References
- Walker SL, Lockwood DNJ. The clinical and immunological features of leprosy. Brit Med Bull. 2006;78:103–121. doi:10.1093/bmb/ldl010
- Han XY, Sizer KC, Thompson EJ, et al. Comparative sequence analysis of Mycobacterium leprae and the new leprosy-causing Mycobacterium lepromatosis. J Bacteriol. 2009;191:6067–6074. doi:10.1128/JB.00762-0919633074
- Han XY, Sizer KC, Velarde-Félix JS, Frias-Castro LO, Vargas-Ocampo F. The Leprosy agents Mycobacterium lepromatosis and Mycobacterium leprae in Mexico. Int J Dermatol. 2012;51:952–959. doi:10.1111/j.1365-4632.2011.05414.x22788812
- Han XY, Zhang J, Li L. Leprosy agents Mycobacterium lepromatosis and Mycobacterium leprae in Mexico: a clarification. J Clin Microbiol. 2015;53:3387–3388. doi:10.1128/JCM.01588-1526224842
- Barreto JG, Bisanzio D, Guimarães LDS, et al. Spatial analysis spotlighting early childhood leprosy transmission in a hyperendemic municipality of the Brazilian Amazon Region. PLoS Negl Trop Dis. 2014;8:e2665. doi:10.1371/journal.pntd.000266524516679
- World Health Organization (WHO). Global leprosy update, 2017: reducing the disease burden due to leprosy. Wkly Epidemiol Rec. 2018;93:445–456.
- Hanseníase – DATASUS – Indicadores epidemiológicos e operacionais de hanseníase, por ano diagnóstico – Municípios/UF/Regiões/Brasil-2017. Brasil: Ministério da Saúde [Leprosy - DATASUS - Leprosy epidemiological and operational indicators, by diagnosis year - Municipalities / UF / Regions / Brazil-2017. Brazil: Ministry of Health. ] Available from: http://tabnet.datasus.gov.br/cgi/sinannetbd/hanseniase/hansDB2017.htm Accessed 126, 2019.
- Singal A, Sonthalia S, Pandhi D. Childhood leprosy in a tertiary-care hospital in Delhi, India: a reappraisal in the post-elimination era. Lepr Rev. 2011;82:259–269.22125934
- Chaitra P, Bhat RM. Post elimination status of childhood leprosy: report from tertiary-care hospital in South India. Biomed Res Int. 2013;2013:1–4. doi:10.1155/2013/328673
- Gitte SV, Sabat RN, Kamble KM. Childhood leprosy in an endemic area of central India. Indian Pediatr. 2016;53:221–224. doi:10.1007/s13312-016-0824-127029684
- Kar BR, Job CK. Visible deformity in childhood leprosy a 10-year study. Int J Lepr Other Mycobact Dis. 2005;73:243–248.16830633
- Raposo MT, Reis MC, Caminha AVDQ, et al. Grade 2 disabilities in leprosy patients from Brasil: need for follow-up after completion of multidrug therapy. PLoS Negl Trop Dis. 2018;12:1–12. doi:10.1371/journal.pntd.0006645
- Ekeke N, Chukwu J, Nwafor C, et al. Children and leprosy in southern Nigeria: burden, challenges and prospects. Lepr Rev. 2014;85:111–117.25255614
- Jain S, Reddy RG, Osmani SN, Lockwood DNJ, Suneetha S. Childhood leprosy in an urban clinic, Hyderabad, India: clinical presentation and the role of household contacts. Lepr Rev. 2002;73:248–253.12449890
- Diretrizes para vigilância, atenção e eliminação da Hanseníase como problema de saúde pública: manual técnico-operacional [Guidelines for surveillance, care and elimination of Leprosy as a Public Health problem: technical and operational manual]. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Brasília: Ministério da Saúde; 2016 [Health Surveillance Secretariat. Department of Communicable Disease Surveillance. Brasilia: Ministry of Health; 2016].
- Madrid Congress. Technical resolutions. Classification of leprosy. Int J Lepr. 1953;21:504–516.
- World Health Organization (WHO). Programme for the elimination of leprosy: a guide to eliminating leprosy as a public health problem. Technical documents. Geneva; 1995:60.
- Scollard DM, Martelli CMT, Stefani MMA, et al. Risk factors for leprosy reactions in three endemic countries. Am J Trop Med Hyg. 2015;92:108–114. doi:10.4269/ajtmh.13-022125448239
- Rao AG. Study of leprosy in children. Indian J Lepr. 2009;81:195–197.20704075
- Horo I, Rao PS, Nanda NK, Abraham S. Childhood leprosy: profiles from a leprosy referral hospital in West Bengal, India. Indian J Lepr. 2010;82:33–37.21229845
- Das L, Meher BK, Das NB, et al. A clinico-bacteriological study of leprosy in pediatric age group. Adv Infect Dis. 2013;3:269–273. doi:10.4236/aid.2013.34041
- Palit A, Inamadar AC, Desai SS, et al. Childhood leprosy in post-elimination phase: data from a tertiary health care hospital in the Kamataka state of south India. Lepr Rev. 2014;85:85–92.25255612
- Nair SP. A clinico-epidemiological study of pediatric leprosy in the urban leprosy center of a tertiary care institute. Ind J Ped Dermatol. 2017;18:24–27. doi:10.4103/2319-7250.187890
- Pinto ACVD, Wachholz PA, Silva GVD, et al. Profile of leprosy in children under 15 years of age monitored in a Brazilian referral center, 2004–2012. An Bras Dermatol. 2017;92:580–582. doi:10.1590/abd1806-4841.2017567628954121
- Antunes DE, Araujo S, Ferreira GP, et al. Identification of clinical, epidemiological and laboratory risk factors for leprosy reactions during and after multidrug therapy. Mem Inst Oswaldo Cruz. 2013;108:901–908. doi:10.1590/0074-027613022224271045
- Queiroz TA, Carvalho FPBD, Simpson CA, et al. Clinical and epidemiological profile of patients with leprosy-related reactions. Rev Gaúcha Enferm. 2015;36:185–191. doi:10.1590/1983-1447.2015.esp.5740527057718
- Lana FCF, Amaral EP, Lanza FM, et al. Hansen’s disease in children under fifteen years-old in Jequitinhonha Valley, Minas Gerais, Brazil. Rev Bras Enferm. 2007;60:696–700. doi:10.1590/s0034-7167200700060001418472544
- Imbiriba EB, Guerrero JCH, Garnelo L, Levino A, Cunha MDG, Pedrosa V. Epidemiological profile of leprosy in children under 15 in Manaus (Northern Brazil), 1998–2005. Rev Saude Publ. 2008;42:1021–1026. doi:10.1590/s0034-89102008005000056
- Ferreira IN, Alvarez RRA. Leprosy in patients under fifteen years of age in the city of Paracatu-MG (1994 to 2001). Rev Bras Epidemiol. 2005;8:41–49. doi:10.1590/S1415-790X2005000100006
- Ramos JM, Reyes F, Lemma D, Tesfamariam A, Belinchón I, Górgolas M. The burden of leprosy in children and adolescents in rural southern Ethiopia. Pediatr Int Child Health. 2014;34:24–28. doi:10.1179/2046905513Y.0000000073
- Motta ACF, Pereira KJ, Tarquínio DC, Vieira MB, Miyake K, Foss NT. Leprosy reactions: coinfections as a possible risk factor. Clinics. 2012;67:1145–1148. doi:10.6061/clinics/2012(10)0523070340
- Hungria EM, Oliveira RM, Penna GO, et al. Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil. Infect Dis Poverty. 2016;5:110. doi:10.1186/s40249-016-0203-027919284
- Leon KE, Jacob JT, Franco-Paredes C, Kozarsky PE, Wu HM, Fairley JK. Delayed diagnosis, leprosy reactions, and nerve injury among individuals with Hansen’s disease seen at a United States clinic. OFID. 2016;ofw063. doi:10.1093/ofid/ofw06327186586
- Silva SFD, Griep RH. Leprosy reaction in patients of health centers from de Planning Area 3.2 of Rio de Janeiro Municipality. Hansen Int. 2007;32:155–162.
- Suchonwanit P, Triamchaisri S, Wittayakornrerk S, et al. Leprosy reaction in Thai population: a 20-year restrospective study. Dermatol Res Pract. 2015;2015:253154. doi:10.1155/2015/25315426508912
- Richardus JH, Nicholls PG, Croft RP, Withington SG, Smith W, Cairns S. Incidence of acute nerve function impairment and reactions in leprosy: a prospective cohort analysis after 5 years of follow-up. Int J Epidemiol. 2004;33:337–343. doi:10.1093/ije/dyg22515082636
- Teixeira MAG, Silveira VMD, França ERD. Characteristics of leprosy reactions in paucibacillary and multibacillary individuals attended at two reference centers in Recife, Pernambuco. Rev Bras Med Trop. 2010;43:287–292. doi:10.1590/S0037-86822010000300015
- Pitts CJD, Kearns AE. Update on medications with adverse skeletal effects. Mayo Clin Proc. 2011;86:338–343. doi:10.4065/mcp.2010.063621389249
- Costa MD, Costa RD, Terra FDS, et al. Assessment of quality of life of patients with leprosy reactional states treated in a dermatology reference center. An Bras Dermatol. 2012;87:26–35. doi:10.1590/s0365-0596201200010000322481648
- Sethi M, Rao PS. Challenges in preventing disabilities among children affected by leprosy: findings from a referral hospital in North India. Lep Rev. 2015;86:296–297.26665368
- Nicholls PG, Wiens C, Smith WC. Delay in presentation in the context of local knowledge and attitude towards leprosy – the results of qualitative fieldwork in Paraguay. Int J Lepr Other Mycobact Dis. 2003;71:198–209. doi:10.1489/1544-581X(2003)71<198:DIPITC>2.0.CO;214608815
- Van Veen NH, Meima A, Richardus JH. The relationship between detection delay and impairment in leprosy control: a comparison of patient cohorts from Bangladesh and Ethiopia. Lepr Rev. 2006;77:356–365.17343222
- Bandeira SS, Pires CA, Quaresma JAS. Nerve damage in young patients with leprosy diagnosed in a endemic area of the Brazilian Amazon: a cross-sectional study. J Pediatr. 2017;185:143–148. doi:10.1016/j.jpeds.2017.02.03528285750
- Lucena-Silva N, Teixeira MA, de Ramos AL, et al. The +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosy. Mol Genet Genomic Med. 2013;1:123–130.24498610
- Fava VM, Manry J, Cobat A, et al. A missense LRRK2 variant is a risk factor for excessive inflammatory responses in leprosy. PLoS Negl Trop Dis. 2016;10:e0004412. doi:10.1371/journal.pntd.000441226844546
- Van Brakel WH, Nicholls PG, Das L, et al. Cohort study: investigating prediction, detection and pathogenesis of neuropathy and reactions in leprosy. Methods and baseline results of a cohort of multibacillary leprosy patients in North India. Lepr Rev. 2005;76:264.
- Oliveira DTD, Sherlock J, Melo EVD, et al. Clinical variables associated with leprosy reactions and persistence of physical impairment. Rev Soc Bras Med Trop. 2013;46:600–604. doi:10.1590/0037-8682-0100-201324270251
- Neder L, Weelden MV, Viola GR, et al. Qualidade de vida relacionada à saúde avaliada pelo Inventário Pediátrico de Qualidade de Vida 4.0 em pacientes pediátricos com hanseníase e manifestações musculoesqueléticas [Health-related quality of life evaluated by Pediatric Quality of Life Inventory 4.0 in pediatric leprosy patients with musculoskeletal manifestations]. Rev Bras Reumatol. 2015;55:414–419. doi:10.1016/j.rbr.2014.12.01326144576