Advanced search
Publication Cover
Infection and Drug Resistance Volume 17, 2024 - Issue
Submit an article Journal homepage
25
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Advancing Precise Syphilis Diagnosis: A Nontreponemal IgM Antibody-Based Model for Latent Syphilis Staging

Jia-Wen Xie1 Center of Clinical Laboratory, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, People’s Republic of China;2 Institute of Infectious Disease, School of Medicine, Xiamen University, Xiamen, People’s Republic of ChinaView further author information
,
Yin-Feng Guo1 Center of Clinical Laboratory, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, People’s Republic of China;2 Institute of Infectious Disease, School of Medicine, Xiamen University, Xiamen, People’s Republic of ChinaView further author information
,
Ya-Wen Zheng1 Center of Clinical Laboratory, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, People’s Republic of China;3 Prenatal Diagnosis Center, Zhangzhou Municipal Hospital Affiliated to Fujian Medical University, Zhangzhou, People’s Republic of ChinaView further author information
,
Mao Wang1 Center of Clinical Laboratory, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, People’s Republic of China;2 Institute of Infectious Disease, School of Medicine, Xiamen University, Xiamen, People’s Republic of ChinaView further author information
,
Qiu-Yan Xu1 Center of Clinical Laboratory, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, People’s Republic of China;2 Institute of Infectious Disease, School of Medicine, Xiamen University, Xiamen, People’s Republic of ChinaView further author information
,
Yu-Yan Chen1 Center of Clinical Laboratory, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, People’s Republic of China;2 Institute of Infectious Disease, School of Medicine, Xiamen University, Xiamen, People’s Republic of ChinaCorrespondence[email protected] [email protected]
View further author information
&
Li-Rong Lin1 Center of Clinical Laboratory, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, People’s Republic of China;2 Institute of Infectious Disease, School of Medicine, Xiamen University, Xiamen, People’s Republic of China;4 Department of Basic Medical Science, Xiamen Medical College, Xiamen, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-4503-9382View further author information
ORCID Icon show all
Pages 2923-2931 | Received 08 Mar 2024, Accepted 02 Jul 2024, Published online: 11 Jul 2024

References

  • Peeling RW, Mabey D, Kamb ML, Chen XS, Radolf JD, Benzaken AS. Syphilis. Nat Rev Dis Primers. 2017;3(1):17073. doi:10.1038/nrdp.2017.73
  • LaFond RE, Lukehart SA. Biological basis for syphilis. Clin Microbiol Rev. 2006;19(1):29–49. doi:10.1128/CMR.19.1.29-49.2006
  • Syphilis - STI Treatment Guidelines; 2022. Available from: https://www.cdc.gov/std/treatment-guidelines/syphilis.htm. Accessed March 6, 2023.
  • Latent Syphilis - STI Treatment Guidelines; 2022. Available from: https://www.cdc.gov/std/treatment-guidelines/latent-syphilis.htm. Accessed March 6, 2023.
  • Brown DL, Frank JE. Diagnosis and management of syphilis. Am Fam Phys. 2003;68(2):283–290.
  • Wu X, Guan Y, Ye J, et al. Association between syphilis seroprevalence and age among blood donors in Southern China: an observational study from 2014 to 2017. BMJ Open. 2019;9(11):e024393. doi:10.1136/bmjopen-2018-024393
  • Tao Y, Chen MY, Tucker JD, et al. A nationwide spatiotemporal analysis of syphilis over 21 years and implications for prevention and control in China. Clinl Infect Dis. 2020;70(1):136–139. doi:10.1093/cid/ciz331
  • Mattei PL, Beachkofsky TM, Gilson RT, Wisco OJ. Syphilis: a reemerging infection. Am Fam Phys. 2012;86(5):433–440.
  • O’Byrne P, MacPherson P. Syphilis. BMJ. 2019;365:l4159. doi:10.1136/bmj.l4159
  • Kersh EN, Workowski KA. Evidence review for centers for disease control and prevention guidance development on laboratory testing to detect Treponema pallidum Infection (Syphilis). Clinl Infect Dis. 2020;71(Supplement_1):S1–S3. doi:10.1093/cid/ciaa348
  • Gao K, Xu DM, Lin XR, Zhu XZ, Zhang HL, Tong ML. Immunization with nontreponemal antigen alters the course of experimental syphilis in the rabbit model. Int Immunopharmacol. 2020;89:107100. doi:10.1016/j.intimp.2020.107100
  • Seña AC, White BL, Sparling PF. Novel Treponema pallidum serologic tests: a paradigm shift in syphilis screening for the 21st century. Clinl Infect Dis. 2010;51(6):700–708. doi:10.1086/655832
  • Workowski KA, Bolan GA. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(RR–03):1–137.
  • Zheng YW, Chen H, Shen X, Lin Y, Lin LR. Evaluation of the nontreponemal IgM antibodies in syphilis serofast patients: a new serologic marker for active syphilis. Clin Chim Acta. 2021;523:196–200. doi:10.1016/j.cca.2021.09.019
  • Janier M, Hegyi V, Dupin N, et al. 2014 European guideline on the management of syphilis. J Eur Acad Dermatol Venereol. 2014;28(12):1581–1593. doi:10.1111/jdv.12734
  • Riley RD, Ensor J, Snell KIE, et al. Calculating the sample size required for developing a clinical prediction model. BMJ. 2020;368:m441. doi:10.1136/bmj.m441
  • Kerr KF, Brown MD, Zhu K, Janes H. Assessing the clinical impact of risk prediction models with decision curves: guidance for correct interpretation and appropriate use. JCO. 2016;34(21):2534–2540. doi:10.1200/JCO.2015.65.5654
  • Chen YY, Qiu XH, Zhang YF, et al. A better definition of active syphilis infection. Clin Chim Acta. 2015;444:1–2. doi:10.1016/j.cca.2015.01.040
  • Clement ME, Okeke NL, Hicks CB. Treatment of syphilis a systematic review. JAMA. 2014;312(18):1905–1917. doi:10.1001/jama.2014.13259
  • Pham MD, Wise A, Garcia ML, et al. Improving the coverage and accuracy of syphilis testing: the development of a novel rapid, point-of-care test for confirmatory testing of active syphilis infection and its early evaluation in China and South Africa. EClin Med. 2020;24:100440. doi:10.1016/j.eclinm.2020.100440
  • Liu K, Wang J. Developing a nomogram model and prognostic analysis of nasopharyngeal squamous cell carcinoma patients: a population-based study. J Cancer Res Clin Oncol. 2023. doi:10.1007/s00432-023-05120-3

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.