A review of the development of tumor vasculature and its effects on the tumor microenvironment

References

• Gimbrone MA Jr, Leapman SB, Cotran RS, Folkman J. Tumor dormancy in vivo by prevention of neovascularization. J Exp Med. 1972;136(2):261–276.
   PubMed Web of Science ®Google Scholar
• Pilat MJ, McCormick J, LoRusso PM. Vascular targeting agents. Curr Oncol Rep. 2004;6(2):103–110.
   PubMedGoogle Scholar
• Park HJ, Griffin RJ, Hui S, et al. Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS). Radiat Res. 2012;177(3):311–327.
   PubMed Web of Science ®Google Scholar
• El Kaffas A, Giles A, Czarnota GJ. Dose-dependent response of tumor vasculature to radiation therapy in combination with sunitinib depicted by three-dimensional high-frequency power Doppler ultrasound. Angiogenesis. 2013;16(2):443–454.
   PubMed Web of Science ®Google Scholar
• Franks KN, Jain P, Snee MP. Stereotactic ablative body radiotherapy for lung cancer. Clin Oncol (R Coll Radiol). 2015;27(5):280–289.
   PubMed Web of Science ®Google Scholar
• Musunuru HB, Loblaw A. Clinical trials of stereotactic ablative radiotherapy for prostate cancer: updates and future direction. Future Oncol. 2015;11(5):819–831.
   PubMed Web of Science ®Google Scholar
• Karam SD, Bhatia S. The radiobiological targets of SBRT: tumor cells or endothelial cells? Ann Transl Med. 2015;3(19):290.
   PubMedGoogle Scholar
• Allen BJ, Huang C-Y, Clarke RA. Targeted alpha anticancer therapies: update and future prospects. Biologics. 2014;4(8):255–267.
   Google Scholar
• Butterworth KT, McMahon SJ, Currell FJ, Prise KM. Physical basis and biological mechanisms of gold nanoparticle radiosensitization. Nanoscale. 2012;4(16):4830–4838.
   PubMed Web of Science ®Google Scholar
• Lin Y, Paganetti H, McMahon SJ, Schuemann J. Gold nanoparticle induced vasculature damage in radiotherapy: comparing protons, megavoltage photons, and kilovoltage photons. Med Phys. 2015;42(10):5890–5902.
   PubMed Web of Science ®Google Scholar
• Becker A, Hänsgen G, Bloching M, Weigel C, Lautenschläger C, Dunst J. Oxygenation of squamous cell carcinoma of the head and neck: comparison of primary tumors, neck node metastases, and normal tissue. Int J Radiat Oncol Biol Phys. 1998;42(1):35–41.
   PubMed Web of Science ®Google Scholar
• Algire GH, Chalkley HW. Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants. J Natl Cancer Inst. 1945;6(1):73–85.
   Google Scholar
• Folkman J. Tumor angiogenesis. Adv Cancer Res. 1985;43(1):175–203.
   PubMedGoogle Scholar
• Chalkley HW. Method for the quantitative morphologic analysis of tissues. J Natl Cancer Inst. 1943;4(1):47–53.
   Google Scholar
• Jain RK. Molecular regulation of vessel maturation. Nat Med. 2003;9(6):685–693.
   PubMed Web of Science ®Google Scholar
• Eddy HA, Casarett GW. Development of the vascular system in the hamster malignant neurilemmoma. Microvasc Res. 1973;6(1):63–82.
   PubMed Web of Science ®Google Scholar
• Yamaura H, Sato H. Quantitative studies on the developing vascular system of rat hepatoma. J Natl Cancer Inst. 1974;53(5):1229–1240.
   PubMedGoogle Scholar
• Peters W, Teixeira M, Intaglietta M, Gross JF. Microcirculatory studies in rat mammary carcinoma. I. Transparent chamber method, development of microvasculature, and pressures in tumor vessels. J Natl Cancer Inst. 1980;65(3):631–642.
   PubMedGoogle Scholar
• Boucher Y, Leunig M, Jain RK. Tumor angiogenesis and interstitial hypertension. Cancer Res. 1996;56(18):4264–4266.
   PubMed Web of Science ®Google Scholar
• Endrich B, Hammersen F, Götz A, Messmer K. Microcirculatory blood flow, capillary morphology, and local oxygen pressure of the hamster amelanotic melanoma A-Mel-3. J Natl Cancer Inst. 1982;68(3):475–485.
   PubMedGoogle Scholar
• Vajkoczy P, Schilling L, Ullrich A, Schmiedek P, Menger MD. Characterization of angiogenesis and microcirculation of high-grade glioma: an intravital multifluorescence microscopic approach in the athymic nude mouse. J Cereb Blood Flow Metab. 1998;18(5):510–520.
   PubMed Web of Science ®Google Scholar
• Leu AJ, Berk DA, Lymboussaki A, Alitalo K, Jain RK. Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation. Cancer Res. 2000;60(16):4324–4327.
   PubMed Web of Science ®Google Scholar
• Goldacre RJ, Sylven B. On the access of blood-borne dyes to various tumour regions. Br J Cancer. 1962;16(1):306–322.
   PubMedGoogle Scholar
• Tozer GM, Lewis S, Michalowski A, Aber V. The relationship between regional variations in blood flow and histology in a transplanted rat fibrosarcoma. Br J Cancer. 1990;61(2):250–257.
   PubMed Web of Science ®Google Scholar
• Tannock IF, Steel GG. Quantitative techniques for study of the anatomy and function of small blood vessels in tumors. J Natl Cancer Inst. 1969;42(5):771–782.
   PubMedGoogle Scholar
• Fallowfield ME. Vascular volume in B16 allografts and human melanoma xenografts estimated by means of Hoechst 33342. J Pathol. 1989;157(3):249–252.
   PubMed Web of Science ®Google Scholar
• Rubin P, Casarett G. Microcirculation of tumors part I: anatomy, function, and necrosis. Clin Radiol. 1966;17(3):220–229.
   PubMedGoogle Scholar
• Deane BR, Lantos PL. The vasculature of experimental brain tumours. Part 1. A sequential light and electron microscope study of angiogenesis. J Neurol Sci. 1981;49(1):55–66.
   PubMed Web of Science ®Google Scholar
• Vogel AW. Intratumoral vascular changes with increased size of a mammary adenocarcinoma: new method and results. J Natl Cancer Inst. 1965;34(5):571–578.
   PubMedGoogle Scholar
• Hilmas DE, Gillette EL. Morphometric analyses of the microvasculature of tumors during growth and after x-irradiation. Cancer. 1974;33(1):103–110.
   PubMed Web of Science ®Google Scholar
• Wijffels KIEM, Kaanders JHAM, Rijken PFJW, et al. Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas. Br J Cancer. 2000;83(5):674–683.
   PubMed Web of Science ®Google Scholar
• Pazouki S, Chisholm DM, Adi MM, et al. The association between tumour progression and vascularity in the oral mucosa. J Pathol. 1997;183(1):39–43.
   PubMed Web of Science ®Google Scholar
• Sawatsubashi M, Yamada T, Fukushima N, Mizokami H, Tokunaga O, Shin T. Association of vascular endothelial growth factor and mast cells with angiogenesis in laryngeal squamous cell carcinoma. Virchows Arch. 2000;436(3):243–248.
   PubMed Web of Science ®Google Scholar
• Pignataro L, Carboni N, Midolo V, et al. Clinical relevance of microvessel density in laryngeal squamous cell carcinomas. Int J Cancer. 2001;92(5):666–670.
   PubMed Web of Science ®Google Scholar
• Shieh YS, Lee HS, Shiah SG, Chu YW, Wu CW, Chang LC. Role of angiogenic and non-angiogenic mechanisms in oral squamous cell carcinoma: correlation with histologic differentiation and tumor progression. J Oral Pathol Med. 2004;33(10):601–606.
   PubMed Web of Science ®Google Scholar
• Li C, Shintani S, Terakado N, et al. Microvessel density and expression of vascular endothelial growth factor, basic fibroblast growth factor, and platelet-derived endothelial growth factor in oral squamous cell carcinomas. Int J Oral Maxillofac Surg. 2005;34(5):559–565.
   PubMed Web of Science ®Google Scholar
• Shieh YS, Hung YJ, Hsieh CB, Chen JS, Chou KC, Liu SY. Tumor-associated macrophage correlated with angiogenesis and progression of mucoepidermoid carcinoma of salivary glands. Ann Surg Oncol. 2009;16(3):751–760.
   PubMed Web of Science ®Google Scholar
• Sharma B, Sriram G, Saraswathi TR, Sivapathasundharam B. Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma. Indian J Dent Res. 2010;21(2):260–265.
   PubMedGoogle Scholar
• Mohtasham N, Babakoohi S, Salehinejad J, et al. Mast cell density and angiogenesis in oral dysplastic epithelium and low- and high-grade oral squamous cell carcinoma. Acta Odontol Scand. 2010;68(5):300–304.
   PubMed Web of Science ®Google Scholar
• Weidner N, Semple JP, Welch WR, et al. Tumor angiogenesis and metastasis – correlation in invasive breast carcinoma. N Engl J Med. 1991;324(1):1–8.
   PubMed Web of Science ®Google Scholar
• Davey KJ, Perrier S, Ohe G, et al. Assessment of vascularity as an index of angiogenesis in periradicular granulomas. Comparison with oral carcinomas and normal tissue counterparts. Int Endod J. 2008;41(11):987–996.
   PubMed Web of Science ®Google Scholar
• Schor AM, Pendleton N, Pazouki S, et al. Assessment of vascularity in histological sections: effects of methodology and value as an index of angiogenesis in breast tumours. Histochem J. 1998;30(12):849–856.
   PubMedGoogle Scholar
• Hagedorn HG, Nerlich AG. Microvessel density and endothelial basement membrane composition in laryngeal squamous cell carcinomas. Acta Otolaryngol. 2000;120(7):891–898.
   PubMed Web of Science ®Google Scholar
• Amelink A, Kaspers OP, Sterenborg HJ, van der Wal JE, Roodenburg JL, Witjes MJ. Non-invasive measurement of the morphology and physiology of oral mucosa by use of optical spectroscopy. Oral Oncol. 2008;44(1):65–71.
   PubMed Web of Science ®Google Scholar
• Amelink A, Sterenborg HJ, Bard MP, Burgers SA. In vivo measurement of the local optical properties of tissue by use of differential path-length spectroscopy. Opt Lett. 2004;29(10):1087–1089.
   PubMed Web of Science ®Google Scholar
• Thomlinson RH, Gray LH. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer. 1955;9(4):539–549.
   PubMed Web of Science ®Google Scholar
• Tannock IF. The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour. Br J Cancer. 1968;22(2):258–273.
   PubMed Web of Science ®Google Scholar
• Hirst DG, Denekamp J. Tumour cell proliferation in relation to the vasculature. Cell Tissue Kinet. 1979;12(1):31–42.
   PubMedGoogle Scholar
• Gross MW, Karbach U, Groebe K, Franko AJ, Mueller-Klieser W. Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids. Int J Cancer. 1995;61(4):567–573.
   PubMed Web of Science ®Google Scholar
• Chou SC, Azuma Y, Varia MA, Raleigh JA. Evidence that involucrin, a marker for differentiation, is oxygen regulated in human squamous cell carcinomas. Br J Cancer. 2004;90(3):728–735.
   PubMed Web of Science ®Google Scholar
• Wykoff CC, Beasley NJ, Watson PH, et al. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res. 2000;60(24):7075–7083.
   PubMed Web of Science ®Google Scholar
• Hoogsteen IJ, Lok J, Marres HA, et al. Hypoxia in larynx carcinomas assessed by pimonidazole binding and the value of CA-IX and vascularity as surrogate markers of hypoxia. Eur J Cancer. 2009;45(16):2906–2914.
   PubMed Web of Science ®Google Scholar
• Beasley NJ, Wykoff CC, Watson PH, et al. Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density. Cancer Res. 2001;61(13):5262–5267.
   PubMed Web of Science ®Google Scholar
• Bussink J, Kaanders JH, Rijken PF, Martindale CA, van der Kogel AJ. Multiparameter analysis of vasculature, perfusion and proliferation in human tumour xenografts. Br J Cancer. 1998;77(1):57–64.
   PubMed Web of Science ®Google Scholar
• Ljungkvist AS, Bussink J, Rijken PF, Kaanders JH, van der Kogel AJ, Denekamp J. Vascular architecture, hypoxia, and proliferation in first-generation xenografts of human head-and-neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys. 2002;54(1):215–228.
   PubMed Web of Science ®Google Scholar
• Wijffels KIEM, Hoogsteen IJ, Lok J, et al. No detectable hypoxia in malignant salivary gland tumors: preliminary results. Int J Radiat Oncol Biol Phys. 2009;73(5):1319–1325.
   PubMed Web of Science ®Google Scholar
• Porschen R, Classen S, Piontek M, Borchard F. Vascularization of carcinomas of the esophagus and its correlation with tumor proliferation. Cancer Res. 1994;54(2):587–591.
   PubMed Web of Science ®Google Scholar
• Schor AM, Pazouki S, Morris J, Smither RL, Chandrachud LM, Pendleton N. Heterogeneity in microvascular density in lung tumours: comparison with normal bronchus. Br J Cancer. 1998;77(6):946–951.
   PubMed Web of Science ®Google Scholar
• Borkenstein K, Levegrun S, Peschke P. Modeling and computer simulations of tumor growth and tumor response to radiotherapy. Radiat Res. 2004;162(1):71–83.
   PubMed Web of Science ®Google Scholar
• Harting C, Peschke P, Borkenstein K, Karger CP. Single-cell-based computer simulation of the oxygen-dependent tumour response to irradiation. Phys Med Biol. 2007;52(16):4775–4789.
   PubMed Web of Science ®Google Scholar