References
- GreishKEnhanced permeability and retention of macromolecular drugs in solid tumors: a royal gate for targeted anticancer nanomedicinesJ Drug Target2007157–845746417671892
- MaedaHNakamuraHFangJThe EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivoAdv Drug Deliv Rev2013651717923088862
- MaedaHWuJSawaTMatsumuraYHoriKTumor vascular permeability and the EPR effect in macromolecular therapeutics: a reviewJ Control Release2000651–227128410699287
- AlimoradiHMatikondaSSGambleABGilesGIGreishKHypoxia responsive drug delivery systems in tumor therapyCurr Pharm Des201622192808282026898739
- BaruaSMitragotriSChallenges associated with penetration of nanoparticles across cell and tissue barriers: a review of current status and future prospectsNano Today20149222324325132862
- NettiPABerkDASwartzMAGrodzinskyAJJainRKRole of extracellular matrix assembly in interstitial transport in solid tumorsCancer Res20006092497250310811131
- BarefordLMSwaanPWEndocytic mechanisms for targeted drug deliveryAdv Drug Deliv Rev200759874875817659804
- YinQShenJZhangZYuHLiYReversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumorAdv Drug Deliv Rev20136513–141699171523611952
- SelbyLICortez-JugoCMSuchGKJohnstonAPRNanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticlesWiley Interdiscip Rev Nanomed Nanobiotechnol201795e1452
- KumarVHongSYMaciagAEStabilization of the nitric oxide (NO) prodrugs and anticancer leads, PABA/NO and double JS-K, through incorporation into PEG-protected nanoparticlesMol Pharm20107129129820000791
- MillerMRMegsonILRecent developments in nitric oxide donor drugsBr J Pharmacol2007151330532117401442
- GilesNMKumariSGangBPYuenCWBillaudEMGilesGIThe molecular design of S-nitrosothiols as photodynamic agents for controlled nitric oxide releaseChem Biol Drug Des201280347147822642531
- KumariSSammutIAGilesGIThe design of nitric oxide donor drugs: s-nitrosothiol tDodSNO is a superior photoactivated donor in comparison to GSNO and SNAPEur J Pharmacol201473716817624858367
- LowensteinCJNitric oxide regulation of protein trafficking in the cardiovascular systemCardiovasc Res200775224024617490627
- GreishKSawaTFangJAkaikeTMaedaHSMA-doxorubicin, a new polymeric micellar drug for effective targeting to solid tumoursJ Control Release200497221923015196749
- KaurPNagarajaGMZhengHA mouse model for triple-negative breast cancer tumor-initiating cells (TNBC-TICs) exhibits similar aggressive phenotype to the human diseaseBMC Cancer20121212022452810
- VermesIHaanenCSteffens-NakkenHReutelingspergerCA novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin VJ Immunol Methods1995184139517622868
- Rello-VaronaSHerrero-MartínDLópez-AlemanyRMuñoz-PinedoCTiradoOM“(Not) all (dead) things share the same breath”: identification of cell death mechanisms in anticancer therapyCancer Res201575691391725724677
- LoewLMCarringtonWTuftRAFayFSPhysiological cytosolic Ca2+ transients evoke concurrent mitochondrial depolarizationsProc Natl Acad Sci U S A1994912612579125837809081
- FarkasDLWeiMDFebbrorielloPCarsonJHLoewLMSimultaneous imaging of cell and mitochondrial membrane potentialsBiophys J1989566105310692611324
- ChouTCDrug combination studies and their synergy quantification using the Chou-Talalay methodCancer Res201070244044620068163
- GreenPSLeeuwenburghCMitochondrial dysfunction is an early indicator of doxorubicin-induced apoptosisBiochim Biophys Acta2002158819410112379319
- DoutheilJAlthausenSTreimanMPaschenWEffect of nitric oxide on endoplasmic reticulum calcium homeostasis, protein synthesis and energy metabolismCell Calcium200027210711510756977
- BossOSamecSKühneFUncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperatureJ Biol Chem19982731589417036
- ZhangSLiJLykotrafitisGBaoGSureshSSize-dependent endocytosis of nanoparticlesAdv Mater20092141942419606281
- Pierzyńska-MachAJanowskiPADobruckiJWEvaluation of acridine orange, LysoTracker Red, and quinacrine as fluorescent probes for long-term tracking of acidic vesiclesCytometry A201485872973724953340
- TraganosFDarzynkiewiczZLysosomal proton pump activity: supravital cell staining with acridine orange differentiates leukocyte subpopulationsMethods Cell Biol1994411851947532261
- BarenholzYDoxil® – the first FDA-approved nano-drug: lessons learnedJ Control Release2012160211713422484195
- BlancoEShenHFerrariMPrinciples of nanoparticle design for overcoming biological barriers to drug deliveryNat Biotechnol201533994195126348965
- RigantiCMiragliaEViarisioDNitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug effluxCancer Res200565251652515695394
- TanLHuangRLiXLiuSShenYMControllable release of nitric oxide and doxorubicin from engineered nanospheres for synergistic tumor therapyActa Biomater20175749851028499633
- SongQTanSZhuangXNitric oxide releasing d-α-tocopheryl polyethylene glycol succinate for enhancing antitumor activity of doxorubicinMol Pharm201411114118412925222114
- KashfiKRigasBMolecular targets of nitric-oxide-donating aspirin in cancerBiochem Soc Trans200533Pt 470170416042578
- RiegerAMNelsonKLKonowalchukJDBarredaDRModified annexin V/propidium iodide apoptosis assay for accurate assessment of cell deathJ Vis Exp2011502597
- WinkDAMitchellJBChemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxideFree Radic Biol Med1998254–54344569741580
- SenSKawaharaBChaudhuriGMitochondrial-associated nitric oxide synthase activity inhibits cytochrome c oxidase: implications for breast cancerFree Radic Biol Med20135721022023089229
- MimnaughEGTrushMABhatnagarMGramTEEnhancement of reactive oxygen-dependent mitochondrial membrane lipid peroxidation by the anticancer drug adriamycinBiochem Pharmacol19853468478563977958
- GoormaghtighEPollakisGRuysschaertJMMitochondrial membrane modifications induced by adriamycin-mediated electron transportBiochem Pharmacol19833258898936838634
- BrownGCNitric oxide and mitochondrial respirationBiochim Biophys Acta199914112–335136910320668
- RigantiCMiragliaEViarisioDNitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug effluxCancer Res200565251652515695394
- FergusonSMDe CamilliPDynamin, a membrane-remodelling GTPaseNat Rev Mol Cell Biol2012132758822233676
- WangGMoniriNHOzawaKStamlerJSDaakaYNitric oxide regulates endocytosis by S-nitrosylation of dynaminProc Natl Acad Sci U S A200610351295130016432212
- EvansCJPhillipsRMJonesPFA mathematical model of doxorubicin penetration through multicellular layersJ Theor Biol2009257459860819183560
- KimJYungBCKimWJChenXCombination of nitric oxide and drug delivery systems: tools for overcoming drug resistance in chemotherapyJ Control Release201726322323028034787
- PetersenNHOlsenODGroth-PedersenLTransformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinaseCancer Cell201324337939324029234
- KirkegaardTRothAGPetersenNHHsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathologyNature2010463728054955320111001
- SarkarSKorolchukVIRennaMComplex inhibitory effects of nitric oxide on autophagyMol Cell2011431193221726807
- YuHXiaoYJinLA lysosome-targetable and two-photon fluorescent probe for monitoring endogenous and exogenous nitric oxide in living cellsJ Am Chem Soc201213442174861748923043509
- RepnikUStokaVTurkVTurkBLysosomes and lysosomal cathepsins in cell deathBiochim Biophys Acta201218241223321914490
- KroemerGJäätteläMLysosomes and autophagy in cell death controlNat Rev Cancer200551188689716239905
- LiYSunYJingLLysosome inhibitors enhance the chemotherapeutic activity of doxorubicin in HepG2 cellsChemotherapy2017622859327764836
- KinoshitaRIshimaYChuangVTGImproved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimerBiomaterials201714016216928651144
- MaedaHMacromolecular therapeutics in cancer treatment: the EPR effect and beyondJ Control Release2012164213814422595146
- IshimaYInoueAFangJPoly-S-nitrosated human albumin enhances the antitumor and antimetastasis effect of bevacizumab, partly by inhibiting autophagy through the generation of nitric oxideCancer Sci2015106219420025457681
- IshimaYAlbumin-based nitric oxide traffic system for the treatment of intractable cancersBiol Pharm Bull201740212813428154250
- GreishKFateelMAbdelghanySRachelNAlimoradiHBakhietMSildenafil citrate improves the delivery and anticancer activity of doxorubicin formulations in a mouse model of breast cancerJ Drug Target201826761061529148852
- ChoudhariSKChaudharyMBagdeSGadbailARJoshiVNitric oxide and cancer: a reviewWorld J Surg Oncol20131111823718886
- MorikawaSBalukPKaidohTHaskellAJainRKMcDonaldDMAbnormalities in pericytes on blood vessels and endothelial sprouts in tumorsAm J Pathol20021603985100011891196
- BonavidaBGarbanHNitric oxide-mediated sensitization of resistant tumor cells to apoptosis by chemo-immunotherapeuticsRedox Biol2015648649426432660
- GreishKTaurinSMorsyMAThe effect of adjuvant therapy with TNF-α on animal model of triple-negative breast cancerTher Deliv20189533334229681232