333
Views
3
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Exploring the Benefits of Metal Ions in Phage Cocktail for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infection

, , , , , , , , & show all
Pages 2689-2702 | Published online: 27 May 2022

References

  • David MZ, Daum RS. Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic. Clin Microbiol Rev. 2010;23(3):616–687.
  • Michels R, Last K, Becker SL, Papan C. Update on Coagulase-Negative Staphylococci-What the Clinician Should Know. Microorganisms. 2021;9(4):625.
  • Foster AP. Staphylococcal skin disease in livestock. Vet Dermatol. 2012;23(4):342–351, e363.
  • Lowder BV, Guinane CM, Ben Zakour NL, et al. Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus. Proc Natl Acad Sci U S A. 2009;106(46):19545–19550.
  • O’Neill J. Tackling Drug-Resistant Infections Globally: Final Report and Recommendations; Review on Antimicrobial Resistance. London, UK; 2016.
  • Lehman SM, Mearns G, Rankin D, et al. Design and Preclinical Development of a Phage Product for the Treatment of Antibiotic-Resistant Staphylococcus aureus Infections. Viruses. 2019;11(1):53.
  • Cong Y, Yang S, Rao X. Vancomycin resistant Staphylococcus aureus infections: a review of case updating and clinical features. J Adv Res. 2020;21:169–176.
  • Yang H, Xu J, Li W, et al. Staphylococcus aureus virulence attenuation and immune clearance mediated by a phage lysin-derived protein. EMBO j. 2018;37:17.
  • Shkoporov AN, Clooney AG, Sutton TDS, et al. The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific. Cell Host Microbe. 2019;26(4):527–541.e525.
  • Song J, Ruan H, Chen L, et al. Potential of bacteriophages as disinfectants to control of Staphylococcus aureus biofilms. BMC Microbiol. 2021;21(1):57.
  • Gutiérrez D, Vandenheuvel D, Martínez B, Rodríguez A, Lavigne R, García P. Two Phages, phiIPLA-RODI and phiIPLA-C1C, Lyse Mono- and Dual-Species Staphylococcal Biofilms. Appl Environ Microbiol. 2015;81(10):3336–3348.
  • Kifelew LG, Warner MS, Morales S, et al. Efficacy of Lytic Phage Cocktails on Staphylococcus aureus and Pseudomonas aeruginosa in Mixed-Species Planktonic Cultures and Biofilms. Viruses. 2020;12(5):536.
  • Petrovic Fabijan A, Lin RCY, Ho J, Maddocks S, Ben Zakour NL, Iredell JR. Safety of bacteriophage therapy in severe Staphylococcus aureus infection. Nat Microbiol. 2020;5(3):465–472.
  • Kifelew LG, Warner MS, Morales S, et al. Efficacy of phage cocktail AB-SA01 therapy in diabetic mouse wound infections caused by multidrug-resistant Staphylococcus aureus. BMC Microbiol. 2020;20(1):204.
  • Ooi ML, Drilling AJ, Morales S, et al. Safety and Tolerability of Bacteriophage Therapy for Chronic Rhinosinusitis Due to Staphylococcus aureus. JAMA Otolaryngol Head Neck Surg. 2019;145(8):723–729.
  • Ingmer H, Gerlach D, Wolz C. Temperate Phages of Staphylococcus aureus. Microbiol Spectr. 2019;7(5):234.
  • Touchon M, Bernheim A, Rocha EP. Genetic and life-history traits associated with the distribution of prophages in bacteria. Isme j. 2016;10(11):2744–2754.
  • Feng T, Leptihn S, Dong K, et al. JD419, a Staphylococcus aureus Phage With a Unique Morphology and Broad Host Range. Front Microbiol. 2021;12:602902.
  • Meader E, Mayer MJ, Steverding D, Carding SR, Narbad A. Evaluation of bacteriophage therapy to control Clostridium difficile and toxin production in an in vitro human colon model system. Anaerobe. 2013;22:25–30.
  • Chung IY, Sim N, Cho YH. Antibacterial efficacy of temperate phage-mediated inhibition of bacterial group motilities. Antimicrob Agents Chemother. 2012;56(11):5612–5617.
  • Monteiro R, Pires DP, Costa AR, Azeredo J. Phage Therapy: going Temperate? Trends Microbiol. 2019;27(4):368–378.
  • Ribeiro M, Monteiro FJ, Ferraz MP. Infection of orthopedic implants with emphasis on bacterial adhesion process and techniques used in studying bacterial-material interactions. Biomatter. 2012;2(4):176–194.
  • Molina-Manso D, Del Prado G, Ortiz-Pérez A, et al. In vitro susceptibility to antibiotics of staphylococci in biofilms isolated from orthopaedic infections. Int J Antimicrob Agents. 2013;41(6):521–523.
  • Cha Y, Son B, Ryu S. Effective removal of staphylococcal biofilms on various food contact surfaces by Staphylococcus aureus phage endolysin LysCSA13. Food Microbiol. 2019;84:103245.
  • Zhang L, Shahin K, Soleimani-Delfan A, et al. Phage JS02, a putative temperate phage, a novel biofilm-degrading agent for Staphylococcus aureus. Lett Appl Microbiol. 2022.
  • Yang D, Chen Y, Sun E, Hua L, Peng Z, Wu B. Characterization of a Lytic Bacteriophage vB_EfaS_PHB08 Harboring Endolysin Lys08 Against Enterococcus faecalis Biofilms. Microorganisms. 2020;8:9.
  • Kirby-Bauer Disk JH. Diffusion Susceptibility Test Protocol. Am Soc Microbiol. 2016;1:1–23.
  • Mangieri N, Picozzi C, Cocuzzi R, Foschino R. Evaluation of a Potential Bacteriophage Cocktail for the Control of Shiga-Toxin Producing Escherichia coli in Food. Front Microbiol. 2020;11:1801.
  • Chen Y, Yang L, Yang D, et al. Specific Integration of Temperate Phage Decreases the Pathogenicity of Host Bacteria. Front Cell Infect Microbiol. 2020;10:14.
  • Chang HC, Chen CR, Lin JW, et al. Isolation and characterization of novel giant Stenotrophomonas maltophilia phage phiSMA5. Appl Environ Microbiol. 2005;71(3):1387–1393.
  • Thomas JA, Hardies SC, Rolando M, et al. Complete genomic sequence and mass spectrometric analysis of highly diverse, atypical Bacillus thuringiensis phage 0305phi8-36. Virology. 2007;368(2):405–421.
  • Chen Y, Li X, Song J, et al. Isolation and characterization of a novel temperate bacteriophage from gut-associated Escherichia within black soldier fly larvae (Hermetia illucens L. [Diptera: stratiomyidae]). Arch Virol. 2019;164(9):2277–2284.
  • Li R, Zhu H, Ruan J, et al. De novo assembly of human genomes with massively parallel short read sequencing. Genome Res. 2010;20(2):265–272.
  • Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. MEGA6: molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol. 2013;30(12):2725–2729.
  • Oliveira H, Mendes A, Fraga AG, et al. K2 Capsule Depolymerase Is Highly Stable, Is Refractory to Resistance, and Protects Larvae and Mice from Acinetobacter baumannii Sepsis. Appl Environ Microbiol. 2019;85:17.
  • Chen Y, Yang L, Sun E, Song J, Wu B. Characterisation of a newly detected bacteriophage infecting Bordetella bronchiseptica in swine. Arch Virol. 2019;164(1):33–40.
  • Forti F, Roach DR, Cafora M, et al. Design of a Broad-Range Bacteriophage Cocktail That Reduces Pseudomonas aeruginosa Biofilms and Treats Acute Infections in Two Animal Models. Antimicrob Agents Chemother. 2018;62:6.
  • Yu L, Wang S, Guo Z, et al. A guard-killer phage cocktail effectively lyses the host and inhibits the development of phage-resistant strains of Escherichia coli. Appl Microbiol Biotechnol. 2018;102(2):971–983.
  • Velikova N, Kavanagh K, Wells JM. Evaluation of Galleria mellonella larvae for studying the virulence of Streptococcus suis. BMC Microbiol. 2016;16(1):291.
  • Chen Y, Li X, Wang S, et al. A Novel Tail-Associated O91-Specific Polysaccharide Depolymerase from a Podophage Reveals Lytic Efficacy of Shiga Toxin-Producing Escherichia coli. Appl Environ Microbiol. 2020;86(9):56.
  • Pandey R, Mishra SK, Shrestha A. Characterisation of ESKAPE Pathogens with Special Reference to Multidrug Resistance and Biofilm Production in a Nepalese Hospital. Infect Drug Resist. 2021;14:2201–2212.
  • Foster TJ. Antibiotic resistance in Staphylococcus aureus. Current status and future prospects. FEMS Microbiol Rev. 2017;41(3):430–449.
  • Chan BK, Abedon ST. Phage therapy pharmacology phage cocktails. Adv Appl Microbiol. 2012;78:1–23.
  • Wu N, Dai J, Guo M, et al. Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients. Emerg Microbes Infect. 2021;10(1):612–618.
  • Anderl JN, Franklin MJ, Stewart PS. Role of antibiotic penetration limitation in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin. Antimicrob Agents Chemother. 2000;44(7):1818–1824.
  • Van Laar TA, Chen T, You T, Leung KP. Sublethal concentrations of carbapenems alter cell morphology and genomic expression of Klebsiella pneumoniae biofilms. Antimicrob Agents Chemother. 2015;59(3):1707–1717.
  • Hughes KA, Sutherland IW, Jones MV. Biofilm susceptibility to bacteriophage attack: the role of phage-borne polysaccharide depolymerase. Microbiology. 1998;144(Pt 11):3039–3047.
  • Hood MI, Skaar EP. Nutritional immunity: transition metals at the pathogen-host interface. Nat Rev Microbiol. 2012;10(8):525–537.
  • Gu J, Feng Y, Feng X, et al. Structural and biochemical characterization reveals LysGH15 as an unprecedented “EF-hand-like” calcium-binding phage lysin. PLoS Pathog. 2014;10(5):e1004109.
  • Vázquez R, Domenech M, Iglesias-Bexiga M, Menéndez M, García P. Csl2, a novel chimeric bacteriophage lysin to fight infections caused by Streptococcus suis, an emerging zoonotic pathogen. Sci Rep. 2017;7(1):16506.
  • Zhang X, Lan Y, Jiao W, et al. Isolation and Characterization of a Novel Virulent Phage of Lactobacillus casei ATCC 393. Food Environ Virol. 2015;7(4):333–341.
  • Latka A, Drulis-Kawa Z. Advantages and limitations of microtiter biofilm assays in the model of antibiofilm activity of Klebsiella phage KP34 and its depolymerase. Sci Rep. 2020;10(1):20338.
  • Mannala GK, Rupp M, Alagboso F, et al. Galleria mellonella as an alternative in vivo model to study bacterial biofilms on stainless steel and titanium implants. Altex. 2021;38(2):245–252.
  • Xie N, Jiang L, Chen M, et al. In vitro and in vivo Antibacterial Activity of Linezolid Plus Fosfomycin Against Staphylococcus aureus with Resistance to One Drug. Infect Drug Resist. 2021;14:639–649.
  • Ngassam-Tchamba C, Duprez JN, Fergestad M, et al. In vitro and in vivo assessment of phage therapy against Staphylococcus aureus causing bovine mastitis. J Glob Antimicrob Resist. 2020;22:762–770.
  • Jeon J, Yong D. Two Novel Bacteriophages Improve Survival in Galleria mellonella Infection and Mouse Acute Pneumonia Models Infected with Extensively Drug-Resistant Pseudomonas aeruginosa. Appl Environ Microbiol. 2019;85:9.
  • Fish R, Kutter E, Bryan D, Wheat G, Kuhl S. Resolving Digital Staphylococcal Osteomyelitis Using Bacteriophage-A Case Report. Antibiotics. 2018;7(4):8978.
  • Morozova VV, Vlassov VV, Tikunova NV. Applications of Bacteriophages in the Treatment of Localized Infections in Humans. Front Microbiol. 2018;9:1696.
  • Prazak J, Valente L, Iten M, et al. Benefits of aerosolized phages for the treatment of pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA): an experimental study in rats. J Infect Dis. 2021.
  • Roach DR, Leung CY, Henry M, et al. Synergy between the Host Immune System and Bacteriophage Is Essential for Successful Phage Therapy against an Acute Respiratory Pathogen. Cell Host Microbe. 2017;22(1):38–47.e34.
  • Lv M, Chen M, Zhang R, et al. Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy. Cell Res. 2020;30(11):966–979.
  • Lentini G, Famà A, De Gaetano GV, et al. Role of Endosomal TLRs in Staphylococcus aureus Infection. J Immunol. 2021;207(5):1448–1455.
  • Hook JS, Patel PA, O’Malley A, et al. Lipoproteins from Staphylococcus aureus Drive Neutrophil Extracellular Trap Formation in a TLR2/1- and PAD-Dependent Manner. J Immunol. 2021;207(3):966–973.
  • Molina F, Menor-Flores M, Fernández L, Vega-Rodríguez MA, García P. Systematic analysis of putative phage-phage interactions on minimum-sized phage cocktails. Sci Rep. 2022;12(1):2458.
  • Ram G, Chen J, Kumar K, et al. Staphylococcal pathogenicity island interference with helper phage reproduction is a paradigm of molecular parasitism. Proc Natl Acad Sci U S A. 2012;109(40):16300–16305.
  • Abedon ST, Thomas-Abedon C. Phage therapy pharmacology. Curr Pharm Biotechnol. 2010;11(1):28–47.
  • Dedrick RM, Guerrero-Bustamante CA, Garlena RA, et al. Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus. Nat Med. 2019;25(5):730–733.
  • Nale JY, Spencer J, Hargreaves KR, et al. Bacteriophage Combinations Significantly Reduce Clostridium difficile Growth In Vitro and Proliferation In Vivo. Antimicrob Agents Chemother. 2016;60(2):968–981.
  • Harrison E, Brockhurst MA. Ecological and Evolutionary Benefits of Temperate Phage: what Does or Doesn’t Kill You Makes You Stronger. Bioessays. 2017;39:12.
  • Kilcher S, Studer P, Muessner C, Klumpp J, Loessner MJ. Cross-genus rebooting of custom-made, synthetic bacteriophage genomes in L-form bacteria. Proc Natl Acad Sci U S A. 2018;115(3):567–572.