Molecular Epidemiology of mcr-1, bla_KPC-2, and bla_NDM-1 Harboring Clinically Isolated Escherichia coli from Pakistan

References

• Theuretzbacher U, Bush K, Harbarth S. Critical analysis of antibacterial agents in clinical development. Nat Rev Microbiol. 2020;18(5):286–298. doi:10.1038/s41579-020-0340-032152509
   PubMed Web of Science ®Google Scholar
• Shafiq M, Huang J, Ur Rahman S, et al. High incidence of multidrug-resistant Escherichia coli coharboring mcr-1 and bla (CTX-M-15) recovered from pigs. Infect Drug Resist. 2019;12:2135–2149. doi:10.2147/IDR.S20947331410033
   PubMed Web of Science ®Google Scholar
• Woerther PL, Burdet C, Chachaty E, Andremont A. Trends in human fecal carriage of extended-spectrum β-lactamases in the community: toward the globalization of CTX-M. Clin Microbiol Rev. 2013;26(4):744–758. doi:10.1128/CMR.00023-1324092853
   PubMed Web of Science ®Google Scholar
• Abrar S, Hussain S, Khan RA, Ul Ain N, Haider H, Riaz S. Prevalence of extended-spectrum-β-lactamase-producing Enterobacteriaceae: first systematic meta-analysis report from Pakistan. Antimicrob Resist Infect Control. 2018;7(1):26. doi:10.1186/s13756-018-0309-129484173
   PubMedGoogle Scholar
• Codjoe FS, Donkor ES. Carbapenem Resistance: a Review. Med Sci (Basel). 2017;6(1). doi:10.3390/medsci6010001
   Google Scholar
• Suay-García B, Pérez-Gracia MT. Present and Future of Carbapenem-resistant Enterobacteriaceae (CRE) Infections. Antibiotics (Basel). 2019;8(3). doi:10.3390/antibiotics8030122
   Google Scholar
• Ain N, Abrar S, Sherwani RAK, Hannan A, Imran N, Riaz S. Systematic surveillance and meta-analysis on the prevalence of metallo-β-lactamase producers among carbapenem resistant clinical isolates in Pakistan. J Glob Antimicrob Resist. 2020;23:55–63. doi:10.1016/j.jgar.2020.07.02432858259
   PubMed Web of Science ®Google Scholar
• Karaiskos I, Lagou S, Pontikis K, Rapti V, Poulakou G. The “Old” and the “New” antibiotics for MDR gram-negative pathogens: For Whom, When, and How. Front Public Health. 2019;7:151.31245348
   PubMed Web of Science ®Google Scholar
• Zhai YJ, Sun HR, Luo XW, et al. CpxR regulates the colistin susceptibility of Salmonella typhimurium by a multitarget mechanism. J Antimicrob Chemother. 2020;75(10):2780–2786. doi:10.1093/jac/dkaa23332620947
   PubMed Web of Science ®Google Scholar
• Liu YY, Wang Y, Walsh TR, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016;16(2):161–168. doi:10.1016/S1473-3099(15)00424-726603172
   PubMed Web of Science ®Google Scholar
• Nang SC, Li J, Velkov T. The rise and spread of mcr plasmid-mediated polymyxin resistance. Crit Rev Microbiol. 2019;45(2):131–161. doi:10.1080/1040841X.2018.149290231122100
   PubMed Web of Science ®Google Scholar
• Mohsin M, Azam M, Ur Rahman S, et al. Genomic background of a colistin-resistant and highly virulent MCR-1-positive Escherichia coli ST6395 from a broiler chicken in Pakistan. Pathog Dis. 2019;77(7). doi:10.1093/femspd/ftz064.
   Google Scholar
• Lv J, Mohsin M, Lei S, et al. Discovery of a mcr-1-bearing plasmid in commensal colistin-resistant Escherichia coli from healthy broilers in Faisalabad, Pakistan. Virulence. 2018;9(1):994–999. doi:10.1080/21505594.2018.146206029667494
   PubMed Web of Science ®Google Scholar
• Azam M, Ehsan I, Sajjad Ur R, Saleemi MK, Javed MR, Mohsin M. Detection of the colistin resistance gene mcr-1 in avian pathogenic Escherichia coli in Pakistan. J Glob Antimicrob Resist. 2017;11:152–153. doi:10.1016/j.jgar.2017.10.01229111482
   PubMed Web of Science ®Google Scholar
• Mohsin M, Raza S, Roschanski N, Guenther S, Ali A, Schierack P. Description of the First Escherichia coli clinical isolate harboring the colistin resistance gene mcr-1 from the Indian Subcontinent. Antimicrob Agents Chemother. 2017;61(1). doi:10.1128/AAC.01945-16
   PubMed Web of Science ®Google Scholar
• Mohsin M, Raza S, Roschanski N, Schaufler K, Guenther S. First description of plasmid-mediated colistin-resistant extended-spectrum β-lactamase-producing Escherichia coli in a wild migratory bird from Asia. Int J Antimicrob Agents. 2016;48(4):463–464. doi:10.1016/j.ijantimicag.2016.07.00127451084
   PubMed Web of Science ®Google Scholar
• Lupindu AM. Isolation and Characterization of Escherichia coli from animals, humans, and environment. In: Samie A, editor. Escherichia Coli - Recent Advances on Physiology, Pathogenesis and Biotechnological Applications. London, United Kingdom: IntechOpen Limited; 2017:187–206.
   Google Scholar
• Wayne P. Performance Standards for Antimicrobial Susceptibility Testing. Clinical and laboratory standards institute, CLSI supplement M100; 2020.
   Google Scholar
• Dilhari A, Sampath A, Gunasekara C, et al. Evaluation of the impact of six different DNA extraction methods for the representation of the microbial community associated with human chronic wound infections using a gel-based DNA profiling method. AMB Express. 2017;7(1):179. doi:10.1186/s13568-017-0477-z28929383
   PubMed Web of Science ®Google Scholar
• Feliciello I, Chinali G. A modified alkaline lysis method for the preparation of highly purified plasmid DNA from Escherichia coli. Anal Biochem. 1993;212(2):394–401. doi:10.1006/abio.1993.13468214582
   PubMed Web of Science ®Google Scholar
• Rahman H, Naeem M, Khan I, et al. Molecular prevalence and antibiotics resistance pattern of class A bla CTX-M-1 and bla TEM-1 beta lactamases in uropathogenic Escherichia coli isolates from Pakistan. Turk J Med Sci. 2016;46(3):897–902. doi:10.3906/sag-1502-1427513271
   PubMed Web of Science ®Google Scholar
• Ali F, Niaz Z, Shah PT, Shakeela Q, Uzma B, Ahmed S. Antibiogram of ESBL and MBL producing Pseudomonas aeruginosa among the population of Hazara division, KPK, Pakistan. J Pak Med Assoc. 2020;70(11):1979–1984. doi:10.5455/JPMA.1908933341844
   PubMedGoogle Scholar
• Ahmed I, Sajed M, Sultan A, et al. The erratic antibiotic susceptibility patterns of bacterial pathogens causing urinary tract infections. EXCLI J. 2015;14:916–925.26648826
   PubMed Web of Science ®Google Scholar
• Nahid F, Khan AA, Rehman S, Zahra R. Prevalence of metallo-β-lactamase NDM-1-producing multi-drug resistant bacteria at two Pakistani hospitals and implications for public health. J Infect Public Health. 2013;6(6):487–493. doi:10.1016/j.jiph.2013.06.00624094832
   PubMed Web of Science ®Google Scholar
• Abrar S, Vajeeha A, Ul-Ain N, Riaz S. Distribution of CTX-M group I and group III β-lactamases produced by Escherichia coli and klebsiella pneumoniae in Lahore, Pakistan. Microb Pathog. 2017;103:8–12. doi:10.1016/j.micpath.2016.12.00427956216
   PubMedGoogle Scholar
• Sid Ahmed MA, Bansal D, Acharya A, et al. Antimicrobial susceptibility and molecular epidemiology of extended-spectrum beta-lactamase-producing Enterobacteriaceae from intensive care units at Hamad Medical Corporation, Qatar. Antimicrob Resist Infect Control. 2016;5(4). doi:10.1186/s13756-016-0103-x.
   Web of Science ®Google Scholar
• Xu Y, Gu B, Huang M, et al. Epidemiology of carbapenem resistant Enterobacteriaceae (CRE) during 2000–2012 in Asia. J Thorac Dis. 2015;7(3):376–385. doi:10.3978/j.issn.2072-1439.2014.12.3325922715
   PubMedGoogle Scholar
• Ain NU, Iftikhar A, Bukhari SS, et al. High frequency and molecular epidemiology of metallo-β-lactamase-producing gram-negative bacilli in a tertiary care hospital in Lahore, Pakistan. Antimicrob Resist Infect Control. 2018;7(1):128. doi:10.1186/s13756-018-0417-y30410749
   PubMedGoogle Scholar
• Safari M, Mozaffari Nejad AS, Bahador A, Jafari R, Alikhani MY. Prevalence of ESBL and MBL encoding genes in Acinetobacter baumannii strains isolated from patients of intensive care units (ICU). Saudi J Biol Sci. 2015;22(4):424–429. doi:10.1016/j.sjbs.2015.01.00426150748
   PubMed Web of Science ®Google Scholar
• Maurya N, Jangra M, Tambat R, Nandanwar H. Alliance of Efflux Pumps with β-lactamases in multidrug-resistant Klebsiella pneumoniae Isolates. Microb Drug Resist. 2019;25(8):1155–1163. doi:10.1089/mdr.2018.041431613200
   PubMed Web of Science ®Google Scholar
• Kim YA, Park YS, Youk T, Lee H, Lee K. Trends in South Korean antimicrobial use and association with changes in Escherichia coli resistance rates: 12-year ecological study using a nationwide surveillance and antimicrobial prescription database. PLoS One. 2018;13(12):e0209580. doi:10.1371/journal.pone.020958030596704
   PubMed Web of Science ®Google Scholar
• Aung MS, San N, Maw WW, et al. Prevalence of extended-spectrum beta-lactamase and carbapenemase genes in clinical isolates of Escherichia coli in Myanmar: dominance of bla(NDM-5) and emergence of bla(OXA-181). Microb Drug Resist. 2018;24(9):1333–1344. doi:10.1089/mdr.2017.038729565227
   PubMed Web of Science ®Google Scholar
• Qamar MU, Walsh TR, Toleman MA, et al. Dissemination of genetically diverse NDM-1, −5, −7 producing-Gram-negative pathogens isolated from pediatric patients in Pakistan. Future Microbiol. 2019;14(8):691–704. doi:10.2217/fmb-2019-001231148474
   PubMed Web of Science ®Google Scholar
• Cai JC, Zhang R, Hu YY, Zhou HW, Chen GX. Emergence of Escherichia coli sequence type 131 isolates producing KPC-2 carbapenemase in China. Antimicrob Agents Chemother. 2014;58(2):1146–1152. doi:10.1128/AAC.00912-1324323475
   PubMed Web of Science ®Google Scholar
• Abd El Ghany M, Sharaf H, Al-Agamy MH, Shibl A, Hill-Cawthorne GA. Genomic characterization of NDM-1 and 5, and OXA-181 carbapenemases in uropathogenic Escherichia coli isolates from Riyadh, Saudi Arabia. PLoS One. 2018;13(8):e0201613. doi:10.1371/journal.pone.020161330110357
   PubMedGoogle Scholar
• Wang D, Mu X, Chen Y, et al. emergence of a clinical escherichia coli sequence Type 131 strain carrying a chromosomal bla (KPC-2) Gene. Front Microbiol. 2020;11:586764. doi:10.3389/fmicb.2020.58676433281782
   PubMedGoogle Scholar
• Pérez-Vazquez M, Oteo-Iglesias J, Sola-Campoy PJ. Characterization of carbapenemase-producing Klebsiella oxytoca in Spain, 2016–2017. Antimicrob Agents Chemother. 2019;63(6):e025029–025018. doi:10.1128/AAC.02529-18
   Google Scholar
• Mohamed ER, Ali MY, Waly N, Halby HM, El-Baky RMA. The Inc FII plasmid and its contribution in the transmission of bla(NDM-1) and bla(KPC-2) in Klebsiella pneumoniae in Egypt. Antibiotics (Basel). 2019;8(4):266.
   Web of Science ®Google Scholar
• Sartor AL, Raza MW, Abbasi SA, et al. Molecular epidemiology of NDM-1-producing Enterobacteriaceae and Acinetobacter baumannii isolates from Pakistan. Antimicrob Agents Chemother. 2014;58(9):5589–5593. doi:10.1128/AAC.02425-1424982081
   PubMed Web of Science ®Google Scholar
• Nahid F, Zahra R, Sandegren L. A blaOXA-181-harbouring multi-resistant ST147 Klebsiella pneumoniae isolate from Pakistan that represent an intermediate stage towards pan-drug resistance. PLoS One. 2017;12(12):e0189438. doi:10.1371/journal.pone.018943829220374
   PubMed Web of Science ®Google Scholar
• Gondal AJ, Saleem S, Jahan S. Novel carbapenem-resistant Klebsiella pneumoniae ST147 Coharboring bla (NDM-1), bla (OXA-48) and extended-spectrum β-lactamases from Pakistan. Infect Drug Resist. 2020;13:2105–2115. doi:10.2147/IDR.S25153232669863
   PubMed Web of Science ®Google Scholar
• Hameed F, Khan MA, Bilal H, Muhammad H, Tayyab Ur R. Detection of MCR-1 gene in multiple drug resistant escherichia coli and klebsiella pneumoniae in human clinical samples from Peshawar, Pakistan. Comb Chem High Throughput Screen. 2020.
   Google Scholar
• Berrazeg M, Hadjadj L, Ayad A, Drissi M, Rolain JM. First detected human case in algeria of mcr-1 plasmid-mediated colistin resistance in a 2011 Escherichia coli isolate. Antimicrob Agents Chemother. 2016;60(11):6996–6997. doi:10.1128/AAC.01117-1627572400
   PubMed Web of Science ®Google Scholar
• Doumith M, Godbole G, Ashton P, et al. Detection of the plasmid-mediated mcr-1 gene conferring colistin resistance in human and food isolates of Salmonella enterica and Escherichia coli in England and Wales. J Antimicrob Chemother. 2016;71(8):2300–2305. doi:10.1093/jac/dkw09327090630
   PubMed Web of Science ®Google Scholar
• Quan J, Li X, Chen Y, et al. Prevalence of mcr-1 in Escherichia coli and Klebsiella pneumoniae recovered from bloodstream infections in China: a multicentre longitudinal study. Lancet Infect Dis. 2017;17(4):400–410. doi:10.1016/S1473-3099(16)30528-X28139430
   PubMed Web of Science ®Google Scholar
• Rhouma M, Letellier A. Extended-spectrum β-lactamases, carbapenemases and the mcr-1 gene: is there a historical link? Int J Antimicrob Agents. 2017;49(3):269–271. doi:10.1016/j.ijantimicag.2016.11.02628161487
   PubMed Web of Science ®Google Scholar
• Jeannot K, Bolard A, Plésiat P. Resistance to polymyxins in Gram-negative organisms. Int J Antimicrob Agents. 2017;49(5):526–535. doi:10.1016/j.ijantimicag.2016.11.02928163137
   PubMed Web of Science ®Google Scholar
• Baloch Z, Lv L, Yi L, et al. Emergence of almost identical F36: a-:B32Plasmids Carrying bla (NDM-5) and qepA in Escherichia coli from both Pakistan and Canada. Infect Drug Resist. 2019;12:3981–3985. doi:10.2147/IDR.S23676631920350
   PubMed Web of Science ®Google Scholar
• Mediavilla JR, Patrawalla A, Chen L, et al. Colistin- and carbapenem-resistant Escherichia coli Harboring mcr-1 and blaNDM-5, causing a complicated urinary tract infection in a patient from the United States. mBio. 2016;7(4). doi:10.1128/mBio.01191-16.
   Web of Science ®Google Scholar
• Bachiri T, Lalaoui R, Bakour S, et al. First Report of the plasmid-mediated colistin resistance gene mcr-1 in Escherichia coli ST405 isolated from Wildlife in Bejaia, Algeria. Microb Drug Resist. 2018;24(7):890–895. doi:10.1089/mdr.2017.002629227182
   PubMed Web of Science ®Google Scholar
• Yang RS, Feng Y, Lv XY, et al. Emergence of NDM-5- and MCR-1-producing Escherichia coli clones ST648 and ST156 from a Single Muscovy Duck (Cairina moschata). Antimicrob Agents Chemother. 2016;60(11):6899–6902. doi:10.1128/AAC.01365-1627550364
   PubMed Web of Science ®Google Scholar
• Rossi F, Girardello R, Morais C, et al. Plasmid-mediated mcr-1 in carbapenem-susceptible Escherichia coli ST156 causing a blood infection: an unnoticeable spread of colistin resistance in Brazil? Clinics (Sao Paulo). 2017;72(10):642–644. doi:10.6061/clinics/2017(10)0929160428
   PubMed Web of Science ®Google Scholar
• Azam M, Mohsin M, Johnson TJ, et al. Genomic landscape of multi-drug resistant avian pathogenic Escherichia coli recovered from broilers. Vet Microbiol. 2020;247:108766. doi:10.1016/j.vetmic.2020.10876632768218
   PubMed Web of Science ®Google Scholar
• Manges AR, Johnson JR. Food-borne origins of Escherichia coli causing extraintestinal infections. Clin Infect Dis. 2012;55(5):712–719. doi:10.1093/cid/cis50222615330
   PubMed Web of Science ®Google Scholar
• Elbediwi M, Wu B, Pan H, Jiang Z, Biswas S, Li Y. Genomic characterization of mcr-1-carrying Salmonella enterica Serovar 4,[5],12:i:- ST 34 clone isolated from Pigs in China. Front Bioeng Biotechnol. 2020;8:663. doi:10.3389/fbioe.2020.0066332714906
   PubMedGoogle Scholar
• Kuo SC, Huang WC, Wang HY, Shiau YR, Cheng MF, Lauderdale TL. Colistin resistance gene mcr-1 in Escherichia coli isolates from humans and retail meats, Taiwan. J Antimicrob Chemother. 2016;71(8):2327–2329. doi:10.1093/jac/dkw12227076107
   PubMed Web of Science ®Google Scholar
• Snesrud E, He S, Chandler M, et al. A model for transposition of the colistin resistance gene mcr-1 by ISApl1. Antimicrob Agents Chemother. 2016;60(11):6973–6976. doi:10.1128/AAC.01457-1627620479
   PubMed Web of Science ®Google Scholar
• Mohsin M, Van Boeckel TP, Saleemi MK, et al. Excessive use of medically important antimicrobials in food animals in Pakistan: a five-year surveillance survey. Glob Health Action. 2019;12(sup1):1697541. doi:10.1080/16549716.2019.169754131795863
   PubMed Web of Science ®Google Scholar