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ORIGINAL RESEARCH

Multi-Drug Resistance Profile, Prevalence of Extended-Spectrum Beta-Lactamase and Carbapenemase-Producing Gram Negative Bacilli Among Admitted Patients After Surgery with Suspected of Surgical Site Nosocomial Infection North East Ethiopia

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Pages 3949-3965 | Published online: 26 Jul 2022

References

  • Morris S, Cerceo E. Trends, epidemiology, and management of multi-drug resistant gram-negative bacterial infections in the hospitalized setting. Antibiotics. 2020;9(4):196. doi:10.3390/antibiotics9040196
  • Rawat D, Nair D. Extended-spectrum β-lactamases in gram negative bacteria. J Glob Infect Dis. 2010;2(3):263. doi:10.4103/0974-777X.68531
  • Cantón R. Co qu e TM. The CTX-M Be Ta-Lac Tama Se Pan de Mic. Curr Opin Mic Ro Bi Ol. 2006;9(5):466–475.
  • Wilmore SS, Kranzer K, Williams A, et al. Carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae in HIV-infected children in Zimbabwe. J Med Microbiol. 2017;66(5):609–615. doi:10.1099/jmm.0.000474
  • Nature E. The antibiotic alarm. Nature. 2013;495(7440):141.
  • Brooks PT, Mansfield LS. Effects of antibiotic resistance (AR) and microbiota shifts on Campylobacter jejuni-mediated diseases. Anim Health Res Rev. 2017;18(2):99–111. doi:10.1017/S1466252318000014
  • Control CfD, Prevention. Antibiotic Resistance Threats in the United States, 2013. Atlanta, GA: CDC; 2013.
  • Sangare SA, Rondinaud E, Maataoui N, et al. Very high prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in bacteriemic patients hospitalized in teaching hospitals in Bamako, Mali. PLoS One. 2017;12(2):e0172652. doi:10.1371/journal.pone.0172652
  • Nordmann P, Naas T, Poirel L. Global spread of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis. 2011;17(10):1791. doi:10.3201/eid1710.110655
  • Codjoe FS, Donkor ES. Carbapenem resistance: a review. Med Sci. 2018;6(1):1. doi:10.3390/medsci6010001
  • Thomson KS. Extended-spectrum-β-lactamase, AmpC, and carbapenemase issues. J Clin Microbiol. 2010;48(4):1019–1025. doi:10.1128/JCM.00219-10
  • Babu R, Kumar A, Karim S, et al. Faecal carriage rate of extended-spectrum β-lactamase-producing Enterobacteriaceae in hospitalised patients and healthy asymptomatic individuals coming for health check-up. J Glob Antimicrob Resist. 2016;6:150–153. doi:10.1016/j.jgar.2016.05.007
  • Vialle‐Valentin C, Lecates R, Zhang F, Desta A, Ross‐Degnan D. Predictors of antibiotic use in African communities: evidence from medicines household surveys in five countries. Trop Med Int Health. 2012;17(2):211–222. doi:10.1111/j.1365-3156.2011.02895.x
  • Khan M, Khalil J, Zarin M, et al. Rate and risk factors for surgical site infection at a tertiary care facility in Peshawar, Pakistan. J Ayub Med Coll Abbottabad. 2011;23(1):15–18.
  • Cheesbrough M. District Laboratory Practice in Tropical Countries, Part 2. Cambridge university press; 2005.
  • Murray PR, Rosenthal KS, Pfaller MA. Medical microbiology E-book. Elsevier Health Sciences; 2020.
  • Weinstein MP, Lewis JS. The clinical and laboratory standards institute subcommittee on antimicrobial susceptibility testing: background, organization, functions, and processes. J Clin Microbiol. 2020;58(3):e01864–e01919. doi:10.1128/JCM.01864-19
  • Magiorakos A-P, Srinivasan A, Carey R, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18(3):268–281. doi:10.1111/j.1469-0691.2011.03570.x
  • Lashoher A, Schneider EB, Juillard C, et al. Implementation of the World Health Organization Trauma Care Checklist Program in 11 centers across multiple economic strata: effect on care process measures. World J Surg. 2017;41(4):954–962. doi:10.1007/s00268-016-3759-8
  • Mama M, Abdissa A, Sewunet T. Antimicrobial susceptibility pattern of bacterial isolates from wound infection and their sensitivity to alternative topical agents at Jimma University Specialized Hospital, South-West Ethiopia. Ann Clin Microbiol Antimicrob. 2014;13(1):1–10. doi:10.1186/1476-0711-13-14
  • Dessie W, Mulugeta G, Fentaw S, Mihret A, Hassen M, Abebe E. Pattern of bacterial pathogens and their susceptibility isolated from surgical site infections at selected referral hospitals, Addis Ababa, Ethiopia. Int J Microbiol. 2016;2016:1–8. doi:10.1155/2016/2418902
  • Mohammed A, Seid ME, Gebrecherkos T, Tiruneh M, Moges F. Bacterial isolates and their antimicrobial susceptibility patterns of wound infections among inpatients and outpatients attending the University of Gondar Referral Hospital, Northwest Ethiopia. Int J Microbiol. 2017;2017:1–10. doi:10.1155/2017/8953829
  • Roy S, Ahmed MU, Uddin BMM, et al. Evaluation of antibiotic susceptibility in wound infections: a pilot study from Bangladesh. F1000Research. 2017;6:2103. doi:10.12688/f1000research.12887.1
  • Shimekaw M, Tigabu A, Tessema B. Bacterial profile, antimicrobial susceptibility pattern, and associated risk factors among patients with wound infections at Debre Markos Referral Hospital, Northwest, Ethiopia. Int J Low Extrem Wounds. 2020;21:1534734620933731.
  • Rijal BP, Satyal D, Parajuli NP. High burden of antimicrobial resistance among Bacteria causing pyogenic wound infections at a tertiary Care Hospital in Kathmandu, Nepal. J Pathog. 2017;2017:1–7. doi:10.1155/2017/9458218
  • Shabnum M. Microbial profile and antibiotic susceptibility pattern of orthopedic infections in a tertiary care hospital: a study from South India. Int J Med Sci Public Health. 2017;6(5):838–842.
  • Omoregie AYEEC, Ohiorenuan R II, Onemu S, Onemu S. Microbiology of wound infections and its associated risk factors among patients of a Tertiary hospital in Benin City, Nigeria. J Res Health Sci. 2011;11:109–113.
  • Zuarez-Easton S, Zafran N, Garmi G, Salim R. Postcesarean wound infection: prevalence, impact, prevention, and management challenges. Int J Womens Health. 2017;9:81. doi:10.2147/IJWH.S98876
  • Mitiku M, Ayenew Z, Desta K. Multi-drug resistant, extended spectrum beta-lactamase and carbapenemase producing bacterial isolates among septicemia suspected under five children in Tikur Anbessa specialized Hospital, Addis Ababa Ethiopia: cross-sectional study; 2019.
  • Kano C. Carbapenem-Resistant Enterobacteriaceae (CRE) in Intensive Care Units and surgical wards of hospitals with no history of carbapenem usage in Kano, North West Nigeria. Niger J Microbiol. 2015;27(1):2612–2618.
  • Alebel M, Mekonnen F, Mulu W. Extended-spectrum β-lactamase and carbapenemase producing gram-negative bacilli infections among patients in intensive care units of felegehiwot referral hospital: a prospective cross-sectional study. Infect Drug Resist. 2021;14:391. doi:10.2147/IDR.S292246
  • Beyene D, Bitew A, Fantew S, Mihret A, Evans M. Multidrug-resistant profile and prevalence of extended spectrum β-lactamase and carbapenemase production in fermentative Gram-negative bacilli recovered from patients and specimens referred to National Reference Laboratory, Addis Ababa, Ethiopia. PLoS One. 2019;14(9):e0222911. doi:10.1371/journal.pone.0222911
  • Kołpa M, Wałaszek M, Gniadek A, Wolak Z, Dobroś W. Incidence, microbiological profile and risk factors of healthcare-associated infections in intensive care units: a 10 year observation in a provincial hospital in Southern Poland. Int J Environ Res Public Health. 2018;15(1):112. doi:10.3390/ijerph15010112
  • Gupta R, Malik A, Rizvi M, Ahmed M. Presence of metallo-beta-lactamases (MBL), extended-spectrum beta-lactamase (ESBL) & AmpC positive non-fermenting Gram-negative bacilli among Intensive Care Unit patients with special reference to molecular detection of blaCTX-M & blaAmpC genes. Indian J Med Res. 2016;144(2):271. doi:10.4103/0971-5916.195043
  • Uc-Cachón AH, Gracida-Osorno C, Luna-Chi IG, Jiménez-Guillermo JG, Molina-Salinas GM. High prevalence of antimicrobial resistance among gram-negative isolated bacilli in intensive care units at a tertiary-care hospital in Yucatán Mexico. Medicina. 2019;55(9):588. doi:10.3390/medicina55090588
  • Singh N, Pattnaik D, Neogi DK, Jena J, Mallick B. Prevalence of ESBL in Escherichia coli isolates among ICU patients in a tertiary care hospital. JCDR. 2016;10(9):DC19. doi:10.7860/JCDR/2016/21260.8544
  • Kayastha K, Dhungel B, Karki S, et al. Extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella species in pediatric patients visiting International Friendship Children’s Hospital, Kathmandu, Nepal. Infect Dis. 2020;13:1178633720909798. doi:10.1177/1178633720909798
  • Kovacevic P, Zlojutro B, Kovacevic T, Baric G, Dragic S, Momcicevic D. Microorganisms profile and antibiotics sensitivity patterns in the only medical intensive care unit in Bosnia and Herzegovina. Microbial Drug Resist. 2019;25(8):1176–1181. doi:10.1089/mdr.2018.0458
  • Siddique SG, Bhalchandra MH, Wyawahare AS, Bansal VP, Mishra JK, Naik S. Prevalence of MRSA, ESBL and Carbapenemase producing isolates obtained from endotracheal and tracheal tubes secretions of ICU patient at tertiary care centre. Int J Curr Microbiol App Sci. 2017;6(4):288–299. doi:10.20546/ijcmas.2017.604.032
  • Hamishehkar H, Shadmehr P, Mahmoodpoor A, Mashayekhi SO, Entezari-Maleki T. Antimicrobial susceptibility patterns among bacteria isolated from intensive care units of the largest teaching hospital at the northwest of Iran. Braz J Pharm Sci. 2016;52(3):403–412. doi:10.1590/s1984-82502016000300006
  • Lamichhane B, Thakur C, Jain S. Antibiotic resistance patterns of Gram-negative isolates in a tertiary care hospital of Nepal. Asian J Pharm Clin Res. 2014;7(3):30–33.
  • Ghimire A, Acharya B, Tuladhar R. Extended Spectrum β-Lactamase (ESBL) producing multidrug resistant gram-negative bacteria from various clinical specimens of patients visiting a Tertiary Care Hospital. TUJM. 2017;4:1–8. doi:10.3126/tujm.v4i0.21667
  • Moges F, Eshetie S, Abebe W, et al. High prevalence of extended-spectrum beta-lactamase-producing Gram-negative pathogens from patients attending Felege Hiwot Comprehensive Specialized Hospital, Bahir Dar, Amhara region. PLoS One. 2019;14(4):e0215177. doi:10.1371/journal.pone.0215177
  • Abera B, Kibret M, Mulu W. Extended-Spectrum beta (β)-lactamases and Antibiogram in Enterobacteriaceae from clinical and drinking water Sources from Bahir Dar City, Ethiopia. PLoS One. 2016;11(11):e0166519. doi:10.1371/journal.pone.0166519
  • Lonchel CM, Melin P, Gangoué-Piéboji J, Assoumou M-C, Boreux R, De Mol P. Extended-spectrum β-lactamase-producing Enterobacteriaceae in Cameroonian hospitals. Eur J Clin Microbiol Infect Dis. 2013;32(1):79–87. doi:10.1007/s10096-012-1717-4
  • Vinodhini R, Moorthy K, Palanivel P, et al. Detection and antimicrobial susceptibility pattern of ESBL producing Gram negative bacteria. Asian J Pharm Clin Res. 2014;7(1):243–247.
  • Oberoi L, Singh N, Sharma P, Aggarwal A. ESBL, MBL and Ampc β lactamases producing superbugs–havoc in the intensive care units of Punjab India. JCDR. 2013;7(1):70. doi:10.7860/JCDR/2012/5016.2673
  • Baron EJ, Miller JM, Weinstein MP, et al. A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2013 recommendations by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM) a. Clin Infect Dis. 2013;57(4):e22–e121. doi:10.1093/cid/cit278
  • Ahmed MAS, Bansal D, Acharya A, et al. Antimicrobial susceptibility and molecular epidemiology of extended-spectrum beta-lactamase-producing Enterobacteriaceae from intensive care units at Hamad Medical Corporation, Qatar. Antimicrob Resist Infect Control. 2016;5(1):1–6. doi:10.1186/s13756-015-0100-5
  • Saeed NK, Kambal AM, El-Khizzi NA. Antimicrobial-resistant bacteria in a general intensive care unit in Saudi Arabia. Saudi Med J. 2010;31(12):1341–1349.
  • Nedjai S, Barguigua A, Djahmi N, et al. Prevalence and characterization of extended spectrum beta-lactamase-producing Enterobacter cloacae strains in Algeria. J Infect Dev Ctries. 2013;7(11):804–811. doi:10.3855/jidc.3127
  • Marie MA, John J, Krishnappa LG, Gopalkrishnan S. Molecular characterization of the β‐lactamases in Escherichia coli and Klebsiella pneumoniae from a tertiary care hospital in Riyadh, Saudi Arabia. Microbiol Immunol. 2013;57(12):805–810. doi:10.1111/1348-0421.12104
  • Habeeb MA, Sarwar Y, Ali A, Salman M, Haque A. Rapid emergence of ESBL producers in E. coli causing urinary and wound infections in Pakistan. Pak J Med Sci. 2013;29(2):540. doi:10.12669/pjms.292.3144
  • Olowo-Okere A, Ibrahim YKE, Olayinka BO. Molecular characterisation of extended-spectrum β-lactamase-producing Gram-negative bacterial isolates from surgical wounds of patients at a hospital in North Central Nigeria. J Glob Antimicrob Resist. 2018;14:85–89. doi:10.1016/j.jgar.2018.02.002
  • Katip W, Yoodee J, Uitrakul S, Oberdorfer P. Efficacy of loading dose colistin versus carbapenems for treatment of extended spectrum beta lactamase producing Enterobacteriaceae. Sci Rep. 2021;11(1):1–8. doi:10.1038/s41598-020-78098-4
  • Andrew B, Kagirita A, Bazira J. Prevalence of extended-spectrum beta-lactamases-producing microorganisms in patients admitted at KRRH, Southwestern Uganda. Int J Microbiol. 2017;2017:1–5. doi:10.1155/2017/3183076
  • Ibrahim ME, Bilal NE, Magzoub MA, Hamid ME. Prevalence of extended-spectrum β-lactamases-producing Escherichia coli from Hospitals in Khartoum State, Sudan. Oman Med J. 2013;28(2):116. doi:10.5001/omj.2013.30
  • Saharman YR, Lestari DC. Phenotype characterization of Beta-lactamase producing Enterobacteriaceae in the intensive care unit (ICU) of Cipto Mangunkusumo hospital in 2011. Acta Medica Indonesiana. 2016;45:1.
  • Hecini-Hannachi A, Bentchouala C, Lezzar A, Laouar H, Benlabed K, Smati F. Multidrug-resistant bacteria isolated from patients hospitalized in Intensive Care Unit in University Hospital of Constantine, Algeria (2011–2015). Afr J Microbiol Res. 2016;10(33):1328–1336. doi:10.5897/AJMR2016.8257
  • Qaddumi JA, Nazzal Z, Yacoup AR, Mansour M. Quality of death notification forms in North West Bank/Palestine: a descriptive study. BMC Res Notes. 2017;10(1):1–6. doi:10.1186/s13104-017-2469-0
  • Leite CAK, Oizumi KY, Caleffi-Ferracioli KR, et al. β-lactamase-producing Gram-negative bacteria in an intensive care unit in southern Brazil. Braz J Pharm Sci. 2017;22:53.
  • Ibrahim ME, Abbas M, Al-Shahrai AM, Elamin BK. Phenotypic characterization and antibiotic resistance patterns of extended-spectrum β -lactamase- and AmpC β -lactamase-producing gram-negative bacteria in a referral hospital, Saudi Arabia. Can J Infect Dis Med Microbiol. 2019;2019:1–9. doi:10.1155/2019/6054694
  • Manoharan A, Sugumar M, Kumar A, Jose H, Mathai D. Group I-Es. Phenotypic & molecular characterization of AmpC β-lactamases among Escherichia coli, Klebsiella spp. & Enterobacter spp. from five Indian Medical Centers. Indian J Med Res. 2012;135(3):359.
  • Abdalhamid B, Albunayan S, Shaikh A, Elhadi N, Aljindan R. Prevalence study of plasmid-mediated AmpC β-lactamases in Enterobacteriaceae lacking inducible ampC from Saudi hospitals. J Med Microbiol. 2017;66(9):1286–1290. doi:10.1099/jmm.0.000504
  • Chang -Y-Y, Chuang Y-C, Siu LK, et al. Clinical features of patients with carbapenem nonsusceptible Klebsiella pneumoniae and Escherichia coli in intensive care units: a nationwide multicenter study in Taiwan. J Microbiol Immunol Infect. 2015;48(2):219–225. doi:10.1016/j.jmii.2014.05.010
  • Stocchetti N, Carbonara M, Citerio G, et al. Severe traumatic brain injury: targeted management in the intensive care unit. Lancet Neurol. 2017;16(6):452–464. doi:10.1016/S1474-4422(17)30118-7
  • Makharita RR, El-Kholy I, Hetta HF, et al. Antibiogram and genetic characterization of carbapenem-resistant gram-negative pathogens incriminated in healthcare-associated infections. Infect Drug Resist. 2020;13:3991. doi:10.2147/IDR.S276975
  • Ramana K, Rao R, Sharada CV, Kareem M, Reddy LR, Mani MR. Modified Hodge test: a useful and the low-cost phenotypic method for detection of carbapenemase producers in Enterobacteriaceae members. J Nat Sci Biol Med. 2013;4(2):346. doi:10.4103/0976-9668.117009
  • Pollack LA, Srinivasan A. Core elements of hospital antibiotic stewardship programs from the Centers for Disease Control and Prevention. Clin Infect Dis. 2014;59(suppl_3):S97–S100. doi:10.1093/cid/ciu542
  • Mushi MF, Mshana SE, Imirzalioglu C, Bwanga F. Carbapenemase genes among multidrug resistant gram negative clinical isolates from a tertiary hospital in Mwanza, Tanzania. Biomed Res Int. 2014;2014:1–6. doi:10.1155/2014/303104
  • Katip W, Uitrakul S, Oberdorfer P. Clinical efficacy and nephrotoxicity of the loading dose colistin for the treatment of carbapenem-resistant Acinetobacter baumannii in critically ill patients. Pharmaceutics. 2021;14(1):31. doi:10.3390/pharmaceutics14010031
  • Katip W, Oberdorfer P. Clinical efficacy and nephrotoxicity of colistin alone versus colistin plus vancomycin in critically ill patients infected with carbapenem-resistant Acinetobacter baumannii: a propensity score-matched analysis. Pharmaceutics. 2021;13(2):162. doi:10.3390/pharmaceutics13020162
  • Katip W, Oberdorfer P, Kasatpibal N. Effectiveness and nephrotoxicity of loading dose colistin–meropenem versus loading dose colistin–imipenem in the treatment of carbapenem-resistant Acinetobacter baumannii infection. Pharmaceutics. 2022;14(6):1266. doi:10.3390/pharmaceutics14061266
  • Wanla W, Katip W, Supakul S, Apiwatnakorn P, Khamsarn S. Effects of an antimicrobial restriction system on appropriate carbapenem use in a hospital without infectious diseases consultation. Int J Gen Med. 2017;10:443. doi:10.2147/IJGM.S145133