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Review

Recent Insights into the Management of Pleural Infection

ORCID Icon, , , , & ORCID Icon
Pages 3415-3429 | Published online: 14 Jul 2021

References

  • Davies HE, Davies RJO, Davies CWH, on behalf of the BTS Pleural Disease Guideline Group. Management of pleural infection in adults: british Thoracic Society pleural disease guideline 2010. Thorax. 2010;65(Suppl 2):ii41–ii53. doi:10.1136/thx.2010.137000
  • Peters RM. Empyema thoracis: historical perspective. Ann Thorac Surg. 1989;48(2):306–308. doi:10.1016/0003-4975(89)90100-8
  • Meyer JA. Gotthard Bülau and closed water-seal drainage for empyema, 1875–1891. Ann Thorac Surg. 1989;48(4):597–599. doi:10.1016/s0003-4975(10)66876-2
  • Bender JM, Ampofo K, Sheng X, Pavia AT, Cannon-Albright L, Byington CL. Parapneumonic Empyema Deaths during Past Century, Utah. Emerg Infect Dis. 2009;15(1):44–48. doi:10.3201/eid1501.080618
  • Meyer CN, Armbruster K, Kemp M, et al. Pleural infection: a retrospective study of clinical outcome and the correlation to known etiology, co-morbidity and treatment factors. BMC Pulm Med. 2018;18(1):160. doi:10.1186/s12890-018-0726-1
  • Gupta I, Eid SM, Gillaspie EA, Broderick S, Shafiq M. Epidemiologic Trends in Pleural Infection. A Nationwide Analysis. Annals ATS. 2021;18(3):452–459. doi:10.1513/AnnalsATS.202001-075OC
  • Bedawi EO, Hassan M, McCracken D, Rahman NM. Pleural infection: a closer look at the etiopathogenesis, microbiology and role of antibiotics. Expert Rev Respir Med. 2019;13(4):337–347. doi:10.1080/17476348.2019.1578212
  • Brims F, Popowicz N, Rosenstengel A, et al. Bacteriology and clinical outcomes of patients with culture-positive pleural infection in Western Australia: a 6-year analysis: empyema in Western Australia 2006–2011. Respirology. 2019;24(2):171–178. doi:10.1111/resp.13395
  • Rahman NM, Kahan BC, Miller RF, Gleeson FV, Nunn AJ, Maskell NA. A clinical score (RAPID) to identify those at risk for poor outcome at presentation in patients with pleural infection. Chest. 2014;145(4):848–855. doi:10.1378/chest.13-1558
  • Corcoran JP, Psallidas I, Gerry S, et al. Prospective validation of the RAPID clinical risk prediction score in adult patients with pleural infection: the PILOT study. Eur Respir J. 2020;56(5):2000130. doi:10.1183/13993003.00130-2020
  • Nayak R, Brogly SB, Lajkosz K, Lougheed MD, Petsikas D. Two decades of thoracic empyema in Ontario, Canada. Chest. 2020;157(5):1114–1116. doi:10.1016/j.chest.2019.11.040
  • Grijalva CG, Zhu Y, Nuorti JP, Griffin MR. Emergence of parapneumonic empyema in the USA. Thorax. 2011;66(8):663–668. doi:10.1136/thx.2010.156406
  • Bobbio A, Bouam S, Frenkiel J, et al. Epidemiology and prognostic factors of pleural empyema. Thorax. 2021:thoraxjnl-2020-215267. doi:10.1136/thoraxjnl-2020-215267.
  • Lehtomäki A, Nevalainen R, Ukkonen M, Nieminen J, Laurikka J, Khan J. Trends in the incidence, etiology, treatment, and outcomes of pleural infections in adults over a decade in a Finnish University Hospital. Scand J Surg. 2020;109(2):127–132. doi:10.1177/1457496919832146
  • Shen H-N, Lu C-L, Li C-Y. Epidemiology of pleural infections in Taiwan from 1997 through 2008: pleural infections in Taiwan. Respirology. 2012;17(7):1086–1093. doi:10.1111/j.1440-1843.2012.02214.x
  • Mitchell MA, Deschner E, Dhaliwal I, Amjadi K, Chee A. Association of patient demographics and comorbidities with clinical outcomes in adults hospitalized for Empyema. Ann Am Thorac Soc. 2021;18(5):904–906. doi:10.1513/AnnalsATS.202008-1011RL
  • Cargill TN, Hassan M, Corcoran JP, et al. A systematic review of comorbidities and outcomes of adult patients with pleural infection. Eur Respir J. 2019. doi:10.1183/13993003.00541-2019
  • Wong D, Yap E. Pleural infection in a New Zealand centre: high incidence in Pacific people and RAPID score as a prognostic tool: pleural infection in New Zealand. Intern Med J. 2016;46(6):703–709. doi:10.1111/imj.13087
  • Ahmed RA, Marrie TJ, Huang JQ. Thoracic empyema in patients with community-acquired pneumonia. Am J Med. 2006;119(10):877–883. doi:10.1016/j.amjmed.2006.03.042
  • Lehtomäki AI, Nevalainen RM, Toikkanen VJ, et al. Pleural infection—an indicator of morbidity and increased burden on health care. Interact Cardiovasc Thorac Surg. 2020;31(4):513–518. doi:10.1093/icvts/ivaa147
  • Schweigert M, Solymosi N, Dubecz A, et al. Surgery for parapneumonic pleural empyema--What influence does the rising prevalence of multimorbidity and advanced age has on the current outcome? Surgeon. 2016;14(2):69–75. doi:10.1016/j.surge.2014.05.002
  • Cohen E, Mahant S, Dell SD, et al. The long-term outcomes of pediatric pleural empyema: a prospective study. Arch Pediatr Adolesc Med. 2012;166(11):999–1004. doi:10.1001/archpediatrics.2012.1055
  • Chalmers JD, Singanayagam A, Murray MP, Scally C, Fawzi A, Hill AT. Risk factors for complicated parapneumonic effusion and empyema on presentation to hospital with community-acquired pneumonia. Thorax. 2009;64(7):592–597. doi:10.1136/thx.2008.105080
  • Amaro R, Sellarés J, Riesco J, Cillloniz C, Abad E, Torres A. Late-breaking abstract: smoking is associated with higher incidence of parapneumonic effusion in community-acquired pneumonia. Eur Respir J. 2014;44(Suppl 58):P318.
  • Noppen M. Normal volume and cellular contents of pleural fluid. Curr Opin Pulm Med. 2001;7(4):180–182. doi:10.1097/00063198-200107000-00002
  • Psallidas I, Kanellakis NI, Bhatnagar R, et al. A pilot feasibility study in establishing the role of ultrasound-guided pleural biopsies in pleural infection (The AUDIO Study). Chest. 2018;154(4):766–772. doi:10.1016/j.chest.2018.02.031
  • Hassan M, Cargill T, Harriss E, et al. The microbiology of pleural infection in adults: a systematic review. Eur Respir J. 2019;54(3):1900542. doi:10.1183/13993003.00542-2019
  • Maskell NA, Batt S, Hedley EL, Davies CWH, Gillespie SH, Davies RJO. The bacteriology of pleural infection by genetic and standard methods and its mortality significance. Am J Respir Crit Care Med. 2006;174(7):817–823. doi:10.1164/rccm.200601-074OC
  • Wrightson JM, Wray JA, Street TL, et al. Absence of atypical pathogens in pleural infection. Chest. 2015;148(3):e102–e103. doi:10.1378/chest.15-1130
  • Lisboa T, Waterer GW, Lee YCG. Pleural infection: changing bacteriology and its implications: pleural infection: changing bacteriology. Respirology. 2011;16(4):598–603. doi:10.1111/j.1440-1843.2011.01964.x
  • Chen KY, Hsueh PR, Liaw YS, Yang PC, Luh KT. A 10-year experience with bacteriology of acute thoracic empyema: emphasis on Klebsiella pneumoniae in patients with diabetes mellitus. Chest. 2000;117(6):1685–1689.
  • Lin Y-C, Tu C-Y, Chen W, et al. An urgent problem of aerobic gram-negative pathogen infection in complicated parapneumonic effusions or empyemas. Internal Med. 2007;46(15):1173–1178. doi:10.2169/internalmedicine.46.6451
  • Tu C-Y, Hsu W-H, Hsia T-C, et al. The changing pathogens of complicated parapneumonic effusions or empyemas in a medical intensive care unit. Intensive Care Med. 2006;32(4):570–576. doi:10.1007/s00134-005-0064-7
  • Richet H. Seasonality in Gram-negative and healthcare-associated infections. Clin Microbiol Infect. 2012;18(10):934–940. doi:10.1111/j.1469-0691.2012.03954.x
  • Hassan M, Corcoran JP, Daneshvar C. Factors associated with variations in the rate of referrals and microbiology of pleural infection. Expert Rev Respir Med. 2020;14(11):1165–1171. doi:10.1080/17476348.2020.1804874
  • Corcoran JP, Wrightson JM, Belcher E, DeCamp MM, Feller-Kopman D, Rahman NM. Pleural infection: past, present, and future directions. Lancet Respir Med. 2015;3(7):563–577. doi:10.1016/S2213-2600(15)00185-X
  • Boyanova L, Djambazov V, Gergova G, et al. Anaerobic microbiology in 198 cases of pleural empyema: a Bulgarian study. Anaerobe. 2004;10(5):261–267. doi:10.1016/j.anaerobe.2004.06.001
  • Dyrhovden R, Nygaard RM, Patel R, Ulvestad E, Kommedal Ø. The bacterial aetiology of pleural empyema. A descriptive and comparative metagenomic study. Clin Microbiol Infect. 2019;25(8):981–986. doi:10.1016/j.cmi.2018.11.030
  • Ko SC, Chen KY, Hsueh PR, Luh KT, Yang PC. Fungal empyema thoracis: an emerging clinical entity. Chest. 2000;117(6):1672–1678.
  • Bedawi EO, Hassan M, Rahman NM. Recent developments in the management of pleural infection: a comprehensive review. Clin Respir J. 2018;12(8):2309–2320. doi:10.1111/crj.12941
  • Brixey AG, Luo Y, Skouras V, Awdankiewicz A, Light RW. The efficacy of chest radiographs in detecting parapneumonic effusions: the efficacy of chest radiographs. Respirology. 2011;16(6):1000–1004. doi:10.1111/j.1440-1843.2011.02006.x
  • Tsujimoto N, Saraya T, Light RW, et al. A simple method for differentiating complicated parapneumonic effusion/empyema from parapneumonic effusion using the split pleura sign and the amount of pleural effusion on thoracic CT. PLoS One. 2015;10(6):e0130141. doi:10.1371/journal.pone.0130141
  • Porcel JM, Pardina M, Alemán C, Pallisa E, Light RW, Bielsa S. Computed tomography scoring system for discriminating between parapneumonic effusions eventually drained and those cured only with antibiotics: CT for parapneumonic effusions. Respirology. 2017;22(6):1199–1204. doi:10.1111/resp.13040
  • Kearney SE, Davies CW, Davies RJ, Gleeson FV. Computed tomography and ultrasound in parapneumonic effusions and empyema. Clin Radiol. 2000;55(7):542–547. doi:10.1053/crad.1999.0480
  • Reissig A, Copetti R, Mathis G, et al. Lung ultrasound in the diagnosis and follow-up of community-acquired pneumonia: a prospective, multicenter, diagnostic accuracy study. Chest. 2012;142(4):965–972. doi:10.1378/chest.12-0364
  • Hassan M, Mercer RM, Rahman NM. Thoracic ultrasound in the modern management of pleural disease. Eur Respir Rev. 2020;29(156):190136. doi:10.1183/16000617.0136-2019
  • Colice GL, Curtis A, Deslauriers J, et al. Medical and surgical treatment of parapneumonic effusions: an evidence-based guideline. Chest. 2000;118(4):1158–1171. doi:10.1378/chest.118.4.1158
  • Varsamas C, Kalkanis A, Gourgoulianis KI, Malli F. The use of a novel quantitative marker of echogenicity of pleural fluid in parapneumonic pleural effusions. Can Respir J. 2020;2020:1283590. doi:10.1155/2020/1283590
  • Heffner JE, Brown LK, Barbieri C, DeLeo JM. Pleural fluid chemical analysis in parapneumonic effusions. A meta-analysis. Am J Respir Crit Care Med. 1995;151(6):1700–1708. doi:10.1164/ajrccm.151.6.7767510
  • Maskell NA, Gleeson FV, Darby M, Davies RJO. Diagnostically significant variations in pleural fluid pH in loculated parapneumonic effusions. CHEST. 2004;126(6):2022–2024. doi:10.1378/chest.126.6.2022
  • Isenstein D, Honig E. Proteus vulgaris empyema and increased pleural fluid pH. CHEST. 1990;97(2):511. doi:10.1378/chest.97.2.511b
  • Fitzgerald DB, Leong SL, Budgeon CA, et al. Relationship of pleural fluid pH and glucose: a multi-centre study of 2,971 cases. J Thorac Dis. 2019;11(1):123–130. doi:10.21037/jtd.2018.12.101
  • Falguera M, Carratalà J, Bielsa S, et al. Predictive factors, microbiology and outcome of patients with parapneumonic effusion. Eur Respir J. 2011;38(5):1173. doi:10.1183/09031936.00000211
  • Porcel JM, Bielsa S, Esquerda A, Ruiz-González A, Falguera M. Pleural fluid C-reactive protein contributes to the diagnosis and assessment of severity of parapneumonic effusions. Eur J Intern Med. 2012;23(5):447–450. doi:10.1016/j.ejim.2012.03.002
  • Porcel JM, Valencia H, Bielsa S. Factors influencing pleural drainage in parapneumonic effusions. Revista Clínica Española. 2016;216(7):361–366. doi:10.1016/j.rce.2016.04.004
  • Menzies SM, Rahman NM, Wrightson JM, et al. Blood culture bottle culture of pleural fluid in pleural infection. Thorax. 2011;66(8):658. doi:10.1136/thx.2010.157842
  • Dixon G, Lama-Lopez A, Bintcliffe OJ, Morley AJ, Hooper CE, Maskell NA. The role of serum procalcitonin in establishing the diagnosis and prognosis of pleural infection. Respir Res. 2017;18(1):30. doi:10.1186/s12931-017-0501-5
  • McCann FJ, Chapman SJ, Yu WC, Maskell NA, Davies RJO, Lee YCG. Ability of procalcitonin to discriminate infection from non-infective inflammation using two pleural disease settings. PLoS One. 2012;7(12):e49894. doi:10.1371/journal.pone.0049894
  • Insa R, Marín M, Martín A, et al. Systematic use of universal 16S rRNA Gene Polymerase Chain Reaction (PCR) and sequencing for processing pleural effusions improves conventional culture techniques. Medicine. 2012;91(2):103–110. doi:10.1097/MD.0b013e31824dfdb0
  • Gadsby NJ, Russell CD, McHugh MP, et al. Comprehensive molecular testing for respiratory pathogens in community-acquired pneumonia. Clin Infect Dis. 2016;62(7):817–823. doi:10.1093/cid/civ1214
  • Zhou F, Sun S, Sun X, Chen Y, Yang X. Rapid and sensitive identification of pleural and peritoneal infections by droplet digital PCR. Folia Microbiol. 2021;66(2):213–219. doi:10.1007/s12223-020-00834-0
  • Franchetti L, Schumann DM, Tamm M, Jahn K, Stolz D. Multiplex bacterial polymerase chain reaction in a cohort of patients with pleural effusion. BMC Infect Dis. 2020;20(1):99. doi:10.1186/s12879-020-4793-6
  • Teixeira LR, Sasse SA, Villarino MA, Nguyen T, Mulligan ME, Light RW. Antibiotic levels in empyemic pleural fluid. Chest. 2000;117(6):1734–1739. doi:10.1378/chest.117.6.1734
  • Bhatnagar R, Skouras VS, Rahman NM, Psallidas I. Antibiotics for pleural infections. In: Aliberti S, Chalmers JD, Pletz MW editors. Anti-Infectives and the Lung. European Respiratory Society; 2017:253–263. doi:10.1183/2312508X.10005816.
  • Shen KR, Bribriesco A, Crabtree T, et al. The American Association for Thoracic Surgery consensus guidelines for the management of empyema. J Thorac Cardiovasc Surg. 2017;153(6):e129–e146. doi:10.1016/j.jtcvs.2017.01.030
  • Porcel JM, Ferreiro L, Rumi L, et al. Two vs. three weeks of treatment with amoxicillin-clavulanate for stabilized community-acquired complicated parapneumonic effusions. A preliminary non-inferiority, double-blind, randomized, controlled trial. Pleura Peritoneum. 2020;5(1). doi:10.1515/pp-2019-0027
  • Ng T, Ryder BA, Maziak DE, Shamji FM. Treatment of postpneumonectomy empyema with debridement followed by continuous antibiotic irrigation. J Am Coll Surg. 2008;206(6):1178–1183. doi:10.1016/j.jamcollsurg.2008.01.005
  • Rana MA, Rahman BAE, Mady AF, et al. Intra-pleural colistin methanesulfonate therapy for pleural infection caused by carbapenem-resistant acinetobacter baumannii: a successful case report. Infect Dis Rep. 2014;6:3. doi:10.4081/idr.2014.5413
  • Chao Y-K, Lee C-H, Liu K-S, Wang Y-C, Wang C-W, Liu S-J. Sustained release of bactericidal concentrations of penicillin in the pleural space via an antibiotic-eluting pigtail catheter coated with electrospun nanofibers: results from in vivo and in vitro studies. Int J Nanomedicine. 2015;10:3329–3336. doi:10.2147/IJN.S82228
  • Rahman NM, Maskell NA, Davies CWH, et al. The relationship between chest tube size and clinical outcome in pleural infection. CHEST. 2010;137(3):536–543. doi:10.1378/chest.09-1044
  • Rahman NM, Maskell NA, West A, et al. Intrapleural use of tissue plasminogen activator and DNase in pleural infection. N Engl J Med. 2011;365(6):518–526. doi:10.1056/NEJMoa1012740
  • Karandashova S, Florova G, Azghani AO, et al. Intrapleural adenoviral delivery of human plasminogen activator inhibitor–1 exacerbates tetracycline-induced pleural injury in rabbits. Am J Respir Cell Mol Biol. 2013;48(1):44–52. doi:10.1165/rcmb.2012-0183OC
  • Idell S, Florova G, Shetty S, et al. Precision-guided, personalized intrapleural fibrinolytic therapy for empyema and complicated parapneumonic pleural effusions: the case for the fibrinolytic potential. Clin Pulm Med. 2017;24(4):163–169. doi:10.1097/CPM.0000000000000216
  • Zhu Z, Hawthorne ML, Guo Y, et al. Tissue plasminogen activator combined with human recombinant deoxyribonuclease is effective therapy for empyema in a rabbit model. CHEST. 2006;129(6):1577–1583. doi:10.1378/chest.129.6.1577
  • Piccolo F, Pitman N, Bhatnagar R, et al. Intrapleural tissue plasminogen activator and deoxyribonuclease for pleural infection. an effective and safe alternative to surgery. Annals ATS. 2014;11(9):1419–1425. doi:10.1513/AnnalsATS.201407-329OC
  • Porcel JM. Dual intracavitary therapy for pleural infections: leaving reluctance behind. Eur Respir J. 2019;54(2):1901001. doi:10.1183/13993003.01001-2019
  • Diacon AH, Theron J, Schuurmans MM, Van de Wal BW, Bolliger CT. Intrapleural streptokinase for empyema and complicated parapneumonic effusions. Am J Respir Crit Care Med. 2004;170(1):49–53. doi:10.1164/rccm.200312-1740OC
  • Davies RJ, Traill ZC, Gleeson FV. Randomised controlled trial of intrapleural streptokinase in community acquired pleural infection. Thorax. 1997;52(5):416–421. doi:10.1136/thx.52.5.416
  • Maskell NA, Davies CWH, Nunn AJ, et al. U.K. controlled trial of intrapleural streptokinase for pleural infection. N Engl J Med. 2005;352(9):865–874. doi:10.1056/NEJMoa042473
  • Gervais DA, Levis DA, Hahn PF, Uppot RN, Arellano RS, Mueller PR. Adjunctive intrapleural tissue plasminogen activator administered via chest tubes placed with imaging guidance: effectiveness and risk for hemorrhage. Radiology. 2008;246(3):956–963. doi:10.1148/radiol.2463070235
  • Kheir F, Cheng G, Rivera E, et al. Concurrent versus sequential intrapleural instillation of tissue plasminogen activator and deoxyribonuclease for pleural infection. J Bronchology Interv Pulmonol. 2018;25(2):125–131. doi:10.1097/LBR.0000000000000461
  • Majid A, Kheir F, Folch A, et al. Concurrent intrapleural instillation of tissue plasminogen activator and dnase for pleural infection. A Single-center experience. Ann Am Thorac Soc. 2016;13(9):1512–1518. doi:10.1513/AnnalsATS.201602-127OC
  • Popowicz N, Bintcliffe O, De Fonseka D, et al. Dose de-escalation of intrapleural tissue plasminogen activator therapy for pleural infection. The Alteplase dose assessment for pleural infection therapy project. Ann Am Thorac Soc. 2017;14(6):929–936. doi:10.1513/AnnalsATS.201609-673OC
  • Chambers A, Routledge T, Dunning J, Scarci M. Is video-assisted thoracoscopic surgical decortication superior to open surgery in the management of adults with primary empyema? Interact Cardiovasc Thorac Surg. 2010;11:171–177. doi:10.1510/icvts.2010.240408
  • Yeung C, Dawson J, Gilbert S. Uniportal video-assisted thoracoscopy approach to the management of non-pulmonary diseases of the chest. J Thorac Dis. 2019;11(S16):S2062–S2068. doi:10.21037/jtd.2019.03.21
  • Migliore M. Nonintubated uniportal video-assisted thoracic surgery for chest infections. Thorac Surg Clin. 2020;30(1):33–39. doi:10.1016/j.thorsurg.2019.08.004
  • Suchar AM, Zureikat AH, Glynn L, Statter MB, Lee J, Liu DC. Ready for the frontline: is early thoracoscopic decortication the new standard of care for advanced pneumonia with empyema? Am Surg. 2006;72(8):688–693. doi:10.1177/000313480607200806
  • Marks DJB, Fisk MD, Koo CY, et al. Thoracic empyema: a 12-year study from a UK tertiary cardiothoracic referral centre. PLoS One. 2012;7(1):e30074–e30074. doi:10.1371/journal.pone.0030074
  • Bilgin M, Akcali Y, Oguzkaya F. Benefits of early aggressive management of empyema thoracis. ANZ J Surg. 2006;76(3):120–122. doi:10.1111/j.1445-2197.2006.03666.x
  • Mondoni M, Saderi L, Trogu F, et al. Medical thoracoscopy treatment for pleural infections: a systematic review and meta-analysis. BMC Pulm Med. 2021;21(1):127. doi:10.1186/s12890-021-01492-9
  • Kheir F, Thakore S, Mehta H, et al. Intrapleural fibrinolytic therapy versus early medical thoracoscopy for treatment of pleural infection. randomized controlled clinical trial. Ann Am Thorac Soc. 2020;17(8):958–964. doi:10.1513/AnnalsATS.202001-076OC
  • Brutsche MH, Tassi G-F, Györik S, et al. Treatment of sonographically stratified multiloculated thoracic empyema by medical thoracoscopy. Chest. 2005;128(5):3303–3309. doi:10.1378/chest.128.5.3303
  • Tassi GF, Marchetti GP, Pinelli V, Chiari S. Practical management of pleural empyema. Monaldi Arch Chest Dis. 2010;73(3):124–129. doi:10.4081/monaldi.2010.296
  • Sumalani KK, Rizvi NA, Asghar A. Role of medical thoracoscopy in the management of multiloculated empyema. BMC Pulm Med. 2018;18(1):179. doi:10.1186/s12890-018-0745-y
  • Hooper CE, Edey AJ, Wallis A, et al. Pleural irrigation trial (PIT): a randomised controlled trial of pleural irrigation with normal saline versus standard care in patients with pleural infection. Eur Respir J. 2015;46(2):456. doi:10.1183/09031936.00147214
  • Porcel JM, Valencia H, Bielsa S. Manual intrapleural saline flushing plus urokinase: a potentially useful therapy for complicated parapneumonic effusions and empyemas. Lung. 2017;195(1):135–138. doi:10.1007/s00408-016-9964-2
  • Light RW. Parapneumonic effusions and empyema. Proc Am Thorac Soc. 2006;3(1):75–80. doi:10.1513/pats.200510-113JH
  • Togo S, Ouattara MA, Sangaré I, et al. Management for pediatric pleural empyema in resource-poor country: is chest tube drainage with antiseptic lavage-irrigation better than tube thoracostomy alone? SS. 2015;06(12):541–548. doi:10.4236/ss.2015.612077
  • Jouneau S, Letheulle J, Desrues B. Repeated therapeutic thoracentesis to manage complicated parapneumonic effusions. Curr Opin Pulm Med. 2015;21(4):387–392. doi:10.1097/MCP.0000000000000171
  • Letheulle J, Tattevin P, Saunders L, et al. Iterative thoracentesis as first-line treatment of complicated parapneumonic effusion. PLoS One. 2014;9(1):e84788. doi:10.1371/journal.pone.0084788
  • Nielsen J, Meyer CN, Rosenlund S. Outcome and clinical characteristics in pleural empyema: a retrospective study. Scand J Infect Dis. 2011;43(6–7):430–435. doi:10.3109/00365548.2011.562527
  • Marks DJB, Fisk MD, Koo CY, et al. Thoracic Empyema: a 12-year study from a uk tertiary cardiothoracic referral centre. Wilkinson RJ, ed. PLoS One. 2012;7(1):e30074. doi:10.1371/journal.pone.0030074
  • Heffner JE, McDonald J, Barbieri C, Klein J. Management of parapneumonic effusions. An analysis of physician practice patterns. Arch Surg. 1995;130(4):433–438. doi:10.1001/archsurg.1995.01430040095021
  • Lindstrom ST, Kolbe J. Community acquired parapneumonic thoracic empyema: predictors of outcome. Respirology. 1999;4(2):173–179.
  • Park C-K, Oh H-J, Choi H-Y, et al. Microbiological characteristics and predictive factors for mortality in pleural infection: a single-center cohort study in Korea. Trottein F, ed. PLoS One. 2016;11(8):e0161280. doi:10.1371/journal.pone.0161280
  • Søgaard M, Nielsen RB, Nørgaard M, Kornum JB, Schønheyder HC, Thomsen RW. Incidence, length of stay, and prognosis of hospitalized patients with pleural empyema. Chest. 2014;145(1):189–192. doi:10.1378/chest.13-1912
  • Ferguson AD, Prescott RJ, Selkon JB, Watson D, Swinburn CR. The clinical course and management of thoracic empyema. QJM. 1996;89(4):285–289. doi:10.1093/qjmed/89.4.285
  • Davies CW, Kearney SE, Gleeson FV, Davies RJ. Predictors of outcome and long-term survival in patients with pleural infection. Am J Respir Crit Care Med. 1999;160(5 Pt 1):1682–1687. doi:10.1164/ajrccm.160.5.9903002
  • White HD, White BAA, Song J, Fader R, Quiroga P, Arroliga AC. Pleural infections: a 9-year review of bacteriology, case characteristics and mortality. Am J Med Sci. 2013;345(5):349–354. doi:10.1097/MAJ.0b013e318259bd24
  • Chen C-H, Chen W, Chen H-J, et al. Transthoracic ultrasonography in predicting the outcome of small-bore catheter drainage in empyemas or complicated parapneumonic effusions. Ultrasound Med Biol. 2009;35(9):1468–1474. doi:10.1016/j.ultrasmedbio.2009.04.021
  • Wu J, Liu C, Lee S, Kuo Y, Hsieh T. Assessment of the charlson comorbidity index score, CHADS2 and CHA2DS2-VASc scores in predicting death in patients with thoracic empyema. Heart Lung. 2018;47(2):157–161. doi:10.1016/j.hrtlng.2017.12.003
  • Porcel JM. PILOTing towards a RAPID predictor of mortality for infectious pleural effusions. Eur Respir J. 2020;56(5):2002425. doi:10.1183/13993003.02425-2020