Host–pathogen interactions and immune evasion strategies in Francisella tularensis pathogenicity

References

• McCoyGA plague-like disease of rodentsPublic Health Bulletin1911435372
   Google Scholar
• WherryWBLambBHInfection of man with Bacterium tularenseJ Infect Dis191418971321132915108712
   PubMed Web of Science ®Google Scholar
• McCrumbFJrSnyderMJWoodwardTEStudies on human infection with Pasteurella tularensis: comparison of streptomycin and chloramphenicol in the prophylaxis of clinical diseaseTrans Assoc Am Physicians1957707479 discussion 79–8013496116
   PubMedGoogle Scholar
• McCoyGWChapinCWFurther observations on a plague-like disease of rodents with a preliminary note on the causative agent, Bacterium tularenseJ Infect Dis19121016172
   Google Scholar
• HesselbrockWFoshayLThe morphology of Bacterium tularenseJ Bacteriol194549320923116560913
   PubMed Web of Science ®Google Scholar
• EllisJOystonPCGreenMTitballRWTularemiaClin Microbiol Rev200215463164612364373
   PubMed Web of Science ®Google Scholar
• TitballRWJohanssonAForsmanMWill the enigma of Francisella tularensis virulence soon be solved?Trends Microbiol200311311812312648943
   PubMed Web of Science ®Google Scholar
• McLendonMKApicellaMAAllenLAFrancisella tularensis: taxonomy, genetics, and immunopathogenesis of a potential agent of biowarfareAnnu Rev Microbiol20066016718516704343
   PubMed Web of Science ®Google Scholar
• GoethertHKTelfordSR3rdDifferential mortality of dog tick vectors due to infection by diverse Francisella tularensis tularensis genotypesVector Borne Zoonotic Dis20111191263126821612530
   PubMed Web of Science ®Google Scholar
• McCrumbFRAerosol infection of man with Pasteurella tularensisBacteriol Rev196125326226716350172
   PubMedGoogle Scholar
• CoxCSAerosol survival of Pasteurella tularensis disseminated from the wet and dry statesAppl Microbiol19712134824864994903
   PubMedGoogle Scholar
• HarrisSJapanese biological warfare research on humans: a case study of microbiology and ethicsAnn N Y Acad Sci199266621521297279
   PubMed Web of Science ®Google Scholar
• DennisDTInglesbyTVHendersonDATularemia as a biological weapon: medical and public health managementJAMA2001285212763277311386933
   PubMed Web of Science ®Google Scholar
• OystonPCSjöstedtATitballRWTularaemia: bioterrorism defence renews interest in Francisella tularensisNat Rev Microbiol200421296797815550942
   PubMed Web of Science ®Google Scholar
• EigelsbachHTDownsCMProphylactic effectiveness of live and killed tularemia vaccines. I. Production of vaccine and evaluation in the white mouse and guinea pigJ Immunol19618741542513889609
   PubMed Web of Science ®Google Scholar
• TigerttWDSoviet viable Pasteurella tularensis vaccines. A review of selected articlesBacteriol Rev19622635437313985026
   PubMedGoogle Scholar
• SalomonssonEKuoppaKForslundALReintroduction of two deleted virulence loci restores full virulence to the live vaccine strain of Francisella tularensisInfect Immun20097783424343119506014
   PubMed Web of Science ®Google Scholar
• NanoFESchmerkCThe Francisella pathogenicity islandAnn N Y Acad Sci2007110512213717395722
   PubMed Web of Science ®Google Scholar
• NanoFEZhangNCowleySCA Francisella tularensis pathogenicity island required for intramacrophage growthJ Bacteriol2004186196430643615375123
   PubMed Web of Science ®Google Scholar
• ChouAYKennettNJNixEBSchmerkCLNanoFEElkinsKLGeneration of protection against Francisella novicida in mice depends on the pathogenicity protein pdpA, but not pdpC or pdpDMicrobes Infect2013151281682723880085
   PubMed Web of Science ®Google Scholar
• de BruinOMDuplantisBNLuduJSThe biochemical properties of the Francisella pathogenicity island (FPI)-encoded proteins IglA, IglB, IglC, pdpB and dotU suggest roles in type VI secretionMicrobiology2011157Pt 123483349121980115
   PubMed Web of Science ®Google Scholar
• BromsJEMeyerLLavanderMLarssonPSjöstedtADotU and vgrG, core components of type VI secretion systems, are essential for Francisella LVS pathogenicityPLoS One201274e3463922514651
   PubMed Web of Science ®Google Scholar
• BarkerJRChongAWehrlyTDThe Francisella tularensis pathogenicity island encodes a secretion system that is required for phagosome escape and virulenceMol Microbiol20097461459147020054881
   PubMed Web of Science ®Google Scholar
• SanticMMolmeretMKloseKEJonesSKwaikYAThe Francisella tularensis pathogenicity island protein IglC and its regulator MglA are essential for modulating phagosome biogenesis and subsequent bacterial escape into the cytoplasmCell Microbiol20057796997915953029
   PubMed Web of Science ®Google Scholar
• DaiSMohapatraNPSchlesingerLSGunnJSRegulation of Francisella tularensis virulenceFront Microbiol2010114421687801
   PubMed Web of Science ®Google Scholar
• WoolardMDBarriganLMFullerJRIdentification of Francisella novicida mutants that fail to induce prostaglandin E(2) synthesis by infected macrophagesFront Microbiol201341623403609
   PubMed Web of Science ®Google Scholar
• BromsJEMeyerLSunKLavanderMSjöstedtAUnique substrates secreted by the type VI secretion system of Francisella tularensis during intramacrophage infectionPLoS One2012711e5047323185631
   PubMed Web of Science ®Google Scholar
• SmulevichGJakopitschCDroghettiEObingerCProbing the structure and bifunctionality of catalase-peroxidase (KatG)J Inorg Biochem2006100456858516516299
   PubMed Web of Science ®Google Scholar
• LindgrenHShenHZingmarkCGolovliovIConlanWSjöstedtAResistance of Francisella tularensis strains against reactive nitrogen and oxygen species with special reference to the role of KatGInfect Immun20077531303130917210667
   PubMed Web of Science ®Google Scholar
• BakshiCSMalikMReganKSuperoxide dismutase B gene (sodB)-deficient mutants of Francisella tularensis demonstrate hypersensitivity to oxidative stress and attenuated virulenceJ Bacteriol2006188176443644816923916
   PubMed Web of Science ®Google Scholar
• MelilloAAMahawarMSellatiTJIdentification of Francisella tularensis live vaccine strain CuZn superoxide dismutase as critical for resistance to extracellularly generated reactive oxygen speciesJ Bacteriol2009191206447645619684141
   PubMed Web of Science ®Google Scholar
• BuddinghGJWomackFCObservations on the infection of chick embryos with Bacterium tularense, brucella, and Pasteurella pestisJ Exp Med194174321322219871129
   PubMedGoogle Scholar
• ShepardCCNonacid-fast bacteria and HeLa cells: their uptake and subsequent intracellular growthJ Bacteriol195977670171413664649
   PubMed Web of Science ®Google Scholar
• FortierAHLeibyDANarayananRBGrowth of Francisella tularensis LVS in macrophages: the acidic intracellular compartment provides essential iron required for growthInfect Immun1995634147814837890413
   PubMed Web of Science ®Google Scholar
• ClemensDLLeeBYHorwitzMAFrancisella tularensis enters macrophages via a novel process involving pseudopod loopsInfect Immun20057395892590216113308
   PubMed Web of Science ®Google Scholar
• ClemensDLHorwitzMAUptake and intracellular fate of Francisella tularensis in human macrophagesAnn N Y Acad Sci2007110516018617435118
   PubMed Web of Science ®Google Scholar
• PieriniLMUptake of serum-opsonized Francisella tularensis by macrophages can be mediated by class A scavenger receptorsCell Microbiol2006881361137016882038
   PubMed Web of Science ®Google Scholar
• BalagopalAMacFarlaneASMohapatraNSoniSGunnJSSchlesingerLSCharacterization of the receptor-ligand pathways important for entry and survival of Francisella tularensis in human macrophagesInfect Immun20067495114512516926403
   PubMed Web of Science ®Google Scholar
• SchulertGSAllenLADifferential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptorJ Leukoc Biol200680356357116816147
   PubMed Web of Science ®Google Scholar
• GeierHCelliJPhagocytic receptors dictate phagosomal escape and intracellular proliferation of Francisella tularensisInfect Immun20117962204221421422184
   PubMed Web of Science ®Google Scholar
• ClemensDLLeeBYHorwitzMAVirulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophagesInfect Immun20047263204321715155622
   PubMed Web of Science ®Google Scholar
• SjöstedtAIntracellular survival mechanisms of Francisella tularensis, a stealth pathogenMicrobes Infect20068256156716239121
   PubMed Web of Science ®Google Scholar
• AsareRAbu KwaikYMolecular complexity orchestrates modulation of phagosome biogenesis and escape to the cytosol of macrophages by Francisella tularensisEnviron Microbiol20101292559258620482590
   PubMed Web of Science ®Google Scholar
• ChecrounCWehrlyTDFischerERHayesSFCelliJAutophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replicationProc Natl Acad Sci U S A200610339145781458316983090
   PubMed Web of Science ®Google Scholar
• SteeleSBruntonJZiehrBTaft-BenzSMoormanNKawulaTFrancisella tularensis harvests nutrients derived via ATG5-independent autophagy to support intracellular growthPLoS Pathog201398e100356223966861
   PubMed Web of Science ®Google Scholar
• LaiXHGolovliovISjöstedtAFrancisella tularensis induces cytopathogenicity and apoptosis in murine macrophages via a mechanism that requires intracellular bacterial multiplicationInfect Immun20016974691469411402018
   PubMed Web of Science ®Google Scholar
• HallJDCravenRRFullerJRPicklesRJKawulaTHFrancisella tularensis replicates within alveolar type II epithelial cells in vitro and in vivo following inhalationInfect Immun20077521034103917088343
   PubMed Web of Science ®Google Scholar
• HallJDWoolardMDGunnBMInfected-host-cell repertoire and cellular response in the lung following inhalation of Francisella tularensis Schu S4, LVS, or U112Infect Immun200876125843585218852251
   PubMed Web of Science ®Google Scholar
• HorzempaJO’DeeDMShanksRMNauGJFrancisella tularensis DeltapyrF mutants show that replication in nonmacrophages is sufficient for pathogenesis in vivoInfect Immun20107862607261920385757
   PubMed Web of Science ®Google Scholar
• ForestalCAMalikMCatlettSVFrancisella tularensis has a significant extracellular phase in infected miceJ Infect Dis2007196113413717538893
   PubMed Web of Science ®Google Scholar
• YuJJRaulieEKMurthyAKGuentzelMNKloseKEArulanandamBPThe presence of infectious extracellular Francisella tularensis subsp. novicida in murine plasma after pulmonary challengeEur J Clin Microbiol Infect Dis200827432332518087734
   PubMed Web of Science ®Google Scholar
• LindgrenHHonnMGolovlevIKadzhaevKConlanWSjöstedtAThe 58-kilodalton major virulence factor of Francisella tularensis is required for efficient utilization of ironInfect Immun200977104429443619651867
   PubMed Web of Science ®Google Scholar
• OlakanmiOGunnJSSuSSoniSHassettDJBritiganBEGallium disrupts iron uptake by intracellular and extracellular Francisella strains and exhibits therapeutic efficacy in a murine pulmonary infection modelAntimicrob Agents Chemother201054124425319917753
   PubMed Web of Science ®Google Scholar
• HazlettKRCaldonSDMcArthurDGAdaptation of Francisella tularensis to the mammalian environment is governed by cues which can be mimicked in vitroInfect Immun200876104479448818644878
   PubMed Web of Science ®Google Scholar
• PanXTamilselvamBHansenEJDaeflerSModulation of iron homeostasis in macrophages by bacterial intracellular pathogensBMC Microbiol2010106420184753
   PubMed Web of Science ®Google Scholar
• LindgrenHHonnMSalomonssonEKuoppaKForsbergASjöstedtAIron content differs between Francisella tularensis subspecies tularensis and subspecies holarctica strains and correlates to their susceptibility to H(2)O(2)-induced killingInfect Immun20117931218122421189323
   PubMed Web of Science ®Google Scholar
• CouncilmanWStrongRPlague-like infections in rodentsTrans Assoc Am Phys192136135143
   Google Scholar
• ChiavoliniDAlroyJKingCAIdentification of immunologic and pathologic parameters of death versus survival in respiratory tularemiaInfect Immun200876248649618025095
   PubMed Web of Science ®Google Scholar
• FoshayLHesselbrockWHWittenbergHJRodenbergAHVaccine prophylaxis against tularemia in manAm J Public Health Nations Health194232101131114518015689
   PubMedGoogle Scholar
• FoshayLA comparative study of the treatment of tularemia with immune serum, hyperimmune serum and streptomycinAm J Med1946118018820993803
   PubMed Web of Science ®Google Scholar
• ConlanJWNorthRJEarly pathogenesis of infection in the liver with the facultative intracellular bacteria Listeria monocytogenes, Francisella tularensis, and Salmonella typhimurium involves lysis of infected hepatocytes by leukocytesInfect Immun19926012516451711452350
   PubMed Web of Science ®Google Scholar
• ConlanJWKuoLeeRShenHWebbADifferent host defences are required to protect mice from primary systemic vs pulmonary infection with the facultative intracellular bacterial pathogen, Francisella tularensis LVSMicrob Pathog200232312713411855943
   PubMed Web of Science ®Google Scholar
• AnthonyLDBurkeRDNanoFEGrowth of Francisella spp. in rodent macrophagesInfect Immun1991599329132961879943
   PubMed Web of Science ®Google Scholar
• FortierAHPolsinelliTGreenSJNacyCAActivation of macrophages for destruction of Francisella tularensis: identification of cytokines, effector cells, and effector moleculesInfect Immun19926038178251541555
   PubMed Web of Science ®Google Scholar
• Bar-HaimEGatOMarkelGCohenHShaffermanAVelanBInterrelationship between dendritic cell trafficking and Francisella tularensis dissemination following airway infectionPLoS Pathog2008411e100021119023422
   PubMed Web of Science ®Google Scholar
• MaresCAOjedaSSMorrisEGLiQTealeJMInitial delay in the immune response to Francisella tularensis is followed by hypercytokinemia characteristic of severe sepsis and correlating with upregulation and release of damage-associated molecular patternsInfect Immun20087673001301018411294
   PubMed Web of Science ®Google Scholar
• SharmaJLiQMishraBBPenaCTealeJMLethal pulmonary infection with Francisella novicida is associated with severe sepsisJ Leukoc Biol200986349150419401387
   PubMed Web of Science ®Google Scholar
• CowleySCEditorial: proinflammatory cytokines in pneumonic tularemia: too much too late?J Leukoc Biol200986346947019720615
   PubMed Web of Science ®Google Scholar
• SharmaJMaresCALiQMorrisEGTealeJMFeatures of sepsis caused by pulmonary infection with Francisella tularensis type A strainMicrob Pathog2011511–2394721440052
   PubMed Web of Science ®Google Scholar
• MaresCASharmaJLiQDefect in efferocytosis leads to alternative activation of macrophages in Francisella infectionsImmunol Cell Biol201189216717220585334
   PubMed Web of Science ®Google Scholar
• MalikMBakshiCSMcCabeKMatrix metalloproteinase 9 activity enhances host susceptibility to pulmonary infection with type A and B strains of Francisella tularensisJ Immunol200717821013102017202364
   PubMed Web of Science ®Google Scholar
• SchwartzJTBarkerJHKaufmanJFayramDCMcCrackenJMAllenLAFrancisella tularensis inhibits the intrinsic and extrinsic pathways to delay constitutive apoptosis and prolong human neutrophil lifespanJ Immunol201218873351336322357630
   PubMed Web of Science ®Google Scholar
• StenmarkSSunnemarkDBuchtASjöstedtARapid local expression of interleukin-12, tumor necrosis factor alpha, and gamma interferon after cutaneous Francisella tularensis infection in tularemia-immune miceInfect Immun19996741789179710085019
   PubMed Web of Science ®Google Scholar
• ElkinsKLCooperAColombiniSMCowleySCKiefferTLIn vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70Infect Immun20027041936194811895957
   PubMed Web of Science ®Google Scholar
• SlightSRLinYMessmerMKhaderSAFrancisella tularensis LVS-induced Interleukin-12 p40 cytokine production mediates dendritic cell migration through IL-12 receptor beta1Cytokine201155337237921669537
   PubMed Web of Science ®Google Scholar
• LopezMCDuckettNSBaronSDMetzgerDWEarly activation of NK cells after lung infection with the intracellular bacterium, Francisella tularensis LVSCell Immunol20042321–2758515922718
   PubMed Web of Science ®Google Scholar
• FuruyaYKirimanjeswaraGSRobertsSMetzgerDWIncreased susceptibility of IgA-deficient mice to pulmonary Francisella tularensis live vaccine strain infectionInfect Immun20138193434344123836815
   PubMed Web of Science ®Google Scholar
• BaronSDSinghRMetzgerDWInactivated Francisella tularensis live vaccine strain protects against respiratory tularemia by intranasal vaccination in an immunoglobulin A-dependent fashionInfect Immun20077552152216217296747
   PubMed Web of Science ®Google Scholar
• ElkinsKLColombiniSMKriegAMDe PascalisRNK cells activated in vivo by bacterial DNA control the intracellular growth of Francisella tularensis LVS. Microbes InfectJan20091114956
   Google Scholar
• ChenWKuoLeeRShenHConlanJWSusceptibility of immunodeficient mice to aerosol and systemic infection with virulent strains of Francisella tularensisMicrob Pathog200436631131815120157
   PubMed Web of Science ®Google Scholar
• DuckettNSOlmosSDurrantDMMetzgerDWIntranasal interleukin-12 treatment for protection against respiratory infection with the Francisella tularensis live vaccine strainInfect Immun20057342306231115784575
   PubMed Web of Science ®Google Scholar
• PolsinelliTMeltzerMSFortierAHNitric oxide-independent killing of Francisella tularensis by IFN-gamma-stimulated murine alveolar macrophagesJ Immunol19941533123812458027551
   PubMed Web of Science ®Google Scholar
• LindgrenHStenmanLTarnvikASjöstedtAThe contribution of reactive nitrogen and oxygen species to the killing of Francisella tularensis LVS by murine macrophagesMicrobes Infect20057346747515788155
   PubMed Web of Science ®Google Scholar
• SjöstedtANorthRJConlanJWThe requirement of tumour necrosis factor-alpha and interferon-gamma for the expression of protective immunity to secondary murine tularaemia depends on the size of the challenge inoculumMicrobiology1996142Pt 6136913748704976
   PubMed Web of Science ®Google Scholar
• HenryTBrotckeAWeissDSThompsonLJMonackDMType I interferon signaling is required for activation of the inflammasome during Francisella infectionJ Exp Med2007204598799417452523
   PubMed Web of Science ®Google Scholar
• ColeLESantiagoABarryEMacrophage proinflammatory response to Francisella tularensis live vaccine strain requires coordination of multiple signaling pathwaysJ Immunol2008180106885689118453609
   PubMed Web of Science ®Google Scholar
• AbplanalpALMorrisIRParidaBKTealeJMBertonMTTLR-dependent control of Francisella tularensis infection and host inflammatory responsesPLoS One2009411e792019936231
   PubMed Web of Science ®Google Scholar
• EdwardsJARockx-BrouwerDNairVCelliJRestricted cytosolic growth of Francisella tularensis subsp. tularensis by IFN-gamma activation of macrophagesMicrobiology2010156Pt 232733919926654
   PubMed Web of Science ®Google Scholar
• SjöstedtAConlanJWNorthRJNeutrophils are critical for host defense against primary infection with the facultative intracellular bacterium Francisella tularensis in mice and participate in defense against reinfectionInfect Immun1994627277927838005668
   PubMed Web of Science ®Google Scholar
• KuoLeeRHarrisGConlanJWChenWRole of neutrophils and NADPH phagocyte oxidase in host defense against respiratory infection with virulent Francisella tularensis in miceMicrobes Infect201113544745621277990
   PubMed Web of Science ®Google Scholar
• MetzgerDWSalmonSLKirimanjeswaraGDiffering effects of IL-10 in cutaneous and pulmonary Francisella tularensis LVS infectionInfect Immun20138162022202723529615
   PubMed Web of Science ®Google Scholar
• GentryMTaorminaJPylesRBRole of primary human alveolar epithelial cells in host defense against Francisella tularensis infectionInfect Immun20077583969397817502386
   PubMed Web of Science ®Google Scholar
• KetavarapuJMRodriguezARYuJJMast cells inhibit intramacrophage Francisella tularensis replication via contact and secreted products including IL-4Proc Natl Acad Sci U S A2008105279313931818591675
   PubMed Web of Science ®Google Scholar
• RodriguezARYuJJGuentzelMNMast cell TLR2 signaling is crucial for effective killing of Francisella tularensisJ Immunol2012188115604561122529298
   PubMed Web of Science ®Google Scholar
• EigelsbachHTHunterDHJanssenWADangerfieldHGRabinowitzSGMurine model for study of cell-mediated immunity: protection against death from fully virulent Francisella tularensis infectionInfect Immun197512599910051193736
   PubMed Web of Science ®Google Scholar
• FortierAHSlayterMVZiembaRMeltzerMSNacyCALive vaccine strain of Francisella tularensis: infection and immunity in miceInfect Immun1991599292229281879918
   PubMed Web of Science ®Google Scholar
• SjöstedtASandstromGTarnvikAHumoral and cell-mediated immunity in mice to a 17-kilodalton lipoprotein of Francisella tularensis expressed by Salmonella typhimuriumInfect Immun1992607285528621612751
   PubMed Web of Science ®Google Scholar
• GolovliovIEricssonMAkerblomLSandstromGTarnvikASjöstedtAAdjuvanticity of ISCOMs incorporating a T cell-reactive lipoprotein of the facultative intracellular pathogen Francisella tularensisVaccine19951332612677631511
   PubMed Web of Science ®Google Scholar
• AndersonRVCraneDDBosioCMLong lived protection against pneumonic tularemia is correlated with cellular immunity in peripheral, not pulmonary, organsVaccine201028406562657220688042
   PubMed Web of Science ®Google Scholar
• MarkelGBar-HaimEZahavyEThe involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensisPLoS One201056e1117620585449
   PubMed Web of Science ®Google Scholar
• MelilloAAForemanOBosioCMElkinsKLT-bet regulates immunity to F. tularensis LVS infection, particularly in lungsInfect Immun20148241477149024421047
   PubMed Web of Science ®Google Scholar
• CowleySCSedgwickJDElkinsKLDifferential requirements by CD4+ and CD8+ T cells for soluble and membrane TNF in control of Francisella tularensis live vaccine strain intramacrophage growthJ Immunol2007179117709771918025217
   PubMed Web of Science ®Google Scholar
• LinYRitcheaSLogarAInterleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensisImmunity200931579981019853481
   PubMed Web of Science ®Google Scholar
• CowleySCElkinsKLMultiple T cell subsets control Francisella tularensis LVS intracellular growth without stimulation through macrophage interferon gamma receptorsJ Exp Med2003198337938912885873
   PubMed Web of Science ®Google Scholar
• CowleySCHamiltonEFrelingerJASuJFormanJElkinsKLCD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivoJ Exp Med2005202230931916027239
   PubMed Web of Science ®Google Scholar
• CowleySCMeierovicsAIFrelingerJAIwakuraYElkinsKLLung CD4-CD8- double-negative T cells are prominent producers of IL-17A and IFN-gamma during primary respiratory murine infection with Francisella tularensis live vaccine strainJ Immunol2010184105791580120393138
   PubMed Web of Science ®Google Scholar
• Rhinehart-JonesTRFortierAHElkinsKLTransfer of immunity against lethal murine Francisella infection by specific antibody depends on host gamma interferon and T cellsInfect Immun1994628312931378039881
   PubMed Web of Science ®Google Scholar
• FulopMMastroeniPGreenMTitballRWRole of antibody to lipopolysaccharide in protection against low- and high-virulence strains of Francisella tularensisVaccine200119314465447211483272
   PubMed Web of Science ®Google Scholar
• SebastianSPinkhamJTLynchJGCellular and humoral immunity are synergistic in protection against types A and B Francisella tularensisVaccine200927459760519022323
   PubMed Web of Science ®Google Scholar
• Mara-KooshamGHuttJALyonsCRWuTHAntibodies contribute to effective vaccination against respiratory infection by type A Francisella tularensis strainsInfect Immun20117941770177821282410
   PubMed Web of Science ®Google Scholar
• Porsch-OzcurumezMKischelNPriebeHSplettstosserWFinkeEJGrunowRComparison of enzyme-linked immunosorbent assay, Western blotting, microagglutination, indirect immunofluorescence assay, and flow cytometry for serological diagnosis of tularemiaClin Diagn Lab Immunol20041161008101515539498
   PubMedGoogle Scholar
• ConlanJOystonPCVaccines against Francisella tularensisAnn N Y Acad Sci2007110532535017395730
   PubMed Web of Science ®Google Scholar
• CowleySCElkinsKLImmunity to FrancisellaFront Microbiol201122621687418
   PubMed Web of Science ®Google Scholar
• ThorpeBDMarcusSPhagocytosis and intracellular fate of Pasteurella tularensis. 3. In vivo studies with passively transferred cells and seraJ Immunol19659457858514299033
   PubMed Web of Science ®Google Scholar
• ElkinsKLRhinehart-JonesTNacyCAWinegarRKFortierAHT-cell-independent resistance to infection and generation of immunity to Francisella tularensisInfect Immun19936138238298432603
   PubMed Web of Science ®Google Scholar
• KirimanjeswaraGSGoldenJMBakshiCSMetzgerDWProphylactic and therapeutic use of antibodies for protection against respiratory infection with Francisella tularensisJ Immunol2007179153253917579074
   PubMed Web of Science ®Google Scholar
• HajjarAMHarveyMDShafferSALack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptorsInfect Immun200674126730673816982824
   PubMed Web of Science ®Google Scholar
• TwineSMPetitMDShenHMykytczukNCKellyJFConlanJWImmunoproteomic analysis of the murine antibody response to successful and failed immunization with live anti-Francisella vaccinesBiochem Biophys Res Commun20063463999100816781667
   PubMed Web of Science ®Google Scholar
• AsareRKwaikYAExploitation of host cell biology and evasion of immunity by Francisella tularensisFront Microbiol2010114521687747
   PubMed Web of Science ®Google Scholar
• FulopMMancheeRTitballRRole of lipopolysaccharide and a major outer membrane protein from Francisella tularensis in the induction of immunity against tularemiaVaccine19951313122012258578807
   PubMed Web of Science ®Google Scholar
• ConlanJWShenHWebbAPerryMBMice vaccinated with the O-antigen of Francisella tularensis LVS lipopolysaccharide conjugated to bovine serum albumin develop varying degrees of protective immunity against systemic or aerosol challenge with virulent type A and type B strains of the pathogenVaccine20022029–303465347112297391
   PubMed Web of Science ®Google Scholar
• AncutaPPedronTGirardRSandstromGChabyRInability of the Francisella tularensis lipopolysaccharide to mimic or to antagonize the induction of cell activation by endotoxinsInfect Immun1996646204120468675305
   PubMed Web of Science ®Google Scholar
• OkanNAKasperDLThe atypical lipopolysaccharide of FrancisellaCarbohydr Res2013378798323916469
   PubMed Web of Science ®Google Scholar
• VinogradovEPerryMBConlanJWStructural analysis of Francisella tularensis lipopolysaccharideEur J Biochem2002269246112611812473106
   PubMedGoogle Scholar
• ZarrellaTMSinghABitsaktsisCHost-adaptation of Francisella tularensis alters the bacterium’s surface-carbohydrates to hinder effectors of innate and adaptive immunityPLoS One201167e2233521799828
   PubMed Web of Science ®Google Scholar
• TelepnevMGolovliovIGrundstromTTarnvikASjöstedtAFrancisella tularensis inhibits Toll-like receptor-mediated activation of intracellular signalling and secretion of TNF-alpha and IL-1 from murine macrophagesCell Microbiol200351415112542469
   PubMed Web of Science ®Google Scholar
• BosioCMDowSWFrancisella tularensis induces aberrant activation of pulmonary dendritic cellsJ Immunol2005175106792680116272336
   PubMed Web of Science ®Google Scholar
• BosioCMBielefeldt-OhmannHBelisleJTActive suppression of the pulmonary immune response by Francisella tularensis Schu4J Immunol200717874538454717372012
   PubMed Web of Science ®Google Scholar
• TelepnevMGolovliovISjöstedtAFrancisella tularensis LVS initially activates but subsequently down-regulates intracellular signaling and cytokine secretion in mouse monocytic and human peripheral blood mononuclear cellsMicrob Pathog2005385–623924715925273
   PubMed Web of Science ®Google Scholar
• GolovliovIEricssonMSandstromGTarnvikASjöstedtAIdentification of proteins of Francisella tularensis induced during growth in macrophages and cloning of the gene encoding a prominently induced 23-kilodalton proteinInfect Immun1997656218321899169749
   PubMed Web of Science ®Google Scholar
• ShireyKAColeLEKeeganADVogelSNFrancisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanismJ Immunol200818164159416718768873
   PubMed Web of Science ®Google Scholar
• WoolardMDWilsonJEHensleyLLFrancisella tularensis-infected macrophages release prostaglandin E2 that blocks T cell proliferation and promotes a Th2-like responseJ Immunol200717842065207417277110
   PubMed Web of Science ®Google Scholar
• WoolardMDHensleyLLKawulaTHFrelingerJARespiratory Francisella tularensis live vaccine strain infection induces Th17 cells and prostaglandin E2, which inhibits generation of gamma interferon-positive T cellsInfect Immun20087662651265918391003
   PubMed Web of Science ®Google Scholar
• WilsonJEKatkereBDrakeJRFrancisella tularensis induces ubiquitin-dependent major histocompatibility complex class II degradation in activated macrophagesInfect Immun200977114953496519703975
   PubMed Web of Science ®Google Scholar
• HuntDWilsonJEWeihKAFrancisella tularensis elicits IL-10 via a PGE(2)-inducible factor, to drive macrophage MARCH1 expression and class II down-regulationPLoS One201275e3733022615981
   PubMed Web of Science ®Google Scholar
• ChaseJCCelliJBosioCMDirect and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4Infect Immun200977118019518981246
   PubMed Web of Science ®Google Scholar
• McCaffreyRLAllenLAFrancisella tularensis LVS evades killing by human neutrophils via inhibition of the respiratory burst and phagosome escapeJ Leukoc Biol20068061224123016908516
   PubMed Web of Science ®Google Scholar
• BrotckeAMonackDMIdentification of fevR, a novel regulator of virulence gene expression in Francisella novicidaInfect Immun20087683473348018559431
   PubMed Web of Science ®Google Scholar
• McCaffreyRLSchwartzJTLindemannSRMultiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensisJ Leukoc Biol201088479180520610796
   PubMed Web of Science ®Google Scholar
• RothKMGunnJSLafuseWSatoskarARFrancisella inhibits STAT1-mediated signaling in macrophages and prevents activation of antigen-specific T cellsInt Immunol2009211192819001470
   PubMed Web of Science ®Google Scholar
• NallaparajuKCYuJJRodriguezSAEvasion of IFN-gamma signaling by Francisella novicida is dependent upon Francisella outer membrane protein CPLoS One201163e1820121483828
   PubMed Web of Science ®Google Scholar
• IrelandRWangRAlingerJBSmallPBosioCMFrancisella tularensis Schu S4 and Schu S4 lipids inhibit IL-12p40 in primary human dendritic cells by inhibition of IRF1 and IRF8J Immunol201319131276128623817430
   PubMed Web of Science ®Google Scholar
• LoegeringDJDrakeJRBanasJAFrancisella tularensis LVS grown in macrophages has reduced ability to stimulate the secretion of inflammatory cytokines by macrophages in vitroMicrob Pathog200641621822516996713
   PubMed Web of Science ®Google Scholar