Total T Cell Density and Expression of T Memory Stem Cell Markers are Associated with Better Prognosis in Colon Cancer

References

• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.21660
   PubMed Web of Science ®Google Scholar
• Pagès F, Mlecnik B, Marliot F, et al. International validation of the consensus immunoscore for the classification of colon cancer: a prognostic and accuracy study. Lancet. 2018;391(10135):2128–2139.
   PubMed Web of Science ®Google Scholar
• Mao W, Cai Y, Chen D, et al. Statin shapes inflamed tumor microenvironment and enhances immune checkpoint blockade in non-small cell lung cancer. JCI Insight. 2022. doi:10.1172/jci.insight.161940
   Web of Science ®Google Scholar
• Hamilton PT, Anholt BR, Nelson BH. Tumour immunotherapy: lessons from predator-prey theory. Nat Rev Immunol. 2022. doi:10.1038/s41577-022-00719-y
   PubMed Web of Science ®Google Scholar
• Ephraim R, Feehan J, Fraser S, Nurgali K, Apostolopoulos V. Cancer immunotherapy: the checkpoint between chronic colitis and colorectal cancer. Cancers. 2022;14(24):6131. doi:10.3390/cancers14246131
   PubMed Web of Science ®Google Scholar
• Gattinoni L, Lugli E, Ji Y, et al. A human memory T cell subset with stem cell-like properties. Nat Med. 2011;17(10):1290–1297. doi:10.1038/nm.2446
   PubMed Web of Science ®Google Scholar
• Yan C, Chang J, Song X, et al. Memory stem T cells generated by Wnt signaling from blood of human renal clear cell carcinoma patients. Cancer Biol Med. 2019;16(1):109–124. doi:10.20892/j.issn.2095-3941.2018.0118
   PubMed Web of Science ®Google Scholar
• Jin K, Yu Y, Zeng H, et al. CD103(+)CD8(+) tissue-resident memory T cell infiltration predicts clinical outcome and adjuvant therapeutic benefit in muscle-invasive bladder cancer. Br J Cancer. 2022;126(11):1581–1588. doi:10.1038/s41416-022-01725-6
   PubMed Web of Science ®Google Scholar
• Guan L, Li X, Wei J, et al. Antigen-specific CD8+ memory stem T cells generated from human peripheral blood effectively eradicate allogeneic targets in mice. Stem Cell Res Ther. 2018;9(1):337. doi:10.1186/s13287-018-1080-1
   PubMedGoogle Scholar
• Siddiqui I, Schaeuble K, Chennupati V, et al. Intratumoral Tcf1(+)PD-1(+)CD8(+) T cells with stem-like properties promote tumor control in response to vaccination and checkpoint blockade immunotherapy. Immunity. 2019;50(1):195–211 e10. doi:10.1016/j.immuni.2018.12.021
   PubMed Web of Science ®Google Scholar
• Zanon V, Pilipow K, Scamardella E, et al. Curtailed T-cell activation curbs effector differentiation and generates CD8(+) T cells with a naturally-occurring memory stem cell phenotype. Eur J Immunol. 2017;47(9):1468–1476. doi:10.1002/eji.201646732
   PubMed Web of Science ®Google Scholar
• Wajant H. Therapeutic targeting of CD70 and CD27. Expert Opin Ther Targets. 2016;20(8):959–973. doi:10.1517/14728222.2016.1158812
   PubMed Web of Science ®Google Scholar
• Buchan S, Manzo T, Flutter B, et al. OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence. J Immunol. 2015;194(1):125–133. doi:10.4049/jimmunol.1401644
   PubMed Web of Science ®Google Scholar
• Guégan JP, Ginestier C, Charafe-Jauffret E, et al. CD95/Fas and metastatic disease: what does not kill you makes you stronger. Semin Cancer Biol. 2020;60:121–131. doi:10.1016/j.semcancer.2019.06.004
   PubMed Web of Science ®Google Scholar
• Rana MK, Aloisio FM, Choi C, Barber DL. Formin-dependent TGF-beta signaling for epithelial to mesenchymal transition. Mol Biol Cell. 2018;29(12):1465–1475. doi:10.1091/mbc.E17-05-0325
   PubMed Web of Science ®Google Scholar
• Beier CP, Schulz JB. CD95/Fas in the brain--not just a killer. Cell Stem Cell. 2009;5(2):128–130. doi:10.1016/j.stem.2009.07.008
   PubMed Web of Science ®Google Scholar
• Jeannet G, Boudousquie C, Gardiol N, Kang J, Huelsken J, Held W. Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory. Proc Natl Acad Sci U S A. 2010;107(21):9777–9782. doi:10.1073/pnas.0914127107
   PubMed Web of Science ®Google Scholar
• Pagès F, Kirilovsky A, Mlecnik B, et al. In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer. J Clin Oncol. 2009;27(35):5944–5951. doi:10.1200/JCO.2008.19.6147
   PubMed Web of Science ®Google Scholar
• Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7–33. doi:10.3322/caac.21708
   PubMed Web of Science ®Google Scholar
• Mlecnik B, Tosolini M, Kirilovsky A, et al. Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J Clin Oncol. 2011;29(6):610–618. doi:10.1200/JCO.2010.30.5425
   PubMed Web of Science ®Google Scholar
• Mlecnik B, Bindea G, Angell HK, et al. Integrative analyses of colorectal cancer show immunoscore is a stronger predictor of patient survival than microsatellite instability. Immunity. 2016;44(3):698–711. doi:10.1016/j.immuni.2016.02.025
   PubMed Web of Science ®Google Scholar
• Li Y, Yao Q, Zhang L, et al. Immunohistochemistry-based consensus molecular subtypes as a prognostic and predictive biomarker for adjuvant chemotherapy in patients with stage II colorectal cancer. Oncologist. 2020;25(12):e1968–e1979. doi:10.1002/ONCO.13521
   PubMed Web of Science ®Google Scholar
• Lugli E, Galletti G, Boi SK, Youngblood BA. Stem, effector, and hybrid states of memory CD8(+) T cells. Trends Immunol. 2020;41(1):17–28. doi:10.1016/j.it.2019.11.004
   PubMed Web of Science ®Google Scholar
• Gattinoni L, Speiser DE, Lichterfeld M, Bonini C. T memory stem cells in health and disease. Nat Med. 2017;23(1):18–27. doi:10.1038/nm.4241
   PubMed Web of Science ®Google Scholar
• Zhang G, Liu A, Yang Y, et al. Clinical predictive value of naive and memory T cells in advanced NSCLC. Front Immunol. 2022;13:996348. doi:10.3389/fimmu.2022.996348
   PubMed Web of Science ®Google Scholar
• Roberts DJ, Franklin NA, Kingeter LM, et al. Control of established melanoma by CD27 stimulation is associated with enhanced effector function and persistence, and reduced PD-1 expression of tumor infiltrating CD8(+) T cells. J Immunother. 2010;33(8):769–779. doi:10.1097/CJI.0b013e3181ee238f
   PubMed Web of Science ®Google Scholar
• He LZ, Prostak N, Thomas LJ, et al. Agonist anti-human CD27 monoclonal antibody induces T cell activation and tumor immunity in human CD27-transgenic mice. J Immunol. 2013;191(8):4174–4183. doi:10.4049/jimmunol.1300409
   PubMed Web of Science ®Google Scholar
• Cieri N, Camisa B, Cocchiarella F, et al. IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors. Blood. 2013;121(4):573–584. doi:10.1182/blood-2012-05-431718
   PubMed Web of Science ®Google Scholar
• Fan CF, Xu HT, Lin XY, Yu JH, Wang EH. A multiple marker analysis of apoptosis-associated protein expression in non-small cell lung cancer in a Chinese population. Folia Histochem Cytobiol. 2011;49(2):231–239. doi:10.5603/FHC.2011.0032
   PubMed Web of Science ®Google Scholar