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ORIGINAL RESEARCH

Prognostic Analysis and Biomarkers Identification of Immune Infiltration in Early and Late Stage Hepatocellular Carcinoma Based on TCGA Data

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Pages 2519-2530 | Received 08 May 2023, Accepted 13 Jun 2023, Published online: 16 Jun 2023

References

  • Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–249. doi:10.3322/caac.21660
  • Yang JD, Hainaut P, Gores GJ, et al. A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nat Rev Gastroenterol Hepatol. 2019;16:589–604. doi:10.1038/s41575-019-0186-y
  • Galle PR, Forner A, Llovet JM, et al. EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2018;69:182–236.
  • Villanueva A, Longo DL. Hepatocellular carcinoma. N Engl J Med. 2019;380:1450–1462. doi:10.1056/NEJMra1713263
  • Forner A, Reig M, Bruix J. Hepatocellular carcinoma. Lancet. 2018;391:1301–1314. doi:10.1016/S0140-6736(18)30010-2
  • Aran D, Hu Z, Butte AJ. xCell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol. 2017;18:220. doi:10.1186/s13059-017-1349-1
  • Guo T, Zhang Z, Zhu L, et al. TRIM55 suppresses malignant biological behavior of lung adenocarcinoma cells by increasing protein degradation of Snail1. Cancer Biol Ther. 2022;2022:1–10.
  • Li N, Wang J, Zhan X. Identification of immune-related gene signatures in lung adenocarcinoma and lung squamous cell carcinoma. Front Immunol. 2021;12:752643. doi:10.3389/fimmu.2021.752643
  • Li X, Huang L, Gao W. Overexpression of tripartite motif containing 55 (TRIM55) inhibits migration and invasion of hepatocellular carcinoma (HCC) cells via epithelial-mesenchymal transition and matrix metalloproteinase-2 (MMP2). Med Sci Monit. 2019;25:771–777. doi:10.12659/MSM.910984
  • Ding GY, Zhu XD, Ji Y, et al. Serum PON1 as a biomarker for the estimation of microvascular invasion in hepatocellular carcinoma. Ann Tran Med. 2020;8:204. doi:10.21037/atm.2020.01.44
  • Zhang Y, Ying X, Zhao Q, et al. Identification of protein expression changes in hepatocellular carcinoma through iTRAQ. Dis Markers. 2020;2020:2632716. doi:10.1155/2020/2632716
  • Yu D, Green B, Marrone A, et al. Suppression of CYP2C9 by microRNA hsa-miR-128-3p in human liver cells and association with hepatocellular carcinoma. Sci Rep. 2015;5:8534. doi:10.1038/srep08534
  • Wang X, Yu T, Liao X, et al. The prognostic value of CYP2C subfamily genes in hepatocellular carcinoma. Cancer Med. 2018;7:966–980. doi:10.1002/cam4.1299
  • Ceylan H. Identification of hub genes associated with obesity-induced hepatocellular carcinoma risk based on integrated bioinformatics analysis. Med Oncol. 2021;38:63. doi:10.1007/s12032-021-01510-0
  • Shen H, Wu H, Sun F, et al. A novel four-gene of iron metabolism-related and methylated for prognosis prediction of hepatocellular carcinoma. Bioengineered. 2021;12:240–251. doi:10.1080/21655979.2020.1866303
  • Mu D, Qin F, Li B, et al. Identification of the sixth complement component as potential key genes in hepatocellular carcinoma via bioinformatics analysis. Biomed Res Int. 2020;2020:7042124. doi:10.1155/2020/7042124
  • Zhang Y, Liu JL, Wang J. SAPCD2 promotes invasiveness and migration ability of breast cancer cells via YAP/TAZ. Eur Rev Med Pharmacol Sci. 2020;24:3786–3794. doi:10.26355/eurrev_202004_20844
  • Zhu B, Wu Y, Niu L, et al. Silencing SAPCD2 represses proliferation and lung metastasis of fibrosarcoma by activating hippo signaling pathway. Front Oncol. 2020;10:574383. doi:10.3389/fonc.2020.574383
  • Luo Y, Wang L, Ran W, et al. Overexpression of SAPCD2 correlates with proliferation and invasion of colorectal carcinoma cells. Cancer Cell Int. 2020;20:43. doi:10.1186/s12935-020-1121-6
  • Sun Z, Mao Y, Zhang X, et al. Identification of ARHGEF38, NETO2, GOLM1, and SAPCD2 associated with prostate cancer progression by bioinformatic analysis and experimental validation. Front Cell Develop Bio. 2021;9:718638. doi:10.3389/fcell.2021.718638
  • Li L, Cao Y, Fan Y, et al. Gene signature to predict prognostic survival of hepatocellular carcinoma. Open Med. 2022;17:135–150. doi:10.1515/med-2021-0405
  • Wang Y, Yang H, Zhang G, et al. hsa-miR-7-5p suppresses proliferation, migration and promotes apoptosis in hepatocellular carcinoma cell lines by inhibiting SPC24 expression. Biochem Biophys Res Commun. 2021;561:80–87. doi:10.1016/j.bbrc.2021.05.020
  • Zhang X, Ma L, Zhai L, et al. Construction and validation of a three-microRNA signature as prognostic biomarker in patients with hepatocellular carcinoma. Int J Med Sci. 2021;18:984–999. doi:10.7150/ijms.49126
  • Jiang W, Wen D, Gong L, et al. Circular RNA hsa_circ_0000673 promotes hepatocellular carcinoma malignance by decreasing miR-767-3p targeting SET. Biochem Biophys Res Commun. 2018;500:211–216. doi:10.1016/j.bbrc.2018.04.041
  • Yin J, Liu Q, Chen C, et al. Small regulatory polypeptide of amino acid response negatively relates to poor prognosis and controls hepatocellular carcinoma progression via regulating microRNA-5581-3p/human cardiolipin synthase 1. J Cell Physiol. 2019;234:17589–17599. doi:10.1002/jcp.28383
  • Dong Z, Yang J, Zheng F, et al. The expression of lncRNA XIST in hepatocellular carcinoma cells and its effect on biological function. J BUON. 2020;25:2430–2437.
  • Wang J, Yin G, Bian H, et al. LncRNA XIST upregulates TRIM25 via negatively regulating miR-192 in hepatitis B virus-related hepatocellular carcinoma. Molecul Med. 2021;27:41. doi:10.1186/s10020-021-00278-3
  • Liu WG, Xu Q. Long non-coding RNA XIST promotes hepatocellular carcinoma progression by sponging miR-200b-3p. Eur Rev Med Pharmacol Sci. 2019;23:9857–9862. doi:10.26355/eurrev_201911_19549
  • Ding S, Jin Y, Hao Q, et al. LncRNA BCYRN1/miR-490-3p/POU3F2, served as a ceRNA network, is connected with worse survival rate of hepatocellular carcinoma patients and promotes tumor cell growth and metastasis. Cancer Cell Int. 2020;20:6. doi:10.1186/s12935-019-1081-x
  • Dai W, Dai JL, Tang MH, et al. lncRNA-SNHG15 accelerates the development of hepatocellular carcinoma by targeting miR-490-3p/ histone deacetylase 2 axis. World J Gastroenterol. 2019;25:5789–5799. doi:10.3748/wjg.v25.i38.5789