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Original Research

Doxycycline-Embedded Nanofibrous Membranes Help Promote Healing of Tendon Rupture

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Pages 125-136 | Published online: 09 Jan 2020

References

  • Jarvinen TA, Kannus P, Maffulli N, Khan KM. Achilles tendon disorders: etiology and epidemiology. Foot Ankle Clin. 2005;10(2):255–266. doi:10.1016/j.fcl.2005.01.01315922917
  • Leppilahti J, Puranen J, Orava S. Incidence of Achilles tendon rupture. Acta Orthop Scand. 1996;67(3):277–279. doi:10.3109/174536796089946888686468
  • Suchak AA, Bostick G, Reid D, Blitz S, Jomha N. The incidence of Achilles tendon ruptures in Edmonton, Canada. Foot Ankle Int. 2005;26(11):932–936. doi:10.1177/10711007050260110616309606
  • McQuillan R, Gregan P. Tendon rupture as a complication of corticosteroid therapy. Palliat Med. 2005;19(4):352–353. doi:10.1177/02692163050190041215984509
  • Seeger JD, West WA, Fife D, Noel GJ, Johnson LN, Walker AM. Achilles tendon rupture and its association with fluoroquinolone antibiotics and other potential risk factors in a managed care population. Pharmacoepidemiol Drug Saf. 2006;15(11):784–792. doi:10.1002/(ISSN)1099-155716456878
  • Kraemer R, Wuerfel W, Lorenzen J, Busche M, Vogt PM, Knobloch K. Analysis of hereditary and medical risk factors in Achilles tendinopathy and Achilles tendon ruptures: a matched pair analysis. Arch Orthop Trauma Surg. 2012;132(6):847–853. doi:10.1007/s00402-012-1476-922350054
  • Moller M, Movin T, Granhed H, Lind K, Faxen E, Karlsson J. Acute rupture of tendon Achillis. A prospective randomised study of comparison between surgical and non-surgical treatment. J Bone Joint Surg Br. 2001;83(6):843–848. doi:10.1302/0301-620X.83B6.083084311521926
  • Twaddle BC, Poon P. Early motion for Achilles tendon ruptures: is surgery important? A randomized, prospective study. Am J Sports Med. 2007;35(12):2033–2038. doi:10.1177/036354650730750317885221
  • Metz R, Verleisdonk EJ, van der Heijden GJ, et al. Acute Achilles tendon rupture: minimally invasive surgery versus nonoperative treatment with immediate full weightbearing – a randomized controlled trial. Am J Sports Med. 2008;36(9):1688–1694. doi:10.1177/036354650831931218645042
  • Nilsson-Helander K, Silbernagel KG, Thomee R, et al. Acute achilles tendon rupture: a randomized, controlled study comparing surgical and nonsurgical treatments using validated outcome measures. Am J Sports Med. 2010;38(11):2186–2193. doi:10.1177/036354651037605220802094
  • Keating JF, Will EM. Operative versus non-operative treatment of acute rupture of tendo Achillis: a prospective randomised evaluation of functional outcome. J Bone Joint Surg Br. 2011;93(8):1071–1078. doi:10.1302/0301-620X.93B8.2599821768631
  • Gong F, Cui L, Zhang X, Zhan X, Gong X, Wen Y. Piperine ameliorates collagenase-induced Achilles tendon injury in the rat. Connect Tissue Res. 2018;59(1):21–29. doi:10.1080/03008207.2017.128918828165813
  • Fernandes de Jesus J, Spadacci-Morena DD, Rabelo N, Pinfildi CE, Fukuda TY, Plapler H. Photobiomodulation of matrix metalloproteinases in rat calcaneal tendons. Photobiomodul Photomed Laser Surg. 2019;37(7):421–427. doi:10.1089/photob.2019.463331184972
  • Molloy TJ, Wang Y, Horner A, Skerry TM, Murrell GA. Microarray analysis of healing rat Achilles tendon: evidence for glutamate signaling mechanisms and embryonic gene expression in healing tendon tissue. J Orthop Res. 2006;24(4):842–855. doi:10.1002/(ISSN)1554-527X16514666
  • Thomopoulos S, Parks WC, Rifkin DB, Derwin KA. Mechanisms of tendon injury and repair. J Orthop Res. 2015;33(6):832–839. doi:10.1002/jor.2280625641114
  • Gotoh M, Mitsui Y, Shibata H, et al. Increased matrix metalloprotease-3 gene expression in ruptured rotator cuff tendons is associated with postoperative tendon retear. Knee Surg Sports Traumatol Arthrosc. 2013;21(8):1807–1812. doi:10.1007/s00167-012-2209-x23000921
  • Jacob J, Eisemon E, Sheibani-Rad S, Patel A, Jacob T, Choueka J. Matrix metalloproteinase levels as a marker for rotator cuff tears. Orthopedics. 2012;35(4):e474–478. doi:10.3928/01477447-20120327-1822495845
  • Baldwin SJ, Kreplak L, Lee JM. MMP-9 selectively cleaves non-D-banded material on collagen fibrils with discrete plasticity damage in mechanically-overloaded tendon. J Mech Behav Biomed Mater. 2019;95:67–75. doi:10.1016/j.jmbbm.2019.03.02030954916
  • Bedi A, Fox AJ, Kovacevic D, Deng XH, Warren RF, Rodeo SA. Doxycycline-mediated inhibition of matrix metalloproteinases improves healing after rotator cuff repair. Am J Sports Med. 2010;38(2):308–317. doi:10.1177/036354650934736619826139
  • Kessler MW, Barr J, Greenwald R, et al. Enhancement of Achilles tendon repair mediated by matrix metalloproteinase inhibition via systemic administration of doxycycline. J Orthop Res. 2014;32(4):500–506. doi:10.1002/jor.v32.424346815
  • Nguyen QT, Norelli JB, Graver A, et al. Therapeutic effects of doxycycline on the quality of repaired and unrepaired achilles tendons. Am J Sports Med. 2017;45(12):2872–2881. doi:10.1177/036354651771663728759732
  • Rooney SI, Torino DJ, Baskin R, et al. Doxycycline improves cage activity, but not exercised, supraspinatus tendon and muscle in a rat model. J Biomech. 2018;80:79–87. doi:10.1016/j.jbiomech.2018.08.02730217557
  • Smith K, Leyden JJ. Safety of doxycycline and minocycline: a systematic review. Clin Ther. 2005;27(9):1329–1342. doi:10.1016/j.clinthera.2005.09.00516291409
  • Sun X, Xu C, Wu G, Ye Q, Wang C. Poly(lactic-co-glycolic acid): applications and future prospects for periodontal tissue regeneration. Polymers (Basel). 2017;9:6. doi:10.3390/polym9060189
  • Ma B, Xie J, Jiang J, Shuler FD, Bartlett DE. Rational design of nanofiber scaffolds for orthopedic tissue repair and regeneration. Nanomedicine. 2013;8(9):1459–1481. doi:10.2217/nnm.13.13223987110
  • Kao CW, Tseng YY, Liu KS, et al. Anesthetics and human epidermal growth factor incorporated into anti-adhesive nanofibers provide sustained pain relief and promote healing of surgical wounds. Int J Nanomedicine. 2019;14:4007–4016. doi:10.2147/IJN.S20240231213812
  • Chen YP, Liu YW, Lee D, Qiu JT, Lee TY, Liu SJ. Biodegradable andrographolide-eluting nanofibrous membranes for the treatment of cervical cancer. Int J Nanomedicine. 2019;14:421–429. doi:10.2147/IJN.S18671430666104
  • Cerrato R, Switaj P. Using arthroscopic techniques for Achilles pathology. Foot Ankle Clin. 2017;22(4):781–799. doi:10.1016/j.fcl.2017.07.00729078828
  • Schlussel MM, Keene DJ, Wagland S, et al. Platelet-rich plasma in Achilles tendon healing 2 (PATH-2) trial: statistical analysis plan for a multicentre, double-blinded, parallel-group, placebo-controlled randomised clinical trial. Trials. 2018;19(1):464. doi:10.1186/s13063-018-2840-z30157940
  • Oliva F, Maffulli N, Gissi C, et al. Combined ascorbic acid and T3 produce better healing compared to bone marrow mesenchymal stem cells in an Achilles tendon injury rat model: a proof of concept study. J Orthop Surg Res. 2019;14(1):54. doi:10.1186/s13018-019-1098-930777116
  • Xie S, Zhou Y, Tang Y, et al. Book-shaped decellularized tendon matrix scaffold combined with bone marrow mesenchymal stem cells-sheets for repair of Achilles tendon defect in Rabbit. J Orthop Res. 2019. doi:10.1002/jorr.v37.4
  • Jeong C, Kim SE, Shim KS, et al. Exploring the in vivo anti-inflammatory actions of simvastatin-loaded porous microspheres on inflamed tenocytes in a collagenase-induced animal model of Achilles Tendinitis. Int J Mol Sci. 2018;19:3. doi:10.3390/ijms19030820
  • Del Buono A, Oliva F, Longo UG, et al. Metalloproteases and rotator cuff disease. J Shoulder Elbow Surg. 2012;21(2):200–208. doi:10.1016/j.jse.2011.10.02022244063
  • Garofalo R, Cesari E, Vinci E, Castagna A. Role of metalloproteinases in rotator cuff tear. Sports Med Arthrosc. 2011;19(3):207–212. doi:10.1097/JSA.0b013e318227b07b21822103
  • Riley GP, Curry V, DeGroot J, et al. Matrix metalloproteinase activities and their relationship with collagen remodelling in tendon pathology. Matrix Biol. 2002;21(2):185–195. doi:10.1016/S0945-053X(01)00196-211852234
  • Pasternak B, Schepull T, Eliasson P, Aspenberg P. Elevation of systemic matrix metalloproteinases 2 and 7 and tissue inhibitor of metalloproteinase 2 in patients with a history of Achilles tendon rupture: pilot study. Br J Sports Med. 2010;44(9):669–672. doi:10.1136/bjsm.2008.04941118628360
  • Karousou E, Ronga M, Vigetti D, Passi A, Maffulli N. Collagens, proteoglycans, MMP-2, MMP-9 and TIMPs in human achilles tendon rupture. Clin Orthop Relat Res. 2008;466(7):1577–1582. doi:10.1007/s11999-008-0255-y18425559
  • Dong M, Zhong L, Chen WQ, et al. Doxycycline stabilizes vulnerable plaque via inhibiting matrix metalloproteinases and attenuating inflammation in rabbits. PLoS ONE. 2012;7(6):e39695. doi:10.1371/journal.pone.003969522737253
  • Golub LM, Lee HM, Ryan ME, Giannobile WV, Payne J, Sorsa T. Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Adv Dent Res. 1998;12(2):12–26. doi:10.1177/089593749801200105019972117
  • Griffin MO, Ceballos G, Villarreal FJ. Tetracycline compounds with non-antimicrobial organ protective properties: possible mechanisms of action. Pharmacol Res. 2011;63(2):102–107. doi:10.1016/j.phrs.2010.10.00420951211
  • Raffetto JD, Khalil RA. Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. Biochem Pharmacol. 2008;75(2):346–359. doi:10.1016/j.bcp.2007.07.00417678629
  • Pasternak B, Missios A, Askendal A, Tengvall P, Aspenberg P. Doxycycline-coated sutures improve the suture-holding capacity of the rat Achilles tendon. Acta Orthop. 2007;78(5):680–686. doi:10.1080/1745367071001439217966029
  • Pasternak B, Fellenius M, Aspenberg P. Doxycycline impairs tendon repair in rats. Acta Orthop Belg. 2006;72(6):756–760.17260615
  • Makadia HK, Siegel SJ. Poly Lactic-co-Glycolic Acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers-Basel. 2011;3(3):1377–1397. doi:10.3390/polym303137722577513
  • Kumbar SG, Nukavarapu SP, James R, Nair LS, Laurencin CT. Electrospun poly(lactic acid-co-glycolic acid) scaffolds for skin tissue engineering. Biomaterials. 2008;29(30):4100–4107. doi:10.1016/j.biomaterials.2008.06.02818639927