Rifapentine Polylactic Acid Sustained-Release Microsphere Complex for Spinal Tuberculosis Therapy: Preparation, in vitro and in vivo Studies

References

• World Health Organization. Global tuberculosis report 2020; 2020. Available from: https://www.who.int/tb/publications/global_report/en/. Accessed 129, 2021.
   Google Scholar
• Xu Z, Wang X, Shen X, et al. One-stage lumbopelvic fixation in the treatment of lumbosacral junction tuberculosis. Eur Spine J. 2015;24(8):1800–1805. doi:10.1007/s00586-015-3863-825757533
   PubMed Web of Science ®Google Scholar
• Ge Z, Wang Z, Wei M. Measurement of the concentration of three antituberculosis drugs in the focus of spinal tuberculosis. Eur Spine J. 2008;17(11):1482–1487. doi:10.1007/s00586-008-0778-718795341
   PubMed Web of Science ®Google Scholar
• Elmorsy E, Attalla SM, Fikry E, et al. Adverse effects of anti-tuberculosis drugs on HepG2 cell bioenergetics. Hum Exp Toxicol. 2017;36(6):616–625. doi:10.1177/096032711666075127461009
   PubMed Web of Science ®Google Scholar
• Yang TW, Park HO, Jang HN, et al. Side effects associated with the treatment of multidrug-resistant tuberculosis at a tuberculosis referral hospital in South Korea: a retrospective study. Medicine (Baltimore). 2017;96(28):e7482. doi:10.1097/MD.000000000000748228700490
   PubMed Web of Science ®Google Scholar
• Shive MS, Anderson JM. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev. 1997;28(1):5–24. doi:10.1016/s0169-409x(97)00048-310837562
   PubMed Web of Science ®Google Scholar
• Rastogi N, Goh KS, Berchel M, Bryskier A. Activity of rifapentine and its metabolite 25-O-desacetylrifapentine compared with rifampicin and rifabutin against Mycobacterium tuberculosis, Mycobacterium africanum, Mycobacterium bovis and M. bovis BCG. J Antimicrob Chemother. 2000;46:565–570. doi:10.1093/jac/46.4.56511020253
   PubMed Web of Science ®Google Scholar
• Alfarisi O, Alghamdi WA, Al-Shaer MH, Dooley KE, Peloquin CA. Rifampin vs. rifapentine: what is the preferred rifamycin for tuberculosis? Expert Rev Clin Pharmacol. 2017;10(10):1027–1036. doi:10.1080/17512433.2017.136631128803492
   PubMed Web of Science ®Google Scholar
• Biver E, Calmy A, Rizzoli R. Bone health in HIV and hepatitis B or C infections. Ther Adv Musculoskelet Dis. 2017;9(1):22–34. doi:10.1177/1759720X1667192728101146
   PubMed Web of Science ®Google Scholar
• Kapasa ER, Giannoudis PV, Jia X, Hatton PV, Yang XB. The effect of RANKL/OPG balance on reducing implant complications. J Funct Biomater. 2017;8(4):42. doi:10.3390/jfb8040042
   Google Scholar
• Liu Y, Duan D, Xin Y, et al. A review of the literature: antibiotic usage and its relevance to the infection in periodontal flaps. Acta Odontol Scand. 2017;75(4):288–293. doi:10.1080/00016357.2017.129516528281367
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhu J, Jiang D. Release characteristics of bonelike hydroxyapatite/poly amino acid loaded with rifapentine microspheres in vivo. Mol Med Rep. 2017;16(2):1425–1430. doi:10.3892/mmr.2017.674728627673
   PubMed Web of Science ®Google Scholar
• Marques CF, Olhero SM, Torres PMC, et al. Novel sintering-free scaffolds obtained by additive manufacturing for concurrent bone regeneration and drug delivery: proof of concept. Mater Sci Eng C Mater Biol Appl. 2019;94:426–436. doi:10.1016/j.msec.2018.09.05030423726
   PubMed Web of Science ®Google Scholar
• Wang Z, Song X, Yang H, Maimaitiaili A, Wang T. Development and in vitro characterization of rifapentine microsphere-loaded bone implants: a sustained drug delivery system. Ann Palliat Med. 2020;9(2):375–387. doi:10.21037/apm.2020.03.1332233632
   PubMed Web of Science ®Google Scholar
• Nilsson OS, Urist MR, Dawson EG, Schmalzried TP, Finerman GA. Bone repair induced by bone morphogenetic protein in ulnar defects in dogs. J Bone Joint Surg Br. 1986;68-B(4):635–642. doi:10.1302/0301-620X.68B4.3733844
   Google Scholar
• Wu P, Wang XY, Li XG, et al. One-stage posterior procedure in treating active thoracic spinal tuberculosis: a retrospective study. Eur J Trauma Emerg Surg. 2015;41(2):189–197. doi:10.1007/s00068-014-0421-8.26038264
   PubMed Web of Science ®Google Scholar
• Rajasekaran S, Khandelwal G. Drug therapy in spinal tuberculosis. Eur Spine J. 2013;22(S4):587–593. doi:10.1007/s00586-012-2337-522581190
   PubMed Web of Science ®Google Scholar
• Guo X, Zhu X, Liu D, Gong Y, Sun J, Dong C. Continuous delivery of propranolol from liposomes-in-microspheres significantly inhibits infantile hemangioma growth. Int J Nanomed. 2017;12:6923–6936. doi:10.2147/IJN.S137634
   PubMed Web of Science ®Google Scholar
• Allison SD. Analysis of initial burst in PLGA microparticles. Expert Opin Drug Deliv. 2008;5(6):615–628. doi:10.1517/17425247.5.6.61518532918
   PubMed Web of Science ®Google Scholar
• Huang J, Chen Z, Li Y, Li L, Zhang G. Rifapentine-linezolid-loaded PLGA microspheres for interventional therapy of cavitary pulmonary tuberculosis: preparation and in vitro characterization. Drug Des Devel Ther. 2017;11:585–592. doi:10.2147/DDDT.S127897
   PubMed Web of Science ®Google Scholar
• Zhang Z, Wu L, Li H, Long Z, Song X. Drug release characteristics and tissue distribution of rifapentine polylactic acid sustained-release microspheres in rabbits after paravertebral implantation. Iran Red Crescent Med J. 2016;18(11):e38661. doi:10.5812/ircmj.3866128210500
   PubMed Web of Science ®Google Scholar
• Rathbone CR, Cross JD, Brown KV, Murray CK, Wenke JC. Effect of various concentrations of antibiotics on osteogenic cell viability and activity. J Orthop Res. 2011;29(7):1070–1074. doi:10.1002/jor.2134321567453
   PubMed Web of Science ®Google Scholar
• Zhang Z, Wang X, Luo F, et al. Effects of rifampicin on osteogenic differentiation and proliferation of human mesenchymal stem cells in the bone marrow. Genet Mol Res. 2014;13(3):6398–6410. doi:10.4238/2014.August.25.325158258
   PubMed Web of Science ®Google Scholar
• Li H, Yue B. Effects of various antimicrobial agents on multi-directional differentiation potential of bone marrow-derived mesenchymal stem cells. World J Stem Cells. 2019;11(6):322–336. doi:10.4252/wjsc.v11.i6.32231293715
   PubMed Web of Science ®Google Scholar
• Gamie Z, Tran GT, Vyzas G, et al. Stem cells combined with bone graft substitutes in skeletal tissue engineering. Expert Opin Biol Ther. 2012;12(6):713–729. doi:10.1517/14712598.2012.67965222500826
   PubMed Web of Science ®Google Scholar
• Bassi G, Guilloton F, Menard C, et al. Effects of a ceramic biomaterial on immune modulatory properties and differentiation potential of human mesenchymal stromal cells of different origin. Tissue Eng Part A. 2015;21(3–4):767–781. doi:10.1089/ten.TEA.2014.026925322665
   PubMed Web of Science ®Google Scholar
• Mebarki M, Coquelin L, Layrolle P, et al. Enhanced human bone marrow mesenchymal stromal cell adhesion on scaffolds promotes cell survival and bone formation. Acta Biomater. 2017;59:94–107. doi:10.1016/j.actbio.2017.06.01828636926
   PubMed Web of Science ®Google Scholar
• Thangavelu M, Narasimha RR, Adithan A, Chandrasekaran A, Jong-Hoon K, Parvathaleswara ST. Reengineered graft copolymers as a potential alternative for the bone tissue engineering application by inducing osteogenic markers expression and biocompatibility. Colloids Surf B Biointerfaces. 2016;143:15–26. doi:10.1016/j.colsurfb.2016.03.02126998863
   PubMed Web of Science ®Google Scholar
• Singh AK, Gupta UD. Animal models of tuberculosis: lesson learnt. Indian J Med Res. 2018;147(5):456–463. doi:10.4103/ijmr.IJMR_554_1830082569
   PubMed Web of Science ®Google Scholar
• Liu P, Jiang H, Li S, Lin Z, Jiang J. Determination of anti-tuberculosis drug concentration and distribution from sustained release microspheres in the vertebrae of a spinal tuberculosis rabbit model. J Orthop Res. 2017;35(1):200–208. doi:10.1002/jor.2323626996958
   PubMed Web of Science ®Google Scholar
• Yan L, Jiang DM, Cao ZD, et al. Treatment of Staphylococcus aureus-induced chronic osteomyelitis with bone-like hydroxyapatite/poly amino acid loaded with rifapentine microspheres. Drug Des Devel Ther. 2015;9:3665–3676. doi:10.2147/DDDT.S84486
   PubMed Web of Science ®Google Scholar
• Dickinson JM, Mitchison DA. In vitro properties of rifapentine (MDL473) relevant to its use in intermittent chemotherapy of tuberculosis. Tubercle. 1987;68(2):113–118. doi:10.1016/0041-3879(87)90026-23116733
   PubMedGoogle Scholar
• Sigal GB, Segal MR, Mathew A, et al. Biomarkers of tuberculosis severity and treatment effect: a directed screen of 70 host markers in a randomized clinical trial. EBioMedicine. 2017;25:112–121. doi:10.1016/j.ebiom.2017.10.01829100778
   PubMed Web of Science ®Google Scholar
• Tam WL, Luyten FP, Roberts SJ. From skeletal development to the creation of pluripotent stem cell-derived bone-forming progenitors. Philos Trans R Soc Lond B Biol Sci. 2018;373(1750):20170218. doi:10.1098/rstb.2017.021829786553
   PubMed Web of Science ®Google Scholar
• Li C, Li G, Liu M, Zhou T, Zhou H. Paracrine effect of inflammatory cytokine-activated bone marrow mesenchymal stem cells and its role in osteoblast function. J Biosci Bioeng. 2016;121(2):213–219. doi:10.1016/j.jbiosc.2015.05.01726315505
   PubMed Web of Science ®Google Scholar
• Wang N, Zhou Z, Wu T, et al. TNF-α-induced NF-κB activation upregulates microRNA-150-3p and inhibits osteogenesis of mesenchymal stem cells by targeting β-catenin. Open Biol. 2016;6(3):150258. doi:10.1098/rsob.15025826935950
   PubMed Web of Science ®Google Scholar
• Bastian OW, Croes M, Alblas J, Koenderman L, Leenen LPH, Blokhuis TJ. Neutrophils inhibit synthesis of mineralized extracellular matrix by human bone marrow-derived stromal cells in vitro. Front Immunol. 2018;9:945. doi:10.3389/fimmu.2018.0094529765377
   PubMed Web of Science ®Google Scholar