Nomogram Incorporating the WNT/β-Catenin Signaling Pathway for Predicting the Survival of Cutaneous Melanoma

References

• Geller AC, Swetter SM, Brooks K, Demierre MF, Yaroch AL. Screening, early detection, and trends for melanoma: current status (2000–2006) and future directions. J Am Acad Dermatol. 2007;57(4):555–572; quiz 573–556. doi:10.1016/j.jaad.2007.06.032.
   PubMed Web of Science ®Google Scholar
• Blateau P, Coyaud E, Laurent E, et al. Promoter mutation as an independent prognostic marker for poor prognosis MAPK inhibitors-treated melanoma. Cancers. 2020;12(8):2224. doi:10.3390/cancers12082224.
   PubMed Web of Science ®Google Scholar
• El Sharouni M-A, Aivazian K, Witkamp AJ, et al. Association of histologic regression with a favorable outcome in patients with stage 1 and stage 2 cutaneous melanoma. JAMA Dermatol. 2020. doi:10.1001/jamadermatol.2020.5032.
   Web of Science ®Google Scholar
• Liao M, Zeng F, Li Y, et al. A novel predictive model incorporating immune-related gene signatures for overall survival in melanoma patients. Sci Rep. 2020;10(1):12462. doi:10.1038/s41598-020-69330-2.
   PubMed Web of Science ®Google Scholar
• Yang J, Pan Z, Zhao F, et al. A nomogram for predicting survival in patients with nodular melanoma: a population-based study. Medicine. 2019;98(24):e16059. doi:10.1097/md.0000000000016059.
   PubMed Web of Science ®Google Scholar
• Weiss SA, Hanniford D, Hernando E, Osman I. Revisiting determinants of prognosis in cutaneous melanoma. Cancer. 2015;121(23):4108–4123. doi:10.1002/cncr.29634.
   PubMed Web of Science ®Google Scholar
• Du Y, Lv G, Jing C, Liu J, Liu J. ZNF750 inhibits the proliferation and invasion of melanoma cells through modulating the Wnt/β-catenin signaling pathway. Folia Histochem Cytobiol. 2020;58(4):255–263. doi:10.5603/FHC.a2020.0026.
   PubMed Web of Science ®Google Scholar
• Kovacs D, Migliano E, Muscardin L, et al. The role of Wnt/β-catenin signaling pathway in melanoma epithelial-to-mesenchymal-like switching: evidences from patients-derived cell lines. Oncotarget. 2016;7(28):43295–43314. doi:10.18632/oncotarget.9232.
   PubMedGoogle Scholar
• Damsky WE, Curley DP, Santhanakrishnan M, et al. β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Cancer Cell. 2011;20(6):741–754. doi:10.1016/j.ccr.2011.10.030.
   PubMed Web of Science ®Google Scholar
• Sinnberg T, Levesque MP, Krochmann J, et al. Wnt-signaling enhances neural crest migration of melanoma cells and induces an invasive phenotype. Mol Cancer. 2018;17(1):59. doi:10.1186/s12943-018-0773-5.
   PubMed Web of Science ®Google Scholar
• Widlund HR, Horstmann MA, Price ER, et al. Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol. 2002;158(6):1079–1087. doi:10.1083/jcb.200202049.
   PubMed Web of Science ®Google Scholar
• Hartman ML, Czyz M. Pro-survival role of MITF in melanoma. J Invest Dermatol. 2015;135(2):352–358. doi:10.1038/jid.2014.319.
   PubMed Web of Science ®Google Scholar
• Carreira S, Goodall J, Aksan I, et al. Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature. 2005;433(7027):764–769. doi:10.1038/nature03269.
   PubMed Web of Science ®Google Scholar
• Kuphal S, Lodermeyer S, Bataille F, Schuierer M, Hoang BH, Bosserhoff AK. Expression of Dickkopf genes is strongly reduced in malignant melanoma. Oncogene. 2006;25(36):5027–5036. doi:10.1038/sj.onc.1209508.
   PubMed Web of Science ®Google Scholar
• Xue G, Romano E, Massi D, Mandalà M. Wnt/β-catenin signaling in melanoma: preclinical rationale and novel therapeutic insights. Cancer Treat Rev. 2016;49:1–12. doi:10.1016/j.ctrv.2016.06.009.
   PubMed Web of Science ®Google Scholar
• Kowalik A, Jurkowska M, Mierzejewska E, et al. The prognostic role of BRAF and WNT pathways activation in kinase inhibitors-naïve clinical stage III cutaneous melanoma. Melanoma Res. 2020;30(4):348–357. doi:10.1097/cmr.0000000000000658.
   PubMed Web of Science ®Google Scholar
• Li P, Gao Y, Li J, et al. LncRNA MEG3 repressed malignant melanoma progression via inactivating Wnt signaling pathway. J Cell Biochem. 2018;119(9):7498–7505. doi:10.1002/jcb.27061.
   PubMed Web of Science ®Google Scholar
• Haass NK, Smalley KSM. Melanoma Biomarkers. Mol Diagn Ther. 2009;13(5):283–296. doi:10.1007/BF03256334.
   PubMed Web of Science ®Google Scholar
• Ługowska I, Kowalska M, Zdzienicki M, et al. [The prognostic role of clinical factors, VEGF, IL-8 and sTNF-R1 in cutaneous melanomas at locoregional stage]. Pol Merkur Lekarski. 2012;32(187):22–27. Croation
   PubMedGoogle Scholar
• Bachmann IM, Straume O, Puntervoll HE, Kalvenes MB, Akslen LA. Importance of P-cadherin, beta-catenin, and Wnt5a/frizzled for progression of melanocytic tumors and prognosis in cutaneous melanoma. Clin Cancer Res. 2005;11(24 Pt 1):8606–8614. doi:10.1158/1078-0432.Ccr-05-0011.
   PubMed Web of Science ®Google Scholar
• Feldmann R, Schierl M, Fink AM, Sator PG, Maiweg J, Steiner A. Serum levels of glycoprotein Dickkopf-1 in patients with cutaneous malignant melanoma: a prospective pilot study. Dermatology. 2011;222(2):171–175. doi:10.1159/000324516.
   PubMed Web of Science ®Google Scholar
• Gajos-Michniewicz A, Czyz M. WNT signaling in melanoma. Int J Mol Sci. 2020;21(14):14. doi:10.3390/ijms21144852.
   Web of Science ®Google Scholar
• Tejera-Vaquerizo A, Pérez-Cabello G, Marínez-Leborans L, et al. Is mitotic rate still useful in the management of patients with thin melanoma? J Eur Acad Dermatol Venereol. 2017;31(12):2025–2029. doi:10.1111/jdv.14485.
   PubMed Web of Science ®Google Scholar
• De Carvalho N, Welzel J, Schuh S, et al. The vascular morphology of melanoma is related to Breslow index: an in vivo study with dynamic optical coherence tomography. Exp Dermatol. 2018;27(11):1280–1286. doi:10.1111/exd.13783.
   PubMed Web of Science ®Google Scholar
• Tas F, Erturk K. Scalp melanoma is associated with high mitotic rate and is a poor prognostic factor for recurrence and outcome. Melanoma Res. 2017;27(4):387–390. doi:10.1097/CMR.0000000000000351.
   PubMed Web of Science ®Google Scholar
• Balch CM, Gershenwald JE, Soong S-J, et al. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol. 2009;27(36):6199–6206. doi:10.1200/JCO.2009.23.4799.
   PubMed Web of Science ®Google Scholar
• Gershenwald JE, Scolyer RA. Melanoma staging: American Joint Committee on Cancer (AJCC) 8th edition and beyond. Ann Surg Oncol. 2018;25(8):2105–2110. doi:10.1245/s10434-018-6513-7.
   PubMed Web of Science ®Google Scholar
• Xiao L, Yang S, Hao J, et al. Endostar attenuates melanoma tumor growth via its interruption of b-FGF mediated angiogenesis. Cancer Lett. 2015;359(1):148–154. doi:10.1016/j.canlet.2015.01.012.
   PubMed Web of Science ®Google Scholar
• Cui C, Mao L, Chi Z, et al. A Phase II, randomized, double-blind, placebo-controlled multicenter trial of endostar in patients with metastatic melanoma. Mol Ther. 2013;21(7):1456–1463. doi:10.1038/mt.2013.79.
   PubMed Web of Science ®Google Scholar
• Spranger S, Bao R, Gajewski TF. Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity. Nature. 2015;523(7559):231–235. doi:10.1038/nature14404.
   PubMed Web of Science ®Google Scholar
• Wang M, Xu Y, Wen G-Z, Wang Q, Yuan S-M. Rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression. Onco Targets Ther. 2019;12:4643–4654. doi:10.2147/OTT.S205160.
   PubMed Web of Science ®Google Scholar
• Park H, Jung HY, Choi H-J, et al. Distinct roles of DKK1 and DKK2 in tumor angiogenesis. Angiogenesis. 2014;17(1):221–234. doi:10.1007/s10456-013-9390-5.
   PubMed Web of Science ®Google Scholar
• Hu Y, Liu M, Xu S, et al. The clinical significance of dickkopf wnt signaling pathway inhibitor gene family in head and neck squamous cell carcinoma. Med Sci Monit. 2020;26:e927368. doi:10.12659/msm.927368.
   PubMed Web of Science ®Google Scholar
• Haas MS, Kagey MH, Heath H, Schuerpf F, Rottman JB, Newman W. mDKN-01, a novel anti-DKK1 mAb, enhances innate immune responses in the tumor microenvironment. Mol Cancer Res. 2020;19(4):717–725. doi:10.1158/1541-7786.MCR-20-0799.
   PubMed Web of Science ®Google Scholar
• Wang X, Chang Y, Gao M, Zhang F. Wogonoside attenuates cutaneous squamous cell carcinoma by reducing epithelial-mesenchymal transition/invasion and cancer stem-like cell property. Onco Targets Ther. 2020;13:10097–10109. doi:10.2147/OTT.S251806.
   PubMed Web of Science ®Google Scholar
• Xu J, Wei Q, He Z. Insight into the function of RIPK4 in keratinocyte differentiation and carcinogenesis. Front Oncol. 2020;10:1562. doi:10.3389/fonc.2020.01562.
   PubMed Web of Science ®Google Scholar
• Gerami P, Busam K, Cochran A, et al. Histomorphologic assessment and interobserver diagnostic reproducibility of atypical spitzoid melanocytic neoplasms with long-term follow-up. Am J Surg Pathol. 2014;38(7):934–940. doi:10.1097/PAS.0000000000000198.
   PubMed Web of Science ®Google Scholar
• Davis LE, Shalin SC, Tackett AJ. Current state of melanoma diagnosis and treatment. Cancer Biol Ther. 2019;20(11):1366–1379. doi:10.1080/15384047.2019.1640032.
   PubMed Web of Science ®Google Scholar
• Saldanha G, Yarrow J, Pancholi J, et al. Breslow density is a novel prognostic feature that adds value to melanoma staging. Am J Surg Pathol. 2018;42(6):715–725. doi:10.1097/PAS.0000000000001034.
   PubMed Web of Science ®Google Scholar
• Gillgren P, Drzewiecki KT, Niin M, et al. 2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: a randomised, multicentre trial. Lancet. 2011;378(9803):1635–1642. doi:10.1016/S0140-6736(11)61546-8.
   PubMed Web of Science ®Google Scholar
• Minca EC, Billings SD, Elson P, Tetzlaff MT, Andea AA, Ko JS. Significance of epidermal mitoses in challenging melanocytic proliferations. J Cutan Pathol. 2017;44(2):135–143. doi:10.1111/cup.12855.
   PubMed Web of Science ®Google Scholar