183
Views
2
CrossRef citations to date
0
Altmetric
Original Research

Ex vivo Sensitivity Profile of Plasmodium falciparum Clinical Isolates to a Panel of Antimalarial Drugs in Ghana 13 Years After National Policy Change

ORCID Icon, ORCID Icon, , , , , , ORCID Icon, & show all
Pages 267-276 | Published online: 28 Jan 2021

References

  • World Health Organization.World Malaria Report 2020: 20 Years of Global Progress and Challenges. World Health Organisation; 2020 https://www.who.int/publications/i/item/9789240015791.
  • Müller O. Malaria in Africa: Challenges for Control and Elimination in the 21st Century. Peter Lang Frankfurt; 2011.
  • Hyde JE. Drug-resistant malaria. Trends Parasitol. 2005;21(11):494–498. doi:10.1016/j.pt.2005.08.02016140578
  • Sibley CH. Understanding drug resistance in malaria parasites: basic science for public health. Mol Biochem Parasitol. 2014;195(2):107–114. doi:10.1016/j.molbiopara.2014.06.00124927641
  • Dondorp AM, Nosten F, Yi P, et al. Artemisinin resistance in Plasmodium falciparum Malaria. N Engl J Med. 2009;361(5):455–467. doi:10.1056/NEJMoa080885919641202
  • WHO. Global Report on Antimalarial Drug Efficacy and Drug Resistance: 2000-2010. 2010.
  • Goldberg DE, Siliciano RF, Jacobs WR. Outwitting evolution: fighting drug-resistant TB, Malaria, and HIV. Cell. 2012;148(6):1271–1283. doi:10.1016/j.cell.2012.02.02122424234
  • Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM. Evidence of artemisinin-resistant malaria in Western Cambodia. N Engl J Med. 2008;359(24):2619–2620. doi:10.1056/nejmc080501119064625
  • Phyo AP, Nkhoma S, Stepniewska K, et al. Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet. 2012;379(9830):1960–1966. doi:10.1016/S0140-6736(12)60484-X22484134
  • Na-Bangchang K, Ruengweerayut R, Mahamad P, Ruengweerayut K, Chaijaroenkul W. Declining in efficacy of a three-day combination regimen of mefloquine-artesunate in a multi-drug resistance area along the Thai-Myanmar border. Malar J. 2010;9(1):1–10. doi:10.1186/1475-2875-9-27320043863
  • Beshir K, Sutherland CJ, Merinopoulos I, et al. Amodiaquine resistance in Plasmodium falciparum malaria in Afghanistan is associated with the pfcrt SVMNT allele at codons 72 to 76. Antimicrob Agents Chemother. 2010;54(9):3714–3716. doi:10.1128/AAC.00358-1020547800
  • Sa JM, Twu O. Protecting the malaria drug arsenal: halting the rise and spread of amodiaquine resistance by monitoring the PfCRT SVMNT type. Malar J. 2010;9(1):374. doi:10.1186/1475-2875-9-37421182787
  • Folarin OA, Bustamante C, Gbotosho GO, et al. In vitro amodiaquine resistance and its association with mutations in pfcrt and pfmdr1 genes of Plasmodium falciparum isolates from Nigeria. Acta Trop. 2011;120(3):224–230. doi:10.1016/j.actatropica.2011.08.01321920347
  • Rogers WO, Sem R, Tero T, et al. Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia. Malar J. 2009;8(1):1–9. doi:10.1186/1475-2875-8-1019118502
  • Wongsrichanalai C, Meshnick SR. Declining artesunate-mefloquine efficacy against falciparum malaria on the Cambodia-Thailand border. Emerg Infect Dis. 2008;14(5):716–719. doi:10.3201/eid1405.07160118439351
  • Witkowski B, Iriart X, Soh PN, et al. pfmdr1 amplification associated with clinical resistance to mefloquine in West Africa: implications for efficacy of artemisinin combination therapies. J Clin Microbiol. 2010;48(10):3797–3799. doi:10.1128/JCM.01057-1020668121
  • Ashley EA, Dhorda M, Fairhurst RM, et al. Spread of artemisinin resistance in Plasmodium falciparum Malaria. N Engl J Med. 2014;371(5):411–423. doi:10.1056/nejmoa131498125075834
  • Mita T, Tanabe K, Kita K. Spread and evolution of Plasmodium falciparum drug resistance. Parasitol Int. 2009;58(3):201–209. doi:10.1016/j.parint.2009.04.00419393762
  • Petersen I, Eastman R, Lanzer M. Drug-resistant malaria: molecular mechanisms and implications for public health. FEBS Lett. 2011;585(11):1551–1562. doi:10.1016/j.febslet.2011.04.04221530510
  • Koram K, Quaye L, Abuaku B. Efficacy of amodiaquine/artesunate combination therapy for uncomplicated malaria in children under five years in ghana. Ghana Med J. 2008;42(2):55–60.19180204
  • Adjei GO, Kurtzhals JAL, Rodrigues OP, et al. Amodiaquine-artesunate vs artemether-lumefantrine for uncomplicated malaria in Ghanaian children: a randomized efficacy and safety trial with one year follow-up. Malar J. 2008;7:127–137. doi:10.1186/1475-2875-7-12718620577
  • Quashie NB, Duah NO, Abuaku B, et al. A SYBR Green 1-based in vitro test of susceptibility of Ghanaian Plasmodium falciparum clinical isolates to a panel of anti-malarial drugs. Malar J. 2013;12(1):1–12. doi:10.1186/1475-2875-12-45023282136
  • Färnert A, Williams TN, Mwangi TW, et al. Transmission‐dependent tolerance to multiclonal Plasmodium falciparum Infection. J Infect Dis. 2009;200(7):1166–1175. doi:10.1086/60565219702508
  • Abuaku BK, Mensah BA, Ofori MF, et al. Efficacy of artesunate/amodiaquine in the treatment of uncomplicated malaria among children in Ghana. Am J Trop Med Hyg. 2017;97(3):690–695. doi:10.4269/ajtmh.15-082628749762
  • Ghana Statistical Service. 2010 Population and Housing Census: Summary Report of Final Results.; 2012 Available from: https://www.statsghana.gov.gh/gssmain/storage/img/marqueeupdater/Census2010_Summary_report_of_final_results.pdf. Accessed 116, 2020.
  • Ministry of Food and Agriculture. Fanteakwa District. Published 2012. Available from: http://mofa.gov.gh/site/sports/district-directorates/eastern-region/225-fanteakwa. Accessed 212 2020.
  • Abuaku B, Duah N, Quaye L, Quashie N, Koram K. Therapeutic efficacy of artemether-lumefantrine combination in the treatment of uncomplicated malaria among children under five years of age in three ecological zones in Ghana. Malar J. 2012;11(1):388. doi:10.1186/1475-2875-11-38823173737
  • Kweku M, Liu D, Adjuik M, et al. Seasonal intermittent preventive treatment for the prevention of anaemia and malaria in Ghanaian children: a randomized, placebo controlled trial. PLoS One. 2008;3(12):12. doi:10.1371/journal.pone.0004000
  • Ndiaye D, Patel V, Demas A, et al. Short report: A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials - Increased sensitivity of P. falciparum to chloroquine in senegal. Am J Trop Med Hyg. 2010;82(2):228–230. doi:10.4269/ajtmh.2010.09-047020133997
  • Le Nagard H, Vincent C, Mentré F, And JLB. Online analysis of in vitro resistance to antimalarial drugs through nonlinear regression. Comput Methods Programs Biomed. 2011;104(1):10–18. doi:10.1016/j.cmpb.2010.08.00320828858
  • Cui L, Mharakurwa S, Ndiaye D, Rathod PK, Rosenthal PJ. Antimalarial drug resistance: literature review and activities and findings of the ICEMR network. Am J Trop Med Hyg. 2015;93:57–68. doi:10.4269/ajtmh.15-0007
  • Ministry of Health. Anti-Malaria Drug Treatment Policy for Ghana: 2nd Revised Version. 2009 Available from: https://www.ghanahealthservice.org/ghs-item-details.php?cid=2&scid=55&id=54. Accessed 116, 2020.
  • Tinto H, Bonkian LN, Nana LA, et al. Ex vivo anti-malarial drugs sensitivity profile of Plasmodium falciparum field isolates from Burkina Faso five years after the national policy change. Malar J. 2014;13(1):1–7. doi:10.1186/1475-2875-13-20724383426
  • Fall B, Diawara S, Sow K, et al. Ex vivo susceptibility of Plasmodium falciparum isolates from Dakar, Senegal, to seven standard anti-malarial drugs. Malar J. 2011;10(1):1–8. doi:10.1186/1475-2875-10-31021214892
  • Pascual A, Parola P, Benoit-Vical F, et al. Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum. Malar J. 2012;11(1):45. doi:10.1186/1475-2875-11-4522333675
  • Mbaye A, Gaye A, Dieye B, et al. Ex vivo susceptibility and genotyping of Plasmodium falciparum isolates from Pikine, Senegal. Malar J. 2017;16(1):1–7. doi:10.1186/s12936-017-1897-628049519
  • Van Tyne D, Dieye B, Valim C, et al. Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal. Malar J. 2013;12:1. doi:10.1186/1475-2875-12-44123282136
  • Fall B, Pascual A, Sarr FD, et al. Plasmodium falciparum susceptibility to anti-malarial drugs in Dakar, Senegal, in 2010: an ex vivo and drug resistance molecular markers study. Malar J. 2013;12:1. doi:10.1186/1475-2875-12-10723282136
  • Wurtz N, Fall B, Pascual A, et al. Prevalence of molecular markers of Plasmodium falciparum drug resistance in Dakar, Senegal. Malar J. 2012:11. doi:10.1186/1475-2875-11-197.22230255
  • Zatra R, Lekana-douki JB, Lekoulou F, Bisvigou U, Ngoungou EB, Ndouo FST. In vitroantimalarial susceptibility and molecular markers of drug resistance in Franceville, Gabon. BMC Infect Dis. 2012;12(1):307. doi:10.1186/1471-2334-12-30723153201
  • Gari-Toussaint M, Pradines B, Médicale VM-LP. 2002 U. Sénégal et paludisme: echec prophylactique vrai de la méfloquine. Presse Med. 2002;31:1136.12162100
  • Duah NO, Wilson MD, Ghansah A, et al. Mutations in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance genes, and treatment outcomes in Ghanaian children with uncomplicated malaria. J Trop Pediatr. 2007;53(1):27–31. doi:10.1093/tropej/fml07617158810
  • Mensah BA, Aydemir O, Myers-Hansen JL, et al. Antimalarial drug resistance profiling of plasmodium falciparum infections in ghana using molecular inversion probes and next-generation sequencing. Antimicrob Agents Chemother. 2020;64(4):e01423–19. doi:10.1128/AAC.01423-1931932374
  • Lu F, Zhang M, Culleton RL, et al. Return of chloroquine sensitivity to Africa? Surveillance of African Plasmodium falciparum chloroquine resistance through malaria imported to China. Parasit Vectors. 2017;10(1):1–9. doi:10.1186/s13071-017-2298-y28049510
  • Fidock D, Nomura T, Talley A. Cell RC-M, 2000 Undefined. Mutations in the P. Falciparum Digestive Vacuole Transmembrane Protein PfCRT and Evidence for Their Role in Chloroquine Resistance. Elsevier; 2021 Available from: https://www.sciencedirect.com/science/article/pii/S1097276505000778. Accessed 14.
  • Valderramos S, sciences DF-T in pharmacological, 2006 undefined. Transporters involved in resistance to antimalarial drugs. Elsevier. Available from: https://www.sciencedirect.com/science/article/pii/S0165614706002240?casa_token=l5Iq2MBNqxkAAAAA:eVkCC-mAbjafh69cY_SSMJ89xe20_ozWU0WFezUZ_2jl_AOi9UUMSw9UAJbvLyX_ct8DbLsPORw.. Accessed 14 2021.
  • Oladipo OO, Wellington OA, Sutherland CJ. Persistence of chloroquine-resistant haplotypes of Plasmodium falciparum in children with uncomplicated Malaria in Lagos, Nigeria, four years after change of chloroquine as first-line antimalarial medicine. Diagn Pathol. 2015;10(1):41. doi:10.1186/s13000-015-0276-225928117
  • Afoakwah R, Boampong JN, Egyir-Yawson A, Nwaefuna EK, Verner ON, Asare KK. High prevalence of PfCRT K76T mutation in Plasmodium falciparum isolates in Ghana. Acta Trop. 2014;136:32–36. doi:10.1016/j.actatropica.2014.03.03024727053
  • Asare KK. Evaluation of Plasmodium falciparum chloroquine resistant markers in selected health facilities in Central Region after seven years of banning chloroquine treatment in Ghana. 2014 https://erl.ucc.edu.gh/jspui/bitstream/123456789/2768/1/ASARE2014.pdf.
  • Wellems T, Plowe C. Chloroquine-resistant malaria. J Infect Dis. 2001;184:770–776. doi:10.1086/32285811517439
  • Ekland E, Fidock D. In vitro evaluations of antimalarial drugs and their relevance to clinical outcomes. Int J Parasitol. 2008;38:743–747. doi:10.1016/j.ijpara.2008.03.00418406409
  • WHO. World Malaria Report 2019; 2019 https://www.who.int/news-room/fact-sheets/detail/malaria.