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Review

A Review on Research Progress in the Application of Glycosylated Hemoglobin and Glycated Albumin in the Screening and Monitoring of Gestational Diabetes

, &
Pages 1155-1165 | Published online: 30 Mar 2021

References

  • Jovanovic L, Savas H, Mehta M, Trujillo A, Pettitt DJ. Frequent monitoring of A1C during pregnancy as a treatment tool to guide therapy. Diabetes Care. 2011;34(1):53–54. doi:10.2337/dc10-1455
  • Desouza CV, Holcomb RG, Rosenstock J, et al. Results of a study comparing glycated albumin to other glycemic indices. J Clin Endocrinol Metab. 2020;105(3):677–687. doi:10.1210/clinem/dgz087
  • Goyal A, Gupta Y, Singla R, Kalra S, Tandon N. American Diabetes Association “standards of medical care-2020 for gestational diabetes mellitus”: a critical appraisal. Diabetes Ther. 2020;11(8):1639–1644. doi:10.1007/s13300-020-00865-3
  • IDF. IDF diabetes atlas- 8th edition [EB/OL]; 2017. Available from: http://diabetesatlas.org/across-the-globe.html. Accessed March 15, 2021.
  • Metzger BE, Lowe LP, Dyer AR, et al.; HAPO Study Cooperative Research Group. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358(19):1991–2002. doi:10.1056/NEJMoa0707943
  • Horie I, Kawasaki E, Sakanaka A, et al. Efficacy of nutrition therapy for glucose intolerance in Japanese women diagnosed with gestational diabetes based on IADPSG criteria during early gestation. Diabetes Res Clin Pract. 2015;107(3):400–406. doi:10.1016/j.diabres.2014.12.011
  • American Diabetes Association. 2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2020. Diabetes Care. 2020;43(Suppl 1):S14–s31. doi:10.2337/dc20-S002
  • Hod M, Kapur A, Sacks DA, et al. The International Federation of Gynecology and Obstetrics (FIGO) initiative on gestational diabetes mellitus: a pragmatic guide for diagnosis, management, and care. Int J Gynaecol Obstet. 2015;131(Suppl 3):S173–s211.
  • Super DM, Edelberg SC, Philipson EH, Hertz RH, Kalhan SC. Diagnosis of gestational diabetes in early pregnancy. Diabetes Care. 1991;14(4):288–294. doi:10.2337/diacare.14.4.288
  • Hinkle SN, Tsai MY, Rawal S, Albert PS, Zhang C. HbA1c measured in the first trimester of pregnancy and the association with gestational diabetes. Sci Rep. 2018;8(1):12249. doi:10.1038/s41598-018-30833-8
  • Kattini R, Hummelen R, Kelly L. Early gestational diabetes mellitus screening with glycated hemoglobin: a systematic review. J Obstet Gynaecol Can. 2020;42(11):1379–1384. doi:10.1016/j.jogc.2019.12.015
  • Fong A, Serra AE, Gabby L, Wing DA, Berkowitz KM. Use of hemoglobin A1c as an early predictor of gestational diabetes mellitus. Am J Obstet Gynecol. 2014;211(6):641.e1–641.e7. doi:10.1016/j.ajog.2014.06.016
  • Rowan JA, Budden A, Ivanova V, Hughes RC, Sadler LC. Women with an HbA1c of 41–49 mmol/mol (5.9–6.6%): a higher risk subgroup that may benefit from early pregnancy intervention. Diabet Med. 2016;33(1):25–31. doi:10.1111/dme.12812
  • Pezeshki B, Chiti H, Arasteh P, Mazloomzadeh S. Early screening of gestational diabetes mellitus using hemoglobin A1C: revising current screening guidelines. Caspian J Intern Med. 2019;10(1):16–24. doi:10.22088/cjim.10.1.16
  • Amylidi S, Mosimann B, Stettler C, Fiedler GM, Surbek D, Raio L. First-trimester glycosylated hemoglobin in women at high risk for gestational diabetes. Acta Obstet Gynecol Scand. 2016;95(1):93–97. doi:10.1111/aogs.12784
  • Benaiges D, Flores-le Roux JA, Marcelo I, et al. Is first-trimester HbA1c useful in the diagnosis of gestational diabetes? Diabetes Res Clin Pract. 2017;133:85–91. doi:10.1016/j.diabres.2017.08.019
  • Arbib N, Shmueli A, Salman L, Krispin E, Toledano Y, Hadar E. First trimester glycosylated hemoglobin as a predictor of gestational diabetes mellitus. Int J Gynecol Obstet. 2019;145(2):158–163. doi:10.1002/ijgo.12794
  • Hughes RC, Moore MP, Gullam JE, Mohamed K, Rowan J. An early pregnancy HbA1c ≥5.9% (41 mmol/mol) is optimal for detecting diabetes and identifies women at increased risk of adverse pregnancy outcomes. Diabetes Care. 2014;37(11):2953–2959. doi:10.2337/dc14-1312
  • Kwon SS, Kwon JY, Park YW, Kim YH, Lim JB. HbA1c for diagnosis and prognosis of gestational diabetes mellitus. Diabetes Res Clin Pract. 2015;110(1):38–43. doi:10.1016/j.diabres.2015.07.014
  • Bender W, McCarthy C, Chittams J, et al. 189: what is the optimal Hemoglobin A1c screening cut-off for the prediction of gestational diabetes mellitus? Am J Obstet Gynecol. 2020;222(1):S132–S133. doi:10.1016/j.ajog.2019.11.205
  • Xiaoli Z, Li S, Xiying H. The Value of ROC curve on the glycated hemoglobin with gestational diabetes. Hebei Med. 2016;22(01):99–102.
  • Amaefule CE, Sasitharan A, Kalra P, et al. The accuracy of haemoglobin A1c as a screening and diagnostic test for gestational diabetes: a systematic review and meta-analysis of test accuracy studies. Curr Opin Obstet Gynecol. 2020;32(5):322–334. doi:10.1097/GCO.0000000000000648
  • Balaji V, Madhuri BS, Ashalatha S, Sheela S, Suresh S, Seshiah V. A1C in gestational diabetes mellitus in Asian Indian women. Diabetes Care. 2007;30(7):1865–1867. doi:10.2337/dc06-2329
  • Renz PB, Chume FC, Timm JRT, Pimentel AL, Camargo JL. Diagnostic accuracy of glycated hemoglobin for gestational diabetes mellitus: a systematic review and meta-analysis. Clin Chem Lab Med (CCLM). 2019;57(10):1435–1449. doi:10.1515/cclm-2018-1191
  • Ye M, Liu Y, Cao X, et al. The utility of HbA1c for screening gestational diabetes mellitus and its relationship with adverse pregnancy outcomes. Diabetes Res Clin Pract. 2016;114:43–49. doi:10.1016/j.diabres.2016.02.007
  • Rajput R, Yadav Y, Rajput M, Nanda S. Utility of HbA1c for diagnosis of gestational diabetes mellitus. Diabetes Res Clin Pract. 2012;98(1):104–107. doi:10.1016/j.diabres.2012.02.018
  • Tonguc M, Tayyar AT, Muderris I, Bayram F, Muhtaroglu S, Tayyar M. An evaluation of two different screening criteria in gestational diabetes mellitus. J Maternal Fetal Neonatal Med. 2018;31(9):1188–1193. doi:10.1080/14767058.2017.1311858
  • McFarland KF, Murtiashaw M, Baynes JW. Clinical value of glycosylated serum protein and glycosylated hemoglobin levels in the diagnosis of gestational diabetes mellitus. Obstet Gynecol. 1984;64(4):516–518.
  • Ryu AJ, Moon HJ, Na JO, et al. The usefulness of the glycosylated hemoglobin level for the diagnosis of gestational diabetes mellitus in the Korean Population. Diabetes Metab J. 2015;39(6):507–511. doi:10.4093/dmj.2015.39.6.507
  • Saglam B, Uysal S, Sozdinler S, Dogan OE, Onvural B. Diagnostic value of glycemic markers HbA1c, 1,5-anhydroglucitol and glycated albumin in evaluating gestational diabetes mellitus. Ther Adv Endocrinol Metab. 2017;8(12):161–167. doi:10.1177/2042018817742580
  • Ho YR, Wang P, Lu MC, Tseng ST, Yang CP, Yan YH. Associations of mid-pregnancy HbA1c with gestational diabetes and risk of adverse pregnancy outcomes in high-risk Taiwanese women. PLoS One. 2017;12(5):e0177563. doi:10.1371/journal.pone.0177563
  • Yexin Z, Haijun W, Hao H, Xiangyu Z. Significance of HbA1c and GA in initial screening of gestational diabetes mellitus. Lab Med. 2014;(11):1151–1153. doi:10.3969/j.issn.1673-8640.2014.11.22
  • Zhu J, Chen Y, Li C, Tao M, Teng Y. The diagnostic value of glycated albumin in gestational diabetes mellitus. J Endocrinol Invest. 2018;41(1):121–128. doi:10.1007/s40618-016-0605-7
  • Xiaoqing J, Yuanqiao W, Feng D, Nan Nan Z. Application of glycated albumin in primary screening of gestational diabetes. Chin J Health Lab Technol. 2019;29(18):2263–2264+2268.
  • Wu K, Cheng Y, Li T, et al. The utility of HbA1c combined with haematocrit for early screening of gestational diabetes mellitus. Diabetol Metab Syndr. 2018;10:14. doi:10.1186/s13098-018-0314-9
  • Yonghong P, Xiaoping W, Haiming T. Significance of HbA1c and GSP in diagnosis of gestational diabetes mellitus. Lab Med Clinic. 2015;(22):3366–3367, 3370. doi:10.3969/j.issn.1672-9455.2015.22.028
  • Shuangyan L, Jingyuan Z, Yajun Z, Xiaosu X. Glycosylated hemoglobin combined body mass index in early pregnancy screening for gestational diabetes mellitus. Chin J Birth Health Heredity. 2011;19(05):73–74+34.
  • Liwei C. Prediction of gestational diabetes mellitus in first trimester with body mass index,fasting blood glucose and glycosylated hemoglobin combined tests. J Pract Med. 2016;32(19):3120–3122.
  • Yuewen J, Chaoyan Y, Chunmei Y. Roles of glycated hemoglobin A1c and glycated albumin in screening gestational diabetes mellitus among elderly pregnant women. Lab Med. 2018;33(04):312–315.
  • Bin L, Huiqiong H. Application of glycosylated hemoglobin and glycosylated albumin in the screening of gestational diabetes mellitus. Labeled Immunoassays Clin Med. 2017;24(3):287–289. doi:10.11748/bjmy.issn.1006-1703.2017.03.012
  • Hua W, Jirong L, Jinting F, Tao Q. Clinical significance of glycosylated hemoglobin and super sensitive C protein in gestational diabetes mellitus. Labeled Immunoassays Clin Med. 2016;23(09):1049–1051.
  • Herman WH, Ma Y, Uwaifo G, et al.; Diabetes Prevention Program Research Group. Differences in A1C by race and ethnicity among patients with impaired glucose tolerance in the Diabetes Prevention Program. Diabetes Care. 2007;30(10):2453–2457. doi:10.2337/dc06-2003
  • Barquiel B, Herranz L, Hillman N, et al. HbA1c and gestational weight gain are factors that influence neonatal outcome in mothers with gestational diabetes. J Womens Health (Larchmt). 2016;25(6):579–585. doi:10.1089/jwh.2015.5432
  • Hashimoto K, Koga M. Influence of iron deficiency on HbA1c levels in pregnant women: comparison with nonpregnant women. J Clin Med. 2018;7(2):pii: E34. doi:10.3390/jcm7020034.44
  • Lowe LP, Metzger BE, Dyer AR, et al.; HAPO Study Cooperative Research Group. Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: associations of maternal A1C and glucose with pregnancy outcomes. Diabetes Care. 2012;35(3):574–580. doi:10.2337/dc11-1687
  • American Diabetes Association. 14. Management of diabetes in pregnancy: standards of medical care in diabetes-2019. Diabetes Care. 2019;42(Suppl1):S165–S172. doi:10.2337/dc19-S014.
  • Ezeaku EC, Alegbeleye JO, Bassey G. Relationship between glycosylated haemoglobin levels and perinatal outcome among women with gestational diabetes mellitus at the University of Port Harcourt Teaching Hospital, Nigeria. J Adv Med Med Res. 2020;54–63. doi:10.9734/jammr/2020/v32i730450
  • Sweeting AN, Ross GP, Hyett J, et al. Baseline HbA1c to identify high-risk gestational diabetes: utility in early vs standard gestational diabetes. J Clin Endocrinol Metab. 2017;102(1):150–156. doi:10.1210/jc.2016-2951
  • Morris MA, Grandis AS, Litton JC. Glycosylated hemoglobin concentration in early gestation associated with neonatal outcome. Am J Obstet Gynecol. 1985;153(6):651–654. doi:10.1016/s0002-9378(85)80253-2
  • Antoniou M, Gilbert L, Gross J, et al. Potentially modifiable predictors of adverse neonatal and maternal outcomes in pregnancies with gestational diabetes mellitus: can they help for future risk stratification and risk-adapted patient care? BMC Pregnancy Childbirth. 2019;19:469. doi:10.1186/s12884-019-2610-2
  • Kurishita M, Nakashima K, Kozu H. A retrospective study of glucose metabolism in mothers of large babies. Diabetes Care. 1994;17(7):649–652. doi:10.2337/diacare.17.7.649
  • Inkster ME, Fahey TP, Donnan PT, et al. Poor glycated haemoglobin control and adverse pregnancy outcomes in type 1 and type 2 diabetes mellitus: systematic review of observational studies. BMC Pregnancy Childbirth. 2006;6(1):50–55. doi:10.1186/1471-2393-6-30
  • Bi J, Ji C, Wu Y, et al. Association between maternal normal range HbA1c values and adverse birth outcomes. J Clin Endocrinol Metab. 2020;105(6):dgaa127. doi:10.1210/clinem/dgaa127
  • Li HP, Wang FH, Tao MF, Huang YJ, Jia WP. Association between glycemic control and birthweight with glycated albumin in Chinese women with gestational diabetes mellitus. J Diabetes Investig. 2016;7(1):48–55. doi:10.1111/jdi.12383
  • Sugawara D, Maruyama A, Imanishi T, Sugiyama Y, Ichihashi K. Complications in infants of diabetic mothers related to glycated albumin and hemoglobin levels during pregnancy. Pediatr Neonatol. 2016;57(6):496–500. doi:10.1016/j.pedneo.2016.02.003
  • Mendes N, Alves M, Andrade R, Ribeiro RT, Papoila AL, Serrano F. Association between glycated albumin, fructosamine, and HbA1c with neonatal outcomes in a prospective cohort of women with gestational diabetes mellitus. Int J Gynecol Obstet. 2019;146(3):326–332. doi:10.1002/ijgo.12897
  • Mañé L, Flores-le Roux JA, Benaiges D, et al. Role of first-trimester HbA1c as a predictor of adverse obstetric outcomes in a multiethnic cohort. J Clin Endocrinol Metab. 2017;102(2):390–397. doi:10.1210/jc.2016-2581
  • Qingchuan Z, Linhua Z, Huiqing W, Xianqun M. The changes of serum fasting blood glucose, 2h postprandial blood glucose and HbA1c levels of patients with gestational diabetes and their relationship with adverse pregnancy outcomes. J Clin Med Pract. 2017;21(24):23–26.
  • Ray JG, Davidson A, Berger H, Dayan N, Park AL. Haemoglobin levels in early pregnancy and severe maternal morbidity: population-based cohort study. BJOG. 2020;127(9):1154–1164. doi:10.1111/1471-0528.16216
  • Mañé L, Flores-le Roux JA, Gómez N, et al. Association of first-trimester HbA1c levels with adverse pregnancy outcomes in different ethnic groups. Diabetes Res Clin Pract. 2019;150:202–210. doi:10.1016/j.diabres.2019.03.017
  • Guerin A, Nisenbaum R, Ray JG. Use of maternal GHb concentration to estimate the risk of congenital anomalies in the offspring of women with prepregnancy diabetes. Diabetes Care. 2007;30(7):1920–1925. doi:10.2337/dc07-0278
  • McGrath RT, Glastras SJ, Seeho SK, Scott ES, Fulcher GR, Hocking SL. Association between glycemic variability, HbA1c, and large-for-gestational-age neonates in women with type 1 diabetes. Diabetes Care. 2017;40(8):e98–e100. doi:10.2337/dc17-0626
  • Lowe WL, Scholtens DM, Lowe LP, et al. Association of gestational diabetes with maternal disorders of glucose metabolism and childhood adiposity. JAMA. 2018;320(10):1005–1016. doi:10.1001/jama.2018.11628
  • Goyal A, Gupta Y, Kalaivani M, et al. Long term (>1 year) postpartum glucose tolerance status among Indian women with history of Gestational Diabetes Mellitus (GDM) diagnosed by IADPSG criteria. Diabetes Res Clin Pract. 2018;142:154–161. doi:10.1016/j.diabres.2018.05.027
  • Retnakaran R, Qi Y, Sermer M, Connelly PW, Zinman B, Hanley AJ. Isolated hyperglycemia at 1 hour on oral glucose tolerance test in pregnancy resembles gestational diabetes mellitus in predicting postpartum metabolic dysfunction. Diabetes Care. 2008;31(7):1275–1281. doi:10.2337/dc08-0126
  • Kugishima Y, Yasuhi I, Yamashita H, et al. Risk factors associated with the development of postpartum diabetes in Japanese women with gestational diabetes. BMC Pregnancy Childbirth. 2018;18(1):19. doi:10.1186/s12884-017-1654-4
  • Katon J, Reiber G, Williams MA, Yanez D, Miller E. Hemoglobin A1c and postpartum abnormal glucose tolerance among women with gestational diabetes mellitus. Obstet Gynecol. 2012;119(3):566. doi:10.1097/AOG.0b013e3182475ac2
  • Katreddy MV, Pappachan JM, Taylor SE, Nevill AM, Indusekhar R, Nayak AU. Hemoglobin A1c in early postpartum screening of women with gestational diabetes. World J Diabetes. 2013;4(3):76–81. doi:10.4239/wjd.v4.i3.76
  • Kim C, Herman WH, Cheung NW, Gunderson EP, Richardson C. Comparison of hemoglobin A1c with fasting plasma glucose and 2-h postchallenge glucose for risk stratification among women with recent gestational diabetes mellitus. Diabetes Care. 2011;34(9):1949–1951. doi:10.2337/dc11-0269
  • Goyal A, Gupta Y, Kubihal S, Kalaivani M, Bhatla N, Tandon N. Utility of screening fasting plasma glucose and glycated hemoglobin to circumvent the need for oral glucose tolerance test in women with prior gestational diabetes. Adv Ther. 2021;38(2):1342–1351. doi:10.1007/s12325-020-01618-1
  • Megia A, Näf S, Herranz L, et al. The usefulness of HbA1c in postpartum reclassification of gestational diabetes. BJOG. 2012;119(7):891–894. doi:10.1111/j.1471-0528.2012.03325.x
  • Claire B, Sharon H. Should HbA1C be used to screen pregnant women for undiagnosed diabetes in the first trimester? A review of the evidence. J Public Health (Oxf). 2020;42(1):132–140. doi:10.1093/pubmed/fdy229
  • Salemans TH, van Dieijen-visser MP, Brombacher PJ. The value of HbA 1 and fructosamine in predicting impaired glucose tolerance—an alternative to OGTT to detect diabetes mellitus or gestational diabetes. Ann Clin Biochem. 1987;24(5):447–452. doi:10.1177/000456328702400504
  • Ryan EA, Stark R, Crockford PM, Suthijumroon A. Assessment of value of glycosylated albumin and protein in detection of gestational diabetes. Diabetes Care. 1987;10(2):213–216. doi:10.2337/diacare.10.2.213
  • Nielsen L, Ekbom P, Damm P, et al. HbA1c levels are significantly lower in early and late pregnancy. Diabetes Care. 2004;27(5):1200–1201. doi:10.2337/diacare.27.5.1200
  • Hiramatsu Y, Shimizu I, Omori Y, Nakabayashi M. Determination of reference intervals of glycated albumin and hemoglobin A1c in healthy pregnant Japanese women and analysis of their time courses and influencing factors during pregnancy. Endocr J. 2012;59:145–151. doi:10.1507/endocrj.K10E-410
  • Suh S, Joung JY, Jin SM, et al. Strong correlation between glycaemic variability and total glucose exposure in type 2 diabetes is limited to subjects with satisfactory glycaemic control. Diabetes Metab. 2014;40(4):272–277. doi:10.1016/j.diabet.2014.01.006
  • Mingzhen D. Application of serum glycated albumin in blood glucose monitoring during pregnancy. Med J Wuhan Univ. 2015;36(04):604–606+620.
  • de Veciana M, Major CA, Morgan MA, et al. Postprandial versus preprandial blood glucose monitoring in women with gestational diabetes mellitus requiring insulin therapy. N Engl J Med. 1995;333(19):1237–1241. doi:10.1056/NEJM199511093331901
  • Wong VW, Chong S, Mediratta S, Jalaludin B. Measuring glycated haemoglobin in women with gestational diabetes mellitus: how useful is it? Aust NZ J Obstet Gynecol. 2017;57(3):260–265. doi:10.1111/ajo.12511
  • Baxi L, Barad D, Reece EA, Farber R. Use of glycosylated hemoglobin as a screen for macrosomia in gestational diabetes. Obstet Gynecol. 1984;64(3):347–350.
  • Tang L, Xu S, Li P, Li L. Predictors of insulin treatment during pregnancy and abnormal postpartum glucose metabolism in patients with gestational diabetes mellitus. Diabetes Metabol Syndr Obes. 2019;12.
  • González-Quintero VH, Istwan NB, Rhea DJ, et al. Antenatal factors predicting subsequent need for insulin treatment in women with gestational diabetes. J Womens Health (Larchmt). 2008;17(7):1183–1187. doi:10.1089/jwh.2007.0667
  • Ducarme G, Desroys Du Roure F, Grange J, Vital M, Le Thuaut A, Crespin-Delcourt I. Predictive factors of subsequent insulin requirement for glycemic control during pregnancy at diagnosis of gestational diabetes mellitus. Int J Gynaecol Obstet. 2019;144(3):265–270. doi:10.1002/ijgo.12753
  • Bakiner O, Bozkirli E, Ozsahin K, Sariturk C, Ertorer E. Risk factors that can predict antenatal insulin need in gestational diabetes. J Clin Med Res. 2013;5(5):381–388. doi:10.4021/jocmr1515w
  • Skajaa GO, Kampmann U, Fuglsang J, Ovesen PG. High prepregnancy HbA1c is challenging to improve and affects insulin requirements, gestational length, and birthweight. J Diabetes. 2020;12:798–806. doi:10.1111/1753-0407.13070
  • Vintzileos AM, Thompson JP. Glycohemoglobin determinations in normal pregnancy and in insulin-dependent diabetics. Obstet Gynecol. 1980;56(4):435–439.
  • Pan J, Zhang F, Zhang L, Bao Y, Tao M, Jia W. Influence of insulin sensitivity and secretion on glycated albumin and hemoglobin A1c in pregnant women with gestational diabetes mellitus. Int J Gynaecol Obstet. 2013;121(3):252–256. doi:10.1016/j.ijgo.2013.01.017
  • Gomes D, von Kries R, Delius M, et al. Late-pregnancy dysglycemia in obese pregnancies after negative testing for gestational diabetes and risk of future childhood overweight: an interim analysis from a longitudinal mother-child cohort study. PLoS Med. 2018;15(10):e1002681. doi:10.1371/journal.pmed.1002681
  • Ensenauer R, Brandlhuber L, Burgmann M, et al. Obese nondiabetic pregnancies and high maternal glycated hemoglobin at delivery as an indicator of offspring and maternal postpartum risks: the prospective PEACHES mother-child cohort. Clin Chem. 2015;61(11):1381–1390. doi:10.1373/clinchem.2015.242206
  • Coustan DR, Lowe LP, Metzger BE, Dyer AR; International Association of Diabetes and Pregnancy Study Groups. The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: paving the way for new diagnostic criteria for gestational diabetes mellitus. Am J Obstet Gynecol. 2010;202(6):654. doi:10.1016/j.ajog.2010.04.006