High Expression of RRM1 Mediated by ncRNAs Correlates with Poor Prognosis and Tumor Immune Infiltration of Hepatocellular Carcinoma

References

• Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.21492
   PubMed Web of Science ®Google Scholar
• Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108. doi:10.3322/caac.21262
   PubMed Web of Science ®Google Scholar
• Yang W, Ma Y, Liu Y, et al. Association of intake of whole grains and dietary fiber with risk of hepatocellular carcinoma in US adults. JAMA Oncol. 2019;5(6):879–886. doi:10.1001/jamaoncol.2018.7159
   PubMed Web of Science ®Google Scholar
• Parker NJ, Begley CG, Fox RM. Human gene for the large subunit of ribonucleotide reductase (RRM1): functional analysis of the promoter. Genomics. 1995;27(2):280–285. doi:10.1006/geno.1995.1043
   PubMed Web of Science ®Google Scholar
• Nordlund P, Reichard P. Ribonucleotide Reductases. Annu Rev Biochem. 2006;75(1):681–706. doi:10.1146/annurev.biochem.75.103004.142443
   PubMed Web of Science ®Google Scholar
• Zhang X, Taoka R, Liu D, et al. Knockdown of RRM1 with adenoviral shRNA vectors to inhibit tumor cell viability and increase chemotherapeutic sensitivity to gemcitabine in bladder cancer cells. Int J Mol Sci. 2021;22(8):4102.
   PubMed Web of Science ®Google Scholar
• Jordheim LP, Sève P, Trédan O, Dumontet C. The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer. Lancet Oncol. 2011;12(7):693–702. doi:10.1016/S1470-2045(10)70244-8
   PubMed Web of Science ®Google Scholar
• Ohtaka K, Kohya N, Sato K, et al. Ribonucleotide reductase subunit M1 is a possible chemoresistance marker to gemcitabine in biliary tract carcinoma. Oncol Rep. 2008;20(2):279–286.
   PubMed Web of Science ®Google Scholar
• Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98–w102. doi:10.1093/nar/gkx247
   PubMed Web of Science ®Google Scholar
• Nagy Á, Lánczky A, Menyhárt O, Győrffy B. Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets. Sci Rep. 2018;8(1):9227. doi:10.1038/s41598-018-27521-y
   PubMed Web of Science ®Google Scholar
• Tay Y, Rinn J, Pandolfi PP. The multilayered complexity of ceRNA crosstalk and competition. Nature. 2014;505(7483):344–352. doi:10.1038/nature12986
   PubMed Web of Science ®Google Scholar
• Wang Z, Fu Y, Xia A, et al. Prognostic and predictive role of a metabolic rate-limiting enzyme signature in hepatocellular carcinoma. Cell Prolif. 2021;54(10):e13117. doi:10.1111/cpr.13117
   PubMed Web of Science ®Google Scholar
• Kong J, Wang T, Zhang Z, Yang X, Shen S, Wang W. Five core genes related to the progression and prognosis of hepatocellular carcinoma identified by analysis of a coexpression network. DNA Cell Biol. 2019;38(12):1564–1576. doi:10.1089/dna.2019.4932
   PubMed Web of Science ®Google Scholar
• Charmpilas N, Daskalaki I, Papandreou ME, Tavernarakis N. Protein synthesis as an integral quality control mechanism during ageing. Ageing Res Rev. 2015;23(Pt A):75–89. doi:10.1016/j.arr.2014.12.008
   PubMed Web of Science ®Google Scholar
• Fabian MR, Sonenberg N, Filipowicz W. Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem. 2010;79:351–379. doi:10.1146/annurev-biochem-060308-103103
   PubMed Web of Science ®Google Scholar
• Wang J, Zhu S, Meng N, He Y, Lu R, Yan GR. ncRNA-encoded peptides or proteins and cancer. Mol Ther. 2019;27(10):1718–1725. doi:10.1016/j.ymthe.2019.09.001
   PubMed Web of Science ®Google Scholar
• Bose R, Ain R. Regulation of transcription by circular RNAs. Adv Exp Med Biol. 2018;1087:81–94.
   PubMed Web of Science ®Google Scholar
• Kamieniarz-Gdula K, Proudfoot NJ. Transcriptional control by premature termination: a forgotten mechanism. Trends Genet. 2019;35(8):553–564. doi:10.1016/j.tig.2019.05.005
   PubMed Web of Science ®Google Scholar
• Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 2015;22(3):256–264. doi:10.1038/nsmb.2959
   PubMed Web of Science ®Google Scholar
• Zhang Z, Lee JH, Ruan H, et al. Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer. Nat Commun. 2019;10(1):4562. doi:10.1038/s41467-019-12543-5
   PubMed Web of Science ®Google Scholar
• Koldobskaya Y, Duguid EM, Shechner DM, et al. A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination. Nat Struct Mol Biol. 2011;18(1):100–106. doi:10.1038/nsmb.1945
   PubMed Web of Science ®Google Scholar
• Anastasiadou E, Jacob LS, Slack FJ. Non-coding RNA networks in cancer. Nat Rev Cancer. 2018;18(1):5–18. doi:10.1038/nrc.2017.99
   PubMed Web of Science ®Google Scholar
• Coker H, Wei G, Brockdorff N. m6A modification of non-coding RNA and the control of mammalian gene expression. Biochim Biophys Acta Gene Regul Mech. 2019;1862(3):310–318. doi:10.1016/j.bbagrm.2018.12.002
   PubMed Web of Science ®Google Scholar
• Panni S, Lovering RC, Porras P, Orchard S. Non-coding RNA regulatory networks. Biochim Biophys Acta Gene Regul Mech. 2020;1863(6):194417. doi:10.1016/j.bbagrm.2019.194417
   PubMed Web of Science ®Google Scholar
• Li S, Shao J, Lou G, Wu C, Liu Y, Zheng M. MiR-144-3p-mediated dysregulation of EIF4G2 contributes to the development of hepatocellular carcinoma through the ERK pathway. J Exp Clin Cancer Res. 2021;40(1):53. doi:10.1186/s13046-021-01853-6
   PubMed Web of Science ®Google Scholar
• Tian Q, Yan X, Yang L, et al. lncRNA NORAD promotes hepatocellular carcinoma progression via regulating miR-144-3p/SEPT2. Am J Transl Res. 2020;12(5):2257–2266.
   PubMed Web of Science ®Google Scholar
• Wu M, Huang C, Huang X, Liang R, Feng Y, Luo X. MicroRNA-144-3p suppresses tumor growth and angiogenesis by targeting SGK3 in hepatocellular carcinoma. Oncol Rep. 2017;38(4):2173–2181. doi:10.3892/or.2017.5900
   PubMed Web of Science ®Google Scholar
• Huang XH, Chen JS, Wang Q, et al. miR-338-3p suppresses invasion of liver cancer cell by targeting smoothened. J Pathol. 2011;225(3):463–472. doi:10.1002/path.2877
   PubMed Web of Science ®Google Scholar
• Pu J, Wang J, Li W, et al. hsa_circ_0000092 promotes hepatocellular carcinoma progression through up-regulating HN1 expression by binding to microRNA-338-3p. J Cell Mol Med. 2020. doi:10.1111/jcmm.15010
   Web of Science ®Google Scholar
• Kuai J, Zheng L, Yi X, et al. ST8SIA6-AS1 promotes the development of hepatocellular carcinoma cells through miR-338-3p/NONO Axis. Dig Liver Dis. 2021;53(9):1192–1200. doi:10.1016/j.dld.2021.02.012
   PubMedGoogle Scholar
• Yang G, Guo S, Liu HT, Yang G. MiR-138-5p predicts negative prognosis and exhibits suppressive activities in hepatocellular carcinoma HCC by targeting FOXC1. Eur Rev Med Pharmacol Sci. 2020;24(17):8788–8800. doi:10.26355/eurrev_202009_22817
   PubMed Web of Science ®Google Scholar
• Zhang S, Lu Y, Jiang HY, et al. CircC16orf62 promotes hepatocellular carcinoma progression through the miR-138-5p/PTK2/AKT axis. Cell Death Dis. 2021;12(6):597. doi:10.1038/s41419-021-03866-7
   PubMed Web of Science ®Google Scholar
• Chen J, Wu FX, Luo HL, et al. Berberine upregulates miR-22-3p to suppress hepatocellular carcinoma cell proliferation by targeting Sp1. Am J Transl Res. 2016;8(11):4932–4941.
   PubMed Web of Science ®Google Scholar
• Shen X, Ding Y, Lu F, Yuan H, Luan W. Long noncoding RNA MIR4435-2HG promotes hepatocellular carcinoma proliferation and metastasis through the miR-22-3p/YWHAZ axis. Am J Transl Res. 2020;12(10):6381–6394.
   PubMed Web of Science ®Google Scholar
• Chang L, Yuan Y, Li C, et al. Upregulation of SNHG6 regulates ZEB1 expression by competitively binding miR-101-3p and interacting with UPF1 in hepatocellular carcinoma. Cancer Lett. 2016;383(2):183–194. doi:10.1016/j.canlet.2016.09.034
   PubMed Web of Science ®Google Scholar
• Sheng Y, Ding S, Chen K, et al. Functional analysis of miR-101-3p and Rap1b involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis. Biochem Cell Biol. 2014;92(2):152–162. doi:10.1139/bcb-2013-0128
   PubMed Web of Science ®Google Scholar
• Yan S, Shan X, Chen K, et al. LINC00052/miR-101-3p axis inhibits cell proliferation and metastasis by targeting SOX9 in hepatocellular carcinoma. Gene. 2018;679:138–149. doi:10.1016/j.gene.2018.08.038
   PubMed Web of Science ®Google Scholar
• Huang L, Chen H, Xu Y, Chen J, Liu Z, Xu Q. Correlation of tumor-infiltrating immune cells of melanoma with overall survival by immunogenomic analysis. Cancer Med. 2020;9(22):8444–8456. doi:10.1002/cam4.3466
   PubMed Web of Science ®Google Scholar
• Petitprez F, Meylan M, de Reyniès A, Sautès-Fridman C, Fridman WH. The tumor microenvironment in the response to immune checkpoint blockade therapies. Front Immunol. 2020;11:784. doi:10.3389/fimmu.2020.00784
   PubMed Web of Science ®Google Scholar
• Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science. 2011;331(6024):1565–1570. doi:10.1126/science.1203486
   PubMed Web of Science ®Google Scholar
• Wang SS, Liu W, Ly D, Xu H, Qu L, Zhang L. Tumor-infiltrating B cells: their role and application in anti-tumor immunity in lung cancer. Cell Mol Immunol. 2019;16(1):6–18. doi:10.1038/s41423-018-0027-x
   PubMed Web of Science ®Google Scholar
• Tuo Z, Zheng X, Zong Y, et al. HK3 is correlated with immune infiltrates and predicts response to immunotherapy in non-small cell lung cancer. Clin Transl Med. 2020;10(1):319–330. doi:10.1002/ctm2.6
   PubMed Web of Science ®Google Scholar
• Slaney CY, Kershaw MH, Darcy PK. Trafficking of T cells into tumors. Cancer Res. 2014;74(24):7168–7174. doi:10.1158/0008-5472.CAN-14-2458
   PubMed Web of Science ®Google Scholar
• Lou W, Wang W, Chen J, Wang S, Huang Y. ncRNAs-mediated high expression of SEMA3F correlates with poor prognosis and tumor immune infiltration of hepatocellular carcinoma. Mol Ther Nucleic Acids. 2021;24:845–855. doi:10.1016/j.omtn.2021.03.014
   PubMedGoogle Scholar