Severe Thrombocytopenic Purpura Associated with COVID-19 in a Pediatric Patient

References

• Ceglie G, De Ioris MA, Mercadante S, et al. Immune thrombocytopenia in a child with COVID‐19: is it the calm after the (cytokine) storm? Pediatr Blood Cancer. 2022;69(1). doi:10.1002/pbc.29326
   Web of Science ®Google Scholar
• Rand ML, Fraser WJ. Virus-associated idiopathic thrombocytopenic purpura. Transfus Sci. 1998;19(3):253–259. doi:10.1016/S0955-3886(98)00039-3
   Google Scholar
• Kuhne T, Berchtold W, Michaels LA, et al. Newly diagnosed immune thrombocytopenia in children and adults: a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group. Haematologica. 2011;96(12):1831–1837. doi:10.3324/haematol.2011.050799
   PubMed Web of Science ®Google Scholar
• Aydin S, Altinkaynak GG, Kocabaş BA. A pediatric case report with immune thrombocytopenic purpura associated with COVID-19. Arch Pediatr. 2021;6(1):196.
   Google Scholar
• Hamada M, Yasumoto S, Furue M. A case of varicella-associated idiopathic thrombocytopenic purpura in adulthood. J Dermatol. 2004;31(6):477–479. doi:10.1111/j.1346-8138.2004.tb00536.x
   Web of Science ®Google Scholar
• Malleson PN, Mackinnon MJ, Sailer-Hoeck M, Spencer CH. Review for the generalist: the antinuclear antibody test in children - when to use it and what to do with a positive titer. Pediatr Rheumatol. 2010;8(1):27. doi:10.1186/1546-0096-8-27
   Web of Science ®Google Scholar
• McCrae K. Immune thrombocytopenia: no longer ‘idiopathic. CCJM. 2011;78(6):358–373. doi:10.3949/ccjm.78gr.10005
   Google Scholar
• Lim JH, Kim YK, Min SH, Kim SW, Lee YH, Lee JM. Epidemiology and viral etiology of pediatric immune thrombocytopenia through Korean Public Health Data Analysis. JCM. 2021;10(7):1356. doi:10.3390/jcm10071356
   Web of Science ®Google Scholar
• Enache A, Ciocan V, Muresan CO, et al. Postmortem documentation of SARS-CoV-2 in utero and postpartum transmission, through amniotic fluid, placental, and pulmonary tissue RT-PCR. Appl Sci. 2021;11(20):9505. doi:10.3390/app11209505
   Google Scholar
• Marinescu AR, Laza R, Musta VF, et al. Clostridium difficile and COVID-19: general data, ribotype, clinical form, treatment-our experience from the largest infectious diseases hospital in Western Romania. Medicina. 2021;57(10):1099. doi:10.3390/medicina57101099
   PubMed Web of Science ®Google Scholar
• Tudoran M, Tudoran C, Lazureanu V, et al. Alterations of left ventricular function persisting during post-acute COVID-19 in subjects without previously diagnosed cardiovascular pathology. JPM. 2021;11(3):225. doi:10.3390/jpm11030225
   Web of Science ®Google Scholar
• Dumache R, Daescu E, Ciocan V, et al. Molecular testing of SARS-CoV-2 infection from blood samples in disseminated intravascular coagulation (DIC) and elevated D-dimer levels. Clin Lab. 2021;67. doi:10.7754/Clin.Lab.2020.200704
   Web of Science ®Google Scholar
• Tiwari NR, Phatak S, Sharma VR, Agarwal SK. COVID-19 and thrombotic microangiopathies. Thromb Res. 2021;202:191–198. doi:10.1016/j.thromres.2021.04.012
   PubMed Web of Science ®Google Scholar
• Cao W, Li T. COVID-19: towards understanding of pathogenesis. Cell Res. 2020;30(5):367–369. doi:10.1038/s41422-020-0327-4
   PubMed Web of Science ®Google Scholar
• Guan W, Ni Z, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708–1720. doi:10.1056/NEJMoa2002032
   PubMed Web of Science ®Google Scholar
• Hashemieh M, Tabatabaee S, Radfar M, Fahim P. COVID-19 associated thrombocytopenia in children: an emerging issue. Int J Pediatr. 2020. doi:10.22038/ijp.2020.52364.4162
   Web of Science ®Google Scholar
• Chen ZM, Fu JF, Shu Q, et al. Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus. World J Pediatr. 2020;16(3):240–246. doi:10.1007/s12519-020-00345-5
   PubMed Web of Science ®Google Scholar
• Alsohime F, Temsah MH, Al-Nemri AM, Somily AM, Al-Subaie S. COVID-19 infection prevalence in pediatric population: etiology, clinical presentation, and outcome. J Infect Public Health. 2020;13(12):1791–1796. doi:10.1016/j.jiph.2020.10.008
   Web of Science ®Google Scholar
• Castagnoli R, Votto M, Licari A, et al. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review. JAMA Pediatr. 2020;174(9):882. doi:10.1001/jamapediatrics.2020.1467
   PubMed Web of Science ®Google Scholar
• Laza R, Musta VF, Nicolescu ND, et al. Cutaneous manifestations in SARS-CoV-2 infection—a series of cases from the largest infectious diseases hospital in Western Romania. Healthcare. 2021;9(7):800. doi:10.3390/healthcare9070800
   Web of Science ®Google Scholar
• Consiglio CR, Cotugno N, Sardh F, et al. The immunology of multisystem inflammatory syndrome in children with COVID-19. Cell. 2020;183(4):968–981.e7. doi:10.1016/j.cell.2020.09.016
   PubMed Web of Science ®Google Scholar
• Patel PA, Chandrakasan S, Mickells GE, Yildirim I, Kao CM, Bennett CM. Severe pediatric COVID-19 presenting with respiratory failure and severe thrombocytopenia. Pediatrics. 2020;146(1):e20201437. doi:10.1542/peds.2020-1437
   Web of Science ®Google Scholar
• Kok EY, Srivaths L, Grimes AB, Vogel TP, Sexson Tejtel SK, Muscal E. Immune thrombocytopenia following multisystem inflammatory syndrome in children (MIS-C) – a case series. Pediatr Hematol Oncol. 2021;38(7):663–668. doi:10.1080/08880018.2021.1917737
   PubMed Web of Science ®Google Scholar
• Rosenzweig JD, McThenia SS, Kaicker S. SARS‐CoV‐2 infection in two pediatric patients with immune cytopenias: a single institution experience during the pandemic. Pediatr Blood Cancer. 2020;67(9). doi:10.1002/pbc.28503
   Web of Science ®Google Scholar
• Schoettler ML, Graham D, Tao W, et al. Increasing observation rates in low-risk pediatric immune thrombocytopenia using a standardized clinical assessment and management plan (SCAMP ®): schoettler et al. Pediatr Blood Cancer. 2017;64(5):e26303. doi:10.1002/pbc.26303
   Web of Science ®Google Scholar
• Zhang Y, Zeng X, Jiao Y, et al. Mechanisms involved in the development of thrombocytopenia in patients with COVID-19. Thromb Res. 2020;193:110–115. doi:10.1016/j.thromres.2020.06.008
   PubMed Web of Science ®Google Scholar
• Behlivani E, Tragiannidis A, Hatzipantelis E, Panagopoulou P. Immune thrombocytopenia secondary to COVID‐19 infection: report of two cases. Pediatr Blood Cancer. 2021;68(10). doi:10.1002/pbc.29175
   Web of Science ®Google Scholar
• Bhattacharjee S, Banerjee M. Immune thrombocytopenia secondary to COVID-19: a systematic review. SN Compr Clin Med. 2020;2(11):2048–2058. doi:10.1007/s42399-020-00521-8
   PubMedGoogle Scholar
• Quinn R, Murakhovskaya I. SARS-CoV-2 and autoimmune cytopenia. Hemato. 2021;2(3):463–476. doi:10.3390/hemato2030029
   Google Scholar
• Gloude NJ, Dandoy CE, Davies SM, et al. Thinking beyond HLH: clinical features of patients with concurrent presentation of hemophagocytic lymphohistiocytosis and thrombotic microangiopathy. J Clin Immunol. 2020;40(5):699–707. doi:10.1007/s10875-020-00789-4
   PubMed Web of Science ®Google Scholar
• Staffa SJ, Joerger JD, Henry E, Christensen RD, Brugnara C, Zurakowski D. Pediatric hematology normal ranges derived from pediatric primary care patients. Am J Hematol. 2020;95. doi:10.1002/ajh.25904
   Web of Science ®Google Scholar
• Diorio C, McNerney KO, Lambert M, et al. Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations. Blood Adv. 2020;4(23):6051–6063. doi:10.1182/bloodadvances.2020003471
   PubMed Web of Science ®Google Scholar
• Yazdanpanah N, Rezaei N. Autoimmune complications of COVID‐19. J Med Virol. 2022;94(1):54–62. doi:10.1002/jmv.27292
   Web of Science ®Google Scholar
• Berchtold P, McMillan R, Tani P, Sommerville-Nielsen S, Blanchette VS. Autoantibodies against platelet membrane glycoproteins in children with acute and chronic immune thrombocytopenic purpura. Blood. 1989;74(5):1600–1602. doi:10.1182/blood.V74.5.1600.1600
   Web of Science ®Google Scholar
• Bobircă A, Bobircă F, Ancuța I, et al. COVID-19—a trigger factor for severe immune-mediated thrombocytopenia in active rheumatoid arthritis. Life. 2022;12(1):77. doi:10.3390/life12010077
   Google Scholar
• Bao C, Tao X, Cui W, et al. SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patients. Exp Hematol Oncol. 2020;9(1):16. doi:10.1186/s40164-020-00172-4
   Web of Science ®Google Scholar
• Liebman HA. Viral-associated immune thrombocytopenic purpura. Hematology. 2008;2008(1):212–218. doi:10.1182/asheducation-2008.1.212
   Google Scholar
• Hoang A, Chorath K, Moreira A, et al. COVID-19 in 7780 pediatric patients: a systematic review. EClinicalMedicine. 2020;24:100433. doi:10.1016/j.eclinm.2020.100433
   PubMedGoogle Scholar
• Soares AC, Loggetto SR, Manga FCM, Faustino LR, Braga JAP. Outcome of SARS-CoV-2 and immune thrombocytopenia in a pediatric patient. Hematol Transfus Cell Ther. 2021;43(1):101–103. doi:10.1016/j.htct.2020.09.145
   Google Scholar
• Chen W, Li Z, Yang B, et al. Delayed‐phase thrombocytopenia in patients with coronavirus disease 2019 (COVID‐19). Br J Haematol. 2020;190(2):179–184. doi:10.1111/bjh.16885
   PubMed Web of Science ®Google Scholar
• Xu P, Zhou Q, Xu J. Mechanism of thrombocytopenia in COVID-19 patients. Ann Hematol. 2020;99(6):1205–1208. doi:10.1007/s00277-020-04019-0
   PubMed Web of Science ®Google Scholar
• Alonso-Beato R, Morales-Ortega A, Fernández FJD, et al. Immune thrombocytopenia and COVID-19: case report and review of literature. Lupus. 2021;30(9):1515–1521. doi:10.1177/09612033211021161
   Web of Science ®Google Scholar
• Dalkıran T, Kandur Y, Kara EM, Dağoğlu B, Taner S, Öncü D. Thrombotic Microangiopathy in a Severe Pediatric Case of COVID-19. Clin Med Insights Pediatr. 2021;15:117955652110498. doi:10.1177/11795565211049897
   Google Scholar
• Oi SSP, Muniz MPR, Faria IM, et al. Multisystemic inflammatory syndrome and thrombotic microangiopathy as complications of COVID-19 in a child: a case report. Front Pediatr. 2021;9:659069. doi:10.3389/fped.2021.659069
   Web of Science ®Google Scholar
• Chen YT, Shao SC, Hsu CK, Wu IW, Hung MJ, Chen YC. Incidence of acute kidney injury in COVID-19 infection: a systematic review and meta-analysis. Crit Care. 2020;24(1):346. doi:10.1186/s13054-020-03009-y
   PubMed Web of Science ®Google Scholar
• Kari JA, Shalaby MA, Albanna AS, Alahmadi TS, Alherbish A, Alhasan KA. Acute kidney injury in children with COVID-19: a retrospective study. BMC Nephrol. 2021;22(1):202. doi:10.1186/s12882-021-02389-9
   Web of Science ®Google Scholar
• Icenogle T. COVID-19: infection or autoimmunity. Front Immunol. 2020;11:2055. doi:10.3389/fimmu.2020.02055
   Web of Science ®Google Scholar
• Whittaker E, Bamford A, Kenny J, et al. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA. 2020;324(3):259. doi:10.1001/jama.2020.10369
   PubMed Web of Science ®Google Scholar
• Rabinowicz S, Leshem E, Pessach IM. COVID-19 in the pediatric population—review and current evidence. Curr Infect Dis Rep. 2020;22(11):29. doi:10.1007/s11908-020-00739-6
   Web of Science ®Google Scholar
• Toubiana J, Poirault C, Corsia A, et al. Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. BMJ. 2020;m2094. doi:10.1136/bmj.m2094
   Web of Science ®Google Scholar
• Algarni AS, Alamri NM, Khayat NZ, Alabdali RA, Alsubhi RS, Alghamdi SH. Clinical practice guidelines in multisystem inflammatory syndrome (MIS-C) related to COVID-19: a critical review and recommendations. World J Pediatr. 2022;18(2):83–90. doi:10.1007/s12519-021-00499-w
   Web of Science ®Google Scholar
• Provan D, Arnold DM, Bussel JB, et al. Updated international consensus report on the investigation and management of primary immune thrombocytopenia. Blood Adv. 2019;3(22):3780–3817. doi:10.1182/bloodadvances.2019000812
   PubMed Web of Science ®Google Scholar
• Song F, Al-Samkari H. Management of adult patients with Immune Thrombocytopenia (ITP): a review on current guidance and experience from clinical practice. JBM. 2021;12:653–664. doi:10.2147/JBM.S259101
   Web of Science ®Google Scholar
• Slichter SJ, Dumont LJ, Cancelas JA, et al. Safety and efficacy of cryopreserved platelets in bleeding patients with thrombocytopenia. Transfusion. 2018;58(9):2129–2138. doi:10.1111/trf.14780
   PubMed Web of Science ®Google Scholar
• Rodeghiero F, Stasi R, Gernsheimer T, et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood. 2009;113(11):2386–2393. doi:10.1182/blood-2008-07-162503
   PubMed Web of Science ®Google Scholar