1,892
Views
9
CrossRef citations to date
0
Altmetric
REVIEW

Biofilm-Associated Multi-Drug Resistance in Hospital-Acquired Infections: A Review

ORCID Icon &
Pages 5061-5068 | Published online: 31 Aug 2022

References

  • Hurlow J, Couch K, Laforet K, Bolton L, Metcalf D, Bowler P. Clinical biofilms: a challenging frontier in wound care. Adv Wound Care. 2015;4(5):295–301. doi:10.1089/wound.2014.0567
  • Jamal M, Ahmad W, Andleeb S, et al. Bacterial biofilm and associated infections. J Chin Med Assoc. 2018;81(1):7–11. doi:10.1016/j.jcma.2017.07.012
  • Santos A, Galdino ACM, Mello T, et al. What are the advantages of living in a community? A microbial biofilm perspective! Mem Inst Oswaldo Cruz. 2018;113. doi:10.1590/0074-02760180212
  • Preda VG, Săndulescu O. Communication is the key: biofilms, quorum sensing, formation and prevention. Discoveries. 2019;7(3):e10. doi:10.15190/d.2019.13
  • Elhabibi T, Ramzy S. Biofilm production by multi drug resistant bacterial pathogens isolated from patients in intensive care units in Egyptian hospitals. J Microb Biochem Technol. 2017;9(4):151–158.
  • Del Pozo JL. Biofilm-related disease. Expert Rev Anti Infect Ther. 2018;16(1):51–65. doi:10.1080/14787210.2018.1417036
  • Khan J, Tarar SM, Gul I, Nawaz U, Arshad M. Challenges of antibiotic resistance biofilms and potential combating strategies: a review. 3 Biotech. 2021;11(4):1–15. doi:10.1007/s13205-021-02707-w
  • Piechota M, Kot B, Frankowska-Maciejewska A, Grużewska A, Woźniak-Kosek A. Biofilm formation by methicillin-resistant and methicillin-sensitive staphylococcus aureus strains from hospitalized patients in Poland. Biomed Res Int. 2018;2018:1–7. doi:10.1155/2018/4657396
  • Neopane P, Nepal HP, Shrestha R, Uehara O, Abiko Y. In vitro biofilm formation by Staphylococcus aureus isolated from wounds of hospital-admitted patients and their association with antimicrobial resistance. Int J Gen Med. 2018;11:25. doi:10.2147/IJGM.S153268
  • Weinbren M, Inkster T. The hospital-built environment: biofilm, biodiversity and bias. J Hosp Infect. 2021;111:50–52. doi:10.1016/j.jhin.2021.02.013
  • Bhatta DR, Hamal D, Shrestha R, et al. Bacterial contamination of frequently touched objects in a tertiary care hospital of Pokhara, Nepal: how safe are our hands? Antimicrob Resist Infect Control. 2018;7(1):1–6. doi:10.1186/s13756-018-0385-2
  • Khatoon Z, McTiernan CD, Suuronen EJ, Mah T-F, Alarcon EI. Bacterial biofilm formation on implantable devices and approaches to its treatment and prevention. Heliyon. 2018;4(12):e01067. doi:10.1016/j.heliyon.2018.e01067
  • Srivastava A, Chandra N, Kumar S. The role of biofilms in medical devices and implants. In: Biofilms in Human Diseases: Treatment and Control. Springer; 2019:151–165.
  • Ramstedt M, Burmølle M. Can multi-species biofilms defeat antimicrobial surfaces on medical devices? Curr Opin Biomed Eng. 2022;22:100370. doi:10.1016/j.cobme.2022.100370
  • Baidya S, Sharma S, Mishra SK, Kattel HP, Parajuli K, Sherchand JB. Biofilm formation by pathogens causing ventilator-associated pneumonia at intensive care units in a tertiary care hospital: an armor for refuge. Biomed Res Int. 2021;2021:1–10. doi:10.1155/2021/8817700
  • Heilmann C, Ziebuhr W, Becker K. Are coagulase-negative staphylococci virulent? Clin Microbiol Infect. 2019;25(9):1071–1080. doi:10.1016/j.cmi.2018.11.012
  • Mishra SK, Basukala P, Basukala O, Parajuli K, Pokhrel BM, Rijal BP. Detection of biofilm production and antibiotic resistance pattern in clinical isolates from indwelling medical devices. Curr Microbiol. 2015;70(1):128–134. doi:10.1007/s00284-014-0694-5
  • Johani K, Abualsaud D, Costa DM, et al. Characterization of microbial community composition, antimicrobial resistance and biofilm on intensive care surfaces. J Infect Public Health. 2018;11(3):418–424. doi:10.1016/j.jiph.2017.10.005
  • Gunardi WD, Karuniawati A, Umbas R, et al. Biofilm-producing bacteria and risk factors (Gender and Duration of Catheterization) characterized as catheter-associated biofilm formation. Int J Microbiol. 2021;2021:1–10. doi:10.1155/2021/8869275
  • Almalki MA, Varghese R. Prevalence of catheter associated biofilm producing bacteria and their antibiotic sensitivity pattern. J King Saud Univ-Sci. 2020;32(2):1427–1433. doi:10.1016/j.jksus.2019.11.037
  • Ledwoch K, Dancer S, Otter J, et al. Beware biofilm! Dry biofilms containing bacterial pathogens on multiple healthcare surfaces; a multi-centre study. J Hosp Infect. 2018;100(3):e47–e56. doi:10.1016/j.jhin.2018.06.028
  • Socohou A, Sina H, Degbey C, et al. Antibiotics resistance and biofilm formation capacity of Staphylococcus spp. strains isolated from surfaces and medicotechnical materials. Int J Microbiol. 2020;2020:1–6. doi:10.1155/2020/6512106
  • Ababneh Q, Abulaila S, Jaradat Z. Isolation of extensively drug resistant Acinetobacter baumannii from environmental surfaces inside intensive care units. Am J Infect Control. 2022;50(2):159–165. doi:10.1016/j.ajic.2021.09.001
  • Khan NA, Khan AH, Ahmed S, et al. Efficient removal of ibuprofen and ofloxacin pharmaceuticals using biofilm reactors for hospital wastewater treatment. Chemosphere. 2022;298:134243. doi:10.1016/j.chemosphere.2022.134243
  • Emami S, Nikokar I, Ghasemi Y, et al. Antibiotic resistance pattern and distribution of pslA gene among biofilm producing Pseudomonas aeruginosa isolated from waste water of a burn center. Jundishapur J Microbiol. 2015;8(11). doi:10.5812/jjm.23669
  • Ory J, Bricheux G, Robin F, Togola A, Forestier C, Traore O. Biofilms in hospital effluents as a potential crossroads for carbapenemase-encoding strains. Sci Total Environ. 2019;657:7–15. doi:10.1016/j.scitotenv.2018.11.427
  • Adetunji V, Odetokun IA. Assessment of biofilm in E. coli O157: H7 and Salmonella strains: influence of cultural conditions. Am J Food Technol. 2012;7:582–595. doi:10.3923/ajft.2012.582.595
  • Dastjerdi EV, Abdolazimi Z, Ghazanfarian M, Amdjadi P, Kamalinejad M, Mahboubi A. Effect of Punica granatum L. flower water extract on five common oral bacteria and bacterial biofilm formation on orthodontic wire. Iran J Public Health. 2014;43(12):1688.
  • Bodelón G, Montes-García V, López-Puente V, et al. Detection and imaging of quorum sensing in Pseudomonas aeruginosa biofilm communities by surface-enhanced resonance Raman scattering. Nat Mater. 2016;15(11):1203–1211. doi:10.1038/nmat4720
  • Allec N, Choi M, Yesupriya N, et al. Small-angle X-ray scattering method to characterize molecular interactions: proof of concept. Sci Rep. 2015;5(1):1–12. doi:10.1038/srep12085
  • Wilson C, Lukowicz R, Merchant S, et al. Quantitative and qualitative assessment methods for biofilm growth: a mini-review. Res Rev J Eng Technol. 2017;6(4):54.
  • Kaiser TDL, Pereira EM, Dos Santos KRN, Maciel ELN, Schuenck RP, Nunes APF. Modification of the Congo red agar method to detect biofilm production by Staphylococcus epidermidis. Diagn Microbiol Infect Dis. 2013;75(3):235–239.
  • Hassan A, Usman J, Kaleem F, Omair M, Khalid A, Iqbal M. Evaluation of different detection methods of biofilm formation in the clinical isolates. Braz J Infect Dis. 2011;15:305–311. doi:10.1016/S1413-8670(11)70197-0
  • Elkhatib WF, Khairalla AS, Ashour HM. Evaluation of different microtiter plate-based methods for the quantitative assessment of Staphylococcus aureus biofilms. Future Microbiol. 2014;9(6):725–735. doi:10.2217/fmb.14.33
  • Kırmusaoğlu S. The methods for detection of biofilm and screening antibiofilm activity of agents. Antimicrob, Antibiotic Resist, Antibiofilm Strat Act Methods. 2019;21:1–17.
  • Priyadharsini JV, Ganesh PS, Girija A, Joshua AA. Distribution of Biofilm-associated Genes among Acinetobacter baumannii by in-silico PCR. J Pharm Res Int. 2021;45:140–149.
  • Ashwath P, Deekshit VK, Rohit A, et al. Biofilm formation and associated gene expression in multidrug-resistant Klebsiella pneumoniae isolated from clinical specimens. Curr Microbiol. 2022;79(3):1–10. doi:10.1007/s00284-022-02766-z
  • Mahmoudi H, Pourhajibagher M, Alikhani MY, Bahador A. The effect of antimicrobial photodynamic therapy on the expression of biofilm associated genes in Staphylococcus aureus strains isolated from wound infections in burn patients. Photodiagnosis Photodyn Ther. 2019;25:406–413. doi:10.1016/j.pdpdt.2019.01.028
  • Rao H, Choo S, Rajeswari Mahalingam SR, et al. Approaches for mitigating microbial biofilm-related drug resistance: a focus on micro-and nanotechnologies. Molecules. 2021;26(7):1870. doi:10.3390/molecules26071870
  • Uruén C, Chopo-Escuin G, Tommassen J, Mainar-Jaime RC, Arenas J. Biofilms as promoters of bacterial antibiotic resistance and tolerance. Antibiotics. 2020;10(1):3. doi:10.3390/antibiotics10010003
  • Dincer S, Uslu FM, Delik A. Antibiotic resistance in biofilm. In: Bacterial Biofilms. IntechOpen; 2020.
  • Carvalho FM, Teixeira-Santos R, Mergulhão FJ, Gomes LC. Targeting biofilms in medical devices using probiotic cells: a systematic review. AIMS Mater Sci. 2021;8(4):501–523. doi:10.3934/matersci.2021031
  • Azeredo J, García P, Drulis-Kawa Z. Targeting biofilms using phages and their enzymes. Curr Opin Biotechnol. 2021;68:251–261. doi:10.1016/j.copbio.2021.02.002
  • Santiago AJ, Burgos-Garay ML, Kartforosh L, Mazher M, Donlan RM. Bacteriophage treatment of carbapenemase-producing Klebsiella pneumoniae in a multispecies biofilm: a potential biocontrol strategy for healthcare facilities. AIMS Microbiol. 2020;6(1):43. doi:10.3934/microbiol.2020003
  • Rakov C, Ben Porat S, Alkalay-Oren S, et al. Targeting biofilm of MDR Providencia stuartii by phages using a catheter model. Antibiotics. 2021;10(4):375. doi:10.3390/antibiotics10040375
  • Bassetti M, Righi E, Vena A, Graziano E, Russo A, Peghin M. Risk stratification and treatment of ICU-acquired pneumonia caused by multidrug-resistant/extensively drug-resistant/pandrug-resistant bacteria. Curr Opin Crit Care. 2018;24(5):385–393. doi:10.1097/MCC.0000000000000534
  • Coraça-Huber DC, Dichtl S, Steixner S, Nogler M, Weiss G. Iron chelation destabilizes bacterial biofilms and potentiates the antimicrobial activity of antibiotics against coagulase-negative Staphylococci. Pathog Dis. 2018;76(5):fty052. doi:10.1093/femspd/fty052
  • Mettrick K, Hassan K, Lamont I, Reid D. The iron-chelator, N, N’-bis (2-hydroxybenzyl) ethylenediamine-N, N’-diacetic acid is an effective colistin adjunct against clinical strains of biofilm-dwelling Pseudomonas aeruginosa. Antibiotics. 2020;9(4):144. doi:10.3390/antibiotics9040144
  • Qiao J, Purro M, Liu Z, Xiong MP. Terpyridine–micelles for inhibiting bacterial biofilm development. ACS Infect Dis. 2018;4(9):1346–1354. doi:10.1021/acsinfecdis.8b00091
  • Mittal S, Sharma M, Chaudhary U. Biofilm and multidrug resistance in uropathogenic Escherichia coli. Pathog Glob Health. 2015;109(1):26–29. doi:10.1179/2047773215Y.0000000001
  • Qi L, Li H, Zhang C, et al. Relationship between antibiotic resistance, biofilm formation, and biofilm-specific resistance in Acinetobacter baumannii. Front Microbiol. 2016;7:483. doi:10.3389/fmicb.2016.00483
  • Ghasemian A, Najar Peerayeh S, Bakhshi B, Mirzaee M. Several virulence factors of multidrug-resistant Staphylococcus aureus isolates from hospitalized patients in Tehran. Int J Enteric Pathog. 2015;3(2):1–6. doi:10.17795/ijep25196
  • Thummeepak R, Kongthai P, Leungtongkam U, Sitthisak S. Distribution of virulence genes involved in biofilm formation in multi-drug resistant Acinetobacter baumannii clinical isolates. Int Microbiol. 2016;19(2):121–129. doi:10.2436/20.1501.01.270
  • Belbase A, Pant ND, Nepal K, et al. Antibiotic resistance and biofilm production among the strains of Staphylococcus aureus isolated from pus/wound swab samples in a tertiary care hospital in Nepal. Ann Clin Microbiol Antimicrob. 2017;16(1):1–5. doi:10.1186/s12941-016-0177-6
  • Shadkam S, Goli HR, Mirzaei B, Gholami M, Ahanjan M. Correlation between antimicrobial resistance and biofilm formation capability among Klebsiella pneumoniae strains isolated from hospitalized patients in Iran. Ann Clin Microbiol Antimicrob. 2021;20(1):1–7. doi:10.1186/s12941-021-00418-x
  • Kamali E, Jamali A, Ardebili A, Ezadi F, Mohebbi A. Evaluation of antimicrobial resistance, biofilm forming potential, and the presence of biofilm-related genes among clinical isolates of Pseudomonas aeruginosa. BMC Res Notes. 2020;13(1):1–6. doi:10.1186/s13104-020-4890-z
  • Nirwati H, Sinanjung K, Fahrunissa F, et al. Biofilm formation and antibiotic resistance of Klebsiella pneumoniae isolated from clinical samples in a tertiary care hospital, Klaten, Indonesia. BMC Proc. 2019;13(11):1–8. doi:10.1186/s12919-019-0176-7
  • Namuq AO, Ali KOM, Al-Ani AH. Correlation between biofilm formation, multi-drug resistance and AlgD gene among Pseudomonas aeruginosa clinical isolates. J Univ Babylon Pure Appl Sci. 2019;27(3):143–150.
  • Katongole P, Nalubega F, Florence NC, Asiimwe B, Andia I. Biofilm formation, antimicrobial susceptibility and virulence genes of Uropathogenic Escherichia coli isolated from clinical isolates in Uganda. BMC Infect Dis. 2020;20(1):1–6. doi:10.1186/s12879-020-05186-1
  • Abdulhaq N, Nawaz Z, Zahoor MA, Siddique AB. Association of biofilm formation with multi drug resistance in clinical isolates of Pseudomonas aeruginosa. EXCLI j. 2020;19:201. doi:10.17179/excli2019-2049
  • Asaad AM, Ansari S, Ajlan SE, Awad SM. Epidemiology of biofilm producing Acinetobacter baumannii nosocomial isolates from a tertiary care hospital in Egypt: a cross-sectional study. Infect Drug Resist. 2021;14:709. doi:10.2147/IDR.S261939
  • Rafiq MU, Ansari F, Tariq M, Azhar A, Arshad F, Nayab A. Evaluation of multi-drug resistance in biofilm forming Klebsiella pneumoniae isolated from urinary catheter tips in patients from ICU and CCU in DHQ teaching hospital Gujranwala. Pak J Med Health Sci. 2020;14(4):1975–1979.