Helicobacter pylori Pathogenicity Islands and Giardia lamblia Cysteine Proteases in Role of Coinfection and Pathogenesis

References

• Noto JM, Peek RM. The Helicobacter pylori cag pathogenicity island. Helicobacter Species. Methods Mol Biol. 2012;921:41–50.
   PubMedGoogle Scholar
• Backert S, Selbach M. Role of type IV secretion in Helicobacter pylori pathogenesis. Cell Microbiol. 2008;10(8):1573–1581. doi:10.1111/j.1462-5822.2008.01156.x
   PubMed Web of Science ®Google Scholar
• Hatakeyama M. SagA of CagA in Helicobacter pylori pathogenesis. Curr Opin Microbiol. 2008;11(1):30–37. doi:10.1016/j.mib.2007.12.003
   Web of Science ®Google Scholar
• Hatakeyama M. The role of Helicobacter pylori CagA in gastric carcinogenesis. Int J Hematol. 2006;84(4):301–308. doi:10.1532/IJH97.06166
   Web of Science ®Google Scholar
• Moreira ED, Nassri VB, Santos RS, et al. Association of Helicobacter pylori infection and giardiasis: results from a study of surrogate markers for fecal exposure among children. World J Gastroenterol. 2005;11(18):2759. doi:10.3748/wjg.v11.i18.2759
   Web of Science ®Google Scholar
• Ryan U, Cacciò SM. Zoonotic potential of Giardia. Int J Parasitol. 2013;43(12–13):943–956. doi:10.1016/j.ijpara.2013.06.001
   Web of Science ®Google Scholar
• Feng Y, Xiao L. Zoonotic potential and molecular epidemiology of Giardia species and giardiasis. Clin Microbiol Rev. 2011;24(1):110–140. doi:10.1128/CMR.00033-10
   PubMed Web of Science ®Google Scholar
• Savioli L, Smith H, Thompson A. Giardia and Cryptosporidium join the ‘neglected diseases initiative’. Trends Parasitol. 2006;22(5):203–208. doi:10.1016/j.pt.2006.02.015
   PubMed Web of Science ®Google Scholar
• Isaeva G, Efimova N. Gastrointestinal giardiasis associated with Helicobacter pylori. Eksperimental’naia I Klinicheskaia Gastroenterologiia. 2010;47(6):30–34.
   Google Scholar
• Rahman M, Sobur M, Islam M, et al. Zoonotic diseases: etiology, impact, and control. Microorganisms. 2020;8(9):1405. doi:10.3390/microorganisms8091405
   PubMed Web of Science ®Google Scholar
• Birrie H, Erko B. Giardiasis in Ethiopia. Ethiop J Health Dev. 1995;9(1):77–80.
   Google Scholar
• Nkrumah B, Nguah SB. Giardia lamblia: a major parasitic cause of childhood diarrhoea in patients attending a district hospital in Ghana. Parasit Vectors. 2011;4(1):163. doi:10.1186/1756-3305-4-163
   Web of Science ®Google Scholar
• Katz DE, Taylor DN. Parasitic infections of the gastrointestinal tract. Gastroenterol Clin. 2001;30(3):797–815. doi:10.1016/S0889-8553(05)70211-9
   Google Scholar
• Cotton JA, Amat CB, Buret AG. Disruptions of host immunity and inflammation by Giardia duodenalis: potential consequences for co-infections in the gastro-intestinal tract. Pathogens. 2015;4(4):764–792. doi:10.3390/pathogens4040764
   Google Scholar
• Buret AG, Amat CB, Manko A, et al. Giardia duodenalis: new research developments in pathophysiology, pathogenesis, and virulence factors. Curr Trop Med Rep. 2015;2(3):110–118. doi:10.1007/s40475-015-0049-8
   Google Scholar
• Ankarklev J, Jerlström-Hultqvist J, Ringqvist E, Troell K, Svärd SG. Behind the smile: cell biology and disease mechanisms of Giardia species. Nat Rev Microbiol. 2010;8(6):413–422. doi:10.1038/nrmicro2317
   PubMed Web of Science ®Google Scholar
• Ankarklev J, Hestvik E, Lebbad M, et al. Common coinfections of Giardia intestinalis and Helicobacter pylori in non-symptomatic Ugandan children. PLoS Negl Trop Dis. 2012;6:e1780. doi:10.1371/journal.pntd.0001780
   PubMed Web of Science ®Google Scholar
• Misra V, Misra S, Dwivedi M, Singh P. Giardia lamblia trophozoites in gastric biopsies. Indian J Pathol Microbiol. 2006;49(4):519–523.
   Google Scholar
• Khalifa MM, Sharaf RR, Aziz RK. Helicobacter pylori: a poor man’s gut pathogen? Gut Pathog. 2010;2(1):2. doi:10.1186/1757-4749-2-2
   PubMed Web of Science ®Google Scholar
• Seid A, Tamir Z, Kasanew B, Senbetay M. Co-infection of intestinal parasites and Helicobacter pylori among upper gastrointestinal symptomatic adult patients attending Mekanesalem Hospital, northeast Ethiopia. BMC Res Notes. 2018;11(1):1–6. doi:10.1186/s13104-018-3246-4
   PubMedGoogle Scholar
• Larussa T, Leone I, Suraci E, Imeneo M, Luzza F. Helicobacter pylori and T helper cells: mechanisms of immune escape and tolerance. J Immunol Res. 2015;2015:1–10. doi:10.1155/2015/981328
   Web of Science ®Google Scholar
• Krzyżek P, Gościniak G. Frequency and immunological consequences of Helicobacter pylori and intestinal parasite co-infections: a brief review. Ann Parasitol. 2017;63(4):255–263. doi:10.17420/ap6304.112
   PubMedGoogle Scholar
• Ridley JW. Parasitology for Medical and Clinical Laboratory Professionals. Cengage Learning; 2012.
   Google Scholar
• Hestvik E, Tylleskar T, Kaddu-Mulindwa DH, et al. Helicobacter pylori in apparently healthy children aged 0–12 years in urban Kampala, Uganda: a community-based cross sectional survey. BMC Gastroenterol. 2010;10(1):62. doi:10.1186/1471-230X-10-62
   Web of Science ®Google Scholar
• Fouad SA, Esmat S, Basyoni MM, Farhan MS, Kobaisi MH. Molecular identification of Giardia intestinalis in patients with dyspepsia. Digestion. 2014;90(1):63–71. doi:10.1159/000362644
   Web of Science ®Google Scholar
• Olokoba A, Gashau W, Bwala S, Adamu A, Salawu F. Helicobacter pylori infection in Nigerians with dyspepsia. Ghana Med J. 2013;47(2):79–81.
   PubMedGoogle Scholar
• Ivanov A. Giardia and giardiasis. Bulgar J Vet Med. 2010;13(2):65–80.
   Google Scholar
• Yakoob J, Jafri W, Abid S, et al. Giardiasis in patients with dyspeptic symptoms. World J Gastroenterol. 2005;11(42):6667. doi:10.3748/wjg.v11.i42.6667
   Web of Science ®Google Scholar
• Al-Mendalawi MD. Prevalence of Helicobacter pylori and parasites in symptomatic children examined for Helicobacter pylori antibodies, antigens, and parasites in Yemen. Saudi Med J. 2015;36(1):126. doi:10.15537/smj.2015.1.10871
   Web of Science ®Google Scholar
• Kazemian H, Shavalipour A, Mohebi R, et al. Estimation of the parasitic infection prevalence in children with Helicobacter pylori infection in Ilam city (2012–2013). Archiv Pediatr Infect Dis. 2014;2(3). doi:10.5812/pedinfect.15294
   Google Scholar
• Zeyrek D, Zeyrek F, Cakmak A, Cekin A. Association of Helicobacter pylori and giardiasis in children with recurrent abdominal pain. Turkiye Parazitol Derg. 2008;32(1):4–7.
   PubMedGoogle Scholar
• Peek RM, Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer. 2002;2(1):28–37. doi:10.1038/nrc703
   PubMed Web of Science ®Google Scholar
• Sainsus N, Cattori V, Lepadatu C, Hofmann-Lehmann R. Liquid culture medium for the rapid cultivation of Helicobacter pylori from biopsy specimens. Eur J Clin Microbiol Infect Dis. 2008;27(12):1209–1217. doi:10.1007/s10096-008-0567-6
   Web of Science ®Google Scholar
• Conteduca V, Sansonno D, Lauletta G, Russi S, Ingravallo G, Dammacco F. H. pylori infection and gastric cancer: state of the art. Int J Oncol. 2013;42(1):5–18. doi:10.3892/ijo.2012.1701
   PubMed Web of Science ®Google Scholar
• McColl KE. Helicobacter pylori infection. N Engl J Med. 2010;362(17):1597–1604. doi:10.1056/NEJMcp1001110
   PubMed Web of Science ®Google Scholar
• Kusters JG, Van Vliet AH, Kuipers EJ. Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev. 2006;19(3):449–490. doi:10.1128/CMR.00054-05
   PubMed Web of Science ®Google Scholar
• Baj J, Forma A, Sitarz M, et al. Helicobacter pylori virulence factors—mechanisms of bacterial pathogenicity in the gastric microenvironment. Cells. 2021;10(1):27. doi:10.3390/cells10010027
   Web of Science ®Google Scholar
• Ansari S, Yamaoka Y. Helicobacter pylori virulence factors exploiting gastric colonization and its pathogenicity. Toxins. 2019;11(11):677. doi:10.3390/toxins11110677
   Web of Science ®Google Scholar
• Lertsethtakarn P, Ottemann KM, Hendrixson DR. Motility and chemotaxis in Campylobacter and Helicobacter. Annu Rev Microbiol. 2011;65:389–410. doi:10.1146/annurev-micro-090110-102908
   PubMed Web of Science ®Google Scholar
• Ding S-Z, Goldberg JB, Hatakeyama M. Helicobacter pylori infection, oncogenic pathways and epigenetic mechanisms in gastric carcinogenesis. Future Oncol. 2010;6(5):851–862. doi:10.2217/fon.10.37
   Web of Science ®Google Scholar
• Knorr J, Ricci V, Hatakeyama M, Backert S. Classification of Helicobacter pylori virulence factors: is CagA a toxin or not? Trends Microbiol. 2019;27(9):731–738. doi:10.1016/j.tim.2019.04.010
   Web of Science ®Google Scholar
• Roesler BM, Rabelo-Gonçalves EM, Zeitune JM. Virulence factors of Helicobacter pylori: a review. Clin Med Insights Gastroenterol. 2014;7:S13760.
   Google Scholar
• Amieva MR, El–Omar EM. Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology. 2008;134(1):306–323. doi:10.1053/j.gastro.2007.11.009
   PubMed Web of Science ®Google Scholar
• Backert S, Clyne M. Pathogenesis of Helicobacter pylori infection. Helicobacter. 2011;16:19–25. doi:10.1111/j.1523-5378.2011.00876.x
   Web of Science ®Google Scholar
• Skoog EC, Deck SL, Entwistle HD, Hansen LM, Solnick JV. Characterization of the Cag pathogenicity island in Helicobacter pylori from naturally infected rhesus macaques. Microbiol Lett. 2016;363(24):fnw275. doi:10.1093/femsle/fnw275
   Web of Science ®Google Scholar
• Shiota S, Suzuki R, Yamaoka Y. The significance of virulence factors in H elicobacter pylori. J Dig Dis. 2013;14(7):341–349. doi:10.1111/1751-2980.12054
   Web of Science ®Google Scholar
• Talaiezadeh A, Hajiani E, Tarshizi MA. The relative frequency of the Helicobacter pylori infection in proximal gastric cancers. Pol Przegl Chir. 2013;85(11):657–662. doi:10.2478/pjs-2013-0099
   Google Scholar
• Celli JP, Turner BS, Afdhal NH, et al. Helicobacter pylori moves through mucus by reducing mucin viscoelasticity. Proc Natl Acad Sci. 2009;106(34):14321–14326. doi:10.1073/pnas.0903438106
   PubMed Web of Science ®Google Scholar
• Kao C-Y, Sheu B-S, Wu -J-J. Helicobacter pylori infection: an overview of bacterial virulence factors and pathogenesis. Biomed J. 2016;39(1):14–23. doi:10.1016/j.bj.2015.06.002
   PubMed Web of Science ®Google Scholar
• Robinson K, Kenefeck R, Pidgeon EL, et al. Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses. Gut. 2008;57(10):1375–1385. doi:10.1136/gut.2007.137539
   PubMed Web of Science ®Google Scholar
• Salama NR, Hartung ML, Müller A. Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nat Rev Microbiol. 2013;11(6):385–399. doi:10.1038/nrmicro3016
   PubMed Web of Science ®Google Scholar
• Gu H. Role of flagella in the pathogenesis of Helicobacter pylori. Curr Microbiol. 2017;74(7):863–869. doi:10.1007/s00284-017-1256-4
   PubMed Web of Science ®Google Scholar
• Skene C, Young A, Every A, Sutton P. Helicobacter pylori flagella: antigenic profile and protective immunity. FEMS Immunol Med Microbiol. 2007;50(2):249–256. doi:10.1111/j.1574-695X.2007.00263.x
   Google Scholar
• Gal‐Mor O, Finlay BB. Pathogenicity islands: a molecular toolbox for bacterial virulence. Cell Microbiol. 2006;8(11):1707–1719. doi:10.1111/j.1462-5822.2006.00794.x
   PubMed Web of Science ®Google Scholar
• Huang Y, Wang Q-L, Cheng D-D, Xu W-T, Lu N-H. Adhesion and invasion of gastric mucosa epithelial cells by Helicobacter pylori. Front Cell Infect Microbiol. 2016;6:159. doi:10.3389/fcimb.2016.00159
   PubMed Web of Science ®Google Scholar
• Gupta N, Maurya S, Verma H, Verma VK. Unraveling the factors and mechanism involved in persistence: host‐pathogen interactions in Helicobacter pylori. J Cell Biochem. 2019;120(11):18572–18587. doi:10.1002/jcb.29201
   Web of Science ®Google Scholar
• Oleastro M, Ménard A. The role of Helicobacter pylori outer membrane proteins in adherence and pathogenesis. Biology. 2013;2(3):1110–1134. doi:10.3390/biology2031110
   PubMedGoogle Scholar
• Mégraud F. Toxic factors of Helicobacter pylori. Eur J Gastroenterol Hepatol. 1994;6:S5–10.
   Web of Science ®Google Scholar
• Jiménez-Soto LF, Haas R. The CagA toxin of Helicobacter pylori: abundant production but relatively low amount translocated. Sci Rep. 2016;6(1):1–7. doi:10.1038/srep23227
   Web of Science ®Google Scholar
• Holland RL, Bosi KD, Harpring GH, et al. Chronic in vivo exposure to Helicobacter pylori VacA: assessing the efficacy of automated and long-term intragastric toxin infusion. Sci Rep. 2020;10(1):1–16. doi:10.1038/s41598-020-65787-3
   Web of Science ®Google Scholar
• Palframan SL, Kwok T, Gabriel K. Vacuolating cytotoxin A (VacA), a key toxin for Helicobacter pylori pathogenesis. Front Cell Infect Microbiol. 2012;2:92. doi:10.3389/fcimb.2012.00092
   PubMed Web of Science ®Google Scholar
• Ansari S, Yamaoka Y. Helicobacter pylori virulence factor cytotoxin-associated Gene A (CagA)-mediated gastric pathogenicity. Int J Mol Sci. 2020;21(19):7430. doi:10.3390/ijms21197430
   Web of Science ®Google Scholar
• Pachathundikandi SK, Tegtmeyer N, Backert S. Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells. Gut Microbes. 2013;4(6):454–474. doi:10.4161/gmic.27001
   PubMed Web of Science ®Google Scholar
• Basso D, Plebani M, Kusters JG. Pathogenesis of Helicobacter pylori infection. Helicobacter. 2010;15:14–20. doi:10.1111/j.1523-5378.2010.00781.x
   Web of Science ®Google Scholar
• Hawrelak J. Giardiasis: pathophysiology and management. Altern Med Rev. 2003;8(2):129–142.
   Google Scholar
• Buret AG. Mechanisms of epithelial dysfunction in giardiasis. Gut. 2007;56(3):316–317. doi:10.1136/gut.2006.107771
   Web of Science ®Google Scholar
• Minetti C, Chalmers RM, Beeching NJ, Probert C, Lamden K. Giardiasis. BMJ. 2016;355. doi:10.1136/bmj.i5369
   Web of Science ®Google Scholar
• Yu LZ, Birky CW, Adam RD. The two nuclei of Giardia each have complete copies of the genome and are partitioned equationally at cytokinesis. Eukaryotic Cell. 2002;1(2):191–199. doi:10.1128/EC.1.2.191-199.2002
   Google Scholar
• Stadelmann B, Hanevik K, Andersson MK, Bruserud O, Svärd SG. The role of arginine and arginine-metabolizing enzymes during Giardia–host cell interactions in vitro. BMC Microbiol. 2013;13(1):256. doi:10.1186/1471-2180-13-256
   Web of Science ®Google Scholar
• Docampo R, Lujan HD, Docampo R. Mechanisms of adaptation in the intestinal parasite Giardia lamblia. Essays Biochem. 2011;51:177–191. doi:10.1042/bse0510177
   Web of Science ®Google Scholar
• Emery SJ, Mirzaei M, Vuong D, et al. Induction of virulence factors in Giardia duodenalis independent of host attachment. Sci Rep. 2016;6(1):1–16. doi:10.1038/srep20765
   Web of Science ®Google Scholar
• Nash TE. Antigenic Variation in Giardia. Springer; 2011:245–257.
   Google Scholar
• Prucca CG, Rivero FD, Luján HD. Regulation of antigenic variation in Giardia lamblia. Annu Rev Microbiol. 2011;65:611–630. doi:10.1146/annurev-micro-090110-102940
   Web of Science ®Google Scholar
• Martinez T, Wright N, Paneda C, Jimenez AI, Lopez-Fraga M. RNA interference-based therapeutics: harnessing the powers of nature. Drug Dev. 2011;265. doi:10.5772/29576
   Google Scholar
• Allain T, Fekete E, Buret AG. Giardia cysteine proteases: the teeth behind the smile. Trends Parasitol. 2019;35(8):636–648. doi:10.1016/j.pt.2019.06.003
   Web of Science ®Google Scholar
• Alvarez VE, Iribarren PA, Niemirowicz GT, Cazzulo JJ. Update on relevant trypanosome peptidases: validated targets and future challenges. Biochimica et Biophysica Acta. 2020;1869:140577.
   Web of Science ®Google Scholar
• Ma’ayeh SY, Liu J, Peirasmaki D, et al. Characterization of the Giardia intestinalis secretome during interaction with human intestinal epithelial cells: the impact on host cells. PLoS Negl Trop Dis. 2017;11(12):e0006120. doi:10.1371/journal.pntd.0006120
   Web of Science ®Google Scholar
• Liu J, Ma’ayeh S, Peirasmaki D, Lundström-Stadelmann B, Hellman L, Svärd SG. Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines. Virulence. 2018;9(1):879–894. doi:10.1080/21505594.2018.1451284
   PubMed Web of Science ®Google Scholar
• Li Z. Serglycin-dependent mast cell-specific proteases and their potential interactions with Giardia intestinalis. 2019.
   Google Scholar
• Evans-Osses I, Reichembach LH, Ramirez MI. Exosomes or microvesicles? Two kinds of extracellular vesicles with different routes to modify protozoan-host cell interaction. Parasitol Res. 2015;114(10):3567–3575. doi:10.1007/s00436-015-4659-9
   PubMed Web of Science ®Google Scholar
• Ma’ayeh SY. Molecular and Cellular Interactions of Four Giardia Duodenalis Isolates with the Murine Intestinal Epithelial Cell Line IEC-6 in Vitro. Monash University; 2013.
   Google Scholar
• Manko A, Motta J-P, Cotton JA, et al. Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease. PLoS One. 2017;12(6):e0178647. doi:10.1371/journal.pone.0178647
   Web of Science ®Google Scholar
• Wang F, Xia P, Wu F, et al. Helicobacter pylori VacA disrupts apical membrane-cytoskeletal interactions in gastric parietal cells. J Biol Chem. 2008;283(39):26714–26725. doi:10.1074/jbc.M800527200
   Web of Science ®Google Scholar
• Angelov TA, Kovacheva-Slavova MD, Iliev HI, Valkov HY, Vladimirov BG. Helicobacter Pylori Infection. Gastritis-New Approaches and Treatments. IntechOpen; 2019.
   Google Scholar
• Rópolo AA, Touz MC. A lesson in survival, by Giardia lamblia. Sci World J. 2010;10:2019–2031. doi:10.1100/tsw.2010.200
   Web of Science ®Google Scholar
• Yamauchi K, Choi I-J, Lu H, Ogiwara H, Graham DY, Yamaoka Y. Regulation of IL-18 in Helicobacter pylori infection. J Immunol. 2008;180(2):1207–1216. doi:10.4049/jimmunol.180.2.1207
   PubMed Web of Science ®Google Scholar
• Lane S, Lloyd D. Current trends in research into the waterborne parasite Giardia. Crit Rev Microbiol. 2002;28(2):123–147. doi:10.1080/1040-840291046713
   Web of Science ®Google Scholar
• Dias A, Garcia C, Majewski M, et al. Gastric juice prostaglandins and peptide growth factors as potential markers of chronic atrophic gastritis, intestinal metaplasia and gastric cancer: their potential clinical implications based on this pilot study. Dig Dis Sci. 2011;56(11):3220–3225. doi:10.1007/s10620-011-1758-z
   Web of Science ®Google Scholar
• Liu Y, Vosmaer G, Tytgat G, Xiao S, Ten Kate F. Gastrin (G) cells and somatostatin (D) cells in patients with dyspeptic symptoms: Helicobacter pylori associated and non-associated gastritis. J Clin Pathol. 2005;58(9):927–931. doi:10.1136/jcp.2003.010710
   Web of Science ®Google Scholar
• Fuenmayor-Boscán AD, Hernández IM, Valero KJ, Paz AM, Sandrea LB, Rivero Z. Association between Helicobacter pylori and intestinal parasites in an Añu indigenous community of Venezuela. Indian J Gastroenterol. 2016;35(2):106–112. doi:10.1007/s12664-016-0641-4
   PubMedGoogle Scholar
• El-Badry AA, Ghieth MA, Ahmed DA, Ismail MA. Giardia intestinalis and helicobacter pylori co-infection: estimated risks and predictive factors in Egypt. J Egypt Soc Parasitol. 2017;47(1):19–24. doi:10.21608/jesp.2017.77957
   PubMedGoogle Scholar
• Torres J, Perez GP, Ximenez C, et al. The association of intestinal parasitosis and H. pylori infection in children and adults from a Mexican community with high prevalence of parasitosis. Helicobacter. 2003;8(3):179–185. doi:10.1046/j.1523-5378.2003.00142.x
   Web of Science ®Google Scholar
• Whary MT, Sundina N, Bravo LE, et al. Intestinal helminthiasis in Colombian children promotes a Th2 response to Helicobacter pylori: possible implications for gastric carcinogenesis. Cancer Epidemiol Prev Biomark. 2005;14(6):1464–1469. doi:10.1158/1055-9965.EPI-05-0095
   Web of Science ®Google Scholar
• Sabah AA, Gneidy MR, Saleh NMK. Prevalence of Helicobacter pylori infection among adult patients with different gastrointestinal parasites in Tanta City district. J Egypt Soc Parasitol. 2015;45(1):101–106. doi:10.21608/jesp.2015.89704
   Google Scholar
• Hasan SM, Shabbir A, Shaikh A, Khan TN, Irshad Z. Endoscopic biopsy proven co-infection of Helicobacter pylori and Giardia lamblia in adult population of Karachi city. Pak J Med Dent. 2019;8(2):4.
   Google Scholar
• Ahmed NFM. Prevalence Rate of Giardia Lamblia/Helicobacter Pylori Co-Infections in Khartoum State-Sudan. Sudan University of Science & Technology; 2016.
   Google Scholar
• Spotts H, Walelign S, Tesfaye M, Desta K, Tsegaye A, Taye B. Concurrent infection of intestinal parasites and Helicobacter pylori among school-age children in Central Ethiopia. Parasite Epidemiol Contr. 2020;11:e00177. doi:10.1016/j.parepi.2020.e00177
   Google Scholar
• Ieni A, Barresi V, Rigoli L, Fedele F, Tuccari G, Caruso R. Morphological and cellular features of innate immune reaction in Helicobacter pylori gastritis: a brief review. Int J Mol Sci. 2016;17(1):109. doi:10.3390/ijms17010109
   Web of Science ®Google Scholar
• Karkhah A, Ebrahimpour S, Rostamtabar M, et al. Helicobacter pylori evasion strategies of the host innate and adaptive immune responses to survive and develop gastrointestinal diseases. Microbiol Res. 2019;218:49–57. doi:10.1016/j.micres.2018.09.011
   PubMed Web of Science ®Google Scholar
• Khamri W, Walker MM, Clark P, et al. Helicobacter pylori stimulates dendritic cells to induce interleukin-17 expression from CD4+ T lymphocytes. Infect Immun. 2010;78(2):845–853. doi:10.1128/IAI.00524-09
   Web of Science ®Google Scholar
• Luzza F, Parrello T, Monteleone G, et al. Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa. J Immunol. 2000;165(9):5332–5337. doi:10.4049/jimmunol.165.9.5332
   Web of Science ®Google Scholar
• Brenchley JM, Douek DC. Microbial translocation across the GI tract. Annu Rev Immunol. 2012;30:149–173. doi:10.1146/annurev-immunol-020711-075001
   PubMed Web of Science ®Google Scholar
• Fink MY, Singer SM. The intersection of immune responses, microbiota, and pathogenesis in giardiasis. Trends Parasitol. 2017;33(11):901–913. doi:10.1016/j.pt.2017.08.001
   PubMed Web of Science ®Google Scholar
• Evering T, Weiss L. The immunology of parasite infections in immunocompromised hosts. Parasite Immunol. 2006;28(11):549–565. doi:10.1111/j.1365-3024.2006.00886.x
   PubMed Web of Science ®Google Scholar
• Bartelt LA, Sartor RB. Advances in understanding Giardia: determinants and mechanisms of chronic sequelae. F1000Prime Rep. 2015;7. doi:10.12703/P7-62
   Google Scholar
• Hanevik K, Kristoffersen E, Svard S, et al. Human cellular immune response against Giardia lamblia 5 years after acute giardiasis. J Infect Dis. 2011;204(11):1779–1786. doi:10.1093/infdis/jir639
   Web of Science ®Google Scholar
• Saghaug CS, Sørnes S, Peirasmaki D, Svärd S, Langeland N, Hanevik K. Human memory CD4+ T cell immune responses against Giardia lamblia. Clin Vaccine Immunol. 2015;23(1):11–18. doi:10.1128/CVI.00419-15
   Google Scholar
• Janeway CA. How the immune system works to protect the host from infection: a personal view. Proc Natl Acad Sci. 2001;98(13):7461–7468. doi:10.1073/pnas.131202998
   PubMed Web of Science ®Google Scholar
• Buret A. Immunopathology of giardiasis: the role of lymphocytes in intestinal epithelial injury and malfunction. Memórias Do Instituto Oswaldo Cruz. 2005;100:185–190. doi:10.1590/S0074-02762005000900032
   Web of Science ®Google Scholar
• Houghton J, Fox JG, Wang TC. Gastric cancer: laboratory bench to clinic. J Gastroenterol Hepatol. 2002;17(4):495–502. doi:10.1046/j.1440-1746.2002.02770.x
   PubMed Web of Science ®Google Scholar
• Kasper LH, Buzoni-Gatel D, Portnoy DA. Ups and downs of mucosal cellular immunity against protozoan parasites. Infect Immun. 2001;69(1):1–8. doi:10.1128/IAI.69.1.1-8.2001
   Web of Science ®Google Scholar
• Andersen LP. Colonization and infection by Helicobacter pylori in humans. Helicobacter. 2007;12:12–15. doi:10.1111/j.1523-5378.2007.00574.x
   PubMed Web of Science ®Google Scholar
• Narayanan M, Reddy KM, Marsicano E. Peptic ulcer disease and Helicobacter pylori infection. Mo Med. 2018;115(3):219.
   PubMedGoogle Scholar
• Paniker CJ. Paniker’s Textbook of Medical Parasitology. JP Medical Ltd; 2017.
   Google Scholar
• Windle HJ, Kelleher D, Crabtree JE. Childhood Helicobacter pylori infection and growth impairment in developing countries: a vicious cycle? Pediatrics. 2007;119(3):e754–e759. doi:10.1542/peds.2006-2196
   Web of Science ®Google Scholar