Exploring Diagnostic Biomarkers and Comorbid Pathogenesis for Osteoarthritis and Metabolic Syndrome via Bioinformatics Approach

References

• Robinson WH, Lepus CM, Wang Q, et al. Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016;12(10):580–592. doi:10.1038/nrrheum.2016.136
   PubMed Web of Science ®Google Scholar
• Obesity A. Osteoarthritis. Nat Rev Dis Primer. 2016;2(1):16073. doi:10.1038/nrdp.2016.73
   PubMedGoogle Scholar
• Marian M, Shah R, Gashi B, et al. Exploring the lubrication mechanisms of synovial fluids for joint longevity - A perspective. Colloids Surf B Biointerfaces. 2021;206:111926. doi:10.1016/j.colsurfb.2021.111926
   PubMed Web of Science ®Google Scholar
• Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum. 2012;64(6):1697–1707. doi:10.1002/art.34453
   PubMed Web of Science ®Google Scholar
• Grässel S, Aszódi A. Cartilage. Springer; 2016.
   Google Scholar
• Lorenzo J, Horowitz M, Choi Y, Takayanagi H, Schett G, eds. Osteoimmunology: Interactions of the Immune and Skeletal Systems. 2nd ed. Academic Press is an imprint of Elsevier; 2016.
   Google Scholar
• Störch H, Zimmermann B, Resch B, et al. Activated human B cells induce inflammatory fibroblasts with cartilage-destructive properties and become functionally suppressed in return. Ann Rheum Dis. 2016;75(5):924–932. doi:10.1136/annrheumdis-2014-206965
   PubMed Web of Science ®Google Scholar
• Platzer H, Nees TA, Reiner T, et al. Impact of Mononuclear Cell Infiltration on Chondrodestructive MMP/ADAMTS Production in Osteoarthritic Knee Joints—An Ex Vivo Study. J Clin Med. 2020;9(5):1279. doi:10.3390/jcm9051279
   PubMed Web of Science ®Google Scholar
• Gkretsi V, Simopoulou T, Tsezou A. Lipid metabolism and osteoarthritis: lessons from atherosclerosis. Prog Lipid Res. 2011;50(2):133–140. doi:10.1016/j.plipres.2010.11.001
   PubMed Web of Science ®Google Scholar
• Dickson BM, Roelofs AJ, Rochford JJ, Wilson HM, De Bari C. The burden of metabolic syndrome on osteoarthritic joints. Arthritis Res Ther. 2019;21(1):289. doi:10.1186/s13075-019-2081-x
   PubMed Web of Science ®Google Scholar
• Reyes C, Leyland KM, Peat G, Cooper C, Arden NK, Prieto-Alhambra D. Association Between Overweight and Obesity and Risk of Clinically Diagnosed Knee, Hip, and Hand Osteoarthritis: a Population-Based Cohort Study: OVERWEIGHT/OBESITY AND THE RISK OF DEVELOPING OA. Arthritis Rheumatol. 2016;68(8):1869–1875. doi:10.1002/art.39707
   PubMed Web of Science ®Google Scholar
• Messier SP, Pater M, Beavers DP, et al. Influences of alignment and obesity on knee joint loading in osteoarthritic gait. Osteoarthritis Cartilage. 2014;22(7):912–917. doi:10.1016/j.joca.2014.05.013
   PubMed Web of Science ®Google Scholar
• Visser A, Ioan-Facsinay A, de Mutsert R, et al. Adiposity and hand osteoarthritis: the Netherlands Epidemiology of Obesity study. Arthritis Res Ther. 2014;16(1):R19. doi:10.1186/ar4447
   PubMed Web of Science ®Google Scholar
• Scotece M, Mobasheri A. Leptin in osteoarthritis: focus on articular cartilage and chondrocytes. Life Sci. 2015;140:75–78. doi:10.1016/j.lfs.2015.05.025
   PubMed Web of Science ®Google Scholar
• Gao Y-H, Zhao C-W, Liu B, et al. An update on the association between metabolic syndrome and osteoarthritis and on the potential role of leptin in osteoarthritis. Cytokine. 2020;129:155043. doi:10.1016/j.cyto.2020.155043
   PubMed Web of Science ®Google Scholar
• Hui W, Litherland GJ, Elias MS, et al. Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases. Ann Rheum Dis. 2012;71(3):455–462. doi:10.1136/annrheumdis-2011-200372
   PubMed Web of Science ®Google Scholar
• Frey N, Hügle T, Jick SS, Meier CR, Spoendlin J. Hyperlipidaemia and incident osteoarthritis of the hand: a population-based case-control study. Osteoarthritis Cartilage. 2017;25(7):1040–1045. doi:10.1016/j.joca.2017.01.014
   PubMed Web of Science ®Google Scholar
• Berenbaum F, Griffin TM, Liu‐Bryan R. Review: metabolic Regulation of Inflammation in Osteoarthritis. Arthritis Rheumatol. 2017;69(1):9–21. doi:10.1002/art.39842
   PubMed Web of Science ®Google Scholar
• Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinform. 2008;9:559. doi:10.1186/1471-2105-9-559
   PubMed Web of Science ®Google Scholar
• Gene Ontology Consortium. Gene Ontology Consortium: going forward. Nucleic Acids Res. 2015;43(Databaseissue):D1049–1056. doi:10.1093/nar/gku1179
   PubMed Web of Science ®Google Scholar
• Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545–15550. doi:10.1073/pnas.0506580102
   PubMed Web of Science ®Google Scholar
• Mobasheri A, Rayman MP, Gualillo O, Sellam J, van der Kraan P, Fearon U. The role of metabolism in the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2017;13(5):302–311. doi:10.1038/nrrheum.2017.50
   PubMed Web of Science ®Google Scholar
• Gkretsi V, Simopoulou T, Tsezou A. Lipid metabolism and osteoarthritis: lessons from atherosclerosis. Prog Lipid Res. 2011;50(2):133–140. doi:10.1016/j.plipres.2010.11.001
   PubMed Web of Science ®Google Scholar
• Andia I, Maffulli N. Platelet-rich plasma for managing pain and inflammation in osteoarthritis. Nat Rev Rheumatol. 2013;9(12):721–730. doi:10.1038/nrrheum.2013.141
   PubMed Web of Science ®Google Scholar
• Isomaa B, Almgren P, Tuomi T, et al. Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome. Diabetes Care. 2001;24(4):683–689. doi:10.2337/diacare.24.4.683
   PubMed Web of Science ®Google Scholar
• Zimmet P, Magliano D, Matsuzawa Y, Alberti G, Shaw J. The metabolic syndrome: a global public health problem and a new definition. J Atheroscler Thromb. 2005;12(6):295–300. doi:10.5551/jat.12.295
   PubMed Web of Science ®Google Scholar
• Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009;2(5–6):231–237. doi:10.1242/dmm.001180
   PubMed Web of Science ®Google Scholar
• Mobasheri A, Henrotin Y. Biomarkers of (osteo)arthritis. Biomarkers. 2015;20(8):513–518. doi:10.3109/1354750X.2016.1140930
   PubMed Web of Science ®Google Scholar
• Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. The Lancet. 2011;377(9783):2115–2126. doi:10.1016/S0140-6736(11)60243-2
   PubMed Web of Science ®Google Scholar
• Shi W, Luo L, Loor L. Fatty Acid Elongase 7 (ELOVL7) Plays a Role in the Synthesis of Long-Chain Unsaturated Fatty Acids in Goat Mammary Epithelial Cells. Animals. 2019;9(6):389. doi:10.3390/ani9060389
   Web of Science ®Google Scholar
• Chen S, Hu Z, He H, Liu X. Fatty acid elongase7 is regulated via SP1 and is involved in lipid accumulation in bovine mammary epithelial cells. J Cell Physiol. 2018;233(6):4715–4725. doi:10.1002/jcp.26255
   PubMed Web of Science ®Google Scholar
• Tamura K, Makino A, Hullin-Matsuda F, et al. Novel Lipogenic Enzyme ELOVL7 Is Involved in Prostate Cancer Growth through Saturated Long-Chain Fatty Acid Metabolism. Cancer Res. 2009;69(20):8133–8140. doi:10.1158/0008-5472.CAN-09-0775
   PubMed Web of Science ®Google Scholar
• Ashraf S, Walsh DA. Angiogenesis in osteoarthritis. Curr Opin Rheumatol. 2008;20(5):573–580. doi:10.1097/BOR.0b013e3283103d12
   PubMed Web of Science ®Google Scholar
• Ratneswaran A, LeBlanc EA, Walser E, et al. Peroxisome Proliferator–Activated Receptor δ Promotes the Progression of Posttraumatic Osteoarthritis in a Mouse Model. Arthritis Rheumatol. 2015;67(2):454–464. doi:10.1002/art.38915
   PubMed Web of Science ®Google Scholar
• van Gastel N, Stegen S, Eelen G, et al. Lipid availability determines fate of skeletal progenitor cells via SOX9. Nature. 2020;579(7797):111–117. doi:10.1038/s41586-020-2050-1
   PubMed Web of Science ®Google Scholar
• Busso N, Chobaz-Péclat V, Hamilton J, Spee P, Wagtmann N, So A. Essential role of platelet activation via protease activated receptor 4 in tissue factor-initiated inflammation. Arthritis Res Ther. 2008;10(2):R42. doi:10.1186/ar2400
   PubMed Web of Science ®Google Scholar
• Kotani K, Sakane N, Saiga K, Mu H, Kurozawa Y. Clustered components of the metabolic syndrome and platelet counts in Japanese females. Clin Chem Lab Med. 2007;45:3. doi:10.1515/CCLM.2007.063
   Web of Science ®Google Scholar
• Kwon Y-J, Koh I-H, Chung K, Lee Y-J, Kim H-S. Association between platelet count and osteoarthritis in women older than 50 years. Ther Adv Musculoskelet Dis. 2020;12:1759720X2091286. doi:10.1177/1759720X20912861
   Web of Science ®Google Scholar
• Fan Z, Wang L, Jiang H, Lin Y, Wang Z. Platelet dysfunction and its role in the pathogenesis of psoriasis. Dermatology. 2021;237(1):56–65. doi:10.1159/000505536
   PubMed Web of Science ®Google Scholar
• Nurden AT, Pillois X, Fiore M, et al. Expanding the mutation spectrum affecting αiibβ3 integrin in glanzmann thrombasthenia: screening of the ITGA2B and ITGB3 Genes in a Large International Cohort. Hum Mutat. 2015;36(5):548–561. doi:10.1002/humu.22776
   PubMed Web of Science ®Google Scholar
• Ali S, Ghosh K, Shetty S. Novel genetic abnormalities in Bernard-Soulier syndrome in India. Ann Hematol. 2014;93(3):381–384. doi:10.1007/s00277-013-1895-x
   PubMed Web of Science ®Google Scholar
• Savoia A, Kunishima S, De Rocco D, et al. Spectrum of the mutations in Bernard-Soulier syndrome. Hum Mutat. 2014;35(9):1033–1045. doi:10.1002/humu.22607
   PubMed Web of Science ®Google Scholar
• Wang Q, Onuma K, Liu C, et al. Dysregulated integrin αVβ3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis. JCI Insight. 2019;4(18):e128616. doi:10.1172/jci.insight.128616
   PubMed Web of Science ®Google Scholar
• Fahy N, Farrell E, Ritter T, Ryan AE, Murphy JM. Immune modulation to improve tissue engineering outcomes for cartilage repair in the osteoarthritic joint. Tissue Eng Part B Rev. 2015;21(1):55–66. doi:10.1089/ten.teb.2014.0098
   PubMed Web of Science ®Google Scholar
• Stegen S, Rinaldi G, Loopmans S, et al. Glutamine metabolism controls chondrocyte identity and function. Dev Cell. 2020;53(5):530–544.e8. doi:10.1016/j.devcel.2020.05.001
   PubMed Web of Science ®Google Scholar