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ORIGINAL RESEARCH

Lectin Complement Pathway Activation is Associated with Massive Proteinuria in PLA2R-Positive Membranous Nephropathy: A Retrospective Study

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Pages 1879-1889 | Received 03 Feb 2023, Accepted 24 Apr 2023, Published online: 17 May 2023

References

  • Debiec H, Ronco P. Immunopathogenesis of membranous nephropathy: an update. Semin Immunopathol. 2014;36(4):381–397. doi:10.1007/s00281-014-0423-y
  • Ronco P, Beck L, Debiec H, et al. Membranous nephropathy. Nat Rev Dis Primers. 2021;7(1):70. doi:10.1038/s41572-021-00310-0
  • Beck LJ, Bonegio RG, Lambeau G, et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. New Engl J Med. 2009;361(1):11–21. doi:10.1056/NEJMoa0810457
  • Debiec H, Ronco P. Immune response against autoantigen PLA2R is not gambling: implications for pathophysiology, prognosis, and therapy. J Am Soc Nephrol. 2016;27(5):1275–1277. doi:10.1681/ASN.2015101170
  • Thompson A, Cattran DC, Blank M, Nachman PH. Complete and partial remission as surrogate end points in membranous nephropathy. J Am Soc Nephrol. 2015;26(12):2930–2937. doi:10.1681/ASN.2015010091
  • van de Logt AE, Fresquet M, Wetzels JF, Brenchley P. The anti-PLA2R antibody in membranous nephropathy: what we know and what remains a decade after its discovery. Kidney Int. 2019;96(6):1292–1302. doi:10.1016/j.kint.2019.07.014
  • Kerjaschki D. Pathomechanisms and molecular basis of membranous glomerulopathy. Lancet. 2004;364(9441):1194–1196. doi:10.1016/S0140-6736(04)17154-7
  • Kerjaschki D, Neale TJ. Molecular mechanisms of glomerular injury in rat experimental membranous nephropathy (Heymann nephritis). J Am Soc Nephrol. 1996;7(12):2518–2526. doi:10.1681/ASN.V7122518
  • Cybulsky AV, Rennke HG, Feintzeig ID, Salant DJ. Complement-induced glomerular epithelial cell injury. Role of the membrane attack complex in rat membranous nephropathy. J Clin Invest. 1986;77(4):1096–1107. doi:10.1172/JCI112408
  • Reddy YN, Siedlecki AM, Francis JM. Breaking down the complement system: a review and update on novel therapies. Curr Opin Nephrol Hy. 2017;26(2):123–128.
  • Gao S, Cui Z, Zhao MH. Complement C3a and C3a receptor activation mediates podocyte injuries in the mechanism of primary membranous nephropathy. J Am Soc Nephrol. 2022;33(9):1742–1756. doi:10.1681/ASN.2021101384
  • Haddad G, Lorenzen JM, Ma H, et al. Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1-associated membranous nephropathy. J Clin Invest. 2021;131(5). doi:10.1172/JCI140453
  • Sinico RA, Mezzina N, Trezzi B, Ghiggeri GM, Radice A. Immunology of membranous nephropathy: from animal models to humans. Clin Exp Immunol. 2016;183(2):157–165. doi:10.1111/cei.12729
  • Huang CC, Lehman A, Albawardi A, et al. IgG subclass staining in renal biopsies with membranous glomerulonephritis indicates subclass switch during disease progression. Modern Pathol. 2013;26(6):799–805. doi:10.1038/modpathol.2012.237
  • Hayashi N, Okada K, Matsui Y, et al. Glomerular mannose-binding lectin deposition in intrinsic antigen-related membranous nephropathy. Nephrol Dial Transpl. 2018;33(5):832–840. doi:10.1093/ndt/gfx235
  • Lhotta K, Würzner R, König P. Glomerular deposition of mannose-binding lectin in human glomerulonephritis. NEPHROL DIAL TRANSPL. 1999;14(4):881–886. doi:10.1093/ndt/14.4.881
  • Zhang Y, Liu Y, Liang L, et al. Effect of glomerular mannose-binding lectin deposition on the prognosis of idiopathic membranous nephropathy. Kidney Blood Press Res. 2020;45(5):713–726. doi:10.1159/000508665
  • Bally S, Debiec H, Ponard D, et al. Phospholipase A2 receptor-related membranous nephropathy and mannan-binding lectin deficiency. J Am Soc Nephrol. 2016;27(12):3539–3544. doi:10.1681/ASN.2015101155
  • Couser WG. Primary Membranous Nephropathy. Clin J Am Soc Nephro. 2017;12(6):983–997. doi:10.2215/CJN.11761116
  • Debiec H, Guigonis V, Mougenot B, et al. Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies. New Engl J Med. 2002;346(26):2053–2060. doi:10.1056/NEJMoa012895
  • Tomas NM, Beck LJ, Meyer-Schwesinger C, et al. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. New Engl J Med. 2014;371(24):2277–2287. doi:10.1056/NEJMoa1409354
  • Rojas-Rivera JE, Ortiz Arduán A. Primary membranous nephropathy in the era of autoantibodies and biological therapies. Med Clín. 2021;157(3):121–129. doi:10.1016/j.medcle.2021.02.004
  • Kerjaschki D, Miettinen A, Farquhar MG. Initial events in the formation of immune deposits in passive Heymann nephritis. gp330-anti-gp330 immune complexes form in epithelial coated pits and rapidly become attached to the glomerular basement membrane. J Exp Med. 1987;166(1):109–128. doi:10.1084/jem.166.1.109
  • Takano T, Elimam H, Cybulsky AV. Complement-mediated cellular injury. Semin Nephrol. 2013;33(6):586–601. doi:10.1016/j.semnephrol.2013.08.009
  • Ronco P, Debiec H. Molecular pathogenesis of membranous nephropathy. ANNU REV PATHOL. 2020;15:287–313. doi:10.1146/annurev-pathol-020117-043811
  • Kon SP, Coupes B, Short CD, et al. Urinary C5b-9 excretion and clinical course in idiopathic human membranous nephropathy. Kidney Int. 1995;48(6):1953–1958. doi:10.1038/ki.1995.496
  • Zhang M, Cui Z, Zhang Y, et al. Clinical and prognostic significance of glomerular C1q deposits in primary MN. Clin Chim Acta. 2018;485:152–157. doi:10.1016/j.cca.2018.06.050
  • Debiec H, Hanoy M, Francois A, et al. Recurrent membranous nephropathy in an allograft caused by IgG3κ targeting the PLA2 receptor. J Am Soc Nephrol. 2012;23(12):1949–1954. doi:10.1681/ASN.2012060577
  • Endo M, Ohi H, Ohsawa I, Fujita T, Matsushita M, Fujita T. Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA nephropathy. Nephrol Dial Transpl. 1998;13(8):1984–1990. doi:10.1093/ndt/13.8.1984
  • Segawa Y, Hisano S, Matsushita M, et al. IgG subclasses and complement pathway in segmental and global membranous nephropathy. Pediatr Nephrol. 2010;25(6):1091–1099. doi:10.1007/s00467-009-1439-8
  • Seifert L, Zahner G, Meyer-Schwesinger C, et al. The classical pathway triggers pathogenic complement activation in membranous nephropathy. Nat Commun. 2023;14(1):473. doi:10.1038/s41467-023-36068-0
  • Tsai SF, Wu MJ, Chen CH. Low serum C3 level, high neutrophil-lymphocyte-ratio, and high platelet-lymphocyte-ratio all predicted poor long-term renal survivals in biopsy-confirmed idiopathic membranous nephropathy. Sci Rep. 2019;9(1):6209. doi:10.1038/s41598-019-42689-7
  • Zipfel PF, Wiech T, Rudnick R, Afonso S, Person F, Skerka C. Complement inhibitors in clinical trials for glomerular diseases. Front Immunol. 2019;10. doi:10.3389/fimmu.2019.02166
  • Larsen CP, Cossey LN, Beck LH. THSD7A staining of membranous glomerulopathy in clinical practice reveals cases with dual autoantibody positivity. Modern Pathol. 2016;29(4):421–426. doi:10.1038/modpathol.2016.32
  • De Vriese AS, Glassock RJ, Nath KA, Sethi S, Fervenza FC. A proposal for a serology-based approach to membranous nephropathy. J Am Soc Nephrol. 2017;28(2):421–430. doi:10.1681/ASN.2016070776
  • Hoxha E, Beck LJ, Wiech T, et al. An Indirect Immunofluorescence method facilitates detection of thrombospondin type 1 domain-containing 7A-specific antibodies in membranous nephropathy. J Am Soc Nephrol. 2017;28(2):520–531. doi:10.1681/ASN.2016010050