The Landscape of Emerging Randomized Clinical Trial Evidence for COVID-19 Disease Stages: A Systematic Review of Global Trial Registries

References

• Sohrabi C, Alsafi Z, O’Neill N, et al. World Health Organization declares global emergency: a review of the 2019 novel coronavirus (COVID-19). Int J Surg. 2020;76:71–76. doi:10.1016/j.ijsu.2020.02.03432112977
   PubMed Web of Science ®Google Scholar
• Fauci AS, Lane HC, Redfield RR. Covid-19—navigating the Uncharted. Mass Medical Soc; 2020.
   Google Scholar
• Sanders JM, Monogue ML, Jodlowski TZ, Cutrell JB. Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review. JAMA. 2020;323(18):1824–1836.32282022
   PubMed Web of Science ®Google Scholar
• Thorlund K, Dron L, Park J, Hsu G, Forrest JI, Mills EJ. A real-time dashboard of clinical trials for COVID-19. Lancet Digit Health. 2020;2(6):e286–e287. doi:10.1016/S2589-7500(20)30086-832363333
   PubMedGoogle Scholar
• McCoy D, Chand S, Sridhar D. Global health funding: how much, where it comes from and where it goes. Health Policy Plan. 2009;24(6):407–417. doi:10.1093/heapol/czp02619570773
   PubMed Web of Science ®Google Scholar
• Bauchner H, Fontanarosa PB, Golub RM. Editorial evaluation and peer review during a pandemic: how journals maintain standards. JAMA. 2020;324(5):453. doi:10.1001/jama.2020.1176432589195
   PubMed Web of Science ®Google Scholar
• Bauchner H, Fontanarosa PB. Randomized clinical trials and COVID-19: managing expectations. JAMA. 2020;04:04.
   Google Scholar
• Glasziou PP, Sanders S, Hoffmann T. Waste in covid-19 research. BMJ. 2020;369:m1847.32398241
   PubMed Web of Science ®Google Scholar
• Collins FS, Morgan M, Patrinos A. The human genome project: lessons from large-scale biology. Science. 2003;300(5617):286–290. doi:10.1126/science.108456412690187
   PubMed Web of Science ®Google Scholar
• Adams MD, Kelley JM, Gocayne JD, et al. Complementary DNA sequencing: expressed sequence tags and human genome project. Science. 1991;252(5013):1651–1656. doi:10.1126/science.20478732047873
   PubMed Web of Science ®Google Scholar
• Collins FS, McKusick VA. Implications of the human genome project for medical science. JAMA. 2001;285(5):540–544. doi:10.1001/jama.285.5.54011176855
   PubMed Web of Science ®Google Scholar
• Ahn D-G, Shin H-J, Kim M-H, et al. Current status of epidemiology, diagnosis, therapeutics, and vaccines for novel coronavirus disease 2019 (COVID-19). J Microbiol Biotechnol. 2020;30(3):313–324. doi:10.4014/jmb.2003.0301132238757
   PubMed Web of Science ®Google Scholar
• Gandhi RT, Lynch JB, Del Rio C. Mild or moderate COVID-19. N Engl J Med. 2020;383(18):1757–1766. doi:10.1056/NEJMcp200924932329974
   PubMed Web of Science ®Google Scholar
• R: A Language and Environment for Statistical Computing [computer program]. Vienna, Austria: R Foundation for Statistical Computing; 2013.
   Google Scholar
• Salanti G, Kavvoura FK, Ioannidis JP. Exploring the geometry of treatment networks. Ann Intern Med. 2008;148(7):544–553. doi:10.7326/0003-4819-148-7-200804010-0001118378949
   PubMed Web of Science ®Google Scholar
• Arab-Zozani M, Hassanipour S. Features and limitations of LitCovid hub for quick access to literature about COVID-19. Balkan Med J. 2020. doi:10.4274/balkanmedj.galenos.2020.2020.4.67
   Web of Science ®Google Scholar
• Siemieniuk RA, Bartoszko JJ, Ge L, et al. Drug treatments for covid-19: living systematic review and network meta-analysis. BMJ. 2020;370:m2980. doi:10.1136/bmj.m298032732190
   PubMed Web of Science ®Google Scholar
• Gates B. Responding to Covid-19—a once-in-a-century pandemic? N Engl J Med. 2020;382(18):1677–1679. doi:10.1056/NEJMp200376232109012
   PubMed Web of Science ®Google Scholar
• Beaglehole R, Bonita R. Global public health: a scorecard. Lancet. 2008;372(9654):1988–1996. doi:10.1016/S0140-6736(08)61558-518945485
   PubMed Web of Science ®Google Scholar
• The RECOVERY Collaborative Group. Dexamethasone in hospitalized patients with Covid-19 — preliminary report. N Engl J Med. 2020:1–11. doi:10.1056/NEJMoa2021436
   Web of Science ®Google Scholar
• Cao X. COVID-19: immunopathology and its implications for therapy. Nat Rev Immunol. 2020;20(5):269–270. doi:10.1038/s41577-020-0308-332273594
   PubMed Web of Science ®Google Scholar
• Liu Y, Yan L-M, Wan L, et al. Viral dynamics in mild and severe cases of COVID-19. Lancet Infect Dis. 2020.
   Web of Science ®Google Scholar
• Grein J, Ohmagari N, Shin D, et al. Compassionate use of remdesivir for patients with severe Covid-19. N Engl J Med. 2020;382(24):2327–2336. doi:10.1056/NEJMoa200701632275812
   PubMed Web of Science ®Google Scholar
• Pan A, Liu L, Wang C, et al. Association of public health interventions with the epidemiology of the COVID-19 outbreak in Wuhan, China. JAMA. 2020;323(19):1915–1923. doi:10.1001/jama.2020.613032275295
   PubMed Web of Science ®Google Scholar
• Garg S, Kim L, Whitaker M. Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019 — COVID-NET, 14 States, March 1 –30, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:458–464. doi:10.15585/mmwr.mm6915e332298251
   PubMed Web of Science ®Google Scholar
• Boulware DR, Pullen MF, Bangdiwala AS, et al. A randomized trial of hydroxychloroquine as postexposure prophylaxis for Covid-19. N Engl J Med. 2020;383(6):517–525. doi:10.1056/NEJMoa201663832492293
   PubMed Web of Science ®Google Scholar
• Skipper CP. Hydroxychloroquine in nonhospitalized adults with early COVID-19. Ann Intern Med. 2020;173:623–631. doi:10.7326/M20-420732673060
   PubMed Web of Science ®Google Scholar
• Mitjà O, Corbacho-Monné M, Ubals M, et al. Hydroxychloroquine for early treatment of adults with mild Covid-19: a randomized-controlled trial. Clin Infect Dis. 2020.
   PubMedGoogle Scholar
• Cavalcanti AB, Zampieri FG, Rosa RG, et al. Hydroxychloroquine with or without azithromycin in mild-to-moderate Covid-19. N Engl J Med. 2020;383(21):2041–2052. doi:10.1056/NEJMoa201901432706953
   PubMed Web of Science ®Google Scholar
• Nicola M, Alsafi Z, Sohrabi C, et al. The socio-economic implications of the coronavirus and COVID-19 pandemic: a review. Int J Surg. 2020;78:185–193. doi:10.1016/j.ijsu.2020.04.01832305533
   PubMed Web of Science ®Google Scholar
• Baker SR, Bloom N, Davis SJ, Terry SJ. Covid-Induced Economic Uncertainty. National Bureau of Economic Research; 2020:0898–2937.
   Google Scholar
• Ma X, Vervoort D, Reddy CL, Park KB, Makasa E. Emergency and essential surgical healthcare services during COVID-19 in low-and middle-income countries: a perspective. Int J Surg. 2020;79:43–46. doi:10.1016/j.ijsu.2020.05.03732426019
   PubMed Web of Science ®Google Scholar
• Miller IF, Becker AD, Grenfell BT, Metcalf CJE. Disease and healthcare burden of COVID-19 in the United States. Nat Med. 2020;1–6.31932805
   PubMed Web of Science ®Google Scholar
• McKee M, Stuckler D. If the world fails to protect the economy, COVID-19 will damage health not just now but also in the future. Nat Med. 2020;26(5):640–642. doi:10.1038/s41591-020-0863-y32273610
   PubMed Web of Science ®Google Scholar