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Oncology

Involvement of the ABCB1 C3435T Variant but Not the MTHFR C677T or MTHFR A1298C Variant in High-Dose Methotrexate-Induced Toxicity in Pediatric Acute Lymphoblastic Leukemia Patients in China

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Pages 1221-1231 | Received 05 Dec 2023, Accepted 18 Mar 2024, Published online: 27 Mar 2024

References

  • Zgheib NK, Akra-Ismail M, Aridi C, et al. Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia. Pharmacogenetics and Genomics. 2014;24(8):387–396. doi:10.1097/FPC.0000000000000069
  • Hao Q, Song Y, Fang Q, et al. Effects of genetic polymorphisms on methotrexate levels and toxicity in Chinese patients with acute lymphoblastic leukemia. Blood Science. 2023;5(1):32–38. doi:10.1097/BS9.0000000000000142
  • Li X, Sui Z, Jing F, et al. Identifying risk factors for high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukemia. Cancer Manage Res. 2019;11:6265–6274. doi:10.2147/CMAR.S207959
  • den Hoed MA, Lopez-Lopez E, te Winkel ML, et al. Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia. Pharmacogenomics J. 2015;15(3):248–254. doi:10.1038/tpj.2014.63
  • D’Angelo V, Ramaglia M, Iannotta A, et al. Methotrexate toxicity and efficacy during the consolidation phase in paediatric acute lymphoblastic leukaemia and MTHFR polymorphisms as pharmacogenetic determinants. Cancer Chemother Pharmacol. 2011;68(5):1339–1346. doi:10.1007/s00280-011-1665-1
  • Shen Y, Wang Z, Zhou F, Jin R. The influence of MTHFR genetic polymorphisms on methotrexate therapy in pediatric acute lymphoblastic leukemia. Open Life Sci. 2021;16(1):1203–1212. doi:10.1515/biol-2021-0121
  • Gregers J, Christensen IJ, Dalhoff K, et al. The association of reduced folate carrier 80G>A polymorphism to outcome in childhood acute lymphoblastic leukemia interacts with chromosome 21 copy number. Blood. 2010;115(23):4671–4677. doi:10.1182/blood-2010-01-256958
  • Sepe DM, McWilliams T, Chen J, et al. Germline genetic variation and treatment response on CCG-1891. Pediatr Blood Cancer. 2012;58(5):695–700. doi:10.1002/pbc.23192
  • Zhu C, Liu YW, Wang SZ, et al. Associations between the C677T and A1298C polymorphisms of MTHFR and the toxicity of methotrexate in childhood malignancies: a meta-analysis. Pharmacogenomics J. 2018;18(3):450–459. doi:10.1038/tpj.2017.34
  • D’Angelo V, Ramaglia M, Iannotta A, et al. Influence of methylenetetrahydrofolate reductase gene polymorphisms on the outcome of pediatric patients with non-Hodgkin lymphoma treated with high-dose methotrexate. Leukemia Lymphoma. 2013;54(12):2639–2644. doi:10.3109/10428194.2013.784758
  • Bottiger AK, Hurtig-Wennlof A, Sjostrom M, Yngve A, Nilsson TK. Association of total plasma homocysteine with methylenetetrahydrofolate reductase genotypes 677C>T,1298A>C, and 1793G>A and the corresponding haplotypes in Swedish children and adolescents. IntJ Mol Med. 2007;19(4):659–665.
  • Liu SG, Li ZG, Cui L, et al. Effects of methylenetetrahydrofolate reductase gene polymorphisms on toxicities during consolidation therapy in pediatric acute lymphoblastic leukemia in a Chinese population. Leukemia Lymphoma. 2011;52(6):1030–1040. doi:10.3109/10428194.2011.563883
  • Tantawy AA, El-Bostany EA, Adly AA, Abou El Asrar M, El-Ghouroury EA, Abdulghaffar EE. Methylene tetrahydrofolate reductase gene polymorphism in Egyptian children with acute lymphoblastic leukemia. Blood Coagul Fibrinolysis. 2010;21(1):28–34. doi:10.1097/MBC.0b013e32833135e9
  • Karathanasis NV, Stiakaki E, Goulielmos GN, Kalmanti M. The role of the methylenetetrahydrofolate reductase 677 and 1298 polymorphisms in Cretan children with acute lymphoblastic leukemia. Genet Test Mol Bioma. 2011;15(1–2):5–10. doi:10.1089/gtmb.2010.0083
  • Frikha R, Rebai T, Lobna BM, et al. Comprehensive analysis of methylenetetrahydrofolate reductase C677T in younger acute lymphoblastic leukemia patients: a single-center experience. J Oncol Pharm Pract. 2019;25(5):1182–1186. doi:10.1177/1078155218818244
  • Ramirez-Pacheco A, Moreno-Guerrero S, Alamillo I, Medina-Sanson A, Lopez B, Moreno-Galvan M. Mexican childhood acute lymphoblastic leukemia: a pilot study of the MDR1 and MTHFR gene polymorphisms and their associations with clinical outcomes. Genet Test Mol Bioma. 2016;20(10):597–602. doi:10.1089/gtmb.2015.0287
  • Haase R, Elsner K, Merkel N, et al. High dose methotrexate treatment in childhood ALL: pilot study on the impact of the MTHFR 677C>T and 1298A>C polymorphisms on MTX-related toxicity. Klin Padiatrie. 2012;224(3):156–159. doi:10.1055/s-0032-1304623
  • Chae H, Kim M, Choi SH, et al. Influence of plasma methotrexate level and MTHFR genotype in Korean paediatric patients with acute lymphoblastic leukaemia. J Chemother. 2020;32(5):251–259. doi:10.1080/1120009X.2020.1764280
  • Faganel Kotnik B, Grabnar I, Bohanec Grabar P, Dolzan V, Jazbec J. Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leukaemia and malignant lymphoma. Eur J Clin Pharmacol. 2011;67(10):993–1006. doi:10.1007/s00228-011-1046-z
  • Mahmoud LB, Mdhaffar M, Frikha R, et al. Use of MTHFR C677T polymorphism and plasma pharmacokinetics to predict methotrexate toxicity in patients with acute lymphoblastic leukemia. Adv Clin Exp Med. 2018;27(8):1061–1068. doi:10.17219/acem/69802
  • Aplenc R, Thompson J, Han P, et al. Methylenetetrahydrofolate reductase polymorphisms and therapy response in pediatric acute lymphoblastic leukemia. Cancer Res. 2005;65(6):2482–2487. doi:10.1158/0008-5472.CAN-04-2606
  • Radtke S, Zolk O, Renner B, et al. Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia. Blood. 2013;121(26):5145–5153. doi:10.1182/blood-2013-01-480335
  • Yazicioglu B, Kaya Z, Guntekin Ergun S, et al. Influence of folate-related gene polymorphisms on high-dose methotrexate-related toxicity and prognosis in Turkish children with acute lymphoblastic leukemia. Turk J Haematol. 2017;34(2):143–150. doi:10.4274/tjh.2016.0007
  • van Kooten Niekerk PB, Schmiegelow K, Schroeder H. Influence of methylene tetrahydrofolate reductase polymorphisms and coadministration of antimetabolites on toxicity after high dose methotrexate. Eur J Haematol. 2008;81(5):391–398. doi:10.1111/j.1600-0609.2008.01128.x
  • Ho GT, Moodie FM, Satsangi J. Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease? Gut. 2003;52(5):759–766. doi:10.1136/gut.52.5.759
  • Maroofi F, Amini S, Roshani D, Ghaderi B, Abdi M. Different frequencies and effects of ABCB1 T3435C polymorphism on clinical and laboratory features of B cell chronic lymphocytic leukemia in kurdish patients. Tumour Biol. 2015;36(4):2863–2868. doi:10.1007/s13277-014-2914-9
  • Rao DN, Anuradha C, Vishnupriya S, et al. Association of an MDR1 gene (C3435T) polymorphism with acute leukemia in India. Asian Pac J Cancer Prev. 2010;11(4):1063–1066.
  • Pongstaporn W, Pakakasama S, Chaksangchaichote P, Pongtheerat T, Hongeng S, Permitr S. MDR1 C3435T and C1236T polymorphisms: association with high-risk childhood acute lymphoblastic leukemia. Asian Pac J Cancer Prev. 2015;16(7):2839–2843. doi:10.7314/APJCP.2015.16.7.2839
  • Tan Y, Kong Q, Li X, et al. Relationship between methylenetetrahydrofolate reductase gene polymorphisms and methotrexate drug metabolism and toxicity. Transl Pediatr. 2023;12(1):31–45. doi:10.21037/tp-22-671
  • Li M, Kong XY, Wang SM. Analysis of the frequency distribution of five single-nucleotide polymorphisms of the MTRRgene in a Chinese pediatric population with acute lymphoblastic leukemia. Pharmacotherapy. 2022;42(6):442–452. doi:10.1002/phar.2685
  • Li M, Kong XY, Wang SM. Effects of splicing-regulatory polymorphisms in ABCC2, ABCG2, and ABCB1 on methotrexate exposure in Chinese children with acute lymphoblastic leukemia. Cancer Chemother Pharmacol. 2023;91(1):77–87. doi:10.1007/s00280-022-04498-0
  • Hu YH, Zhou L, Wang SS, et al. Methotrexate disposition in pediatric patients with acute lymphoblastic leukemia: what have we learnt from the genetic variants of drug transporters. Curr Pharm Des. 2019;25(6):627–634. doi:10.2174/1381612825666190329141003
  • Zhang YX, Ma Y, Zhang H, Zhang WP, Yang XY. Genetic polymorphism in MDR1 C3435T is a determinant of methotrexate cerebrospinal fluid concentrations in Chinese children with acute lymphoblastic leukemia. Int J Clin Pharm Ther. 2020;58(5):254–260. doi:10.5414/CP203462
  • Lopez‐Lopez E, Martin‐Guerrero I, Ballesteros J, et al. Polymorphisms of the SLCO1B1 gene predict methotrexate-related toxicity in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2011;57(4):612–619. doi:10.1002/pbc.23074
  • Wang SM, Sun LL, Zeng WX, Wu WS, Zhang GL. Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia. Cancer Chemother Pharmacol. 2014;74(2):283–289. doi:10.1007/s00280-014-2507-8
  • Esmaili MA, Kazemi A, Faranoush M, et al. Polymorphisms within methotrexate pathway genes: relationship between plasma methotrexate levels, toxicity experienced and outcome in pediatric acute lymphoblastic leukemia. Iran J Basic Med Sci. 2020;23(6):800–809. doi:10.22038/ijbms.2020.41754.9858
  • Cwiklinska M, Czogala M, Kwiecinska K, et al. Polymorphisms of SLC19A1 80 G>A,MTHFR 677 C>T, and tandem ts repeats influence pharmacokinetics, acute liver toxicity, and vomiting in children with acute lymphoblastic leukemia treated with high doses of methotrexate. Frontiers in Pediatrics. 2020;8:307. doi:10.3389/fped.2020.00307
  • El-Khodary NM, El-Haggar SM, Eid MA, Ebeid EN. Study of the pharmacokinetic and pharmacogenetic contribution to the toxicity of high-dose methotrexate in children with acute lymphoblastic leukemia. Med Oncol. 2012;29(3):2053–2062. doi:10.1007/s12032-011-9997-6
  • Yao P, He X, Zhang R, Tong R, Xiao H. The influence of MTHFR genetic polymorphisms on adverse reactions after methotrexate in patients with hematological malignancies: a meta-analysis. Hematology. 2019;24(1):10–19. doi:10.1080/10245332.2018.1500750
  • Frikha R, Jemaa MB, Frikha F, et al. Involvement of C677T MTHFR variant but not A1298C in methotrexate-induced toxicity in acute lymphoblastic leukemia. J Oncol Pharm Pract. 2021;27(6):1382–1387. doi:10.1177/1078155220951898
  • Erdelyi DJ, Kamory E, Zalka A, et al. The role of ABC-transporter gene polymorphisms in chemotherapy induced immunosuppression, a retrospective study in childhood acute lymphoblastic leukaemia. Cell Immunol. 2006;244(2):121–124. doi:10.1016/j.cellimm.2007.02.007
  • Liu SG, Gao C, Zhang RD, et al. Polymorphisms in methotrexate transporters and their relationship to plasma methotrexate levels, toxicity of high-dose methotrexate, and outcome of pediatric acute lymphoblastic leukemia. Oncotarget. 2017;8(23):37761–37772. doi:10.18632/oncotarget.17781