Fibrinogen-to-Lymphocyte Ratio Was an Independent Predictor of Lymph Node Metastasis in Patients with Clinically Node-Negative Advanced-Stage Gastric Cancer

References

• Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.21660
   PubMed Web of Science ®Google Scholar
• Schirren R, Reim D, Novotny AR. Adjuvant and/or neoadjuvant therapy for gastric cancer? A perspective review. Ther Adv Med Oncol. 2015;7:39–48.
   PubMed Web of Science ®Google Scholar
• Deng J, Zhang R, Pan Y, et al. N stages of the seventh edition of TNM Classification are the most intensive variables for predictions of the overall survival of gastric cancer patients who underwent limited lymphadenectomy. Tumour Biol. 2014;35:3269–3281.
   PubMedGoogle Scholar
• Chen ZD, Zhang PF, Xi HQ, et al. Recent Advances in the Diagnosis, Staging, Treatment, and Prognosis of Advanced Gastric Cancer: a Literature Review. Front Med. 2021;8:744839.
   Web of Science ®Google Scholar
• Xiong B, Ma L, Cheng Y, et al. Clinical effectiveness of neoadjuvant chemotherapy in advanced gastric cancer: an updated meta-analysis of randomized controlled trials. Eur J Surg Oncol. 2014;40:1321–1330.
   PubMed Web of Science ®Google Scholar
• Kwee RM, Kwee TC. Imaging in assessing lymph node status in gastric cancer. Gastric Cancer. 2009;12:6–22.
   PubMed Web of Science ®Google Scholar
• Fairweather M, Jajoo K, Sainani N, et al. Accuracy of EUS and CT imaging in preoperative gastric cancer staging. J Surg Oncol. 2015;111:1016–1020.
   PubMed Web of Science ®Google Scholar
• Li W, Ye F, Wang D, et al. Protein predictive signatures for lymph node metastasis of gastric cancer. Int J Cancer. 2013;132:1851–1859.
   PubMed Web of Science ®Google Scholar
• Huang KH, Lan YT, Fang WL, et al. The correlation between miRNA and lymph node metastasis in gastric cancer. Biomed Res Int. 2015;2015:543163.
   PubMed Web of Science ®Google Scholar
• McMillan DC. Systemic inflammation, nutritional status and survival in patients with cancer. Curr Opin Clin Nutr Metab Care. 2009;12(3):223–226. doi:10.1097/MCO.0b013e32832a7902
   PubMed Web of Science ®Google Scholar
• Kosuga T, Konishi T, Kubota T, et al. Value of Prognostic Nutritional Index as a Predictor of Lymph Node Metastasis in Gastric Cancer. Anticancer Res. 2019;39(12):6843–6849. doi:10.21873/anticanres.13901
   PubMed Web of Science ®Google Scholar
• Zhang L-X, Wei Z-J, Xu A-M, et al. Can the neutrophil-lymphocyte ratio and platelet-lymphocyte ratio be beneficial in predicting lymph node metastasis and promising prognostic markers of gastric cancer patients? Tumor maker retrospective study. Int J Surg. 2018;56:320–327. doi:10.1016/j.ijsu.2018.06.037
   PubMed Web of Science ®Google Scholar
• Du D, Han Z, Lian D, et al. The value of preoperative lymphocytes-to-monocytes ratio in predicting lymph node metastasis in gastric cancer. Transl Cancer Res. 2019;8(5):2053–2058. doi:10.21037/tcr.2019.09.17
   PubMed Web of Science ®Google Scholar
• Lee SE, Lee JH, Ryu KW, et al. Preoperative plasma fibrinogen level is a useful predictor of adjacent organ involvement in patients with advanced gastric cancer. Journal of Gastric Cancer. 2012;12(2):81–87. doi:10.5230/jgc.2012.12.2.81
   PubMedGoogle Scholar
• Yamashita H, Kitayama J, Nagawa H. Hyperfibrinogenemia is a useful predictor for lymphatic metastasis in human gastric cancer. Jpn J Clin Oncol. 2005;35(10):595–600. doi:10.1093/jjco/hyi150
   PubMed Web of Science ®Google Scholar
• Liu M, Yang J, Wan L, et al. Elevated Pretreatment Fibrinogen-to-Lymphocyte Percentage Ratio Predict Tumor Staging and Poor Survival in Non-Small Cell Lung Cancer Patients with Chemotherapy or Surgery Combined with Chemotherapy. Cancer Manag Res. 2021;13:4921–4933. doi:10.2147/CMAR.S308659
   PubMed Web of Science ®Google Scholar
• Fan N, Chen D, Zheng J, et al. A novel preoperative plasma indicator to predict prognoses for patients with esophageal squamous cell carcinoma after radical esophagectomy: fibrinogen-to-lymphocyte ratio. Cancer Manag Res. 2019;11:4719–4728.
   PubMed Web of Science ®Google Scholar
• Li Y, Li Z, Deng K, et al. Fibrinogen/Lymphocyte Count Ratio Can Be Used as a New Indicator of Prognosis in Patients with Hepatocellular Carcinoma After Radical Resection. Cancer Manag Res. 2020;12:9057–9066.
   PubMed Web of Science ®Google Scholar
• Brkic FF, Stoiber S, Friedl M, et al. The Potential Prognostic Value of a Novel Hematologic Marker Fibrinogen-to-Lymphocyte Ratio in Head and Neck Adenoid-Cystic Carcinoma. J Pers Med. 2021;2:11.
   Google Scholar
• Huang C, Liu Z, Xiao L, et al. Clinical Significance of Serum CA125, CA19-9, CA72-4, and Fibrinogen-to-Lymphocyte Ratio in Gastric Cancer With Peritoneal Dissemination. Front Oncol. 2019;9:1159.
   PubMed Web of Science ®Google Scholar
• Tong C, Wang W, Xia Y, et al. A potential novel biomarker in predicting lymph node metastasis of gastric signet ring cell carcinoma: a derived monocyte to lymphocyte ratio. Am J Surg. 2022;223:1144–1150.
   PubMed Web of Science ®Google Scholar
• Fluss R, Faraggi D, Reiser B. Estimation of the Youden Index and its associated cutoff point. Biom J. 2005;47:458–472.
   PubMed Web of Science ®Google Scholar
• Fukagawa T, Katai H, Mizusawa J, et al. A prospective multi-institutional validity study to evaluate the accuracy of clinical diagnosis of pathological stage III gastric cancer (JCOG1302A). Gastric Cancer. 2018;21:68–73.
   PubMed Web of Science ®Google Scholar
• Kubota K, Suzuki A, Shiozaki H, et al. Accuracy of Multidetector-Row Computed Tomography in the Preoperative Diagnosis of Lymph Node Metastasis in Patients with Gastric Cancer. Gastrointest Tumors. 2017;3:163–170.
   PubMedGoogle Scholar
• Harrell FE, Lee KL, Pollock BG. Regression models in clinical studies: determining relationships between predictors and response. J Natl Cancer Inst. 1988;80:1198–1202.
   PubMed Web of Science ®Google Scholar
• Wang T, Wu Y, Zhou H, et al. Development and validation of a novel competing risk model for predicting survival of esophagogastric junction adenocarcinoma: a SEER population-based study and external validation. BMC Gastroenterol. 2021;21:38.
   PubMed Web of Science ®Google Scholar
• Huang YQ, Liang CH, He L, et al. Development and Validation of a Radiomics Nomogram for Preoperative Prediction of Lymph Node Metastasis in Colorectal Cancer. J Clin Oncol. 2016;34:2157–2164.
   PubMed Web of Science ®Google Scholar
• DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;44:837–845.
   PubMed Web of Science ®Google Scholar
• Falanga A, Marchetti M, Vignoli A. Coagulation and cancer: biological and clinical aspects. J Thromb Haemost. 2013;11:223–233.
   PubMed Web of Science ®Google Scholar
• Steinbrecher KA, Horowitz NA, Blevins EA, et al. Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen. Cancer Res. 2010;70:2634–2643.
   PubMed Web of Science ®Google Scholar
• Palumbo JS, Kombrinck KW, Drew AF, et al. Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells. Blood. 2000;96:3302–3309.
   PubMed Web of Science ®Google Scholar
• Palumbo JS, Talmage KE, Massari JV, et al. Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms. Blood. 2007;110:133–141.
   PubMed Web of Science ®Google Scholar
• Palaj J, Kečkéš Š, Marek V, et al. Fibrinogen Levels Are Associated with Lymph Node Involvement and Overall Survival in Gastric Cancer Patients. Anticancer Res. 2018;38:1097–1104.
   PubMed Web of Science ®Google Scholar
• Kim JY, Kim CH, Lee Y, et al. Tumour infiltrating lymphocytes are predictors of lymph node metastasis in early gastric cancers. Pathology. 2017;49:589–595.
   PubMed Web of Science ®Google Scholar
• Man YG, Stojadinovic A, Mason J, et al. Tumor-infiltrating immune cells promoting tumor invasion and metastasis: existing theories. J Cancer. 2013;4:84–95.
   PubMed Web of Science ®Google Scholar
• Kosuga T, Konishi T, Kubota T, et al. Clinical significance of neutrophil-to-lymphocyte ratio as a predictor of lymph node metastasis in gastric cancer. BMC Cancer. 2019;19:1187.
   PubMed Web of Science ®Google Scholar
• Yin X, Fang T, Wang Y, et al. Prognostic significance of serum inflammation indexes in different Lauren classification of gastric cancer. Cancer Med. 2021;10:1103–1119.
   PubMed Web of Science ®Google Scholar
• Oda I, Gotoda T, Sasako M, et al. Treatment strategy after non-curative endoscopic resection of early gastric cancer. Br J Surg. 2008;95:1495–1500.
   PubMed Web of Science ®Google Scholar