The Clinical Significance of the Expression of FEN1 in Primary Osteosarcoma

References

• Lindsey BA, Markel JE, Kleinerman ES. Osteosarcoma overview. Rheumatol Ther. 2017;4:25–43.
   PubMed Web of Science ®Google Scholar
• Czarnecka AM, Synoradzki K, Firlej W, et al. Molecular biology of osteosarcoma. Cancers. 2020;12:2130.
   PubMed Web of Science ®Google Scholar
• Eaton BR, Schwarz R, Vatner R, et al. Osteosarcoma. Pediatr Blood Cancer. 2021;68(Suppl.2):e28352.
   PubMedGoogle Scholar
• Zhang Y, Yang JQ, Zhao N, et al. Progress in the chemotherapeutic treatment of osteosarcoma (Review). Oncol Lett. 2018;16:6228–6237.
   PubMed Web of Science ®Google Scholar
• Kansara M, Teng MW, Smyth MJ, Thomas DM. Translational biology of osteosarcoma. Nat Rev Cancer. 2014;14:722–735.
   PubMed Web of Science ®Google Scholar
• Brown HK, Tellez-Gabriel M, Heymann D. Cancer stem cells in osteosarcoma. Cancer Lett. 2017;386:189–195.
   PubMed Web of Science ®Google Scholar
• Shaikh AB, Li FF, Li M, et al. Present advances and future perspectives of molecular targeted therapy for osteosarcoma. Int J Mol Sci. 2016;17(4):506.
   PubMed Web of Science ®Google Scholar
• Liu Y, Kao HI, Bambara RA. Flap endonuclease 1: a central component of DNA metabolism. Annu Rev Biochem. 2004;73:589–615.
   PubMed Web of Science ®Google Scholar
• Balakrishnan L, Bambara RA. Flap endonuclease 1. Annu Rev Biochem. 2013;82:119–138.
   PubMed Web of Science ®Google Scholar
• Rossi ML, Bambara RA. Reconstituted Okazaki fragment processing indicates two pathways of primer removal. J Biol Chem. 2006;281:26051–26061.
   PubMed Web of Science ®Google Scholar
• He L, Luo L, Zhu H, et al. FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer. Mol Oncol. 2017;11(9):1302–1303.
   PubMed Web of Science ®Google Scholar
• Ma L, Cao X, Wang H, Lu K. Discovery of myricetin as a potent inhibitor of human flap endonuclease 1, which potentially can be used as sensitizing agent against ht-29 human colon cancer cells. J Agric Food Chem. 2019;67(6):1656–1665.
   PubMed Web of Science ®Google Scholar
• Chen YD, Zhang X, Qiu XG, et al. Functional FEN1 genetic variants and haplotypes are associated with glioma risk. J Neuro-Oncol. 2013;111(2):145–151.
   PubMed Web of Science ®Google Scholar
• Zhang K, Keymeulen S, Nelson R, et al. Overexpression of flap endonuclease 1 correlates with enhanced proliferation and poor prognosis of non-small-cell lung cancer. Am J Pathol. 2018;188(1):242–251.
   PubMed Web of Science ®Google Scholar
• Zeng X, Qu XJ, Zhao CY, et al. FEN1 mediates miR-200a methylation and promotes breast cancer cell growth via MET and EGFR signaling. FASEB J. 2019;33(10):10717–10730.
   PubMed Web of Science ®Google Scholar
• Lam JS, Seligson DB, Yu H, et al. Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score. BJU Int. 2006;98(2):445–451.
   PubMed Web of Science ®Google Scholar
• Zhao MS, Ji HJ, Fu Q, Cheng Q, Zhang Y, Yang Y. MicroRNA-134-3p inhibits ovarian cancer progression by targeting flap structure-specific endonuclease 1 in vitro. Oncol Rep. 2021;45(1):119–128.
   PubMed Web of Science ®Google Scholar
• Dong SW, Xiao YB, Ma X, et al. miR-193b increases the chemosensitivity of osteosarcoma cells by promoting FEN1-mediated autophagy. Onco Targets Ther. 2019;12:10089–10098.
   PubMed Web of Science ®Google Scholar
• Xu L, Shen JM, Qu JL, et al. FEN1 is a prognostic biomarker for ER+ breast cancer and associated with tamoxifen resistance through the ERα/cyclin D1/Rb axis. Ann Transl Med. 2021;9(3):258.
   PubMed Web of Science ®Google Scholar
• Liu Q, Hao L, Lou Z, et al. Survival time and prognostic factors of patients with initial noncurative colorectal liver metastases. Medicine (Baltimore). 2017;96:e8831.
   PubMed Web of Science ®Google Scholar
• Li WQ, Hu N, Hyland PL, et al. Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population. Carcinogenesis. 2013;34(7):1536–1542.
   PubMed Web of Science ®Google Scholar
• Becker JR, Gallo D, Leung W, et al. Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner. Nucleic Acids Res. 2018;46(11):5634–5650.
   PubMed Web of Science ®Google Scholar
• Zhao J, Wang G, Del Mundo IM, et al. Distinct mechanisms of nuclease-directed DNA-structure-induced genetic instability in cancer genomes. Cell Rep. 2018;22(5):1200–1210.
   PubMed Web of Science ®Google Scholar
• He L, Zhang Y, Sun H, et al. Targeting DNA flap endonuclease 1 to impede breast cancer progression. eBioMedicine. 2016;14:32–43.
   PubMed Web of Science ®Google Scholar
• Zhang KQ, Keymeulen S, Nelson R, et al. Overexpression of flap endonuclease 1 correlates with enhanced proliferation and poor prognosis of non-small-cell lung cancer. Am J Pathol. 2018;188(1):242–251.
   PubMed Web of Science ®Google Scholar
• Urbanucci A, Sahu B, Seppälä J, et al. Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer. Oncogene. 2012;31(17):2153–2163.
   PubMed Web of Science ®Google Scholar
• Hwang JC, Sung WW, Tu HP, et al. The overexpression of FEN1 and RAD54B may act as independent prognostic factors of lung adenocarcinoma. PLoS One. 2015;10(10):e0139435.
   PubMed Web of Science ®Google Scholar
• Liu ZZ, Cui ST, Tang B, Wang ZZ, Luan ZX. Identification of key biomarkers involved in osteosarcoma using altered modules. Genet Mol Res. 2016;15(3):gmr.15038277.
   Web of Science ®Google Scholar
• Zhang YY, Liu X, Liu LW, et al. Upregulation of FEN1 is associated with the tumor progression and prognosis of Hepatocellular carcinoma. Dis Markers. 2020;2020:2514090.
   PubMed Web of Science ®Google Scholar
• Wang JW, Zhou LN, Li Z, et al. YY1 suppresses FEN1 over-expression and drug resistance in breast cancer. BMC Cancer. 2015;15:50.
   PubMed Web of Science ®Google Scholar
• Dong SW, Xiao YB, Zhu ZQ, et al. Metformin sensitizes osteosarcoma cells to chemotherapy through IGF-1R/miR-610/FEN1 pathway. Res Square. 2021. doi:10.21203/rs.3.rs-147084/v1
   Google Scholar