2:64–67. doi:10.1002/cld.172
  • Li YM, Fan JG, Wang BY, et al. Guidelines for the diagnosis and management of alcoholic liver disease: update 2010: (published in Chinese on Chinese Journal of Hepatology 2010; 18: 167–170). J Dig Dis. 2011;12(1):45–50. doi:10.1111/j.1751-2980.2010.00477.x21276208
  • Gustot T, Fernandez J, Szabo G. Sepsis in alcohol-related liver disease. J Hepatol. 2017;67(5):1031–1050. doi:10.1016/j.jhep.2017.06.01328647569
  • Sersté T, Cornillie A, Njimi H, et al. The prognostic value of acute-on-chronic liver failure during the course of severe alcoholic hepatitis. J Hepatol. 2018;69(2):318–324. doi:10.1016/j.jhep.2018.02.02229524528
  • Lee M, Kim W, Choi Y, et al. Spontaneous evolution in bilirubin levels predicts liver-related mortality in patients with alcoholic hepatitis [published correction appears in PLoS One. 2016;11(11):e0167184]. PLoS One. 2014;9(7):e100870. doi:10.1371/journal.pone.010087025013906
  • Rahimi E, Pan JJ. Prognostic models for alcoholic hepatitis. Biomark Res. 2015;3:20. doi:10.1186/s40364-015-0046-z26203357
  • Das S, Maras JS, Maiwall R, et al. Molecular ellipticity of circulating albumin-bilirubin complex associates with mortality in patients with severe alcoholic hepatitis. Clin Gastroenterol Hepatol. 2018;16:1322–1332. doi:10.1016/j.cgh.2017.11.02229155355
  • Mathurin P, O’Grady J, Carithers RL, et al. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data. Gut. 2011;60(2):255–260. doi:10.1136/gut.2011.23772720940288
  • Altamirano J, Miquel R, Katoonizadeh A, et al. A histologic scoring system for prognosis of patients with alcoholic hepatitis. Gastroenterology. 2014;146:1231–1239.e1–e6. doi:10.1053/j.gastro.2014.01.018
  • Farooq MO, Bataller R. Pathogenesis and management of alcoholic liver disease. Dig Dis. 2016;34:347–355. doi:10.1159/00044454527170388
  • Dhanda AD, Di Mambro AJ, Hunt VL, et al. Long-term outcome in patients with severe alcoholic hepatitis can be reliably determined using an in vitro measure of steroid sensitivity. Hepatology. 2015;61(3):1099. doi:10.1002/hep.2721124811769
  • Rossi RE, Conte D, Massironi S. Diagnosis and treatment of nutritional deficiencies in alcoholic liver disease: overview of available evidence and open issues. Dig Liver Dis. 2015;47:819–825. doi:10.1016/j.dld.2015.05.02126164399
  • Moreno C, Deltenre P, Senterre C, et al. Intensive enteral nutrition is ineffective for patients with severe alcoholic hepatitis treated with corticosteroids. Gastroenterology. 2016;150:903–910.e8. doi:10.1053/j.gastro.2015.12.03826764182
  • Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O. Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial. Gastroenterology. 2000;119(6):1637–1648. doi:10.1053/gast.2000.2018911113085
  • De BK, Gangopadhyay S, Dutta D, Baksi SD, Pani A, Ghosh P. Pentoxifylline versus prednisolone for severe alcoholic hepatitis: a randomized controlled trial. World J Gastroenterol. 2009;15(13):1613–1619. doi:10.3748/wjg.15.91919340904
  • Whitfield K, Rambaldi A, Wetterslev J, Gluud C. Pentoxifylline for alcoholic hepatitis. Cochrane Database Syst Rev. 2009;CD007339.19821406
  • Thursz MR, Richardson P, Allison M, et al. Prednisolone or pentoxifylline for alcoholic hepatitis. N Engl J Med. 2015;372:1619–1628. doi:10.1056/NEJMoa141227825901427
  • Singh S, Murad MH, Chandar AK, et al. Comparative effectiveness of pharmacological interventions for severe alcoholic hepatitis: a systematic review and network meta-analysis. Gastroenterology. 2015;149:958–70. e12. doi:10.1053/j.gastro.2015.06.00626091937
  • Vergis N, Atkinson SR, Knapp S, et al. In patients with severe alcoholic hepatitis, prednisolone increases susceptibility to infection and infection-related mortality, and is associated with high circulating levels of bacterial DNA. Gastroenterology. 2017;152(5):1068–1077.e4. doi:10.1053/j.gastro.2016.12.01928043903
  • Spahr L, Lambert JF, Rubbia-Brandt L, et al. Granulocyte-colony stimulating factor induces proliferation of hepatic progenitors in alcoholic steatohepatitis: a randomized trial. Hepatology. 2008;48:221–229. doi:10.1002/hep.2231718537187
  • Spahr L, Chalandon Y, Terraz S, et al. Autologous bone marrow mononuclear cell transplantation in patients with decompensated alcoholic liver disease: a randomized controlled trial. PLoS One. 2013;8:e53719. doi:10.1371/journal.pone.005371923341981
  • Singh V, Sharma AK, Narasimhan RL, Bhalla A, Sharma N, Sharma R. Granulocyte colony-stimulating factor in severe alcoholic hepatitis: a randomized pilot study. Am J Gastroenterol. 2014;109:1417–1423. doi:10.1038/ajg.2014.15424935272
  • Singh V, Keisham A, Bhalla A, et al. Efficacy of Granulocyte Colony-Stimulating Factor and N-acetylcysteine therapies in patients with severe alcoholic hepatitis. Clin Gastroenterol Hepatol. 2018;16:1650–1656.e2. doi:10.1016/j.cgh.2018.01.04029391265
  • Naveau S, Chollet-Martin S, Dharancy S, et al. A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis. Hepatology. 2004;39:1390–1397. PMID: 15122768. doi:10.1002/hep.2020615122768
  • Boetticher NC, Peine CJ, Kwo P, et al. A randomized, double-blinded, placebo controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis. Gastroenterology. 2008;135:1953–1960. doi:10.1053/j.gastro.2008.08.05718848937
  • Higuera-de la Tijera F, Servín-Caamaño AI, Serralde-Zúñiga AE, et al. Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis. World J Gastroenterol. 2015;21:4975–4985. doi:10.3748/wjg.v21.i16.497525945012
  • Mathurin P, Moreno C, Samuel D, et al. Early liver transplantation for severe alcoholic hepatitis. N Engl J Med. 2011;365:1790–1800. doi:10.1056/NEJMoa110570322070476
  • Im GY, Kim-Schluger L, Shenoy A, et al. Early liver transplantation for severe alcoholic hepatitis in the United States–A single-center experience. Am J Transplant. 2016;16:841–849. doi:10.1111/ajt.1358626710309
  • Lee BP, Chen PH, Haugen C, et al. Three-year results of a pilot program in early liver transplantation for severe alcoholic hepatitis. Ann Surg. 2017;265:20–29. doi:10.1097/SLA.000000000000183127280501
  • Thompson J, Jones N, Al-Khafaji A, et al. Extracorporeal cellular therapy (ELAD) in severe alcoholic hepatitis: a multinational, prospective, controlled, randomized trial. Liver Transpl. 2018;24(3):380–393. doi:10.1002/lt.2498629171941
  • Singal AK, Shah VH. Current trials and novel therapeutic targets for alcoholic hepatitis. J Hepatol. 2019;70(2):305–313. doi:10.1016/j.jhep.2018.10.02630658731
  • Vergis N, Atkinson SR, Thursz MR. The future of therapy for alcoholic hepatitis - Beyond corticosteroids. J Hepatol. 2019;70(4):785–787. doi:10.1016/j.jhep.2019.01.01630791978
  • Peeraphatdit TB, Simonetto DA, Shah VH. Exploring new treatment paradigms for alcoholic hepatitis by extrapolating from NASH and cholestasis. J Hepatol. 2018;69(2):275–277. doi:10.1016/j.jhep.2018.05.01229792896
  • Mathurin P, Dufour JF, Bzowej NH, et al. Selonsertib in combination with prednisolone for the treatment of severe alcoholic hepatitis: a phase 2 randomized controlled trial. Oral abstracts (Abstracts 1–299). Hepatology. 2018;68:1–183. doi:10.1002/hep.30256
  • Bajaj JS. Alcohol, liver disease and the gut microbiota. Nat Rev Gastroenterol Hepatol. 2019;16(4):235–246. doi:10.1038/s41575-018-0099-130643227
  • Philips CA, Pande A, Shasthry SM, et al. Healthy donor faecal microbiota transplantation in steroid ineligible severe alcoholic hepatitis: a pilot study. Clin Gastroenterol Hepatol. 2017;15:600–602. doi:10.1016/j.cgh.2016.10.02927816755
  • Philips CA, Phadke N, Ganesan K, Ranade S, Augustine P. Corticosteroids, nutrition, pentoxifylline, or fecal microbiota transplantation for severe alcoholic hepatitis. Indian J Gastroenterol. 2018;37(3):215–225. doi:10.1007/s12664-018-0859-429931479
  • Philips CA, Augustine P, Padsalgi G, Ahamed R, Jose A, Rajesh S. Only in the darkness can you see the stars: severe alcoholic hepatitis and higher grades of acute-on-chronic liver failure. J Hepatol. 2019;70(3):550–551. doi:10.1016/j.jhep.2018.10.00430470480