Usefulness of Serum Translocator Protein as a Potential Predictive Biochemical Marker of Three-Month Cognitive Impairment After Acute Intracerebral Hemorrhage: A Prospective Observational Cohort Study

References

• Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H, Hanley DF. Spontaneous intracerebral hemorrhage. N Engl J Med. 2001;344(19):1450–1460. doi:10.1056/NEJM200105103441907
   PubMed Web of Science ®Google Scholar
• Rost NS, Brodtmann A, Pase MP, et al. Post-Stroke Cognitive Impairment and Dementia. Circ Res. 2022;130(8):1252–1271. doi:10.1161/CIRCRESAHA.122.319951
   PubMed Web of Science ®Google Scholar
• Kazim SF, Ogulnick JV, Robinson MB, et al. Cognitive impairment after intracerebral hemorrhage: a systematic review and meta-analysis. World Neurosurg. 2021;148:141–162. doi:10.1016/j.wneu.2021.01.026
   PubMed Web of Science ®Google Scholar
• Griauzde J, Lisabeth LD, Li C, et al. A population-based study of the outcomes of intracerebral hemorrhage survivors. J Stroke Cerebrovasc Dis. 2019;28(1):49–55. doi:10.1016/j.jstrokecerebrovasdis.2018.09.005
   PubMed Web of Science ®Google Scholar
• Gao Y, Wang B, Miao Y, Han Y. Serum neuroglobin as a potential prognostic biomarker for cognitive impairment after intracerebral hemorrhage. Front Neurol. 2022;13:885323. doi:10.3389/fneur.2022.885323
   PubMed Web of Science ®Google Scholar
• Xia M, Su Y, Fu J, et al. Use of serum matrix metalloproteinases in cerebral amyloid angiopathy-related intracerebral hemorrhage and cognitive impairment. J Alzheimers Dis. 2021;82(3):1159–1170. doi:10.3233/JAD-210288
   PubMed Web of Science ®Google Scholar
• Lan TY, Cui DY, Liu TT, Pan JY, Wang X. Correlation of serum ferritin levels with neurological function-related indices and cognitive dysfunction in patients with cerebral hemorrhage. Clin Neuropathol. 2021;40(6):333–340. doi:10.5414/NP301368
   PubMed Web of Science ®Google Scholar
• Papadopoulos V, Baraldi M, Guilarte TR, et al. Translocator protein (18kDa): a new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci. 2006;27(8):402–409. doi:10.1016/j.tips.2006.06.005
   PubMed Web of Science ®Google Scholar
• Singh P, Adhikari A, Singh D, Gond C, Tiwari AK. The 18-kDa translocator protein PET tracers as a diagnostic marker for neuroinflammation: development and current standing. ACS Omega. 2022;7(17):14412–14429. doi:10.1021/acsomega.2c00588
   PubMed Web of Science ®Google Scholar
• Liu GJ, Middleton RJ, Hatty CR, et al. The 18 kDa translocator protein, microglia and neuroinflammation. Brain Pathol. 2014;24(6):631–653. doi:10.1111/bpa.12196
   PubMed Web of Science ®Google Scholar
• Messmer K, Reynolds GP. Increased peripheral benzodiazepine-binding sites in the brains of patients with Huntington disease. Neurosci Lett. 1998;241(1):53–56. doi:10.1016/s0304-3940(97)00967-1
   PubMed Web of Science ®Google Scholar
• Zhou R, Ji B, Kong Y, et al. PET imaging of neuroinflammation in Alzheimer’s disease. Front Immunol. 2021;12:739130. doi:10.3389/fimmu.2021.739130
   PubMed Web of Science ®Google Scholar
• Dupont AC, Largeau B, Santiago Ribeiro MJ, Guilloteau D, Tronel C, Arlicot N. Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) imaging and its clinical impact in neurodegenerative diseases. Int J Mol Sci. 2017;18(4):785. doi:10.3390/ijms18040785
   PubMed Web of Science ®Google Scholar
• Li HD, Li M, Shi E, et al. A translocator protein 18 kDa agonist protects against cerebral ischemia/reperfusion injury. J Neuroinflammation. 2017;14(1):151. doi:10.1186/s12974-017-0921-7
   PubMed Web of Science ®Google Scholar
• Li M, Ren H, Sheth KN, Shi FD, Liu Q. TSPO ligands attenuate brain injury after intracerebral hemorrhage. FASEB J. 2017;31(8):3278–3287. doi:10.1096/fj.201601377RR
   PubMed Web of Science ®Google Scholar
• Papadopoulos V, Lecanu L. Translocator protein (18 kDa) TSPO: an emerging therapeutic target in neurotrauma. Exp Neurol. 2009;219(1):53–57. doi:10.1016/j.expneurol.2009.04.016
   PubMed Web of Science ®Google Scholar
• Luo LF, Weng JF, Cen M, et al. Prognostic significance of serum translocator protein in patients with traumatic brain injury. Clin Chim Acta. 2019;488:25–30. doi:10.1016/j.cca.2018.10.035
   PubMed Web of Science ®Google Scholar
• Chen WH, Yeh HL, Tsao CW, et al. Plasma translocator protein levels and outcomes of acute ischemic stroke: a pilot study. Dis Markers. 2018;2018:9831079. doi:10.1155/2018/9831079
   PubMed Web of Science ®Google Scholar
• Jiang W, Jin P, Bao Q, Wei W, Jiang W. Prognostic significance of serum translocator protein in patients with spontaneous intracerebral hematoma: preliminary findings. Neurol Res. 2021;43(5):412–417. doi:10.1080/01616412.2020.1866372
   PubMed Web of Science ®Google Scholar
• Li Y, Chen X, Zhou R, et al. Correlation between cognitive impairment, homocysteine, and S100B levels in patients with progressive ischemic stroke. Neuropsychiatr Dis Treated. 2023;19:209–217. doi:10.2147/NDT.S393624
   PubMed Web of Science ®Google Scholar
• Huang YY, Chen SD, Leng XY, et al. Post-stroke cognitive impairment: epidemiology, risk factors, and management. J Alzheimers Dis. 2022;86(3):983–999. doi:10.3233/JAD-215644
   PubMed Web of Science ®Google Scholar
• Sanford AM. Mild Cognitive Impairment. Clin Geriatr Med. 2017;33(3):325–337. doi:10.1016/j.cger.2017.02.005
   PubMed Web of Science ®Google Scholar
• Kim KY, Shin KY, Chang KA. Potential biomarkers for post-stroke cognitive impairment: a systematic review and meta-analysis. Int J Mol Sci. 2022;23(2):602. doi:10.3390/ijms23020602
   PubMed Web of Science ®Google Scholar
• Zhang X, Bi X. Post-stroke cognitive impairment: a review focusing on molecular biomarkers. J Mol Neurosci. 2020;70(8):1244–1254. doi:10.1007/s12031-020-01533-8
   PubMed Web of Science ®Google Scholar
• Choi J, Ifuku M, Noda M, et al. Translocator protein (18 kDa)/peripheral benzodiazepine receptor-specific ligands induce microglial functions consistent with an activated state. Glia. 2011;59(2):219–230. doi:10.1002/glia.21091
   PubMed Web of Science ®Google Scholar
• Karlstetter M, Nothdurfter C, Aslanidis A, et al. The translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis. J Neuroinflammation. 2014;11:3. doi:10.1186/1742-2094-11-3
   PubMed Web of Science ®Google Scholar
• Yao R, Pan R, Shang C, et al. Translocator protein 18 kDa (TSPO) deficiency inhibits microglial activation and impairs mitochondrial function. Front Pharmacol. 2020;11:986. doi:10.3389/fphar.2020.00986
   PubMed Web of Science ®Google Scholar
• Barron AM, Garcia-Segura LM, Caruso D, et al. The ligand for the translocator protein reverses the pathology in a mouse model of Alzheimer’s disease. J Neurosci. 2013;33(20):8891–8897. doi:10.1523/JNEUROSCI.1350-13.2013
   PubMed Web of Science ®Google Scholar
• Fairley LH, Sahara N, Aoki I, et al. Neuroprotective effects of the mitochondrial translocator protein ligand in a mouse model of tauopathy. J Neuroinflammation. 2021;18(1):76. doi:10.1186/s12974-021-02122-1
   PubMed Web of Science ®Google Scholar
• Christensen A, Pike CJ. TSPO ligand PK11195 improves Alzheimer-related outcomes in aged female 3xTg-AD mice. Neurosci Lett. 2018;683:7–12. doi:10.1016/j.neulet.2018.06.029
   PubMed Web of Science ®Google Scholar
• Fairley LH, Lai KO, Wong JH, et al. Mitochondrial control of microglial phagocytosis by translocator protein and hexokinase 2 in Alzheimer’s disease. Proc Natl Acad Sci U S A. 2023;120(8):e2209177120. doi:10.1073/pnas.2209177120
   PubMed Web of Science ®Google Scholar
• Shi Y, Cui M, Ochs K, et al. Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO). Nat Neurosci. 2022;25(3):317–329. doi:10.1038/s41593-022-01013-9
   PubMed Web of Science ®Google Scholar
• Kreisl WC, Lyoo CH, McGwier M, et al. In vivo radioligand binding to translocator proteins correlates with AD severity. Brain. 2013;136(Pt 7):2228–2238. doi:10.1093/brain/awt145
   PubMedGoogle Scholar
• Bradburn S, Murgatroyd C, Ray N. Neuroinflammation in mild cognitive impairment and Alzheimer’s disease: a meta-analysis. Ageing Res Rev. 2019;50:1–8. doi:10.1016/j.arr.2019.01.002
   PubMed Web of Science ®Google Scholar
• Feng H, Wang X, Wang W, Zhao X. Lipid levels and 3-month prognosis after spontaneous intracerebral hemorrhage in women. Front Neurol. 2021;12:690194. doi:10.3389/fneur.2021.690194
   PubMed Web of Science ®Google Scholar
• James ML, Langefeld CD, Sekar P, et al. Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage. Neurology. 2017;89(10):1011–1019. doi:10.1212/WNL.0000000000004255
   PubMed Web of Science ®Google Scholar
• Sagar R, Kumar A, Verma V, et al. Incremental accuracy of blood biomarkers for predicting clinical outcomes after intracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2021;30(3):105537. doi:10.1016/j.jstrokecerebrovasdis.2020.105537
   PubMed Web of Science ®Google Scholar
• You S, Wang X, Lindley RI, et al. Early cognitive impairment after intracerebral hemorrhage in the INTERACT1 Study. Cerebrovasc Dis. 2017;44(5–6):320–324. doi:10.1159/000481443
   PubMed Web of Science ®Google Scholar