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Review

Main trends of immune effects triggered by nanomedicines in preclinical studies

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Pages 5419-5431 | Published online: 17 Sep 2018

References

  • HerrmannIKRössleinMPersonalized medicine: the enabling role of nanotechnologyNanomedicine20161111326652931
  • KononenkoVNaratMDrobneDNanoparticle interaction with the immune systemArh Hig Rada Toksikol20156629710826110471
  • CedervallTLynchIFoyMDetailed identification of plasma proteins adsorbed on copolymer nanoparticlesAngew Chem Int Ed Engl200746305754575617591736
  • LundqvistMStiglerJEliaGLynchICedervallTDawsonKANanoparticle size and surface properties determine the protein corona with possible implications for biological impactsProc Natl Acad Sci U S A200810538142651427018809927
  • NeaguMPiperigkouZKaramanouKProtein biocorona: critical issue in immune nanotoxicologyArch Toxicol20179131031104827438349
  • EnginABNikitovicDNeaguMMechanistic understanding of nanoparticles’ interactions with extracellular matrix: the cell and immune systemPart Fibre Toxicol20171412228646905
  • LibuttiSKPaciottiGFByrnesAAPhase I and pharmacokinetic studies of CYT-6091, a novel PEGylated colloidal gold-rhTNF nanomedicineClin Cancer Res201016246139614920876255
  • KoshySTMooneyDJBiomaterials for enhancing anti-cancer immunityCurr Opin Biotechnol2016401826896596
  • BrodinPDavisMMHuman immune system variationNat Rev Immunol2017171212927916977
  • WickiAWitzigmannDBalasubramanianVHuwylerJNanomedicine in cancer therapy: challenges, opportunities, and clinical applicationsJ Control Release201520013815725545217
  • BawageSSTiwariPMSinghAGold nanorods inhibit respiratory syncytial virus by stimulating the innate immune responseNanomedicine20161282299231027381068
  • ZhengHWenSZhangYSunZOrganosilane and polyethylene glycol functionalized magnetic mesoporous silica nanoparticles as carriers for CpG immunotherapy in vitro and in vivoPLoS One20151010e014026526451735
  • CampbellDFSaenzRBharatiISEnhanced anti-tumor immune responses and delay of tumor development in human epidermal growth factor receptor 2 mice immunized with an immunostimulatory peptide in poly(d,l-lactic-co-glycolic) acid nanoparticlesBreast Cancer Res20151714825882711
  • FaghfuriEYazdiMHMahdaviMDose–response relationship study of selenium nanoparticles as an immunostimulatory agent in cancer-bearing miceArch Med Res2015461313725604604
  • ZamanMGoodMFTothINanovaccines and their mode of actionMethods201360322623123623821
  • WangXTianJYongK-TImmunotoxicity assessment of CdSe/ZnS quantum dots in macrophages, lymphocytes and BALB/c miceJ Nanobiotechnology20161411026846666
  • MishraVBaranwalVMishraRKSharmaSPaulBPandeyACTitanium dioxide nanoparticles augment allergic airway inflammation and Socs3 expression via NF-κB pathway in murine model of asthmaBiomaterials2016929010227057692
  • HutterEBoridySLabrecqueSMicroglial response to gold nanoparticlesACS Nano2010452595260620329742
  • PinsinoARussoRBonaventuraRBrunelliAMarcominiAMatrangaVTitanium dioxide nanoparticles stimulate sea urchin immune cell phagocytic activity involving TLR/p38 MAPK-mediated signalling pathwaySci Rep2015511449226412401
  • NgC-TLiJJBalasubramanianSKYouFYungL-YLBayB-HInflammatory changes in lung tissues associated with altered inflammation-related microRNA expression after intravenous administration of gold nanoparticles in vivoACS Biomater Sci Eng201621119591967
  • ZhangX-DWuDShenXLiuP-XFanF-YFanS-JInvivo renal clearance, biodistribution, toxicity of gold nanoclustersBiomaterials201233184628463822459191
  • RabolliVBadissiAADevosseRThe alarmin IL-1α is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticlesPart Fibre Toxicol20141116925497724
  • ChoYCPakPJJooYHLeeH-SChungNIn vitro and in vivo comparison of the immunotoxicity of single- and multi-layered graphene oxides with or without pluronic F-127Sci Rep2016613888427941848
  • ErfGFFalconDMSullivanKSBourdoSET lymphocytes dominate local leukocyte infiltration in response to intradermal injection of functionalized graphene-based nanomaterialJ Appl Toxicol201737111317132428621440
  • GustafsonHHHolt-CasperDGraingerDWGhandehariHNanoparticle uptake: the phagocyte problemNano Today201510448751026640510
  • RojasJMSanz-OrtegaLMulens-AriasVGutiérrezLPérez-YagüeSBarberDFSuperparamagnetic iron oxide nanoparticle uptake alters M2 macrophage phenotype, iron metabolism, migration and invasionNanomedicine20161241127113826733263
  • MaJLiuRWangXCrucial role of lateral size for graphene oxide in activating macrophages and stimulating pro-inflammatory responses in cells and animalsACS Nano2015910104981051526389709
  • BartneckMRitzTKeulHAPeptide-functionalized gold nanorods increase liver injury in hepatitisACS Nano20126108767877722994679
  • NorisMRemuzziGOverview of complement activation and regulationSemin Nephrol201333647949224161035
  • PhamCTNMitchellLMHuangJLVariable antibody-dependent activation of complement by functionalized phospholipid nanoparticle surfacesJ Biol Chem2011286112313021047788
  • WangGGriffinJIInturiSIn vitro and in vivo differences in murine third complement component (C3) opsonization and macrophage/leukocyte responses to antibody-functionalized iron oxide nanowormsFront Immunol20178215128239384
  • ChenFWangGGriffinJIComplement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivoNat Nanotechnol201712438739327992410
  • van den HovenJMNemesRMetselaarJMComplement activation by PEGylated liposomes containing prednisoloneEur J Pharm Sci201349226527123528740
  • MengJJiYLiuJUsing gold nanorods core/silver shell nanostructures as model material to probe biodistribution and toxic effects of silver nanoparticles in miceNanotoxicology20148668669623837638
  • HamadIChristy HunterARuttKJLiuZDaiHMoein MoghimiSComplement activation by PEGylated single-walled carbon nanotubes is independent of C1q and alternative pathway turnoverMol Immunol200845143797380318602161
  • WibroePPAnselmoACNilssonPHBypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytesNat Nanotechnol201712658959428396605
  • SzebeniJHemocompatibility testing for nanomedicines and biologicals: predictive assays for complement mediated infusion reactionsEur J Nanomed2012113353
  • SzebeniJStormGComplement activation as a bioequivalence issue relevant to the development of generic liposomes and other nanoparticulate drugsBiochem Biophys Res Commun2015468349049726182876
  • JackmanJAMészárosTFülöpTUrbanicsRSzebeniJChoN-JComparison of complement activation-related pseudoallergy in miniature and domestic pigs: foundation of a validatable immune toxicity modelNanomedicine201612493394326767512
  • DézsiLFülöpTMészárosTFeatures of complement activation-related pseudoallergy to liposomes with different surface charge and PEGylation: comparison of the porcine and rat responsesJ Control Release201419521025148822
  • BenasuttiHWangGVuVPVariability of complement response toward preclinical and clinical nanocarriers in the general populationBioconjug Chem201728112747275529090582
  • WangKPanDSchmiederAHSynergy between surface and core entrapped metals in a mixed manganese–gadolinium nanocolloid affords safer MR imaging of sparse biomarkersNanomedicine201511360160925652900
  • OommenOPDuehrkopCNilssonBHilbornJVargheseOPMultifunctional hyaluronic acid and chondroitin sulfate nanoparticles: impact of glycosaminoglycan presentation on receptor mediated cellular uptake and immune activationACS Appl Mater Interfaces2016832206142062427468113
  • MoghimiSMSimbergDComplement activation turnover on surfaces of nanoparticlesNano Today20171581029399037
  • MoghimiSMAndersenAJAhmadvandDWibroePPAndresenTLHunterACMaterial properties in complement activationAdv Drug Deliv Rev201163121000100721689701
  • CotyJ-BEleamen OliveiraEVauthierCTuning complement activation and pathway through controlled molecular architecture of dextran chains in nanoparticle coronaInt J Pharm2017532276977828450168
  • ParkE-JOhSYLeeSJChronic pulmonary accumulation of iron oxide nanoparticles induced Th1-type immune response stimulating the function of antigen-presenting cellsEnviron Res201514313814726492398
  • ParkE-JKimHKimYYiJChoiKParkKInflammatory responses may be induced by a single intratracheal instillation of iron nanoparticles in miceToxicology20102751–3657120540983
  • YoshidaTYoshiokaYFujimuraMPromotion of allergic immune responses by intranasally-administrated nanosilica particles in miceNanoscale Res Lett20116119521711705
  • HaraEMakinoAKuriharaKYamamotoFOzekiEKimuraSPharmacokinetic change of nanoparticulate formulation “Lactosome” on multiple administrationsInt Immunopharmacol201214326126622841811
  • WangGInturiSSerkovaNJHigh-relaxivity superparamagnetic iron oxide nanoworms with decreased immune recognition and long-circulating propertiesACS Nano2014812124371244925419856
  • LiaoLZhangMLiuHSubchronic toxicity and immunotoxicity of MeO-PEG-poly(d,l-lactic-co-glycolic acid)-PEG-OMe triblock copolymer nanoparticles delivered intravenously into ratsNanotechnology2014252424570524869981
  • GaucherGAsahinaKWangJLerouxJ-CEffect of poly(N-vinyl-pyrrolidone)-block-poly(d, l-lactide) as coating agent on the opsonization, phagocytosis, and pharmacokinetics of biodegradable nanoparticlesBiomacromolecules200910240841619133718
  • ShanXYuanYLiuCTaoXShengYXuFInfluence of PEG chain on the complement activation suppression and longevity in vivo prolongation of the PCL biomedical nanoparticlesBiomed Microdevices20091161187119419609680
  • ZhangTTangMZhangSSystemic and immunotoxicity of pristine and PEGylated multi-walled carbon nanotubes in an intravenous 28 days repeated dose toxicity studyInt J Nanomedicine2017121539155428280324
  • YangQLaiSKAnti-PEG immunity: emergence, characteristics, and unaddressed questionsWiley Interdiscip Rev Nanomed Nanobiotechnol20157565567725707913
  • YangQMaYZhaoYAccelerated drug release and clearance of PEGylated epirubicin liposomes following repeated injections: a new challenge for sequential low-dose chemotherapyInt J Nanomedicine201381257126823576868
  • IchiharaMMoriyoshiNLilaASAIshidaTKiwadaHAnti-PEG IgM Production via a PEGylated Nano-Carrier System for Nucleic Acid DeliveryMethods in Molecular Biology (Clifton, N.J.)20139483547
  • JudgeAMcclintockKPhelpsJRMaclachlanIHypersensitivity and loss of disease site targeting caused by antibody responses to PEGylated liposomesMol Ther200613232833716275098
  • WangCChengXSuiYA noticeable phenomenon: thiol terminal PEG enhances the immunogenicity of PEGylated emulsions injected intravenously or subcutaneously into ratsEur J Pharm Biopharm201385374475124129310
  • ZhangQDengCFuYSunXGongTZhangZRepeated administration of hyaluronic acid coated liposomes with improved pharmacokinetics and reduced immune responseMol Pharm20161361800180827112287
  • Abu LilaASUeharaYIshidaTKiwadaHApplication of polyglycerol coating to plasmid DNA lipoplex for the evasion of the accelerated blood clearance phenomenon in nucleic acid deliveryJ Pharm Sci2014103255756624347396
  • HiraiTYoshiokaYUdakaAPotential suppressive effects of two C60 fullerene derivatives on acquired immunityNanoscale Res Lett201611144927709563
  • JovanovićBAnastasovaLRoweEWPalićDHydroxylated fullerenes inhibit neutrophil function in fathead minnow (Pimephales promelas Rafinesque, 1820)Aquat Toxicol2011101247448221122929
  • RyanJJBatemanHRStoverAFullerene nanomaterials inhibit the allergic responseJ Immunol2007179166567217579089
  • HamiltonRFBufordMCWoodMBArnoneBMorandiMHolianAEngineered carbon nanoparticles alter macrophage immune function and initiate airway hyper-responsiveness in the BALB/c mouse modelNanotoxicology200712104117
  • JohnsonBMFraiettaJAGraciasDTAcute exposure to ZnO nanoparticles induces autophagic immune cell deathNanotoxicology20159673774825378273
  • KimCSNguyenHDIgnacioRMImmunotoxicity of zinc oxide nanoparticles with different size and electrostatic chargeInt J Nanomedicine20149Suppl 219520525565837
  • MoonE-YYiG-HKangJ-SLimJ-SKimH-MPyoSAn increase in mouse tumor growth by an in vivo immunomodulating effect of titanium dioxide nanoparticlesJ Immunotoxicol201181566721288165
  • de JongWHvan der VenLTMSleijffersASystemic and immunotoxicity of silver nanoparticles in an intravenous 28 days repeated dose toxicity study in ratsBiomaterials201334338333834323886731
  • ShenCCWangCCLiaoMHJanTRA single exposure to iron oxide nanoparticles attenuates antigen-specific antibody production and T-cell reactivity in ovalbumin-sensitized BALB/c miceInt J Nanomedicine201161229123521753874
  • SherwoodRLMccormickDLZhengSBeissingerRLInfluence of steric stabilization of liposome-encapsulated hemoglobin on Listeria monocytogenes host defenseArtif Cells Blood Substit Immobil Biotechnol19952366656798556140
  • ZhengSBeissingerRSherwoodRLMccormickDLLasicDDMartinFJLiposome-encapsulated hemoglobin: a red blood cell substituteJ Liposome Res199333575588
  • BallyMBNayarRMasinDCullisPRMayerLDStudies on the myelosuppressive activity of doxorubicin entrapped in liposomesCancer Chemother Pharmacol199027113192245488
  • GibaudSAndreuxJPWeingartenCRenardMCouvreurPIncreased bone marrow toxicity of doxorubicin bound to nanoparticlesEur J Cancer1994306820826
  • BastogneTQuality-by-design of nanopharmaceuticals – a state of the artNanomedicine20171372151215728579437
  • KumarVQinJJiangYShielding of lipid nanoparticles for siRNA delivery: impact on physicochemical properties, cytokine induction, and efficacyMol Ther Nucleic Acids20143e21025405467
  • KimJHKimCSIgnacioRMImmunotoxicity of silicon dioxide nanoparticles with different sizes and electrostatic chargeInt J Nano-medicine20149Suppl 2183
  • HuZSongBXuLAqueous synthesized quantum dots interfere with the NF-κB pathway and confer anti-tumor, anti-viral and anti-inflammatory effectsBiomaterials201610818719627639114
  • HiraiTYoshikawaTNabeshiHSize-dependent immune-modulating effect of amorphous nanosilica particlesPharmazie201166972772822026132
  • D’AddioSMSaadWAnsellSMEffects of block copolymer properties on nanocarrier protection from in vivo clearanceJ Control Release2012162120821722732478
  • MoyanoDFGoldsmithMSolfiellDJNanoparticle hydrophobicity dictates immune responseJ Am Chem Soc201213493965396722339432
  • LeeYKChoiEJWebsterTJKimSHKhangDEffect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicityInt J Nanomedicine2015109711325565807
  • NelAEMädlerLVelegolDUnderstanding biophysicochemical interactions at the nano–bio interfaceNat Mater20098754355719525947
  • SaptarshiSRDuschlALopataALInteraction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticleJ Nanobiotechnology20131112623870291
  • FröhlichEValue of phagocyte function screening for immunotoxicity of nanoparticles in vivoInt J Nanomedicine2015103761377826060398
  • LiYItalianiPCasalsEAssessing the immunosafety of engineered nanoparticles with a novel in vitro model based on human primary monocytesACS Appl Mater Interfaces2016842284372844727670583
  • ElsabahyMWooleyKLCytokines as biomarkers of nanoparticle immunotoxicityChem Soc Rev20134212555223549679
  • DobrovolskaiaMAMcneilSEUnderstanding the correlation between in vitro and in vivo immunotoxicity tests for nanomedicinesJ Control Release2013172245646623742883
  • GuadagniniRHalamoda KenzaouiBCartwrightLToxicity screenings of nanomaterials: challenges due to interference with assay processes and components of classic in vitro testsNanotoxicology20159Suppl 1132423889211
  • PhamCTNThomasDGBeiserJApplication of a hemolysis assay for analysis of complement activation by perfluorocarbon nanoparticlesNanomedicine201410365166024211337
  • MeerasaAG HuangJGuFXCH(50): A revisited hemolytic complement consumption assay for evaluation of nanoparticles and blood plasma protein interactionCurr Drug Deliv20118329029821291380
  • QuagliaFOstacoloLde RosaGNanoscopic core–shell drug carriers made of amphiphilic triblock and stardiblock copolymersInt J Pharm20063241566616920288
  • WalkeyCDOlsenJBSongFProtein corona fingerprinting predicts the cellular interaction of gold and silver nanoparticlesACS Nano2014832439245524517450
  • OostinghGJCasalsEItalianiPProblems and challenges in the development and validation of human cell-based assays to determine nanoparticle-induced immunomodulatory effectsPart Fibre Toxicol201181821306632
  • DobrovolskaiaMAPre-clinical immunotoxicity studies of nanotechnology-formulated drugs: challenges, considerations and strategyJ Control Release201522057158326348388
  • CristRMGrossmanJHPatriAKCommon pitfalls in nanotechnology: lessons learned from NCI’s Nanotechnology Characterization LaboratoryIntegr Biol (Camb)201351667322772974
  • International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use. Preclinical safety evaluation of biotechnology-derived pharmaceuticals S6(R1)2011 Available from: http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S6_R1/Step4/S6_R1_Guideline.pdfAccessed August 27, 2018
  • International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use. Immunotoxicity studies for human pharmaceuticals S82005 Available from: http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S8/Step4/S8_Guideline.pdfAccessed August 27, 2018
  • Global summit on regulatory science: nanotechnology standards and applications. Final report2016
  • Bremer-HoffmannSHalamoda-KenzaouiBBorgosSEIdentification of regulatory needs for nanomedicinesJ Interdiscip Nanomed201831415
  • European Medicines AgencyReflection paper on the data requirements for intravenous liposomal products developed with reference to an innovator liposomal productLondonEuropean Medicines agency2013 Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2013/03/WC500140351.pdfAccessed August 27, 2018
  • European Medicines AgencyReflection paper on the data requirements for intravenous iron-based nano-colloidal products developed with reference to an innovator medicinal productLondonEuropean Medicines agency2015 Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2015/03/WC500184922.pdfAccessed August 27, 2018
  • EMA/CHMPJoint MHLW/EMA reflection paper on the development of block copolymer micelle medicinal productsEMA/CHMP/13099/20132013
  • ASTMStandard Test Method for Evaluation of the Effect of Nanoparticulate Materials on the Formation of Mouse Granulocyte-Macrophage ColoniesASTME2525 – 08(2013)2013
  • ASTMStandard Practice for Testing for Whole Complement Activation in Serum by Solid MaterialsASTM F1984 – 99(2013)2013
  • EUNCL | Nanomedicine Characterisation Laboratory Available from: http://www.euncl.eu/Accessed October 28, 2016
  • TaoYHanJDouHSurface modification of paclitaxel-loaded polymeric nanoparticles: evaluation of invitro cellular behavior and invivo pharmacokineticPolymer2012532250785086
  • BucharskayaABPakhomySSZlobinaOVAlterations of morphology of lymphoid organs and peripheral blood indicators under the influence of gold nanoparticles in ratsJ Innov Opt Health Sci201609011640004
  • EasoSLMohananPVIn vitro hematological and in vivo immunotoxicity assessment of dextran stabilized iron oxide nanoparticlesColloids Surf B Biointerfaces201513412213026183082
  • IlinskayaANClogstonJDMcneilSEDobrovolskaiaMAInduction of oxidative stress by Taxol® vehicle Cremophor-EL triggers production of interleukin-8 by peripheral blood mononuclear cells through the mechanism not requiring de novo synthesis of mRNANanomedicine20151181925193826282378
  • PondmanKMTsolakiAGPaudyalBComplement deposition on nanoparticles can modulate immune responses by macrophage, B and T cellsJ Biomed Nanotechnol201612119721627301184
  • HerdHLBartlettKTGustafsonJAMcgillLDGhandehariHMacrophage silica nanoparticle response is phenotypically dependentBiomaterials20155357458225890753
  • RudinCMMarshallJLHuangCHDelivery of a liposomal c-raf-1 antisense oligonucleotide by weekly bolus dosing in patients with advanced solid tumors: a Phase I studyClin Cancer Res200410217244725115534098
  • LiuJTianXLuoNSub-10 nm monoclinic Gd2O3:Eu +3 nanoparticles as dual-modal nanoprobes for magnetic resonance and fluorescence imagingLangmuir20143043130051301325289961
  • ParkEJParkKOxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitroToxicol Lett20091841182519022359
  • LeeSKimMSLeeDThe comparative immunotoxicity of mesoporous silica nanoparticles and colloidal silica nanoparticles in miceInt J Nanomedicine2013814715823326190
  • BeyerleABraunAMerkelOKochFKisselTStoegerTComparative in vivo study of poly(ethylene imine)/siRNA complexes for pulmonary delivery in miceJ Control Release20111511515621223987
  • MurrayARKisinELeonardSSOxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubesToxicology2009257316117119150385
  • ArancibiaSBarrientosATorrejónJEscobarABeltránCJCopper oxide nanoparticles recruit macrophages and modulate nitric oxide, proinflammatory cytokines and PGE2 production through arginase activationNanomedicine201611101237125127079258
  • LiuHYangDYangHComparative study of respiratory tract immune toxicity induced by three sterilisation nanoparticles: silver, zinc oxide and titanium dioxideJ Hazard Mater2013248249147848623972665
  • HuangYJHungKCHsiehFYHsuSHCarboxyl-functionalized polyurethane nanoparticles with immunosuppressive properties as a new type of anti-inflammatory platformNanoscale2015748203522036426602242