The Genomic Characterization of KPC-Producing Klebsiella pneumoniae from the ICU of a Teaching Hospital in Shanghai, China

References

• Pitout JD, Nordmann P, Poirel L. Carbapenemase-producing Klebsiella pneumoniae, a key pathogen set for global nosocomial dominance. Antimicrob Agents Chemother. 2015;59(10):5873–5884. doi:10.1128/aac.01019-15
   PubMed Web of Science ®Google Scholar
• Yigit H, Queenan AM, Anderson GJ, et al. Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother. 2001;45(4):1151–1161. doi:10.1128/aac.45.4.1151-1161.2001
   PubMed Web of Science ®Google Scholar
• Grundmann H, Glasner C, Albiger B, et al. Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study. Lancet Infect Dis. 2017;17(2):153–163. doi:10.1016/s1473-3099(16)30257-2
   PubMed Web of Science ®Google Scholar
• Adler A, Khabra E, Paikin S, et al. Dissemination of the blaKPC gene by clonal spread and horizontal gene transfer: a comparative study of incidence and molecular mechanisms. J Antimicrob Chemother. 2016;71(8):2143–2146. doi:10.1093/jac/dkw106
   Web of Science ®Google Scholar
• Chen L, Mathema B, Chavda KD, et al. Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding. Trends Microbiol. 2014;22(12):686–696. doi:10.1016/j.tim.2014.09.003
   PubMed Web of Science ®Google Scholar
• Hansen GT. Continuous evolution: perspective on the epidemiology of carbapenemase resistance among enterobacterales and other gram-negative bacteria. Infect Dis Ther. 2021;10(1):75–92. doi:10.1007/s40121-020-00395-2
   PubMed Web of Science ®Google Scholar
• Hu Y, Liu C, Shen Z, et al. Prevalence, risk factors and molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae in patients from Zhejiang, China, 2008-2018. Emerg Microbes Infect. 2020;9(1):1771–1779. doi:10.1080/22221751.2020.1799721
   PubMed Web of Science ®Google Scholar
• Shi Q, Yin D, Han R, et al. Emergence and recovery of ceftazidime-avibactam resistance in blaKPC-33-harboring Klebsiella pneumoniae sequence Type 11 isolates in China. Clin Infect Dis. 2020;71(Suppl4):S436–s439. doi:10.1093/cid/ciaa1521
   Web of Science ®Google Scholar
• Li X, Quan J, Ke H, et al. Emergence of a KPC variant conferring resistance to ceftazidime-avibactam in a widespread ST11 carbapenem-resistant Klebsiella pneumoniae Clone in China. Front Microbiol. 2021;12:724272. doi:10.3389/fmicb.2021.724272
   PubMed Web of Science ®Google Scholar
• Carattoli A, Zankari E, García-Fernández A, et al. In silico detection and typing of plasmids using PlasmidFinder and plasmid multilocus sequence typing. Antimicrob Agents Chemother. 2014;58(7):3895–3903. doi:10.1128/aac.02412-14
   PubMed Web of Science ®Google Scholar
• Alcock BP, Raphenya AR, Lau TTY, et al. CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database. Nucleic Acids Res. 2020;48(D1):D517–d525. doi:10.1093/nar/gkz935
   PubMed Web of Science ®Google Scholar
• Tompkins K, van Duin D. Treatment for carbapenem-resistant Enterobacterales infections: recent advances and future directions. Eur J Clin Microbiol Infect Dis. 2021;40(10):2053–2068. doi:10.1007/s10096-021-04296-1
   PubMed Web of Science ®Google Scholar
• Effah CY, Sun T, Liu S, et al. Klebsiella pneumoniae: an increasing threat to public health. Ann Clin Microbiol Antimicrob. 2020;19(1):1. doi:10.1186/s12941-019-0343-8
   PubMed Web of Science ®Google Scholar
• Kaye KS, Rice LB, Dane AL, et al. Fosfomycin for Injection (ZTI-01) versus piperacillin-tazobactam for the treatment of complicated urinary tract infection including acute pyelonephritis: ZEUS, a phase 2/3 randomized trial. Clin Infect Dis. 2019;69(12):2045–2056. doi:10.1093/cid/ciz181
   PubMed Web of Science ®Google Scholar
• Bassetti M, Graziano E, Berruti M, et al. The role of fosfomycin for multidrug-resistant gram-negative infections. Curr Opin Infect Dis. 2019;32(6):617–625. doi:10.1097/qco.0000000000000597
   PubMed Web of Science ®Google Scholar
• Endimiani A, Patel G, Hujer KM, et al. In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin. Antimicrob Agents Chemother. 2010;54(1):526–529. doi:10.1128/aac.01235-09
   PubMed Web of Science ®Google Scholar
• Neuner EA, Sekeres J, Hall GS, et al. Experience with fosfomycin for treatment of urinary tract infections due to multidrug-resistant organisms. Antimicrob Agents Chemother. 2012;56(11):5744–5748. doi:10.1128/aac.00402-12
   PubMed Web of Science ®Google Scholar
• Aghamali M, Sedighi M, Zahedi Bialvaei A, et al. Fosfomycin: mechanisms and the increasing prevalence of resistance. J Med Microbiol. 2019;68(1):11–25. doi:10.1099/jmm.0.000874
   PubMed Web of Science ®Google Scholar
• Bassetti M, Peghin M. How to manage KPC infections. Ther Advan Infect Dis. 2020;7:20499361–20912049. doi:10.1177/2049936120912049
   Web of Science ®Google Scholar
• Lai CC, Yu WL. Klebsiella pneumoniae harboring carbapenemase genes in Taiwan: its evolution over 20 years, 1998-2019. Int J Antimicrob Agents. 2021;58(1):106354. doi:10.1016/j.ijantimicag.2021.106354
   Web of Science ®Google Scholar
• Jiang Y, Shen P, Wei Z, et al. Dissemination of a clone carrying a fosA3-harbouring plasmid mediates high fosfomycin resistance rate of KPC-producing Klebsiella pneumoniae in China. Int J Antimicrob Agents. 2015;45(1):66–70. doi:10.1016/j.ijantimicag.2014.08.010
   PubMed Web of Science ®Google Scholar
• Ito R, Mustapha MM, Tomich AD, et al. Widespread fosfomycin resistance in gram-negative bacteria attributable to the chromosomal fosA gene. mBio. 2017;8:4. doi:10.1128/mBio.00749-17
   Web of Science ®Google Scholar
• Li G, Zhang Y, Bi D, et al. First report of a clinical, multidrug-resistant Enterobacteriaceae isolate coharboring fosfomycin resistance gene fosA3 and carbapenemase gene blaKPC-2 on the same transposon, Tn1721. Antimicrob Agents Chemother. 2015;59(1):338–343. doi:10.1128/aac.03061-14
   Web of Science ®Google Scholar
• Gomez-Simmonds A, Uhlemann AC. Clinical implications of genomic adaptation and evolution of carbapenem-resistant Klebsiella pneumoniae. J Infect Dis. 2017;215(suppl_1):S18–s27. doi:10.1093/infdis/jiw378
   Web of Science ®Google Scholar
• Han Y, Huang L, Liu C, et al. Characterization of carbapenem-resistant Klebsiella pneumoniae ST15 Clone coproducing KPC-2, CTX-M-15 and SHV-28 spread in an intensive care unit of a Tertiary Hospital. Infect Drug Resist. 2021;14:767–773. doi:10.2147/idr.s298515
   Web of Science ®Google Scholar
• Kopotsa K, Osei Sekyere J, Mbelle NM. Plasmid evolution in carbapenemase-producing Enterobacteriaceae: a review. Ann N Y Acad Sci. 2019;1457(1):61–91. doi:10.1111/nyas.14223
   PubMed Web of Science ®Google Scholar
• Carattoli A. Resistance plasmid families in Enterobacteriaceae. Antimicrob Agents Chemother. 2009;53(6):2227–2238. doi:10.1128/aac.01707-08
   PubMed Web of Science ®Google Scholar
• Mansour W, Grami R, Ben Haj Khalifa A, et al. Dissemination of multidrug-resistant blaCTX-M-15/IncFIIk plasmids in Klebsiella pneumoniae isolates from the hospital- and community-acquired human infections in Tunisia. Diagn Microbiol Infect Dis. 2015;83(3):298–304. doi:10.1016/j.diagmicrobio.2015.07.023
   Web of Science ®Google Scholar
• Cuzon G, Naas T, Nordmann P. Functional characterization of Tn4401, a Tn3-based transposon involved in blaKPC gene mobilization. Antimicrob Agents Chemother. 2011;55(11):5370–5373. doi:10.1128/aac.05202-11
   PubMed Web of Science ®Google Scholar
• Nicolas E, Lambin M, Dandoy D, et al. The Tn3-family of Replicative Transposons. Microbiology Spectrum. 2015;3:4. doi:10.1128/microbiolspec.MDNA3-0060-2014
   Google Scholar
• Yang X, Dong N, Chan EW, et al. Carbapenem resistance-encoding and virulence-encoding conjugative plasmids in Klebsiella pneumoniae. Trends Microbiol. 2021;29(1):65–83. doi:10.1016/j.tim.2020.04.012
   PubMed Web of Science ®Google Scholar
• Zhao J, Liu C, Liu Y, et al. Genomic characteristics of clinically important ST11 Klebsiella pneumoniae strains worldwide. J Global Antimicrob Resist. 2020;22:519–526. doi:10.1016/j.jgar.2020.03.023
   Web of Science ®Google Scholar