References
- GrozavAMiclausVVostinaruOAcute toxicity evaluation of a thiazolo arene ruthenium (II) complex in ratsRegul Toxicol Pharmacol20168023324027375008
- GambinoDOteroLPerspectives on what ruthenium-based compounds could offer in the development of potential antiparasitic drugsInorganica Chim Acta2012393103114
- VidimarVMengXKlajnerMInduction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicityBiochem Pharmacol201284111428143622964219
- MohanrajMAyyannanGRajaGJayabalakrishnanCEvaluation of DNA binding, DNA cleavage, protein binding, radical scavenging and in vitro cytotoxic activities of ruthenium(II) complexes containing 2,4-dihydroxy benzylidene ligandsMater Sci Eng C Mater Biol Appl2016691297130627612830
- AllardyceCSDysonPJRuthenium in medicine: current clinical uses and future prospectsPlatinum Metals Rev20014526269
- UdeZRomero-CanelónITwamleyBFitzgerald HughesDSadlerPJMarmionCJA novel dual-functioning ruthenium (II)-arene complex of an anti-microbial ciprofloxacin derivative – anti-proliferative and anti-microbial activityJ Inorg Biochem201616021021726993079
- LiuWGustRUpdate on metal N-heterocyclic carbene complexes as potential anti-tumor metallodrugsCoord Chem Rev2016329191213
- MariCPierrozVFerrariSGasserGCombination of Ru(II) complexes and light: new frontiers in cancer therapyChem Sci2015626602686
- WaniWAPrasharSShreazSGomez-RuizSNanostructured materials functionalized with metal complexes: in search of alternatives for administering anticancer metallodrugsCoord Chem Rev20163126798
- ViswanathBKimSRecent insights into the development of nanotechnology to detect circulating tumor cellsTrends Analyt Chem201682191198
- LeónIECadavid-VargasJFDi VirgilioALEtcheverrySVanadium, ruthenium and copper compounds: a new class of non-platinum metallodrugs with anticancer activityCurr Med Chem2016242112148
- HaasKLFranzKJApplication of metal coordination chemistry to explore and manipulate cell biologyChem Rev20091094921496019715312
- FrezzaMHindoSChenDNovel metals and metal complexes as platforms for cancer therapyCurr Pharm Des201016161813182520337575
- LiFCollinsJGKeeneFRRuthenium complexes as antimicrobial agentsChem Soc Rev20154482529254225724019
- Colina-VegasLDutraJLVillarrealWRu(II)/clotrimazole/diphenylphosphine/bipyridine complexes: interaction with DNA, BSA and biological potential against tumor cell lines and Mycobacterium tuberculosisJ Inorg Biochem201616213514527383651
- DragutanIDragutanVDemonceauAEditorial of special issue ruthenium complex: the expanding chemistry of the ruthenium complexesMolecules2015209172441727426393560
- ChenJCLiGDPengFInvestigation of inducing apoptosis in human lung cancer A549 cells and related mechanism of a ruthenium (II) polypyridyl complexInorg Chem Commun2016693539
- LimaAPPereiraFCAlmeidaMACytoxicity and apoptotic mechanism of ruthenium(II) amino acid complexes in sarcoma-180 tumor cellsPLoS One2014910e10586525329644
- MotswainyanaWMAjibadePAAnticancer activities of mononuclear ruthenium (II) coordination complexesAdv Chem20152015859730
- FurrerJSüss-FinkGSThiolato-bridged dinuclear arene ruthenium complexes and their potential as anticancer drugsCoord Chem Rev20163093650
- YangJCaoQHuWLTheranostic TEMPO-functionalized Ru(ii) complexes as photosensitizers and oxidative stress indicatorsDalton Trans201746244545427942635
- GillMRHarunSNHalderSA ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibitionSci Rep201663197327558808
- Koceva-ChyłaAMatczakKHikiszMPInsights into the in vitro anticancer effects of Diruthenium-1Chem Med Chem201611192171218727561129
- LevinaA1MitraALayPARecent developments in ruthenium anticancer drugsMetallomics20091645847021305154
- RehmanHUFreitasTFGomesRNColquhounAde Oliveria SilvaDAxially-modified paddlewheel diruthenium(II,III)-ibuprofenato metallodrugs and the influence of the structural modification on U87MG and A172 human glioma cell proliferation, apoptosis, mitosis and migrationJ Inorg Biochem201616518119128340940
- BaeKHChungHJParkTGNanomaterials for cancer therapy and imagingMol Cells201131429530221360197
- MohamedNKHamadMAHafezMZWooleyKLElsabahyMNanomedicine in management of hepatocellular carcinoma: challenges and opportunitiesInt J Cancer20161401475148427861850
- WuJLiuBWuHA gold nanoparticle platform for the delivery of functional TGF-β1 siRNA into cancer cellsJ Biomed Nanotechnol201612480081027301206
- LopezTOrtizEGuevaraPGómezENovaroOPhysicochemical characterization of functionalized-nanostructured-titania as a carrier of copper complexes for cancer treatmentMater Chem Phys201414613749
- ScintillaSBrustolinLGambalungaARu(III) anticancer agents with aromatic and non-aromatic dithiocarbamates as ligands: loading into nanocarriers and preliminary biological studiesJ Inorg Biochem2016166768627838581
- DömötörOde AlmeidaRFMCôrte-RealLStudies on the mechanism of action of antitumor bis(aminophenolate) ruthenium(III) complexesJ Inorg Biochem2017168273728006663
- HuangYHuangWChanLZhouBChenTA multifunctional DNA origami as carrier of metal complexes to achieve enhanced tumoral delivery and nullified systemic toxicityBiomaterials201610318319627388944
- ChenLFuCDengYWuWFuAA pH-sensitive nanocarrier for tumor targeting: delivery of ruthenium complex for tumor theranostic by pH-sensitive nanocapsulePharm Res201633122989299827590630
- LvGQiuLLiuGpH sensitive chitosan-mesoporous silica nanoparticles for targeted delivery of a ruthenium complex with enhanced anticancer effectsDalton Trans20164545181471815527785492
- ShiHFangTTianYHuangHLiuYA dual-fluorescent nano-carrier for delivering photoactive ruthenium polypyridyl complexesJ Mater Chem B201644746
- RojasSCarmonaFJBareaEMaldonadoCRInorganic mesoporous silicas as vehicles of two novel anthracene-based ruthenium metalloarenesJ Inorg Biochem2017166879327838582
- XueSSTanCPChenMHTumor-targeted supramolecular nanoparticles self-assembled from a ruthenium-β-cyclodextrin complex and an adamantane-functionalized peptideChem Commun (Camb)201753584284527917426
- ZhangPHuangHHuangJNoncovalent ruthenium (II) complexes–single-walled carbon nanotube composites for bimodal photothermal and photodynamic therapy with near-infrared irradiationACS Appl Mater Interfaces20157232782329026430876
- WangNFengYZengLZhaoZChenTFunctionalized multiwalled carbon nanotubes as carriers of ruthenium complexes to antagonize cancer multidrug resistance and radioresistanceACS Appl Mater Interfaces20157149331494526107995
- ZhangWLiBMaHCombining ruthenium(II) complexes with metal-organic frameworks to realize effective two-photon absorption for singlet oxygen generationACS Appl Mater Interfaces2016833214652147127483010
- WangJQZhaoZZBoHBChenQZSynthesis, characterization, and antitumor properties of ruthenium (II) anthraquinone complexesJ Coord Chem201669177189
- Robles-EscajedaEMartínezAVarela-RamirezASánchez-DelgadoRAAguileraRJAnalysis of the cytotoxic effects of ruthenium–ketoconazole and ruthenium–clotrimazole complexes on cancer cellsCell Biol Toxicol201329643144324272524
- BytzekAKKoellenspergerGKepplerBKHartingerCGBiodistribution of the novel anticancer drug sodium trans-[tetrachloridobis (1H-indazole) ruthenate (III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of actionJ Inorg Biochem201616025025526993078
- JovanovicKKGligorijevicNGaurRMishraLRadulovicSAnticancer activity of two ruthenium (II)-DMSO-chalcone complexes: comparison of cytotoxic, pro-apoptotic and antimetastatic potentialJ BUON201521482490
- MoraisTSSilvaTJMarquesFSynthesis of organometallic ruthenium (II) complexes with strong activity against several human cancer cell linesJ Inorg Biochem2012114657422698866
- JayanthiEKalaiselviSPadmaVVBhuvaneshNSDharmarajNSolvent assisted formation of ruthenium (III) and ruthenium (II) hydrazone complexes in one-pot with potential in vitro cytotoxicity and enhanced LDH, NO and ROS releaseDalton Trans20164541693170726699435
- YuHJLiuJPHaoZFSynthesis, characterization and biological evaluation of ruthenium (II) complexes [Ru (dtzp)(dppz) Cl]+ and [Ru (dtzp)(dppz) CH 3 CN] 2+ for photodynamic therapyDyes Pigm2017136416426
- ZhangCZengCCLaiSHSynthesis, cytotoxicity in vitro, apoptosis, cell cycle arrest and comet assay of asymmetry ruthenium (II) complexesPolyhedron2016106115124
- HeinrichTATedescoACFukutoJMda SilvaRSProduction of reactive oxygen and nitrogen species by light irradiation of a nitrosyl phthalocyanine ruthenium complex as a strategy for cancer treatmentDalton Trans2014434021402524452093
- MiserachsHGCiprianiMGrauJAntitumor and antiparasitic activity of novel ruthenium compounds with polycyclic aromatic ligandsJ Inorg Biochem2015150384726079954
- CarneiroZABiazzottoJCAlexiouADNikolaouSNitric oxide photo-release from a trinuclear ruthenium nitrosyl complex and its in vitro cytotoxicity against melanoma cellsJ Inorg Biochem2014134363824522147
- SchmittFDonnellyKMuenznerJKEffects of histidin-2-ylidene vs. imidazol-2-ylidene ligands on the anticancer and antivascular activity of complexes of ruthenium, iridium, platinum, and goldJ Inorg Biochem201616322122827491634
- KuhnPSMeierSMJovanovićKKRuthenium carbonyl complexes with azole heterocycles–synthesis, X-ray diffraction structures, DFT calculations, solution behavior, and antiproliferative activityEur J Inorg Chem201620161015661576
- DavidSPerkinsRSFronczekFRKasiriSMandalSSSrivastavaRSSynthesis, characterization, and anticancer activity of ruthenium-pyrazole complexesJ Inorg Biochem2012111333922484498
- KamatchiTSKalaivaniPFronczekFRNatarajanKPrabhakaranRImpact of chelation on anticancer activities of organometallic ruthenium (ii) complexes containing 2, 5-di (1 H-pyrazol-1-yl)-1, 4-benzoquinone: synthesis, structure, DNA/protein binding, antioxidant activity and cytotoxicityRSC Adv201664653146547
- MehtaJVGajeraSBPatelMNBiological applications of pyrazoline-based half-sandwich ruthenium (III) coordination compoundsJ Biomol Struct Dyn20161619
- LazićDArsenijevićAPuchtaRBugarčićŽDRilakADNA binding properties, histidine interaction and cytotoxicity studies of water soluble ruthenium (II) terpyridine complexesDalton Trans201645114633464626855406
- LordRMAllisonSJRaffertyKGhandhiLPaskCMMcGowanPCCytotoxic hydrogen bridged ruthenium quinaldamide complexes showing induced cancer cell death by apoptosisDalton Trans20164533131961320327417660
- DaltonSRGlazierSLeungBWinSMegatulskiCBurgmayerSJDNA binding by Ru (II)–bis (bipyridine)–pteridinyl complexesJ Inorg Biochem20081311331148
- HuangHZhangPChenHJiLChaoHComparison between polypyridyl and cyclometalated ruthenium (II) complexes: anticancer activities against 2D and 3D cancer modelsChemistry20152171572525388328
- GuptaGOgguGSNageshNBokaraKKTherrienBAnticancer activity of large metalla-assemblies built from half-sandwich complexesCryst Eng Comm20161849524957
- SuWTangZLiPDevelopment of arene ruthenium antitumor complexesMini Rev Med Chem20161678779527161008
- KaurRRanjan DwivediAKumarBKumarVRecent developments on 1,2,4-triazole nucleus in anticancer compounds: a reviewAnticancer Agents Med Chem201616446548926286663
- KubanikMKandiollerWKimKTowards targeting anticancer drugs: ruthenium (ii)–arene complexes with biologically active naphthoquinone-derived ligand systemsDalton Trans201645130911310327214822
- LiGSunLJiLChaoHRuthenium (ii) complexes with dppz: from molecular photoswitch to biological applicationsDalton Trans201645132611327627426487
- CarusoFPettinariRRossiMThe in vitro antitumor activity of arene-ruthenium (II) curcuminoid complexes improves when decreasing curcumin polarityJ Inorg Biochem2016162445127293144
- EnyedyÉASijaÉJakuschTSolution equilibria of anticancer ruthenium (II)-(η 6-p-cymene)-hydroxy (thio) pyr (id) one complexes: impact of sulfur vs. oxygen donor systems on the speciation and bioactivityJ Inorg Biochem201312716116823721887
- LiXHeimannKDinhXTKeeneFRCollinsJGBiological processing of dinuclear ruthenium complexes in eukaryotic cellsMol BioSyst201612103032304527453040
- SinghAKSaxenaGDixitSSynthesis, characterization and biological activities of some Ru (II) complexes with substituted chalcones and their applications as chemotherapeutics against breast cancerJ Mol Struct201611119099
- ChenYQinMYWuJHSynthesis, characterization, and anticancer activity of ruthenium (II)-β-carboline complexEur J Med Chem20137012012924141202
- HeLLiaoSYTanCPRuthenium–arene–β-carboline complexes as potent inhibitors of cyclin-dependent kinase 1: synthesis, characterization and anticancer mechanism studiesChemistry20131936121521216023878093
- ChowMJBabakMVWongDYPastorinGGaiddonCAngWHStructural determinants of p53-independence in anticancer ruthenium–arene Schiff–base complexesMol Pharm20161372543255427174050
- GuLLiXRanQKangCLeeCShenJAntimetastatic activity of novel ruthenium (III) pyridine complexesCancer Med20165102850286027605356
- MazurykOŁomzikMMartineauDAnticancer activity of ruthenium (II) polypyridine complexes bearing pyrrolidine substituentsInorganica Chim Acta20164438690
- AlmodaresZLucasSJCrossleyBDRhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agentsInorg Chem201453272773624397747
- QianCWuJJiLChaoHTopoisomerase IIα poisoning and DNA double-strand breaking by chiral ruthenium (ii) complexes containing 2-furanyl-imidazo [4, 5-f][1, 10] phenanthroline derivativesDalton Trans20164526105461055527226117
- ChowMJLiconaCYuan Qiang WongDPastorinGGaiddonCAngWHDiscovery and investigation of anticancer ruthenium–arene Schiff–base complexes via water-promoted combinatorial three-component assemblyJ Med Chem201457146043605925023617
- ZhangYZhengWLuoQDual-targeting organometallic ruthenium (II) anticancer complexes bearing EGFR-inhibiting 4-anilinoquinazoline ligandsDalton Trans20154429131001311126106875
- ZhangXHuangZWuSLinRLiuJSuNInvestigation of antitumor mechanism of the chiral ruthenium complex Λ-[Ru (phen) 2 p-MOPIP] 2+ in human gastric cancer MGC-803 cellsInorg Chem Commun20167216
- KasperCAlborziniaHCanSSynthesis and cellular impact of diene–ruthenium (II) complexes: a new class of organoruthenium anticancer agentsJ Inorg Biochem2012106112613322115828
- DhanarajCJHassanIUJohnsonJJosephJJoseyphusRSSynthesis, spectral characterization, DNA interaction, anticancer and molecular docking studies on some transition metal complexes with bidentate ligandJ Photochem Photobiol B201616211512427367456
- KurzwernhartAKandiollerWBächlerSStructure–activity relationships of targeted RuII (η6-p-Cymene) anticancer complexes with flavonol-derived ligandsJ Med Chem20125523105121052223134291
- PrajapatiRDubeySKGaurRStructural characterization and cytotoxicity studies of ruthenium (II)–DMSO–chloro complexes of chalcone and flavone derivativesPolyhedron20102910551061
- GaurRMishraLSynthesis and characterization of Ru (II)–DMSO–Cl–chalcone complexes: DNA binding, nuclease, and topoisomerase II inhibitory activityInorg Chem20125153059307022352801
- SubasingheAPereraICPakhomovaSPereraTSynthesis, characterization, and biological studies of a piperidinyl appended dipicolylamine ligand and its rhenium tricarbonyl complex as potential therapeutic agents for human breast cancerBioinorg Chem Appl20162016267593727847444
- SavaGZorzetSTurrinCDual action of NAMI-A in inhibition of solid tumor metastasis selective targeting of metastatic cells and binding to collagenClin Cancer Res2003951898190512738748
- SavaGFrausinFCocchiettoMActin-dependent tumour cell adhesion after short-term exposure to the antimetastasis ruthenium complex NAMI-AEur J Cancer20044091383139615177498
- HeffeterPRiabtsevaASenkivYNanoformulation improves activity of the (pre) clinical anticancer ruthenium complex KP1019J Biomed Nanotechnol201410587788424734541
- TrondlRHeffeterPKowolCRJakupecMABergerWKepplerBKNKP-1339, the first ruthenium-based anticancer drug on the edge to clinical applicationChem Sci2014529252932