CLEC4D as a Novel Prognostic Marker Boosts the Proliferation and Migration of Gastric Cancer via the NF-κB/AKT Signaling Pathway

References

• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.21660
   PubMed Web of Science ®Google Scholar
• Liu X, Meltzer SJ. Gastric cancer in the era of precision medicine. Cell Mol Gastroenterol Hepatol. 2017;3(3):348–358. doi:10.1016/j.jcmgh.2017.02.003
   PubMed Web of Science ®Google Scholar
• Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010;140(6):805–820. doi:10.1016/j.cell.2010.01.022
   PubMed Web of Science ®Google Scholar
• Li D, Wu M. Pattern recognition receptors in health and diseases. Signal Transduct Target Ther. 2021;6(1):291. doi:10.1038/s41392-021-00687-0
   PubMed Web of Science ®Google Scholar
• Shekarian T, Valsesia-Wittmann S, Brody J, et al. Pattern recognition receptors: immune targets to enhance cancer immunotherapy. Ann Oncol. 2017;28(8):1756–1766. Erratum in: Ann Oncol. Dec 2019;30(12):2017. doi:10.1093/annonc/mdx179
   PubMed Web of Science ®Google Scholar
• Li K, Underhill DM. C-type lectin receptors in phagocytosis. Curr Top Microbiol Immunol. 2020;429:1–18. doi:10.1007/82_2020_198
   PubMed Web of Science ®Google Scholar
• Scur M, Parsons BD, Dey S, et al. The diverse roles of C-type lectin-like receptors in immunity. Front Immunol. 2023;14:1126043. doi:10.3389/fimmu.2023.1126043
   PubMed Web of Science ®Google Scholar
• Li M, Zhang R, Li J, et al. The role of C-type lectin receptor signaling in the intestinal microbiota-inflammation-cancer axis. Front Immunol. 2022;13:894445. doi:10.3389/fimmu.2022.894445
   PubMedGoogle Scholar
• Fischer S, Stegmann F, Gnanapragassam VS, et al. From structure to function - Ligand recognition by myeloid C-type lectin receptors. Comput Struct Biotechnol J. 2022;20:5790–5812. doi:10.1016/j.csbj.2022.10.019
   PubMed Web of Science ®Google Scholar
• Balch SG, McKnight AJ, Seldin MF, Gordon S. Cloning of a novel C-type lectin expressed by murine macrophages. J Biol Chem. 1998;273(29):18656–18664. doi:10.1074/jbc.273.29.18656
   PubMed Web of Science ®Google Scholar
• Arce I, Martínez-Muñoz L, Roda-Navarro P, Fernández-Ruiz E. The human C-type lectin CLECSF8 is a novel monocyte/macrophage endocytic receptor. Eur J Immunol. 2004;34(1):210–220. doi:10.1002/eji.200324230
   PubMed Web of Science ®Google Scholar
• Graham LM, Gupta V, Schafer G, et al. The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through Syk kinase. J Biol Chem. 2012;287(31):25964–25974. doi:10.1074/jbc.M112.384164
   PubMed Web of Science ®Google Scholar
• Zhu LL, Zhao XQ, Jiang C, et al. C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection. Immunity. 2013;39(2):324–334. doi:10.1016/j.immuni.2013.05.017
   PubMed Web of Science ®Google Scholar
• Miyake Y, Toyonaga K, Mori D, et al. C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. Immunity. 2013;38(5):1050–1062. doi:10.1016/j.immuni.2013.03.010
   PubMed Web of Science ®Google Scholar
• Lobato-Pascual A, Saether PC, Fossum S, Dissen E, Daws MR. Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and FcεRI-γ. Eur J Immunol. 2013;43(12):3167–3174. doi:10.1002/eji.201343752
   PubMed Web of Science ®Google Scholar
• Wilson GJ, Marakalala MJ, Hoving JC, et al. The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity. Cell Host Microbe. 2015;17(2):252–259. doi:10.1016/j.chom.2015.01.004
   PubMed Web of Science ®Google Scholar
• Li Q. The multiple roles of C-type lectin receptors in cancer. Front Oncol. 2023;13:1301473. doi:10.3389/fonc.2023.1301473
   PubMed Web of Science ®Google Scholar
• Ohe R, Aung NY, Tamura Y, et al. Diagnostic utility of CD205 in breast cancer: simultaneous detection of myoepithelial cells and dendritic cells in breast tissue by CD205. Histol Histopathol. 2020;35(5):481–488. doi:10.14670/HH-18-164
   PubMed Web of Science ®Google Scholar
• Fu C, Fu Z, Jiang C, et al. CD205+ polymorphonuclear myeloid-derived suppressor cells suppress antitumor immunity by overexpressing GLUT3. Cancer Sci. 2021;112(3):1011–1025. doi:10.1111/cas.14783
   PubMed Web of Science ®Google Scholar
• Ren CX, Leng RX, Fan YG, et al. Intratumoral and peritumoral expression of CD68 and CD206 in hepatocellular carcinoma and their prognostic value. Oncol Rep. 2017;38(2):886–898. doi:10.3892/or.2017.5738
   PubMed Web of Science ®Google Scholar
• Zhu Y, Shi T, Lu X, et al. Fungal-induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL-22. EMBO J. 2021;40(11):e105320. doi:10.15252/embj.2020105320
   PubMed Web of Science ®Google Scholar
• Caba O, Prados J, Ortiz R, et al. Transcriptional profiling of peripheral blood in pancreatic adenocarcinoma patients identifies diagnostic biomarkers. Dig Dis Sci. 2014;59(11):2714–2720. doi:10.1007/s10620-014-3291-3
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wei H, Fan L, et al. CLEC4s as potential therapeutic targets in hepatocellular carcinoma microenvironment. Front Cell Dev Biol. 2021;9:681372. doi:10.3389/fcell.2021.681372
   PubMed Web of Science ®Google Scholar
• Fang X, Liu D, Zhao J, et al. Using proteomics and metabolomics to identify therapeutic targets for senescence mediated cancer: genetic complementarity method. Front Endocrinol. 2023;14:1255889. doi:10.3389/fendo.2023.1255889
   PubMed Web of Science ®Google Scholar
• Ma G, Jing C, Li L, et al. MicroRNA-92b represses invasion-metastasis cascade of esophageal squamous cell carcinoma. Oncotarget. 2016;7(15):20209–20222. doi:10.18632/oncotarget.7747
   PubMedGoogle Scholar
• Sun W, Ma G, Zhang L, et al. DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells. Cell Death Dis. 2021;12(5):428. doi:10.1038/s41419-021-03628-5
   PubMed Web of Science ®Google Scholar
• Li D, Lu L, Kong W, et al. C-type lectin receptor Dectin3 deficiency balances the accumulation and function of FoxO1-mediated LOX-1(+) M-MDSCs in relieving lupus-like symptoms. Cell Death Dis. 2021;12(9):829. doi:10.1038/s41419-021-04052-5
   PubMed Web of Science ®Google Scholar
• Kerscher B, Wilson GJ, Reid DM, et al. Mycobacterial receptor, Clec4d (CLECSF8, MCL), is coregulated with Mincle and upregulated on mouse myeloid cells following microbial challenge. Eur J Immunol. 2016;46(2):381–389. doi:10.1002/eji.201545858
   PubMed Web of Science ®Google Scholar
• Wang T, Pan D, Zhou Z, et al. Dectin-3 deficiency promotes colitis development due to impaired antifungal innate immune responses in the gut. PLoS Pathog. 2016;12(6):e1005662. doi:10.1371/journal.ppat.1005662
   PubMed Web of Science ®Google Scholar
• Marshall KW, Mohr S, Khettabi FE, et al. A blood-based biomarker panel for stratifying current risk for colorectal cancer. Int J Cancer. 2010;126(5):1177–1186. doi:10.1002/ijc.24910
   PubMed Web of Science ®Google Scholar
• Yang N, Ji F, Cheng L, et al. Knockout of immunotherapy prognostic marker genes eliminates the effect of the anti-PD-1 treatment. NPJ Precis Oncol. 2021;5(1):37. doi:10.1038/s41698-021-00175-2
   PubMed Web of Science ®Google Scholar
• Zhao XQ, Zhu LL, Chang Q, et al. C-type lectin receptor dectin-3 mediates trehalose 6,6’-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation. J Biol Chem. 2014;289(43):30052–30062. doi:10.1074/jbc.M114.588574
   PubMed Web of Science ®Google Scholar
• Li C, Xue VW, Wang QM, et al. The mincle/Syk/NF-κB signaling circuit is essential for maintaining the protumoral activities of tumor-associated macrophages. Cancer Immunol Res. 2020;8(8):1004–1017. doi:10.1158/2326-6066.Cir-19-0782
   PubMed Web of Science ®Google Scholar
• Turner M, Schweighoffer E, Colucci F, Di Santo JP, Tybulewicz VL. Tyrosine kinase SYK: essential functions for immunoreceptor signalling. Immunol Today. 2000;21(3):148–154. doi:10.1016/s0167-5699(99)01574-1
   PubMedGoogle Scholar
• Hou X, Lin L, Xing W, et al. Spleen tyrosine kinase regulates mammary epithelial cell proliferation in mammary glands of dairy cows. J Dairy Sci. 2016;99(5):3858–3868. doi:10.3168/jds.2015-10118
   PubMed Web of Science ®Google Scholar