Contribution of Aflatoxin B₁ Exposure to Liver Cirrhosis in Eastern Ethiopia: A Case-Control Study

References

• Huang DQ, Terrault NA, Tacke F, et al. Global epidemiology of cirrhosis — aetiology, trends and predictions. Nat Rev Gastroenterol Hepatol. 2023;20 (6) :388–398.
   PubMed Web of Science ®Google Scholar
• World Health Organization. Global health estimates 2020: deaths by cause, age, sex, by country and by region, 2000–2019. Available from: https://who.int/data/gho/data/themes/mortality-andglobal-health-estimates/ghe-leadingcauses-of-death. Accessed May 28, 2023.
   Google Scholar
• Tapper EB, Ufere NN, Huang DQ, et al. Review article: current and emerging therapies for the management of cirrhosis and its complications. Aliment Pharmacol Ther. 2022;55(9):1099–1115. doi:10.1111/apt.16831
   PubMed Web of Science ®Google Scholar
• Wang K, Yang F, Zhang P, et al. Genetic effects of iron levels on liver injury and risk of liver diseases: a two-sample Mendelian randomization analysis. Front Nutr. 2022;9:964163.
   PubMedGoogle Scholar
• Mokdad AA, Lopez AD, Shahraz S, et al. Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis. BMC Med. 2014;12(1):145. doi:10.1186/s12916-014-0145-y
   PubMedGoogle Scholar
• Orlien SMS, Ismael NY, Ahmed TA, et al. Unexplained chronic liver disease in Ethiopia: a cross sectional study. BMC Gastroenterol. 2018;18(1):27. doi:10.1186/s12876-018-0755-5
   PubMedGoogle Scholar
• Kuniholm MH, Lesi OA, Mendy M, et al. Aflatoxin exposure and viral hepatitis in the etiology of liver cirrhosis in the Gambia, West Africa. Environ Health Perspect. 2008;116(11):1553–1557. doi:10.1289/ehp.11661
   PubMed Web of Science ®Google Scholar
• Chu YJ, Yang HI, Wu HC, et al. Aflatoxin B1 exposure increases the risk of cirrhosis and hepatocellular carcinoma in chronic hepatitis B virus carriers. Int J Cancer. 2017;141(4):711–720. doi:10.1002/ijc.30782
   PubMed Web of Science ®Google Scholar
• Alvarez CS, Hernández E, Escobar K, et al. Aflatoxin B1exposure and liver cirrhosis in Guatemala: a case–control study. BMJ Open Gastroenterol. 2020;7(1):e000380. doi:10.1136/bmjgast-2020-000380
   PubMed Web of Science ®Google Scholar
• Mekuria AN, Routledge MN, Gong YY, et al. Aflatoxins as a risk factor for liver cirrhosis: a systematic review and meta-analysis. BMC Pharmacol Toxicol. 2020;21(1):39.
   PubMed Web of Science ®Google Scholar
• Chala A, Mohammed A, Ayalew A, et al. Natural occurrence of aflatoxins in groundnut (Arachis hypogaea L.) from eastern Ethiopia. Food Control. 2013;30(2):602–605. doi:10.1016/j.foodcont.2012.08.023
   Web of Science ®Google Scholar
• Chala A, Taye W, Ayalew A, et al. Multimycotoxin analysis of sorghum (Sorghum bicolor L. Moench) and finger millet (Eleusine coracana L. Garten) from Ethiopia. Food Control. 2014;45:29–35. doi:10.1016/j.foodcont.2014.04.018
   Web of Science ®Google Scholar
• Taye W, Ayalew A, Chala A, et al. Aflatoxin B 1 and total fumonisin contamination and their producing fungi in fresh and stored sorghum grain in East Hararghe, Ethiopia. Food Addit Contam Part B Surveill. 2016;9(4):237–245. doi:10.1080/19393210.2016.1184190
   PubMed Web of Science ®Google Scholar
• Mamo FT, Abate BA, Tesfaye K, et al. Mycotoxins in Ethiopia: a review on prevalence, economic and health impacts. Toxins. 2020;12(10):648. doi:10.3390/toxins12100648
   PubMed Web of Science ®Google Scholar
• Mohammed A, Bekeko Z, Yusufe M, et al. Fungal species and multi-mycotoxin associated with post-harvest Sorghum (Sorghum bicolor (L.) Moench) Grain in Eastern Ethiopia. Toxins. 2022;14(7):473. doi:10.3390/toxins14070473
   PubMed Web of Science ®Google Scholar
• Lin D-Y, Sheen I-S, Chiu C-T, et al. Ultrasonographic changes of early liver cirrhosis in chronic hepatitis B: a longitudinal study. J Clin Ultrasound. 1993;21(5):303–308. doi:10.1002/jcu.1870210502
   PubMed Web of Science ®Google Scholar
• Shen L, Li JQ, Zeng MD, et al. Correlation between ultrasonographic and pathologic diagnosis of liver fibrosis due to chronic virus hepatitis. World J Gastroenterol. 2006;12(8):1292–1295. doi:10.3748/wjg.v12.i8.1292
   PubMed Web of Science ®Google Scholar
• Hagström H. Alcohol consumption in concomitant liver disease: how much is too much? Curr Hepatol Rep. 2017;16(2):152–157. doi:10.1007/s11901-017-0343-0
   PubMedGoogle Scholar
• Heikkinen H, Jallinoja P, Saarni SI, et al. The impact of smoking on health-related and overall quality of life: a general population survey in Finland. Nicotine Tob Res. 2008;10(7):1199–1207. doi:10.1080/14622200802163142
   PubMed Web of Science ®Google Scholar
• Hidese S, Ota M, Matsuo J, et al. Association of body mass index and its classifications with gray matter volume in individuals with a wide range of body mass index group: a whole-brain magnetic resonance imaging study. Original Research. Front Human Neurosci. 2022;16. doi:10.3389/fnhum.2022.926804
   PubMed Web of Science ®Google Scholar
• Chapot B, Wild CP. ELISA for quantification of aflatoxin-albumin adducts and their application to human exposure assessment. In: Warhol M, van Velzen D, Bullock GR, editors. Techniques in Diagnostic Pathology. San Diego CA: Academic Press; 1991:135–155.
   Google Scholar
• Orlien SMS, Sandven I, Berhe NB, et al. Khat chewing increases the risk for developing chronic liver disease: a hospital-based case-control study. Hepatol. 2018;68(1):248–257. doi:10.1002/hep.29809
   PubMed Web of Science ®Google Scholar
• Hung TH, Liang CM, Hsu CN, et al. Association between complicated liver cirrhosis and the risk of hepatocellular carcinoma in Taiwan. PLoS One. 2017;12(7):e0181858. doi:10.1371/journal.pone.0181858
   PubMed Web of Science ®Google Scholar
• Kedar Mukthinuthalapati VVP, Sewram V, Ndlovu N, et al. Hepatocellular carcinoma in Sub- Saharan Africa. JCO Glob Oncol. 2021;7:756–766. doi:10.1200/GO.20.00425
   PubMedGoogle Scholar
• Sonderup MW, Spearman CW. Global disparities in hepatitis B elimination-a focus on Africa. Viruses. 2022;14(1):82. doi:10.3390/v14010082
   PubMed Web of Science ®Google Scholar
• Ansari A, Vincent JP, Moorhouse L, et al. Risk of early horizontal transmission of hepatitis B virus in children of uninfected mothers in sub-Saharan Africa: a systematic review and meta-analysis. Lancet Glob Health. 2023;11(5):e715–e728. doi:10.1016/S2214-109X(23)00131-6
   PubMed Web of Science ®Google Scholar
• Ismail A, Naeem I, Gong YY, et al. Early life exposure to dietary aflatoxins, health impact and control perspectives: a review. Trends Food Sci Technol. 2021;112:212–224. doi:10.1016/j.tifs.2021.04.002
   Web of Science ®Google Scholar
• Edmunds WJ, Medley GF, Nokes DJ, et al. The influence of age on the development of the hepatitis B carrier state. Proc Biol Sci. 1993;253:197–201.
   PubMed Web of Science ®Google Scholar
• Shimakawa Y, Yan H-J, Tsuchiya N, et al. Association of early age at establishment of chronic hepatitis B infection with persistent viral replication, liver cirrhosis and hepatocellular carcinoma: a systematic review. PLoS One. 2013;8(7):e69430. doi:10.1371/journal.pone.0069430
   PubMed Web of Science ®Google Scholar
• Malik A, Ali S, Shahid M, et al. Occupational exposure to Aspergillus and aflatoxins among food-grain workers in India. Int J Occup Environ Health. 2014;20(3):189–193. doi:10.1179/2049396714Y.0000000055
   PubMed Web of Science ®Google Scholar
• Wangia RN, Tang L, Wang J-S. Occupational exposure to aflatoxins and health outcomes: a review. J Environ Sci Health C. 2019;37(4):215–234. doi:10.1080/10590501.2019.1664836
   PubMedGoogle Scholar
• Udomkun P, Wossen T, Nabahungu NL, et al. Incidence and farmers’ knowledge of aflatoxin contamination and control in Eastern Democratic Republic of Congo. Food Sci Nutr. 2018;6(6):1607–1620. doi:10.1002/fsn3.735
   PubMed Web of Science ®Google Scholar
• Gichohi-Wainaina WN, Kumwenda N, Zulu R, et al. Aflatoxin contamination: knowledge disparities among agriculture extension officers, frontline health workers and small holder farming households in Malawi. Food Control. 2021;121:107672. doi:10.1016/j.foodcont.2020.107672
   Web of Science ®Google Scholar
• Manfo FPT, Mboe SA, Nantia EA, et al. Evaluation of the effects of agro pesticides use on liver and kidney function in farmers from Buea, Cameroon. J Toxicol. 2020;2020:2305764. doi:10.1155/2020/2305764
   PubMed Web of Science ®Google Scholar
• Huang X, Zhang C, Hu R, et al. Association between occupational exposures to pesticides with heterogeneous chemical structures and farmer health in China. Sci Rep. 2016;6(1):25190. doi:10.1038/srep25190
   PubMedGoogle Scholar
• Prado-Lu JL D. Pesticide exposure, risk factors, and health problems among cut-flower farmers: a cross-sectional study. J Occup Med Toxicol. 2007;2:9. doi:10.1186/1745-6673-2-9
   PubMedGoogle Scholar
• Nigatu AW, Bråtveit M, Moen BE. Self-reported acute pesticide intoxications in Ethiopia. BMC Public Health. 2016;16(1):575. doi:10.1186/s12889-016-3196-5
   PubMedGoogle Scholar
• Tessema RA, Nagy K, Ádám B. Pesticide use, perceived health risks and management in Ethiopia and in Hungary: a comparative analysis. Int J Environ Res Public Health. 2021;18(19):10431. doi:10.3390/ijerph181910431
   PubMed Web of Science ®Google Scholar
• Alebachew F, Azage M, Kassie GG, et al. Pesticide use safety practices and associated factors among farmers in Fogera district wetland areas, south Gondar zone, Northwest Ethiopia. PLoS One. 2023;18(1):e0280185. doi:10.1371/journal.pone.0280185
   PubMed Web of Science ®Google Scholar
• Derso AG, Dagnew GG. Exposure and health risk assessment of farmers to DDT during khat production in Chiro Woreda, West Hararghe Zone: Ethiopia. World J Agri Res. 2019;7:29–35.
   Google Scholar
• Regassa G, Regassa C. Knowledge and attitude of khat growing farmers on the safe use and handling of pesticides in Haromaya Wereda, Oromia Regional State, Eastern Ethiopia. Afr J Environ Sci Technol. 2021;15:16–26. doi:10.5897/AJEST2020.2916
   Google Scholar
• Robinson O. Aetiology of an Unknown Liver Disease in Northern Ethiopia. Imperial College London; 2012.
   Google Scholar
• Coumoul X, Diry M, Barouki R. PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides. Biochem Pharmacol. 2002;64(10):473–479. doi:10.1016/S0006-2952(02)01298-4
   PubMed Web of Science ®Google Scholar
• Zhao B, Shen H, Liu F, et al. Exposure to organochlorine pesticides is independent risk factor of hepatocellular carcinoma: a case–control study. J Expo Sci Environ Epidemiol. 2011;21(6):601–608. doi:10.1038/jes.2011.24
   PubMed Web of Science ®Google Scholar
• Seen S. Chronic liver disease and oxidative stress – a narrative review. Expert Rev Gastroenterol Hepatol. 2021;15(9):1021–1035.
   PubMed Web of Science ®Google Scholar
• Conde de la Rosa L, Goicoechea L, Torres S, et al. Role of oxidative stress in liver disorders. Livers. 2022;2(4):283–314.
   Google Scholar
• Rybicka M, Woziwodzka A, Sznarkowska A, et al. Liver cirrhosis in chronic hepatitis B patients is associated with genetic variations in DNA repair pathway genes. Cancers. 2020;12(11):3295. doi:10.3390/cancers12113295
   PubMed Web of Science ®Google Scholar
• Ashouri S, Khor SS, Hitomi Y, et al. Genome-wide association study for chronic hepatitis B infection in the Thai Population. Front Genet. 2022;13:887121. doi:10.3389/fgene.2022.887121
   PubMed Web of Science ®Google Scholar
• Deng J, Zhao L, Zhang NY, et al. Aflatoxin B1 metabolism: regulation by phase I and II metabolizing enzymes and chemoprotective agents. Mutat Res/Rev Mutat Res. 2018;778:79–89. doi:10.1016/j.mrrev.2018.10.002
   PubMed Web of Science ®Google Scholar
• Eom SY, Yim DH, Zhang Y, et al. Dietary aflatoxin B1 intake, genetic polymorphisms of CYP1A2, CYP2E1, EPHX1, GSTM1, and GSTT1, and gastric cancer risk in Korean. Cancer Causes Control. 2013;24(11):1963–1972. doi:10.1007/s10552-013-0272-3
   PubMed Web of Science ®Google Scholar
• Alberts CJ, Clifford GM, Georges D, et al. Worldwide prevalence of hepatitis B virus and hepatitis C virus among patients with cirrhosis at country, region, and global levels: a systematic review. Lancet Gastroenterol Hepatol. 2022;7(8):724–735. doi:10.1016/S2468-1253(22)00050-4
   PubMed Web of Science ®Google Scholar
• Tesfaye BT, Feyissa TM, Workneh AB, et al. Chronic liver disease in Ethiopia with a particular focus on the etiological spectrums: a systematic review and meta-analysis of observational studies. Can J Gastroenterol Hepatol. 2021;2021:8740157. doi:10.1155/2021/8740157
   PubMed Web of Science ®Google Scholar
• Chuang YC, Tsai K-N, Ou JHJ. Pathogenicity and virulence of Hepatitis B virus. Virulence. 2022;13(1):258–296. doi:10.1080/21505594.2022.2028483
   PubMed Web of Science ®Google Scholar
• Suhail M, Abdel-Hafiz H, Ali A, et al. Potential mechanisms of hepatitis B virus induced liver injury. World J Gastroenterol. 2014;20(35):12462–12472. doi:10.3748/wjg.v20.i35.12462
   PubMed Web of Science ®Google Scholar
• Zhang Z, Wang C, Liu Z, et al. Host genetic determinants of hepatitis B virus infection. Front Genet. 2019;10:696. doi:10.3389/fgene.2019.00696
   PubMed Web of Science ®Google Scholar
• Lin J, Wu JF, Zhang Q, et al. Virus-related liver cirrhosis: molecular basis and therapeutic options. World J Gastroenterol. 2014;20(21):6457–6469. doi:10.3748/wjg.v20.i21.6457
   PubMed Web of Science ®Google Scholar
• Hosny G, Farahat N, Tayel H, et al. Ser-249 TP53 and CTNNB1 mutations in circulating free DNA of Egyptian patients with hepatocellular carcinoma versus chronic liver diseases. Cancer Lett. 2008;264(2):201–208. doi:10.1016/j.canlet.2008.01.031
   PubMed Web of Science ®Google Scholar
• Aydın M, Aydın S, Bacanlı M, et al. Aflatoxin levels in chronic hepatitis B patients with cirrhosis or hepatocellular carcinoma in Balıkesir, Turkey. J Viral Hepat. 2015;22(11):926–935. doi:10.1111/jvh.12410
   PubMed Web of Science ®Google Scholar
• Chen CH, Wang MH, Wang JH, et al. Aflatoxin exposure and hepatitis C virus in advanced liver disease in a hepatitis C virus endemic area in Taiwan. Am J Trop Med Hyg. 2007;77(4):747–752. doi:10.4269/ajtmh.2007.77.747
   PubMed Web of Science ®Google Scholar
• Yen YH, Kuo FY, Chen CH, et al. Ultrasound is highly specific in diagnosing compensated cirrhosis in chronic hepatitis C patients in real world clinical practice. Med. 2019;98(27):e16270. doi:10.1097/MD.0000000000016270
   PubMed Web of Science ®Google Scholar
• Kelly EMM, Feldstein VA, Parks M, et al. An assessment of the clinical accuracy of ultrasound in diagnosing cirrhosis in the absence of portal hypertension. Gastroenterol Hepatol. 2018;14(6):367–373.
   Google Scholar