Carbapenem-Resistant Gram-Negative Bacilli Causing Ventilator Associated Pneumonia: Study of MASTDISCS Combi Carba Plus for Detection of Carbapenemase Producing Enterobacterales

References

• Rosenthal VD, Al-Abdely HM, El-Kholy AA, et al. International nosocomial infection control consortium report, data summary of 50 countries for 2010–2015: device-associated module. Am J Infect Control. 2016;44(12):1495–1504. doi:10.1016/j.ajic.2016.08.007
   PubMed Web of Science ®Google Scholar
• Kalanuria AA, Mirski M, Ziai W. Ventilator-associated pneumonia in the ICU. In: Annual Update in Intensive Care and Emergency Medicine; Vol. 2014, 2014: 65–77.
   Google Scholar
• Koenig SM, Truwit JD. Ventilator-associated pneumonia: diagnosis, treatment, and prevention. Clin Microbiol Rev. 2006;19(4):637–657. doi:10.1128/CMR.00051-05
   PubMed Web of Science ®Google Scholar
• Abdeta A, Bitew A, Fentaw S, et al. Phenotypic characterization of carbapenem non-susceptible gram-negative bacilli isolated from clinical specimens. PLoS One. 2021;16(12):e0256556. doi:10.1371/journal.pone.0256556
   Web of Science ®Google Scholar
• Yan WJ, Jing N, Wang SM, et al. Molecular characterization of carbapenem-resistant Enterobacteriaceae and emergence of tigecycline non-susceptible strains in the Henan province in China: a multicentrer study. J Med Microbiol. 2021;70(3). doi:10.1099/jmm.0.001325.
   Web of Science ®Google Scholar
• Shaker OA, Gomaa HE, ElMasry SA, Halim RM, Abdelrahman AH, Kamal JS. Evaluation of combined use of temocillin disk and mastdisks inhibitor combination set against polymerase chain reaction for detection of carbapenem-resistant Enterobacteriaceae. Open Access Maced J Med Sci. 2018;6(2):242. doi:10.3889/oamjms.2018.090
   Google Scholar
• Paskeh MD, Moghaddam MJ, Salehi Z. Prevalence of plasmid-encoded carbapenemases in multi-drug resistant Escherichia coli from patients with urinary tract infection in northern Iran. Iran J Basic Med Sci. 2020;23(5):586. doi:10.22038/ijbms.2020.34563.8199
   Web of Science ®Google Scholar
• Sheikh AF, Shahin M, Shokoohizadeh L, Ghanbari F, Solgi H, Shahcheraghi F. Emerge of NDM-1-producing multidrug-resistant Pseudomonas aeruginosa and co-harboring of carbapenemase genes in South of Iran. Iran J Public Health. 2020;49(5):959.
   Web of Science ®Google Scholar
• Han R, Shi Q, Wu S, et al. Dissemination of carbapenemases (KPC, NDM, OXA-48, IMP, and VIM) among carbapenem-resistant Enterobacteriaceae isolated from adult and children patients in China. Front Cell Infect Microbiol. 2020;10:314. doi:10.3389/fcimb.2020.00314
   PubMed Web of Science ®Google Scholar
• Algammal AM, El-Sayed ME, Youssef FM, et al. Prevalence, the antibiogram and the frequency of virulence genes of the most predominant bacterial pathogens incriminated in calf pneumonia. AMB Express. 2020;10(1):1–8. doi:10.1186/s13568-020-01037-z
   Web of Science ®Google Scholar
• Hu W, Li M, Lu W, Guo S, Li J. Evaluation of MASTDISCS combi Carba plus for the identification of metallo‐β‐lactamases, KPC and OXA‐48 carbapenemase genes in Enterobacteriaceae clinical isolates. Lett Appl Microbiol. 2020;70(1):42–47. doi:10.1111/lam.13240
   Web of Science ®Google Scholar
• Ohsaki Y, Kubo R, Hobson J, et al. MASTDISCS combi Carba plus, a simple method for discriminating carbapenemase‐producing Enterobacteriaceae, including OXA‐48‐type producers. Microbiol Immunol. 2018;62(1):60–65. doi:10.1111/1348-0421.12553
   PubMed Web of Science ®Google Scholar
• Elkolaly RM, Bahr HM, El-Shafey BI, Basuoni AS, Elber EH. Incidence of ventilator-associated pneumonia: Egyptian study. Egypt J Bronchol. 2019;13(2):258–266. doi:10.4103/ejb.ejb_43_18
   Google Scholar
• Daniel W. Biostatistics: A Foundation for Analysis in the Health Sciences. 7th ed. New York: Wiley; 1999:141–142.
   Google Scholar
• Forbes BA, Sahm DF, Weissfeld AS. Study Guide for Bailey and Scott’s Diagnostic Microbiology-E-Book. Elsevier Health Sciences; 2016.
   Google Scholar
• Clinical and Laboratory Standards Institute [CLSI]. Performance Standards for Antimicrobial Susceptibility Testing; Supplement M100. 31th ed. 2021.
   Google Scholar
• Michodigni NF, Nyacheo A, Akhwale JK, Magoma G, Kimang’a AN. Molecular Identification of Co-existence of Carbapenemase and extended-spectrum β-lactamase genes in Klebsiella pneumoniae clinical isolates, and their phylogenetic patterns in Kenya. Adv Microbiol. 2021;11(8):399–415. doi:10.4236/aim.2021.118030
   Google Scholar
• Farag AM, Tawfick MM, Abozeed MY, Shaban EA, Abo-Shadi MA. Microbiological profile of ventilator-associated pneumonia among intensive care unit patients in tertiary Egyptian hospitals. J Infect Dev Countries. 2020;14(02):153–161. doi:10.3855/jidc.12012
   Web of Science ®Google Scholar
• Nordmann P, Poirel L. Epidemiology and diagnostics of carbapenem resistance in gram-negative bacteria. Clin Infect Dis. 2019;69(Supplement_7):S521–8. doi:10.1093/cid/ciz824
   PubMed Web of Science ®Google Scholar
• Djordjevic ZM, Folic MM, Jankovic SM. Distribution and antibiotic susceptibility of pathogens isolated from adults with hospital-acquired and ventilator-associated pneumonia in intensive care unit. J Infect Public Health. 2017;10(6):740–744. doi:10.1016/j.jiph.2016.11.016
   Web of Science ®Google Scholar
• Rana G, Sharma S, Hans C. Ventilator-associated pneumonia in the ICU: microbiological Profile. J Bacteriol Mycol. 2017;4:165–168.
   Google Scholar
• Khairy RM, Mahmoud MS, Shady RR, Esmail MA. Multidrug‐resistant Klebsiella pneumoniae in hospital‐acquired infections: concomitant analysis of antimicrobial resistant strains. Int J Clin Pract. 2020;74(4). doi:10.1111/ijcp.13463
   Web of Science ®Google Scholar
• Gao B, Li X, Yang F, et al. Molecular epidemiology and risk factors of ventilator-associated pneumonia infection caused by carbapenem-resistant Enterobacteriaceae. Front Pharmacol. 2019;10:262. doi:10.3389/fphar.2019.00262
   PubMed Web of Science ®Google Scholar
• Michetti CP, Prentice HA, Rodriguez J, Newcomb A. Supine position and nonmodifiable risk factors for ventilator-associated pneumonia in trauma patients. Am J Surg. 2017;213(2):405–412.
   Web of Science ®Google Scholar
• Arumugam SK, Mudali I, Strandvik G, El-Menyar A, Al-Hassani A, Al-Thani H. Risk factors for ventilator-associated pneumonia in trauma patients: a descriptive analysis. World J Emerg Med. 2018;9(3):203. doi:10.5847/wjem.j.1920-8642.2018.03.007
   PubMed Web of Science ®Google Scholar
• Younan D, Lin E, Griffin R, et al. Early trauma-induced coagulopathy is associated with increased ventilator-associated pneumonia in spinal cord injury patients. Shock. 2016;45(5):502–505.
   PubMed Web of Science ®Google Scholar
• Chang L, Dong Y, Zhou P. Investigation on risk factors of ventilator-associated pneumonia in acute cerebral hemorrhage patients in intensive care unit. Can Respir J. 2017;2017:1–4. doi:10.1155/2017/7272080
   Web of Science ®Google Scholar
• Jiménez-Trujillo I, Jiménez-García R, de Miguel-Díez J, et al. Incidence, characteristic and outcomes of ventilator-associated pneumonia among type 2 diabetes patients: an observational population-based study in Spain. Eur J Intern Med. 2017;40:72–78. doi:10.1016/j.ejim.2017.01.019
   Web of Science ®Google Scholar
• Liu Y, Di Y, Fu S. Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgery for head and neck cancer. Front Med. 2017;11(2):239–246. doi:10.1007/s11684-017-0509-8
   PubMed Web of Science ®Google Scholar
• Kalil AC, Metersky ML, Klompas M, et al. Executive summary: management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016;63(5):575–582. doi:10.1093/cid/ciw504
   PubMed Web of Science ®Google Scholar
• Chouhdari A, Shokouhi S, Bashar FR, et al. Is a low incidence rate of ventilation associated pneumonia associated with lower mortality? A descriptive longitudinal study in Iran. Tanaffos. 2018;17(2):110.
   Google Scholar
• Melsen WG, Rovers MM, Koeman M, Bonten MJ. Estimating the attributable mortality of ventilator-associated pneumonia from randomized prevention studies. Crit Care Med. 2011;39(12):2736–2742. doi:10.1097/CCM.0b013e3182281f33
   Web of Science ®Google Scholar
• Melsen WG, Rovers MM, Groenwold RH, et al. Attributable mortality of ventilator-associated pneumonia: a meta-analysis of individual patient data from randomised prevention studies. Lancet Infect Dis. 2013;13(8):665–671. doi:10.1016/S1473-3099(13)70081-1
   PubMed Web of Science ®Google Scholar
• Mohamed A, Daef E, Nafie A, Shaban L, Ibrahim M. Characteristics of Carbapenem-resistant gram-negative bacilli in patients with ventilator-associated pneumonia. Antibiotics. 2021;10(11):1325. doi:10.3390/antibiotics10111325
   Web of Science ®Google Scholar
• Gajdács M, Ábrók M, Lázár A, et al. Detection of VIM, NDM and OXA-48 producing carbapenem resistant Enterobacterales among clinical isolates in Southern Hungary. Acta Microbiol Immunol Hung. 2020;67(4):209–215. doi:10.1556/030.2020.01181
   Web of Science ®Google Scholar
• Gupta R, Malik A, Rizvi M, Ahmed M, Singh A. Epidemiology of multidrug-resistant Gram-negative pathogens isolated from ventilator-associated pneumonia in ICU patients. J Glob Antimicrob Resist. 2017;9:47–50. doi:10.1016/j.jgar.2016.12.016
   PubMed Web of Science ®Google Scholar
• Rezai MS, Ahangarkani F, Rafiei A, Hajalibeig A, Bagheri-Nesami M. Extended-spectrum beta-lactamases producing Pseudomonas aeruginosa isolated from patients with ventilator associated nosocomial infection. Arch Clin Infect Dis. 2018;13(4). doi:10.5812/archcid.13974
   Web of Science ®Google Scholar
• Chen CY, Yang KY, Peng CK, et al. Clinical outcome of nosocomial pneumonia caused by Carbapenem-resistant gram-negative bacteria in critically ill patients: a multicenter retrospective observational study. Sci Rep. 2022;12(1):1. doi:10.1038/s41598-021-99269-x
   Web of Science ®Google Scholar
• Kumari M, Verma S, Venkatesh V, et al. Emergence of blaNDM-1 and blaVIM producing Gram-negative bacilli in ventilator-associated pneumonia at AMR Surveillance Regional Reference Laboratory in India. PLoS One. 2021;16(9):e0256308. doi:10.1371/journal.pone.0256308
   Web of Science ®Google Scholar
• Sadigov A, Mamedova I, Mammmadov K. Ventilator-associated pneumonia and in-hospital mortality: which risk factors may predict in-hospital mortality in such patients? J Lung Health Dis. 2019;3(4):8–12. doi:10.29245/2689-999X/2019/4.1157
   Google Scholar
• Tsai YM, Wang S, Chiu HC, Kao CY, Wen LL. Combination of modified carbapenem inactivation method (mCIM) and EDTA-CIM (eCIM) for phenotypic detection of carbapenemase-producing Enterobacteriaceae. BMC Microbiol. 2020;20(1):1–7. doi:10.1186/s12866-020-02010-3
   Web of Science ®Google Scholar
• Hussein NH, Hussein AL-Kakei SN, Taha BM. The predominance of Klebsiella pneumoniae carbapenemase (KPC-type) gene among high-level carbapenem-resistant Klebsiella pneumoniae isolates in Baghdad, Iraq. Mol Biol Rep. 2022;26:1–6.
   Google Scholar
• Lopes E, Saavedra MJ, Costa E, de Lencastre H, Poirel L, Aires-de-Sousa M. Epidemiology of carbapenemase-producing Klebsiella pneumoniae in northern Portugal: predominance of KPC-2 and OXA-48. J Glob Antimicrob Resist. 2020;22:349–353. doi:10.1016/j.jgar.2020.04.007
   Web of Science ®Google Scholar
• Raheel A, Azab H, Hessam W, Abbadi S, Ezzat A. Detection of carbapenemase enzymes and genes among carbapenem-resistant Enterobacteriaceae isolates in Suez Canal University Hospitals in Ismailia, Egypt. Microbes Infect Dis. 2020;1(1):24–33. doi:10.21608/mid.2020.25702.1007
   Google Scholar
• Memish ZA, Assiri A, Almasri M, et al. Molecular characterization of carbapenemase production among gram-negative bacteria in Saudi Arabia. Microb Drug Resist. 2015;21(3):307–314. doi:10.1089/mdr.2014.0121
   PubMed Web of Science ®Google Scholar
• Vamsi SK, Moorthy RS, Hemiliamma MN, Shravani S. Phenotypic and genotypic detection of carbapenemase production among gram negative bacteria isolated from hospital acquired infections. Saudi Med J. 2022;43(3):236–243. doi:10.15537/smj.2022.43.3.20210809
   PubMed Web of Science ®Google Scholar
• Naim H, Rizvi M, Gupta R, et al. Drug resistance and molecular epidemiology of carbapenem resistant gram-negative bacilli isolates. J Glob Infect Dis. 2018;10(3):133. doi:10.4103/jgid.jgid_74_17
   Web of Science ®Google Scholar
• Al-Ouqaili MT. Identification of an OprD and blaIMP gene-mediated carbapenem resistance in Acinetobacter baumannii and Pseudomonas aeruginosa among patients with wound infections in Iraq. Asian J Pharmaceut. 2018;12:03.
   Web of Science ®Google Scholar
• Ain NU, Iftikhar A, Bukhari SS, et al. High frequency and molecular epidemiology of metallo-β-lactamase-producing gram-negative bacilli in a tertiary care hospital in Lahore, Pakistan. Antimicrob Resist Infect Control. 2018;7(1):1–9. doi:10.1186/s13756-018-0417-y
   Web of Science ®Google Scholar
• Sadeghi MR, Ghotaslou R, Akhi MT, Asgharzadeh M, Hasani A. Molecular characterization of extended-spectrum β-lactamase, plasmid-mediated AmpC cephalosporinase and carbapenemase genes among Enterobacteriaceae isolates in five medical centres of East and West Azerbaijan, Iran. J Med Microbiol. 2016;65(11):1322–1331. doi:10.1099/jmm.0.000356
   Web of Science ®Google Scholar
• Masseron A, Poirel L, Ali BJ, Syed MA, Nordmann P. Molecular characterization of multidrug-resistance in Gram-negative bacteria from the Peshawar teaching hospital, Pakistan. New Microbes New Infect. 2019;32:100605. doi:10.1016/j.nmni.2019.100605
   Web of Science ®Google Scholar
• Haji SH, Aka ST, Ali FA. Prevalence and characterisation of carbapenemase encoding genes in multidrug-resistant Gram-negative bacilli. PLoS One. 2021;16(11):e0259005. doi:10.1371/journal.pone.0259005
   PubMed Web of Science ®Google Scholar
• Okoche D, Asiimwe BB, Katabazi FA, Kato L, Najjuka CF. Prevalence and characterization of carbapenem-resistant Enterobacteriaceae isolated from Mulago National Referral Hospital, Uganda. PLoS One. 2015;10(8):e0135745. doi:10.1371/journal.pone.0135745
   Web of Science ®Google Scholar
• Solgi H, Badmasti F, Aminzadeh Z, et al. Molecular characterization of intestinal carriage of carbapenem-resistant Enterobacteriaceae among inpatients at two Iranian university hospitals: first report of co-production of bla NDM-7 and bla OXA-48. Eur J Clin Microbiol Infect Dis. 2017;36(11):2127–2135. doi:10.1007/s10096-017-3035-3
   PubMed Web of Science ®Google Scholar
• Di Tella D, Tamburro M, Guerrizio G, Fanelli I, Sammarco ML, Ripabelli G. Molecular epidemiological insights into colistin-resistant and carbapenemases-producing clinical Klebsiella pneumoniae isolates. Infect Drug Resist. 2019;12:3783. doi:10.2147/IDR.S226416
   PubMed Web of Science ®Google Scholar
• Zioga A, Miriagou V, Tzelepi E, et al. The ongoing challenge of acquired carbapenemases: a hospital outbreak of Klebsiella pneumoniae simultaneously producing VIM-1 and KPC-2. Int J Antimicrob Agents. 2010;36(2):190–191. doi:10.1016/j.ijantimicag.2010.04.002
   Web of Science ®Google Scholar
• Mathers AJ, Crook D, Vaughan A, et al. Klebsiella quasipneumoniae provides a window into carbapenemase gene transfer, plasmid rearrangements, and patient interactions with the hospital environment. Antimicrob Agents Chemother. 2019;63(6):13–18. doi:10.1128/AAC.02513-18
   Web of Science ®Google Scholar
• Micek ST, Wunderink RG, Kollef MH, et al. An international multicenter retrospective study of Pseudomonas aeruginosa nosocomial pneumonia: impact of multidrug resistance. Crit Care. 2015;19(1):1–8. doi:10.1186/s13054-015-0926-5
   Web of Science ®Google Scholar
• Torres A, Niederman MS, Chastre J, et al. International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia: guidelines for the management of hospital-acquired pneumonia (HAP)/ventilator-associated pneumonia (VAP) of the European Respiratory Society (ERS), European Society of Intensive Care Medicine (ESICM), European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and Asociación Latinoamericana del Tórax (ALAT). Eur Respir J. 2017;50(3):23.
   Google Scholar
• Tuon FF, Graf ME, Merlini A, et al. Risk factors for mortality in patients with ventilator-associated pneumonia caused by carbapenem-resistant Enterobacteriaceae. Brazil J Infect Dis. 2017;21(1):1–6. doi:10.1016/j.bjid.2016.09.008
   Web of Science ®Google Scholar
• Feng DY, Zhou YQ, Zou XL, et al. Factors influencing mortality in hospital-acquired pneumonia caused by Gram-negative bacteria in China. J Infect Public Health. 2019;12(5):630–633. doi:10.1016/j.jiph.2019.02.014
   Web of Science ®Google Scholar