Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications

References

• Krishnaiah YS. Pharmaceutical technologies for enhancing oral bioavailability of poorly soluble drugs. J Bioequivalence Bioavailab. 2010;2(2):28–36. doi:10.4172/jbb.1000027
   Google Scholar
• Teeranachaideekul V, Müller RH, Junyaprasert VB. Encapsulation of ascorbyl palmitate in nanostructured lipid carriers (NLC) effects of formulation parameters on physicochemical stability. Int J Pharm. 2007;340(1–2):198–206. doi:10.1016/j.ijpharm.2007.03.02217482778
   PubMed Web of Science ®Google Scholar
• Siddiqui IA, Sanna V. Impact of nanotechnology on the delivery of natural products for cancer prevention and therapy. Mol Nutr Food Res. 2016;60(6):1330–1341. doi:10.1002/mnfr.20160003526935239
   PubMed Web of Science ®Google Scholar
• Aqil F, Munagala R, Jeyabalan J, Vadhanam MV. Bioavailability of phytochemicals and its enhancement by drug delivery systems. Cancer Lett. 2013;334:133–141. doi:10.1016/j.canlet.2013.02.03223435377
   PubMed Web of Science ®Google Scholar
• Adhami VM, Mukhtar H. Human cancer chemoprevention: hurdles and challenges. Top Curr Chem. 2013;329:203–220.22790416
   PubMed Web of Science ®Google Scholar
• Bharali DJ, Siddiqui IA, Adhami VM, et al. Nanoparticle delivery of natural products in the prevention and treatment of cancers: current status and future prospects. Cancers. 2011;3(4):4024–4045. doi:10.3390/cancers304402424213123
   PubMedGoogle Scholar
• Wang S, Su R, Nie S, et al. Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals. J Nutr Biochem. 2014;25:363–376. doi:10.1016/j.jnutbio.2013.10.00224406273
   PubMed Web of Science ®Google Scholar
• ud Din F, Aman W, Ullah I, et al. Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. Int J Nanomed. 2017;12:7291–7309. doi:10.2147/IJN.S146315
   PubMed Web of Science ®Google Scholar
• Saraf A. Applications of novel drug delivery system for herbal formulations. Fitoterapia. 2010;81(7):680–689. doi:10.1016/j.fitote.2010.05.00120471457
   PubMed Web of Science ®Google Scholar
• Ni S. Nanoparticles carrying natural product for drug delivery. J Drug Delivery Ther. 2017;7(3):73–75. doi:10.22270/jddt.v7i3.1425
   Google Scholar
• Nagalingam A. Drug delivery aspects of herbal medicines. Jpn Kampo Med Treat Common Dis Focus Inflammation. 2017;17:143.
   Google Scholar
• Liu Y, Feng N. Nanocarriers for the delivery of active ingredients and fractions extracted from natural products used in traditional Chinese medicine (TCM). Adv Colloid Interface Sci. 2015;221:60–76. doi:10.1016/j.cis.2015.04.00625999266
   PubMed Web of Science ®Google Scholar
• Lin CH, Chen CH, Lin ZC, Fang JY. Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers. J Food Drug Anal. 2017;25(2):219–234. doi:10.1016/j.jfda.2017.02.00128911663
   PubMed Web of Science ®Google Scholar
• Yingchoncharoen P, Kalinowski DS, Richardson DR. Lipid-based drug delivery systems in cancer therapy: what is available and what is yet to come. Pharmacol Rev. 2016;68(3):701–787.27363439
   PubMed Web of Science ®Google Scholar
• Luo CF, Yuan M, Chen MS, et al. Pharmacokinetics, tissue distribution and relative bioavailability of puerarin solid lipid nanoparticles following oral administration. Int J Pharm. 2011;410:138–144. doi:10.1016/j.ijpharm.2011.02.06421392565
   PubMed Web of Science ®Google Scholar
• Rostami E, Kashanian S, Azandaryani AH, Faramarzi H, Dolatabadi JE, Omidfar K. Drug targeting using solid lipid nanoparticles. Chem Phys Lipids. 2014;18:56–61. doi:10.1016/j.chemphyslip.2014.03.006
   Google Scholar
• Luo CF, Hou N, Tian J, et al. Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles. Int J Nanomed. 2013;8:933–940. doi:10.2147/IJN.S39349
   PubMed Web of Science ®Google Scholar
• Zhang C, Gu C, Peng F, et al. Preparation and optimization of triptolide-loaded solid lipid nanoparticles for oral delivery with reduced gastric irritation. Molecules. 2013;18(18):13340–13356. doi:10.3390/molecules18111334024172242
   PubMedGoogle Scholar
• Dang YJ, Zhu CY. Oral bioavailability of cantharidin-loaded solid lipid nanoparticles. Chin Med. 2013;8:1–6. doi:10.1186/1749-8546-8-123298453
   PubMed Web of Science ®Google Scholar
• Madan J, Pandey RS, Jain V, Katare OP, Chandra R, Katyal A. Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells. Nanomedicine. 2013;9(4):492–503. doi:10.1016/j.nano.2012.10.00323117045
   PubMed Web of Science ®Google Scholar
• Li J, Guo X, Liu Z, et al. Preparation and evaluation of charged solid lipid nanoparticles of tetrandrine for ocular drug delivery system: pharmacokinetics, cytotoxicity and cellular uptake studies. Drug Dev Ind Pharm. 2014;40:980–987. doi:10.3109/03639045.2013.79558223662696
   PubMed Web of Science ®Google Scholar
• Rahman HS, Rasedee A, How CW, et al. Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect. Int J Nanomed. 2013;8:2769–2781. doi:10.2147/IJN.S45313
   PubMed Web of Science ®Google Scholar
• Das S, Ng WK, Tan RB. Are nanostructured lipid carriers (NLCs) better than solid lipid nanoparticles (SLNs): development, characterizations and comparative evaluations of clotrimazole-loaded SLNs and NLCs? Eur J Pharm Sci. 2012;47(1):139–151. doi:10.1016/j.ejps.2012.05.01022664358
   PubMed Web of Science ®Google Scholar
• Muhammad HS. Anti-Leukemic Effects of Zerumbone Nanoparticle on Human Jurkat T Lymphoblastoid Cell Lines In vitro and Murine Leukemic WEHI-3B Model In vivo [Doctoral dissertation]. Universiti Putra Malaysia; 2014.
   Google Scholar
• Shangguan M, Feng Q, Zhao J, et al. Binary lipids-based nanostructured lipid carriers for improved oral bioavailability of silymarin. Food Chem Toxicol. 2012;50:1460–1467.22285414
   PubMedGoogle Scholar
• Nahr FK, Ghanbarzadeh B, Hamishehkar H, Kafil HS. Food grade nanostructured lipid carrier for cardamom essential oil: preparation, characterization and antimicrobial activity. J Funct Foods. 2018;40:1–8. doi:10.1016/j.jff.2017.09.028
   Web of Science ®Google Scholar
• Rahman HS, Rasedee A, Abdul AB, et al. Zerumbone-loaded nanostructured lipid carrier induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in a human lymphoblastic leukemia cell line. Int J Nanomed. 2014;9:527–538. doi:10.2147/IJN.S54346
   PubMed Web of Science ®Google Scholar
• Ng WK, Saiful Yazan L, Yap LH, et al. Thymoquinone-loaded nanostructured lipid carrier exhibited cytotoxicity towards breast cancer cell lines (MDA-MB-231 and MCF-7) and cervical cancer cell lines (HeLa and SiHa). Biomed Res Int. 2015;2015:1–10.
   Web of Science ®Google Scholar
• Ong YS, Saiful Yazan L, Ng WK, et al. Thymoquinone loaded in nanostructured lipid carrier showed enhanced anticancer activity in 4T1 tumor-bearing mice. Nanomedicine. 2018;13(13):1567–1582. doi:10.2217/nnm-2017-032230028248
   PubMed Web of Science ®Google Scholar
• Nordin N, Yeap SK, Zamberi NR, et al. Characterization and toxicity of citral incorporated with nanostructured lipid carrier. Peer J. 2018;6:e3916. doi:10.7717/peerj.391629312812
   PubMed Web of Science ®Google Scholar
• Mohamad NE, Abu N, Rahman HS, et al. Nanostructured lipid carrier improved in vivo anti-tumor and immunomodulatory effect of zerumbone in 4T1 challenged mice. RSC Adv. 2015;5(28):22066–22074. doi:10.1039/C5RA00144G
   Web of Science ®Google Scholar
• Hosseinpour M, Abdul AB, Rahman HS, et al. Comparison of apoptotic inducing effect of zerumbone and zerumbone-loaded nanostructured lipid carrier on human mammary adenocarcinoma MDA-MB-231 cell line. J Nanomater. 2014;2014:1–10. doi:10.1155/2014/742738
   Web of Science ®Google Scholar
• Rahman HS, Rasedee A, How CW, et al. Antileukemic effect of zerumbone-loaded nanostructured lipid carrier in WEHI-3B cell-induced murine leukemia model. Int J Nanomed. 2015;10:1649–1666. doi:10.2147/IJN.S67113
   PubMed Web of Science ®Google Scholar
• Rahman HS, Rasedee A, Othman HH, et al. Acute toxicity study of zerumbone-loaded nanostructured lipid carrier on BALB/c mice model. Biomed Res Int. 2014;2014:1–15.
   Web of Science ®Google Scholar
• Jia Ning F, Gayathri TS, Rahman HS, et al. Zerumbone-loaded nanostructured lipid carrier induces apoptosis of canine mammary adenocarcinoma cells. Biomed Res Int. 2018;2018:1–18.
   Web of Science ®Google Scholar
• Nathaniel C, Elaine-Lee YL, Yee BC, et al. Zerumbone-loaded nanostructured lipid carrier induces apoptosis in human colorectal adenocarcinoma (Caco-2) cell line. Nanosci Nanotechnol Lett. 2016;8(4):294–302. doi:10.1166/nnl.2016.2136
   Google Scholar
• Shi F, Yang G, Ren J, Guo T, Du Y, Feng NP. Formulation design, preparation, and in vitro and in vivo characterizations of β-elemene-loaded nanostructured lipid carriers. Int J Nanomed. 2013;8:2533–2541. doi:10.2147/IJN.S46578
   PubMed Web of Science ®Google Scholar
• Jaiswal M, Dudhe R, Sharma PK. Nanoemulsion: an advanced mode of drug delivery system. 3 Biotech. 2015;5(2):123–127. doi:10.1007/s13205-014-0214-0
   PubMedGoogle Scholar
• Mahato R. Nanoemulsion as targeted drug delivery system for cancer therapeutics. J Pharm Sci Pharmacol. 2017;3(2):83–97. doi:10.1166/jpsp.2017.1082
   Google Scholar
• Lovelyn C, Attama AA. Current state of nanoemulsions in drug delivery. J Biomater Nanobiotechnol. 2011;2(05):626–639. doi:10.4236/jbnb.2011.225075
   Google Scholar
• Chhabra G, Chuttani K, Mishra AK, Pathak K. Design and development of nanoemulsion drug delivery system of amlodipine besilate for improvement of oral bioavailability. Drug Dev Ind Pharm. 2011;37(8):907–916. doi:10.3109/03639045.2010.55005021401341
   PubMed Web of Science ®Google Scholar
• Topuz OK, Özvural EB, Zhao Q, Huang Q, Chikindas M, Gölükçü M. Physical and antimicrobial properties of anise oil loaded nanoemulsions on the survival of food-borne pathogens. Food Chem. 2016;203:117–123. doi:10.1016/j.foodchem.2016.02.05126948596
   PubMed Web of Science ®Google Scholar
• Zhang S, Zhang M, Fang Z, Liu Y. Preparation and characterization of blended cloves/cinnamon essential oil nanoemulsions. LWT-Food Sci Tech. 2017;75:316–322. doi:10.1016/j.lwt.2016.08.046
   Web of Science ®Google Scholar
• Kotta S, Khan AW, Pramod K, Ansari SH, Sharma RK, Ali J. Exploring oral nanoemulsions for bioavailability enhancement of poorly water-soluble drugs. Expert Opin Drug Deliv. 2012;9(5):585–598. doi:10.1517/17425247.2012.66852322512597
   PubMed Web of Science ®Google Scholar
• Mahajan HS, Mahajan MS, Nerkar PP, Agrawal A. Nanoemulsion-based intranasal drug delivery system of saquinavir mesylate for brain targeting. Drug Deliv. 2014;21(2):148–154. doi:10.3109/10717544.2013.83801424128122
   PubMed Web of Science ®Google Scholar
• Khani S, Keyhanfar F, Amani A. Design and evaluation of oral nanoemulsion drug delivery system of mebudipine. Drug Deliv. 2016;23(6):2035–2043. doi:10.3109/10717544.2015.108859726406153
   PubMed Web of Science ®Google Scholar
• Patel RP, Joshi JR. An overview on nanoemulsion: a novel approach. Int J Pharm Sci Res. 2012;3(12):4640–4650.
   Google Scholar
• Wang X, Wang YW, Huang Q Enhancing stability and oral bioavailability of polyphenols using nanoemulsions. Micro/Nanoencapsulation of Active Food Ingredients, ACS Symposium Series; 2009;1007:198–212.
   Google Scholar
• Mezadri H. Development of Nanoemulsions Containing Extracts of Fruits of Syagrus Romanzoffiana (Cham.) Glassman and Phytochemical Study of These Extracts [Dissertation] Ouro Preto, Brazil: Faculdade de Ciências Farmacêuticas, UFOP; 2010 Portuguese.
   Google Scholar
• Zeng Z, Zhou G, Wang X, et al. Preparation, characterization and relative bioavailability of oral elemene o/w microemulsion. Int J Nanomed. 2010;7:567–572. doi:10.2147/IJN.S12485
   Google Scholar
• Ghosh V, Mukherjee A, Chandrasekaran N. Ultrasonic emulsification of food-grade nanoemulsion formulation and evaluation of its bactericidal activity. Ultrason Sonochem. 2013;20:338e344. doi:10.1016/j.ultsonch.2012.08.01022954686
   PubMed Web of Science ®Google Scholar
• Bonifácio BV, Da Silva PB, dos Santos Ramos MA, Negri KM, Bauab TM, Chorilli M. Nanotechnology-based drug delivery systems and herbal medicines: a review. Int J Nanomed. 2014;9:1–15.
   PubMed Web of Science ®Google Scholar
• Censi R, Martena V, Hoti E, Malaj L, Di Martino P. Permeation and skin retention of quercetin from microemulsions containing Transcutol® P. Drug Dev Ind Pharm. 2012;38(9):1128–1133. doi:10.3109/03639045.2011.64156422188183
   PubMed Web of Science ®Google Scholar
• Chen Y, Lin X, Park H, Greever R. Study of artemisin in nanocapsules as anticancer drug delivery system. Nanomed. 2009;5(3):316–322. doi:10.1016/j.nano.2008.12.005
   PubMed Web of Science ®Google Scholar
• Mora-Huertas CE, Fessi H, Elaissari A. Polymer-based nanocapsules for drug delivery. Int J Pharm. 2010;385(1–2):113–142. doi:10.1016/j.ijpharm.2009.10.01819825408
   PubMed Web of Science ®Google Scholar
• Abellan-Pose R, Teijeiro-Valiño C, Santander-Ortega MJ, et al. Polyaminoacid nanocapsules for drug delivery to the lymphatic system: effect of the particle size. Int J Pharm. 2016;509(1–2):107–117. doi:10.1016/j.ijpharm.2016.05.03427210735
   PubMedGoogle Scholar
• Zhao YQ, Wang LP, Ma C, Zhao K, Liu Y, Feng NP. Preparation and characterization of tetrandrine-phospholipid complex loaded lipid nanocapsules as potential oral carriers. Int J Nanomed. 2013;8:4169–4181. doi:10.2147/IJN.S50557
   PubMed Web of Science ®Google Scholar
• Alshamsan A. Nanoprecipitation is more efficient than emulsion solvent evaporation method to encapsulate cucurbitacin I in PLGA nanoparticles. Saudi Pharm J. 2014;22(3):219–222. doi:10.1016/j.jsps.2013.12.00225061407
   PubMed Web of Science ®Google Scholar
• Christofoli M, Costa EC, Bicalho KU, et al. Insecticidal effect of nanoencapsulated essential oils from Zanthoxylum rhoifolium (Rutaceae) in bemisia tabaci populations. Ind Crops Prod. 2015;70:301–308. doi:10.1016/j.indcrop.2015.03.025
   Web of Science ®Google Scholar
• Souza CF, Baldissera MD, Cossetin LF, Dalla Lana DF, Monteiro SG. Achyrocline satureioides essential oil loaded in nanocapsules ameliorate the antioxidant/oxidant status in heart of rats infected with Trypanosoma evansi. Microb Pathog. 2017;105:30–36. doi:10.1016/j.micpath.2017.02.00528185949
   PubMed Web of Science ®Google Scholar
• Rivas CJ, Tarhini M, Badri W, et al. Nanoprecipitation process: from encapsulation to drug delivery. Int J Pharm. 2017;532(1):66–81. doi:10.1016/j.ijpharm.2017.08.06428801107
   PubMedGoogle Scholar
• Sneha S, Swarnlata S, Chanchal DK, Shailendra S. Biocompatible nanoparticles for sustained topical delivery of anticancer phytoconstituent quercetin. Pak J Biol Sci. 2013;16(13):601–609. doi:10.3923/pjbs.2013.601.60924505982
   PubMedGoogle Scholar
• Adhikari P, Pal P, Das AK, Ray S, Bhattacharjee A, Mazumder B. Nano lipid-drug conjugate: an integrated review. Int J Pharm. 2017;529(1–2):629–641. doi:10.1016/j.ijpharm.2017.07.03928723407
   PubMed Web of Science ®Google Scholar
• Saracibar BL, Mendoza AEH, Guada M, Vieitez CD, Prieto MJB. Lipid nanoparticles for cancer therapy: state of the art and future prospects. Expert Opin Drug Deliv. 2012;9(10):1245–1261. doi:10.1517/17425247.2012.71792822950878
   PubMed Web of Science ®Google Scholar
• Neupane YB, Sabir MD, Ahmad N, Ali M, Kohli K. Lipid drug conjugate nanoparticle as a novel lipid nanocarrier for the oral delivery of decitabine: ex vivo gut permeation studies. Nanotechnology. 2013;24(41):1–11. doi:10.1088/0957-4484/24/41/415102
   Web of Science ®Google Scholar
• Guo W, Li A, Jia Z, Yuan Y, Dai H, Li H. Transferrin modied PEG-PLA-resveratrol conjugates: in vitro and in vivo studies for glioma. Eur J Pharmacol. 2013;718:41–47. doi:10.1016/j.ejphar.2013.09.03424070814
   PubMed Web of Science ®Google Scholar
• Shen J, Zhang D, Zhao Z, et al. Synthesis, characterization, in vitro and in vivo evaluation of PEGylated oridonin conjugates. Int J Pharm. 2013;456:80–86. doi:10.1016/j.ijpharm.2013.08.01423973480
   PubMed Web of Science ®Google Scholar
• Maiti K, Mukherjee K, Gantait A, Saha BP, Mukherjee PK. Curcumin-phospholipid complex: preparation, therapeutic evaluation and pharmacokinetic study in rats. Int J Pharm. 2007;330(1–2):155–163. doi:10.1016/j.ijpharm.2006.09.02517112692
   PubMed Web of Science ®Google Scholar
• Singh M, Bhatnagar P, Mishra S, et al. PLGA encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing ehrlich ascites carcinoma. Int J Nanomed. 2015;10:6789–6809. doi:10.2147/IJN.S79489
   PubMed Web of Science ®Google Scholar
• Sanna V, Siddiqui IA, Sechi M, Mukhtar H. Resveratrol-loaded nanoparticles based on poly(epsiloncaprolactone) and poly(D,L-lactic-co-glycolic acid)-poly(ethylene glycol) blend for prostate cancer treatment. Mol Pharm. 2013;10:3871–3881. doi:10.1021/mp400342f23968375
   PubMed Web of Science ®Google Scholar
• Pan M, Li W, Yang J, et al. Plumbagin-loaded aptamer-targeted poly D, L-lactic-co-glycolic acid-b-polyethylene glycol nanoparticles for prostate cancer therapy. Medicine. 2017;96(30):e7405. doi:10.1097/MD.000000000000740528746182
   PubMed Web of Science ®Google Scholar
• Ganesan P, Narayanasamy D. Lipid nanoparticles: different preparation techniques, characterization, hurdles, and strategies for the production of solid lipid nanoparticles and nanostructured lipid carriers for oral drug delivery. Sustain Chem Pharm. 2017;6:37–56. doi:10.1016/j.scp.2017.07.002
   Web of Science ®Google Scholar
• Robson AL, Dastoor PC, Flynn J, et al. Advantages and limitations of current imaging techniques for characterizing liposome morphology. Front Pharmacol. 2018;9(80):1–8. doi:10.3389/fphar.2018.0008029387012
   PubMedGoogle Scholar
• Lee WH, Loo CY, Young PM, Traini D, Rohanizadeh R. The development and achievement of polymeric nanoparticles for cancer drug treatment. Part Technol Delivery Ther. 2017;25–82.
   Google Scholar
• Song Z, Lin Y, Zhang X, et al. Cyclic RGD peptide-modified liposomal drug delivery system for targeted oral apatinib administration: enhanced cellular uptake and improved therapeutic effects. Int J Nanomed. 2017;12:1941–1958. doi:10.2147/IJN.S125573
   PubMed Web of Science ®Google Scholar
• Hong SS, Kim SH, Lim SJ. Effects of triglycerides on the hydrophobic drug loading capacity of saturated phosphatidylcholine-based liposomes. Int J Pharm. 2015;483(1–2):142–150. doi:10.1016/j.ijpharm.2015.02.01325667981
   PubMedGoogle Scholar
• Thangapazham RL, Puri A, Tele S, Blumenthal R, Maheshwari RK. Evaluation of nanotechnology-based carrier for delivery of curcumin in prostate cancer cells. Int J Oncol. 2008;32:1119–1123.18425340
   PubMed Web of Science ®Google Scholar
• Hong SS, Choi JY, Kim JO, Lee MK, Kim SH, Lim SJ. Development of paclitaxel-loaded liposomal nanocarrier stabilized by triglyceride incorporation. Int J Nanomed. 2016;11:4465–4477. doi:10.2147/IJN.S113723
   PubMed Web of Science ®Google Scholar
• Kannan V, Balabathula P, Divi MK, Thoma LA, Wood GC. Optimization of drug loading to improve physical stability of paclitaxel-loaded long-circulating liposomes. J Liposome Res. 2015;25(4):308–315. doi:10.3109/08982104.2014.99567125541107
   PubMed Web of Science ®Google Scholar
• Li N, Feng L, Tan Y, Xiang Y, Zhang R, Yang M. Preparation, characterization, pharmacokinetics and biodistribution of baicalin-loaded liposome on cerebral ischemia-reperfusion after iv administration in rats. Molecules. 2018;23(7):1747–1761. doi:10.3390/molecules23071747
   PubMed Web of Science ®Google Scholar
• Wang X, Guan Q, Chen W, Hu X, Li L. Novel nanoliposomal delivery system for polydatin: preparation, characterization, and in vivo evaluation. Drug Des Devel Ther. 2015;9:1805–1813. doi:10.2147/DDDT.S77615
   PubMed Web of Science ®Google Scholar
• Yi C, Fu M, Cao X, et al. Enhanced oral bioavailability and tissue distribution of a new potential anticancer agent, flammulina velutipes sterols, through liposomal encapsulation. J Agric Food Chem. 2013;61(25):5961–5971. doi:10.1021/jf305527823721187
   PubMed Web of Science ®Google Scholar
• Wang Y, Wang S, Firempong CK, et al. Enhanced solubility and bioavailability of naringenin via liposomal nanoformulation: preparation and in vitro and in vivo evaluations. AAPS PharmSciTech. 2017;18(3):586–594. doi:10.1208/s12249-016-0537-827151135
   PubMed Web of Science ®Google Scholar
• Prabhu RH, Patravale VB, Joshi MD. Polymeric nanoparticles for targeted treatment in oncology: current insights. Int J Nanomed. 2015;10:1001–1018. doi:10.2147/IJN.S56932
   PubMed Web of Science ®Google Scholar
• Chauhan P, Tyagi BK. Herbal novel drug delivery systems and transferosomes. J Drug Delivery Ther. 2018;8(3):162–168. doi:10.22270/jddt.v8i3.1772
   Google Scholar
• Rai S, Pandey V, Rai G. Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art. Nano Rev Exp. 2017;8(1):1–18. doi:10.1080/20022727.2017.1325708
   Google Scholar
• El-Refaie WM, Elnaggar YS, El-Massik MA, Abdallah OY. Novel curcumin-loaded gel-core hyaluosomes with promising burn-wound healing potential: development, in-vitro appraisal and in-vivo studies. Int J Pharm. 2015;486(1–2):88–98. doi:10.1016/j.ijpharm.2015.03.05225818063
   PubMedGoogle Scholar
• Choi JH, Cho SH, Yun JJ, Yu YB, Cho CW. Ethosomes and transfersomes for topical delivery of ginsenoside Rh1 from red ginseng: characterization and in vitro evaluation. J Nanosci Nanotechnol. 2015;15(8):5660–5662. doi:10.1166/jnn.2015.1046226369134
   PubMed Web of Science ®Google Scholar
• Ma H, Guo D, Fan Y, Wang J, Cheng J, Zhang X. Paeonol-loaded ethosomes as transdermal delivery carriers: design, preparation and evaluation. Molecules. 2018;23(7):1756–1771. doi:10.3390/molecules23071756
   PubMed Web of Science ®Google Scholar
• Sarwa KK, Mazumder B, Rudrapal M, Verma VK. Potential of capsaicin-loaded transfersomes in arthritic rats. Drug Deliv. 2015;22(5):638–646. doi:10.3109/10717544.2013.87160124471764
   PubMed Web of Science ®Google Scholar
• Jangdey MS, Gupta A, Saraf S, Saraf S. Development and optimization of apigenin-loaded transfersomal system for skin cancer delivery: in vitro evaluation. Artif Cells Nanomed Biotechnol. 2017;45(7):1452–1462. doi:10.1080/21691401.2016.124785028050929
   PubMed Web of Science ®Google Scholar
• Avadhani KS, Manikkath J, Tiwari M, et al. Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage. Drug Deliv. 2017;24(1):61–74. doi:10.1080/10717544.2016.122871828155509
   PubMed Web of Science ®Google Scholar
• Lu K, Xie S, Han S, et al. Preparation of a nano emodin transfersome and study on its anti-obesity mechanism in adipose tissue of diet-induced obese rats. J Transl Med. 2014;12(1):72–86. doi:10.1186/1479-5876-12-7224641917
   PubMedGoogle Scholar
• Nagalakshmi S, Krishnaraj K, Jothy AM, Chaudhari PS, Pushpalatha HB, Shanmuganthan S. Fabrication and characterization of herbal drug-loaded nonionic surfactant based niosomal topical gel. J Pharm Sci Res. 2016;8(11):1271–1278.
   Google Scholar
• Un RN, Barlas FB, Yavuz M, et al. Phyto-niosomes: in vitro assessment of the novel nanovesicles containing marigold extract. Int J Polym Mater Polym Bio Mater. 2015;64(17):927–937. doi:10.1080/00914037.2015.1030663
   Web of Science ®Google Scholar
• Rohilla R, Garg T, Goyal AK, Rath G. Herbal and polymeric approaches for liver-targeting drug delivery: novel strategies and their significance. Drug Deliv. 2016;23(5):1645–1661. doi:10.3109/10717544.2014.94501825101832
   PubMed Web of Science ®Google Scholar
• Thakkar M, Brijesh S. Physicochemical investigation and in vivo activity of anti-malarial drugs co-loaded in tween 80 niosomes. J Liposome Res. 2017;28:1–7.
   Web of Science ®Google Scholar
• Ambwani S, Tandon R, Ambwani TK, Malik YS. Current knowledge on nanodelivery systems and their beneficial applications in enhancing the efficacy of herbal drugs. J Exp Biol Agric Sci. 2018;6(1):87–107. doi:10.18006/2018.6(1).87.107
   Google Scholar
• Rameshk M, Sharififar F, Mehrabani M, Pardakhty A, Farsinejad A, Mehrabani M. Proliferation and in vitro wound healing effects of the microniosomes containing Narcissus tazetta L. bulb extract on primary human fibroblasts (HDFs). DARU. 2018;26(1):31–42. doi:10.1007/s40199-018-0211-7
   PubMed Web of Science ®Google Scholar
• Pando D, Matos M, Gutiérrez G, Pazos C. Formulation of resveratrol entrapped niosomes for topical use. Colloids Surf B Biointerfaces. 2015;128:398–404. doi:10.1016/j.colsurfb.2015.02.03725766923
   PubMed Web of Science ®Google Scholar
• Priprem A, Janpim K, Nualkaew S, Mahakunakorn P. Topical niosome gel of Zingiber cassumunar Roxb. extract for anti-inflammatory activity enhanced skin permeation and stability of compound D. AAPS PharmSciTech. 2016;17(3):631–639. doi:10.1208/s12249-015-0376-z26292930
   PubMed Web of Science ®Google Scholar
• Barani M, Mirzaei M, Torkzadeh-Mahani M, Nematollahi MH. Lawsone-loaded niosome and its antitumor activity in MCF-7 breast cancer cell line: a nano-herbal treatment for cancer. DARU. 2018;26(1):11–27. doi:10.1007/s40199-018-0207-330159762
   PubMed Web of Science ®Google Scholar
• Anghore D, Kulkarni GT. Development of novel nano niosomes as drug delivery system of spermacoce hispida extract and in vitro antituberculosis activity. Curr Nanomat. 2017;2(1):17–23. doi:10.2174/2405461502666170314151949
   Google Scholar
• Alam MS, Ahad A, Abidin L, Aqil M, Mir SR, Mujeeb M. Embelin-loaded oral niosomes ameliorate streptozotocin-induced diabetes in wistar rats. Biomed Pharmacother. 2018;97:1514–1520. doi:10.1016/j.biopha.2017.11.07329793314
   PubMed Web of Science ®Google Scholar
• Gunes A, Guler E, Un RN, et al. Niosomes of nerium oleander extracts: in vitro assessment of bioactive nanovesicular structures. J Drug Deliv Sci Technol. 2017;37:158–165. doi:10.1016/j.jddst.2016.12.013
   Web of Science ®Google Scholar
• Budhiraja A, Dhingra G. Development and characterization of a novel antiacne niosomal gel of rosmarinic acid. Drug Deliv. 2015;22(6):723–730. doi:10.3109/10717544.2014.90301024786487
   PubMed Web of Science ®Google Scholar
• Scognamiglio I, De Stefano D, Campani V, et al. Nanocarriers for topical administration of resveratrol: a comparative study. Int J Pharm. 2013;440:179–187. doi:10.1016/j.ijpharm.2012.08.00922909994
   PubMed Web of Science ®Google Scholar
• Shen LN, Zhang YT, Wang Q, Xu L, Feng NP. Enhanced in vitro and in vivo skin deposition of apigenin delivered using ethosomes. Int J Pharm. 2014;460:280–288. doi:10.1016/j.ijpharm.2013.11.01724269286
   PubMed Web of Science ®Google Scholar
• Abdulbaqi IM, Darwis Y, Assi RA, Khan NA. Transethosomal gels as carriers for the transdermal delivery of colchicine: statistical optimization, characterization, and ex vivo evaluation. Drug Des Devel Ther. 2018;12:795–813. doi:10.2147/DDDT.S158018
   PubMed Web of Science ®Google Scholar
• Zhao YZ, Lu CT, Zhang Y, et al. Selection of high efficient transdermal lipid vesicle for curcumin skin delivery. Int J Pharm. 2013;454:302–309. doi:10.1016/j.ijpharm.2013.06.05223830940
   PubMed Web of Science ®Google Scholar
• Yu Z, Lv H, Han G, Ma K. Ethosomes loaded with cryptotanshinone for acne treatment through topical gel formulation. PLoS One. 2016;11(7):e0159967. doi:10.1371/journal.pone.015996727441661
   PubMed Web of Science ®Google Scholar
• Fatima Z. Formulation and performance evaluation of berberis aristata extract loaded ethosomal gel. Asian J Pharm. 2017;11(03):176–183.
   Google Scholar
• Liu F, Sun Y, Kang C, Zhu H. Pegylated drug delivery systems: from design to biomedical applications. Nano Life. 2016;6:1642002. doi:10.1142/S1793984416420022
   Google Scholar
• Tolia GT, Choi HH. The role of dendrimers in topical drug delivery. Pharm Technol. 2008;32(11):88–98.
   Google Scholar
• Estanqueiro M, Amaral MH, Conceicao J, SousaLobo JM. Nanotechnological carriers for cancer chemotherapy: the state of the art. Colloids Surf B Biointerfaces. 2015;126:631–648. doi:10.1016/j.colsurfb.2014.12.04125591851
   PubMed Web of Science ®Google Scholar
• Iacobazzi RM, Porcelli L, Lopedota AA, et al. Targeting human liver cancer cells with lactobionic acid-G (4)-PAMAM-FITC sorafenib loaded dendrimers. Int J Pharm. 2017;528(1–2):485–497. doi:10.1016/j.ijpharm.2017.06.04928624661
   PubMedGoogle Scholar
• Chittasupho C, Anuchapreeda S, Sarisuta N. CXCR4 targeted dendrimer for anti-cancer drug delivery and breast cancer cell migration inhibition. Eur J Pharm Biopharm. 2017;119:310–321. doi:10.1016/j.ejpb.2017.07.00328694161
   PubMed Web of Science ®Google Scholar
• Luong D, Kesharwani P, Deshmukh R, et al. PEGylated PAMAM dendrimers: enhancing efficacy and mitigating toxicity for effective anticancer drug and gene delivery. Acta Biomater. 2016;43:14–29. doi:10.1016/j.actbio.2016.07.01527422195
   PubMed Web of Science ®Google Scholar
• Ertürk AS, Gürbüz MU, Tülü M. The effect of PAMAM dendrimer concentration, generation size and surface functional group on the aqueous solubility of Candesartan cilexetil. Pharm Dev Technol. 2017;22(1):111–121. doi:10.1080/10837450.2016.121937227484586
   PubMed Web of Science ®Google Scholar
• Abderrezak A, Bourassa P, Mandeville JS, Sedaghat-Herati R, Tajmir-Riahi HA. Dendrimers bind antioxidant polyphenols and cisplatin drug. PLoS One. 2012;7:e33102. doi:10.1371/journal.pone.003310222427960
   PubMed Web of Science ®Google Scholar
• Madaan K, Lather V, Pandita D. Evaluation of polyamidoamine dendrimers as potential carriers for quercetin, a versatile flavonoid. Drug Deliv. 2016;23(1):254–262. doi:10.3109/10717544.2014.91056424845475
   PubMed Web of Science ®Google Scholar
• Wang L, Xu X, Zhang Y, et al. Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells. J Mater Sci Mater Med. 2013;24:2137–2144. doi:10.1007/s10856-013-4969-323779153
   PubMed Web of Science ®Google Scholar
• Falconieri MC, Adamo M, Monasterolo C, Bergonzi MC, Coronnello M, Bilia AR. New dendrimer-based nanoparticles enhance curcumin solubility. Planta Med. 2017;83(5):420–425. doi:10.1055/s-0042-10316127002394
   PubMed Web of Science ®Google Scholar
• Gu L, Wu ZH, Qi X, et al. Polyamidomine dendrimers: an excellent drug carrier for improving the solubility and bioavailability of puerarin. Pharm Dev Technol. 2013;18(5):1051–1057. doi:10.3109/10837450.2011.65382222303809
   PubMed Web of Science ®Google Scholar
• Kambhampati SP, Kannan RM. Dendrimer nanoparticles for ocular drug delivery. J Ocul Pharmacol Ther. 2013;29(2):151–165. doi:10.1089/jop.2012.023223410062
   PubMed Web of Science ®Google Scholar
• Diaz C, Guzmán J, Jiménez VA, Alderete JB. Partially PEGylated PAMAM dendrimers as solubility enhancers of silybin. Pharm Dev Technol. 2018;23(7):689–696. doi:10.1080/10837450.2017.131513428368674
   PubMed Web of Science ®Google Scholar
• Yesil Celiktas O, Pala C, Cetin Uyanikgil EO, Sevimli Gur C. Synthesis of silica-PAMAM dendrimer nanoparticles as promising carriers in neuro blastoma cells. Anal Biochem. 2017;519:1–7. doi:10.1016/j.ab.2016.12.00427939389
   PubMed Web of Science ®Google Scholar
• Qu WJ, Li HF, Su YY, Dong ZQ, Ge YR. Absorption enhancing effects and safety of PAMAM dendrimers on liquiritin. China J Chi Mater Med. 2017;42(9):1766–1771. doi:10.19540/j.cnki.cjcmm.2017.0070
   Google Scholar
• Biswas S, Kumari P, Lakhani PM, Ghosh B. Recent advances in polymeric micelles for anti-cancer drug delivery. Eur J Pharm Sci. 2016;83:184–202. doi:10.1016/j.ejps.2015.12.03126747018
   PubMed Web of Science ®Google Scholar
• Boutet E. Scheme of a micelle formed by phospholipids in an aqueous solution. Available from: https://commons.wikimedia.org/wiki/File:Micelle_scheme-en.svg. Accessed 12 5, 2019.
   Google Scholar
• Zou F, Wei K, Peng X. Thermodynamics of micellization and sustained release of folate targeted capecitabine loaded nanomicelles. Nanosci Nanotechnol. 2016;16:8519–8527. doi:10.1166/jnn.2016.12710
   Web of Science ®Google Scholar
• Han R, Sun Y, Kang C, Sun H, Wei W. Amphiphilic dendritic nanomicelle-mediated co-delivery of 5-fluorouracil and doxorubicin for enhanced therapeutic efficacy. J Drug Target. 2017;25:140–148. doi:10.1080/1061186X.2016.120764927356094
   PubMed Web of Science ®Google Scholar
• Wang Z, Yu Y, Ma J, et al. LyP-1 modification to enhance delivery of artemisinin or fluorescent probe loaded polymeric micelles to highly metastatic tumor and its lymphatics. Mol Pharm. 2012;9:2646–2657. doi:10.1021/mp300210722853186
   PubMed Web of Science ®Google Scholar
• Ren J, Fang Z, Yao L, et al. A micelle-like structure of poloxamer–methotrexate conjugates as nanocarrier for methotrexate delivery. Int J Pharm. 2015;487(1–2):177–186. doi:10.1016/j.ijpharm.2015.04.01425865570
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhang H, Wang X, Wang J, Zhang X, Zhang Q. The eradication of breast cancer and cancer stem cells using octreotide modified paclitaxel active targeting micelles and salinomycin passive targeting micelles. Biomaterials. 2012;33(2):679−691.22019123
   PubMed Web of Science ®Google Scholar
• Gou M, Men K, Shi H, et al. Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo. Nanoscale. 2011;3(4):1558–1567. doi:10.1039/c0nr00758g21283869
   PubMed Web of Science ®Google Scholar
• Abdelmoneem MA, Mahmoud M, Zaky A. et al. Dual-targeted casein micelles as green nanomedicine for synergistic phytotherapy of hepatocellular carcinoma. J Control Release;2018 78–93. doi:10.1016/j.jconrel.2018.08.026
   PubMed Web of Science ®Google Scholar
• Wu H, Yu T, Tian Y, Wang Y, Zhao R, Mao S. Enhanced liver-targeting via coadministration of 10-hydroxycamptothecin polymeric micelles with vinegar baked radix bupleuri. Phytomedicine. 2018;44:1–8. doi:10.1016/j.phymed.2018.04.02229895488
   PubMed Web of Science ®Google Scholar
• Su Y, Huang N, Chen D, et al. Successful in vivo hyperthermal therapy toward breast cancer by Chinese medicine shikonin-loaded thermosensitive micelle. Int J Nanomed. 2017;12:4019. doi:10.2147/IJN.S132639
   PubMed Web of Science ®Google Scholar
• Anantaworasakul P, Okonogi S. Encapsulation of sesbania grandiflora extract in polymeric micelles to enhance its solubility, stability, and antibacterial activity. J Microencapsul. 2017;34(1):73–81. doi:10.1080/02652048.2017.128427728097930
   PubMed Web of Science ®Google Scholar
• Baldissera MD, Souza CF, Boligon AA, et al. Solving the challenge of the blood–brain barrier to treat infections caused by Trypanosoma evansi: evaluation of nerolidol-loaded nanospheres in mice. Parasitology. 2017;144(11):1543–1550. doi:10.1017/S003118201700110X28641606
   PubMed Web of Science ®Google Scholar
• Harper 3D. Nano sphere from carbon atoms isolated on white background. Available from: https://www.shutterstock.com/image-illustration/nano-sphere-carbon-atoms-isolated-on-50117683. Accessed 125, 2019.
   Google Scholar
• Wang T, Wu C, Fan G, Li T, Gong H, Cao F. Ginkgo biloba extracts-loaded starch nano-spheres: preparation, characterization, and in vitro release kinetics. Int J Biol Macromol. 2018;106:148–157. doi:10.1016/j.ijbiomac.2017.08.01228780415
   PubMed Web of Science ®Google Scholar
• Pirouzmand H, Khameneh B, Tafaghodi M. Immunoadjuvant potential of cross-linked dextran microspheres mixed with chitosan nanospheres encapsulated with tetanus toxoid. Pharm Biol. 2017;55(1):212–227. doi:10.1080/13880209.2016.125703227927058
   PubMed Web of Science ®Google Scholar
• Elzoghby A. Polymeric nanocarriers as robust platforms for cancer therapy. Curr Pharm Des. 2017;23(35):5211–5212. doi:10.2174/138161282399917110612580129110600
   PubMed Web of Science ®Google Scholar
• Li C, Zhang D, Guo H, et al. Preparation and characterization of galactosylated bovine serum albumin nanoparticles for liver-targeted delivery of oridonin. Int J Pharm. 2013;448:79–86. doi:10.1016/j.ijpharm.2013.03.01923518367
   PubMed Web of Science ®Google Scholar
• Snima KS, Arunkumar P, Jayakumar R, Lakshmanan VK. Silymarin encapsulated poly(D, L-lactic-co-glycolic acid) nanoparticles: a prospective candidate for prostate cancer therapy. J Biomed Nanotechnol. 2014;10:559–570. doi:10.1166/jbn.2014.173524734508
   PubMed Web of Science ®Google Scholar
• Pereira K, Quintela E, Da Silva D, et al. Characterization of nanospheres containing Zanthoxylum riedelianum Fruit essential oil and their insecticidal and deterrent activities against Bemisia tabaci (hemiptera: aleyrodidae). Molecules. 2018;23(8):2052–2070. doi:10.3390/molecules23082052
   PubMed Web of Science ®Google Scholar
• Holz JP, Bottene MK, Jahno VD, Einloft S, Ligabue R. Menthol-loaded PLGA micro and nanospheres: synthesis, characterization and degradation in artificial saliva. Mater Res. 2018;21(2):1–9. doi:10.1590/1980-5373-mr-2017-0488
   Web of Science ®Google Scholar
• Pawar VK, Singh Y, Meher JG, Gupta S, Chourasia MK. Engineered nanocrystal technology: in-vivo fate, targeting and applications in drug delivery. J Control Release. 2014;183:51–66. doi:10.1016/j.jconrel.2014.03.03024667572
   PubMed Web of Science ®Google Scholar
• Lu Y, Qi J, Dong X, Zhao W, Wu W. The in vivo fate of nanocrystals. Drug Discov Today. 2017;22(4):744–750. doi:10.1016/j.drudis.2017.01.00328088442
   PubMed Web of Science ®Google Scholar
• Lu Y, Li Y, Wu W. Injected nanocrystals for targeted drug delivery. Acta Pharm Sin B. 2016;6(2):106–113. doi:10.1016/j.apsb.2015.11.00527006893
   PubMed Web of Science ®Google Scholar
• Sharma OP, Patel V, Mehta T, et al. Nanocrystal for ocular drug delivery: hope or hype. Drug Deliv Transl Res. 2016;6:399–413. doi:10.1007/s13346-016-0292-027165145
   PubMed Web of Science ®Google Scholar
• Choi JS, Park JS. Development of docetaxel nanocrystals surface modified with transferrin for tumor targeting. Drug Des Devel Ther. 2017;11:17–26. doi:10.2147/DDDT.S122984
   PubMed Web of Science ®Google Scholar
• Zhang H, Hollis CP, Zhang Q, Li T. Preparation and antitumor study of camptothecin nanocrystals. Int J Pharm. 2011;415(1–2):293–300. doi:10.1016/j.ijpharm.2011.05.07521679755
   PubMedGoogle Scholar
• de Waard H, Frijlink HW, Hinrichs WL. Bottom up preparation techniques for nanocrystals of lipophilic drugs. Pharmtech Res. 2011;28:1220e1223.
   Google Scholar
• Junyaprasert VB, Morakul B. Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs. Asian J Pharm Sci. 2015;10(1):13–23. doi:10.1016/j.ajps.2014.08.005
   Web of Science ®Google Scholar
• Malamatari M, Taylor KM, Malamataris S, Douroumis D, Kachrimanis K. Pharmaceutical nanocrystals: production by wet milling and applications. Drug Discov Today. 2018;23:534–547. doi:10.1016/j.drudis.2018.01.01629326082
   PubMed Web of Science ®Google Scholar
• Al Shaal L, Shegokar R, Müller RH. Production and characterization of antioxidant apigenin nanocrystals as a novel UV skin protective formulation. Int J Pharm. 2011;420(1):133–140. doi:10.1016/j.ijpharm.2011.08.01821871547
   PubMedGoogle Scholar
• Srivalli KM, Mishra B. Drug nanocrystals: a way toward scale-up. Saudi Pharm J. 2016;24(4):386–404. doi:10.1016/j.jsps.2014.04.00727330370
   PubMed Web of Science ®Google Scholar
• Vidlarova L, Romero GB, Hanuš J, et al. Nanocrystals for dermal penetration enhancement – effect of concentration and underlying mechanisms using curcumin as model. Eur J Pharm Biopharm. 2016;104:216–225. doi:10.1016/j.ejpb.2016.05.00427163241
   PubMed Web of Science ®Google Scholar
• Pi J, Liu Z, Wang H, et al. Ursolic acid nanocrystals for dissolution rate and bioavailability enhancement: influence of different particle size. Curr Drug Deliv. 2016;13(8):1358–1366. doi:10.2174/156720181366616030714275726953239
   PubMed Web of Science ®Google Scholar
• Sahoo NG, Kakran M, Shaal LA, et al. Preparation and characterization of quercetin nanocrystals. J Pharm Sci. 2011;100(6):2379–2390. doi:10.1002/jps.2244621491450
   PubMed Web of Science ®Google Scholar
• Sathishkumar P, Gu FL, Zhan Q, Palvannan T, Yusoff AR. Flavonoids mediated ‘green' nanomaterials: a novel nanomedicine system to treat various diseases–current trends and future perspective. Mater Lett. 2018;210:26–30. doi:10.1016/j.matlet.2017.08.078
   Web of Science ®Google Scholar
• Mir M, Ishtiaq S, Rabia S, et al. Nanotechnology: from in vivo imaging system to controlled drug delivery. Nanoscale Res Lett. 2017;12(1):500–515. doi:10.1186/s11671-017-2249-828819800
   PubMed Web of Science ®Google Scholar
• Singh RP, Gangadharappa HV, Mruthunjaya K. Phytosome loaded novel herbal drug delivery system: a review. Int Res J Pharm. 2016;7(6):15–21. doi:10.7897/2230-8407
   Google Scholar
• Rasaie S, Ghanbarzadeh S, Mohammadi M, Hamishehkar H. Nano phytosomes of quercetin: a promising formulation for fortification of food products with antioxidants. Pharm Sci. 2014;20(3):96–101.
   Google Scholar
• Onoue S, Yamada S, Chan HK. Nanodrugs: pharmacokinetics and safety. Int J Nanomed. 2014;9:1025–1037. doi:10.2147/IJN
   PubMed Web of Science ®Google Scholar
• Karthivashan G, Masarudin MJ, Kura AU, Abas F, Fakurazi S. Optimization, formulation, and characterization of multiflavonoids-loaded flavanosome by bulk or sequential technique. Int J Nanomed. 2016;11:3417–3434. doi:10.2147/IJN.S112045
   PubMed Web of Science ®Google Scholar
• Anwar E, Farhana N. Formulation and evaluation of phytosome-loaded maltodextrin-gum Arabic microsphere system for delivery of Camellia sinensis extract. J Young Pharm. 2018;10(2s):S56. doi:10.5530/jyp
   Google Scholar
• El-Menshawe SF, Ali AA, Rabeh MA, Khalil NM. Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product. Int J Nanomed. 2018;13:307–318. doi:10.2147/IJN.S153429
   PubMed Web of Science ®Google Scholar
• Hooresfand Z, Ghanbarzadeh S, Hamishehkar H. Preparation and characterization of rutin-loaded nanophytosomes. Pharm Sci. 2015;21(3):145–151. doi:10.15171/PS.2015.29
   Google Scholar
• Vu HT, Hook SM, Siqueira SD, Müllertz A, Rades T, McDowell A. Are phytosomes a superior nanodelivery system for the antioxidant rutin? Int J Pharm. 2018;122:214–229.
   Google Scholar
• Gahandule MB, Jadhav SJ, Gadhave MV, Gaikwad DD. Formulation and development of hepato-protective butea monosperma-phytosome. Int J Res Pharm Pharm Sci. 2016;1(4):21–27.
   Google Scholar
• Singh RP, Gangadharappa HV, Mruthunjaya K. Phytosome complexed with chitosan for gingerol delivery in the treatment of respiratory infection: in vitro and in vivo evaluation. Eur J Pharm Sci. 2018;122:214–229. doi:10.1016/j.ejps.2018.06.02829966737
   PubMed Web of Science ®Google Scholar
• Kassem AA, Mohsen AM, Ahmed RS, Essam TM. Self-nanoemulsifying drug delivery system (SNEDDS) with enhanced solubilization of nystatin for treatment of oral candidiasis: design, optimization, in vitro and in vivo evaluation. J Mol Liq. 2016;218:219–232. doi:10.1016/j.molliq.2016.02.081
   Web of Science ®Google Scholar
• Senapati PC, Sahoo SK, Sahu AN. Mixed surfactant based (SNEDDS) self-nanoemulsifying drug delivery system presenting efavirenz for enhancement of oral bioavailability. Biomed Pharmacother. 2016;80:42–51. doi:10.1016/j.biopha.2016.02.03927133038
   PubMed Web of Science ®Google Scholar
• Chatterjee B, Hamed Almurisi S, Ahmed Mahdi Dukhan A, Mandal UK, Sengupta P. Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view. Drug Deliv. 2016;23(9):3639–3652. doi:10.1080/10717544.2016.121499027685505
   PubMed Web of Science ®Google Scholar
• Agrawal AG, Kumar A, Gide PS. Formulation of solid self-nanoemulsifying drug delivery systems using N-methyl pyrrolidone as cosolvent. Drug Dev Ind Pharm. 2015;41:594–604. doi:10.3109/03639045.2014.88669524517575
   PubMed Web of Science ®Google Scholar
• Li W, Yi S, Wang Z, et al. Self-nanoemulsifying drug delivery system of persimmon leaf extract: optimization and bioavailability studies. Int J Pharm. 2011;420(1):161–171. doi:10.1016/j.ijpharm.2011.08.02421884770
   PubMed Web of Science ®Google Scholar
• Avachat AM, Patel VG. Self-nanoemulsifying drug delivery system of stabilized ellagic acid–phospholipid complex with improved dissolution and permeability. Saudi Pharm J. 2015;23(3):276–289. doi:10.1016/j.jsps.2014.11.00126106276
   PubMed Web of Science ®Google Scholar
• Tran TH, Guo Y, Song D, Bruno RS, Lu X. Quercetin-containing self-nanoemulsifying drug delivery system for improving oral bioavailability. J Pharm Sci. 2014;103(3):840–852. doi:10.1002/jps.2385824464737
   PubMed Web of Science ®Google Scholar
• Shen J, Bi J, Tian H, et al. Preparation and evaluation of a self-nanoemulsifying drug delivery system loaded with akebia saponin D–phospholipid complex. Int J Nanomed. 2016;11:4919–4929. doi:10.2147/IJN.S108765
   PubMed Web of Science ®Google Scholar
• Shukla M, Jaiswal S, Sharma A, et al. A combination of complexation and self-nanoemulsifying drug delivery system for enhancing oral bioavailability and anticancer efficacy of curcumin. Drug Dev Ind Pharm. 2017;43(5):847–861. doi:10.1080/03639045.2016.123973227648633
   PubMed Web of Science ®Google Scholar
• Khan AW, Kotta S, Ansari SH, Sharma RK, Ali J. Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid naringenin: design, characterization, in vitro and in vivo evaluation. Drug Deliv. 2015;22(4):552–561. doi:10.3109/10717544.2013.87800324512268
   PubMed Web of Science ®Google Scholar
• Yeom DW, Chae BR, Son HY, et al. Enhanced oral bioavailability of valsartan using a polymer-based supersaturable self-microemulsifying drug delivery system. Int J Nanomed. 2017;12:3533–3545. doi:10.2147/IJN.S136599
   PubMed Web of Science ®Google Scholar
• Yan B, Wang Y, Ma Y, Zhao J, Liu Y, Wang L. In vitro and in vivo evaluation of poly (acrylic acid) modified mesoporous silica nanoparticles as pH response carrier for β-elemene self-micro emulsifying. International Journal of Pharmaceutics. 2019;572:118768- 18778.
   Google Scholar
• Allen JL. Basics of compounding-nonsterile: compounding self-emulsifying drug delivery systems and other self-emulsifying lipid formulations, part 1. Int J Pharm Compd. 2018;22(3):220–228.29878890
   PubMedGoogle Scholar
• Jakab G, Fülöp V, Santha K, Szeröczei D, Balogh E, Antal L. Formulation possibilities of self-emulsifying drug delivery systems, microemulsions and nanoemulsions. Acta Pharm Hung. 2017;87(1):27–34.29489095
   PubMedGoogle Scholar
• Zhang L, Zhu W, Yang C, et al. A novel folate-modified self-microemulsifying drug delivery system of curcumin for colon targeting. Int J Nanomed. 2012;7:151–162. doi:10.2147/IJN.S27639
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhang H, Yang J, Sun H. Improved antioxidant capacity of optimization of a self-microemulsifying drug delivery system for resveratrol. Molecules. 2015;20:21167–21177. doi:10.3390/molecules20121975026633319
   PubMed Web of Science ®Google Scholar
• Jaisamut P, Wiwattanawongsa K, Graidist P, Sangsen Y, Wiwattanapatapee R. Enhanced oral bioavailability of curcumin using a supersaturatable self-microemulsifying system incorporating a hydrophilic polymer; in vitro and in vivo investigations. AAPS PharmSciTech. 2018;19(2):730–740. doi:10.1208/s12249-017-0857-328975598
   PubMed Web of Science ®Google Scholar
• Qiao J, Ji D, Sun S, et al. Oral bioavailability and lymphatic transport of pueraria flavone-loaded self-emulsifying drug-delivery systems containing sodium taurocholate in rats. Pharmaceutics. 2018;10(3):147–160. doi:10.3390/pharmaceutics10030147
   PubMed Web of Science ®Google Scholar
• Sornsuvit C, Hongwiset D, Yotsawimonwat S, Toonkum M, Thongsawat S, Taesotikul W. The bioavailability and pharmacokinetics of silymarin SMEDDS formulation study in healthy thai volunteers. Evid Based Complement Altern Med. 2018;1:1–7. doi:10.1155/2018/1507834
   Google Scholar
• Dhumal DM, Akamanchi KG. Self-microemulsifying drug delivery system for camptothecin using new bicephalous heterolipid with tertiary-amine as branching element. Int J Pharm. 2018;541(1–2):48–55. doi:10.1016/j.ijpharm.2018.02.03029462684
   PubMedGoogle Scholar
• Sato Y, Joumura T, Nashimoto S, et al. Enhancement of lymphatic transport of lutein by oral administration of a solid dispersion and a self-microemulsifying drug delivery system. Eur J Pharm Biopharm. 2018;127:171–176. doi:10.1016/j.ejpb.2018.02.01329428792
   PubMed Web of Science ®Google Scholar
• Karami Z, Rezaeian I, Zahedi P, Abdollahi M. Preparation and performance evaluations of electrospun poly (ε‐caprolactone), poly (lactic acid), and their hybrid (50/50) nanofibrous mats containing thymol as an herbal drug for effective wound healing. J Appl Polym Sci. 2013;129(2):756–766. doi:10.1002/app.38683
   Web of Science ®Google Scholar
• Available from: http://science.sciencemag.org/content/294/5547/1684/F1. Accessed 125, 2019.
   Google Scholar
• Wang H, Wei J, Yang C, et al. The inhibition of tumor growth and metastasis by self-assembled nanofibers of taxol. Biomaterials. 2012;33(24):5848–5853. doi:10.1016/j.biomaterials.2012.04.04722607913
   PubMed Web of Science ®Google Scholar
• Wagh A, Singh J, Qian S, Law B. A short circulating peptide nanofiber as a carrier for tumoral delivery. Nanomedicine. 2013;9(4):449–457. doi:10.1016/j.nano.2012.10.00923178287
   PubMed Web of Science ®Google Scholar
• Liu J, Xu H, Zhang Y, et al. Novel tumor-targeting, selfassembling peptide nanofiber as a carrier for effective curcumin delivery. Int J Nanomed. 2014;9:197–207. doi:10.2147/IJN.S55875
   PubMed Web of Science ®Google Scholar
• Ranjbar MM, Bahrami SH. Electrospun curcumin loaded poly (ε-caprolactone)/gum tragacanth nanofibers for biomedical application. Int J Biol Macromol. 2016;84:448–456. doi:10.1016/j.ijbiomac.2015.12.02426706845
   PubMed Web of Science ®Google Scholar
• Choi J, Yang BJ, Bae GN, Jung JH. Herbal extract incorporated nanofiber fabricated by an electrospinning technique and its application to antimicrobial air filtration. J Ocul Pharmacol Ther. 2015;7(45):25313–25320. doi:10.1021/acsami.5b07441
   Google Scholar
• Bonan RF, Bonan PR, Batista AU, et al. In vitro antimicrobial activity of solution blow spun poly (lactic acid)/polyvinylpyrrolidone nanofibers loaded with copaiba (Copaifera sp.) oil. Mater Sci Eng C. 2015;48:372–377. doi:10.1016/j.msec.2014.12.021
   PubMed Web of Science ®Google Scholar
• Jouybar A, Seyedjafari E, Ardeshirylajimi A, et al. Enhanced skin regeneration by herbal extract‐coated poly‐L‐lactic acid nanofibrous scaffold. Artif Organs. 2017;41(11):E296–E307. doi:10.1111/aor.1292628621889
   PubMed Web of Science ®Google Scholar
• Parvathi K, Krishnan AG, Anitha A, Jayakumar R, Nair MB. Poly (L-lactic acid) nanofibers containing cissus quadrangularis induced osteogenic differentiation in vitro. Int J Biol Macromol. 2018;110:514–521. doi:10.1016/j.ijbiomac.2017.11.09429155154
   PubMed Web of Science ®Google Scholar
• Wang J, Tian L, He L, et al. Lycium barbarum polysaccharide encapsulated poly lactic-co-glycolic acid nanofibers: cost effective herbal medicine for potential application in peripheral nerve tissue engineering. Sci Rep. 2018;8(1):8669–8683. doi:10.1038/s41598-018-26837-z29875468
   PubMed Web of Science ®Google Scholar
• Lee JS, Feijen J. Biodegradable polymersomes as carriers and release systems for paclitaxel using oregon green® 488 labeled paclitaxel as a model compound. J Control Release. 2012;158(2):312–318. doi:10.1016/j.jconrel.2011.10.02522063005
   PubMed Web of Science ®Google Scholar
• Pijpers IA, Abdelmohsen LK, Xia Y, et al. Adaptive polymersome and micelle morphologies in anticancer nanomedicine: from design rationale to fabrication and proof‐of‐concept studies. Adv Ther. 2018;1:1800068–1800081. doi:10.1002/adtp.201800068
   Google Scholar
• Gupta PK, Jaiswal AK, Asthana S, Dube A, Mishra PR. Antigen presenting cells targeting and stimulation potential of lipoteichoic acid functionalized lipo-polymerosome: a chemo-immunotherapeutic approach against intracellular infectious disease. Biomacromolecules. 2015;16(4):1073–1087. doi:10.1021/bm501515625671728
   PubMed Web of Science ®Google Scholar
• Gupta PK, Asthana S, Jaiswal AK, et al. Exploitation of lectinized lipo-polymerosome encapsulated amphotericin B to target macrophages for effective chemotherapy of visceral leishmaniasis. Bioconjug Chem. 2014;25(6):1091–1102. doi:10.1021/bc500087h24842628
   PubMed Web of Science ®Google Scholar
• Gupta PK, Jaiswal AK, Kumar V, et al. Covalent functionalized self-assembled lipo-polymerosome bearing amphotericin B for better management of leishmaniasis and its toxicity evaluation. Mol Pharm. 2014;11(3):951–963. doi:10.1021/mp400603t24495144
   PubMedGoogle Scholar
• Hammer DA, Robbins GP, Haun JB, et al. Leukopolymersomes. Faraday Discuss. 2008;139:129–141. doi:10.1039/b717821b19048993
   PubMed Web of Science ®Google Scholar
• Xu J, Zhao Q, Jin Y, Qiu L. High loading of hydrophilic/hydrophobic doxorubicin into polyphosphazene polymersome for breast cancer therapy. Nanomedicine. 2014;10(2):349–358. doi:10.1016/j.nano.2013.08.00423969103
   PubMed Web of Science ®Google Scholar
• Yang J, Dai G, Hou Y, et al. Quantification of oxymatrine in rat plasma by UPLC-MS/MS to support the pharmacokinetic analyses of oxymatrine-loaded polymersomes. Anal Methods. 2014;6(6):1811–1817. doi:10.1039/C3AY42294A
   Web of Science ®Google Scholar
• Goyal K, Konar A, Kumar BH, Koul V. Lactoferrin-conjugated pH and redox-sensitive polymersomes based on PEG-SS-PLA-PCL-OH boost delivery of bacosides to the brain. Nanoscale. 2018;10(37):17781–17798. doi:10.1039/C8NR03828G30215650
   PubMed Web of Science ®Google Scholar
• Pang Z, Feng L, Hua R, et al. Lactoferrin-conjugated biodegradable polymersome holding doxorubicin and tetrandrine for chemotherapy of glioma rats. Mol Pharm. 2010;7(6):1995–2005. doi:10.1021/mp100277h20957995
   PubMedGoogle Scholar
• Tu YS, Fu JW, Sun DM, et al. Preparation, characterisation and evaluation of curcumin with piperine-loaded cubosome nanoparticles. J Microencapsul. 2014;31(6):551–559. doi:10.3109/02652048.2014.88560724641575
   PubMed Web of Science ®Google Scholar
• Rizwan SB, Boyd BJ. Cubosomes: structure, preparation and use as an antigen delivery system In: Subunit Vaccine Delivery. New York, NY, USA: Springer; 2015:125–140.
   Google Scholar
• Tian Y, Li JC, Zhu JX, et al. Folic acid-targeted etoposide cubosomes for theranostic application of cancer cell imaging and therapy. Med Sci Monit. 2017;23:2426–2435. doi:10.12659/MSM.90468328529305
   PubMed Web of Science ®Google Scholar
• Azmi ID, Moghimi SM, Yaghmur A. Cubosomes and hexosomes as versatile platforms for drug delivery. Ther Deliv. 2015;6(12):1347–1364. doi:10.4155/tde.15.8126652281
   PubMed Web of Science ®Google Scholar
• Saraf S, Gupta A, Alexander A, Khan J, Jangde M, Saraf S. Advancements and avenues in nanophytomedicines for better pharmacological responses. J Nanosci Nanotechnol. 2015;15(6):4070–4079. doi:10.1166/jnn.2015.1033326369014
   PubMed Web of Science ®Google Scholar
• Nithya R, Jerold P, Siram K. Cubosomes of dapsone enhanced permeation across the skin. J Drug Deliv Sci Technol. 2018;48:75–81. doi:10.1016/j.jddst.2018.09.002
   Web of Science ®Google Scholar
• Bazylińska U, Kulbacka J, Schmidt J, Talmon Y, Murgia S. Polymer-free cubosomes for simultaneous bioimaging and photodynamic action of photosensitizers in melanoma skin cancer cells. J Colloid Interface Sci. 2018;522:163–173. doi:10.1016/j.jcis.2018.03.06329601958
   PubMed Web of Science ®Google Scholar
• Elnaggar YS, Etman SM, Abdelmonsif DA, Abdallah OY. Novel piperine-loaded tween-integrated monoolein cubosomes as brain-targeted oral nanomedicine in alzheimer’s disease: pharmaceutical, biological, and toxicological studies. Int J Nanomed. 2015;10:5459–5473. doi:10.2147/IJN.S87336
   PubMed Web of Science ®Google Scholar
• Herman A, Herman AP. Mechanism of action of herbs and their active constituents used in hair loss treatment. Fitoterapia. 2016;114:18–25. doi:10.1016/j.fitote.2016.08.00827552901
   PubMed Web of Science ®Google Scholar
• Archana A, Vijayasri K, Madhurim M, Kumar CA. Curcumin loaded nano cubosomal hydrogel: preparation, in vitro characterization and antibacterial activity. Chem Sci Trans. 2014;4(1):75–80.
   Google Scholar
• Ou N, Sun Y, Zhou S, et al. Evaluation of optimum conditions for achyranthes bidentata polysaccharides encapsulated in cubosomes and immunological activity in vitro. Int J Biol Macromol. 2018;109:748–760. doi:10.1016/j.ijbiomac.2017.11.06429157913
   PubMed Web of Science ®Google Scholar
• Matloub AA, AbouSamra MM, Salama AH, Rizk MZ, Aly HF, Fouad GI. Cubic liquid crystalline nanoparticles containing a polysaccharide from ulva fasciata with potent antihyperlipidaemic activity. Saudi Pharm J. 2018;26(2):224–231. doi:10.1016/j.jsps.2017.12.00730166920
   PubMed Web of Science ®Google Scholar
• Nitta SK, Numata K. Biopolymer-based nanoparticles for drug/gene delivery and tissue engineering. Int J Mol Sci. 2013;14(1):1629–1654. doi:10.3390/ijms1401162923344060
   PubMed Web of Science ®Google Scholar
• Fathi M, Martin A, McClements DJ. Nanoencapsulation of food ingredients using carbohydrate based delivery systems. Trends Food Sci Tech. 2014;39(1):18–39. doi:10.1016/j.tifs.2014.06.007
   Web of Science ®Google Scholar
• Biranje SS, Madiwale PV, Patankar KC, Chhabra R, Dandekar-Jain P, Adivarekar RV. Hemostasis and anti-necrotic activity of wound-healing dressing containing chitosan nanoparticles. Int J Biol Macromol. 2018;121:936–946. doi:10.1016/j.ijbiomac.2018.10.12530342937
   PubMed Web of Science ®Google Scholar
• Tan Q, Liu W, Guo C, Zhai G. Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery. Int J Nanomed. 2011;6:16211630. doi:10.2147/IJN.S25646
   Web of Science ®Google Scholar
• Bu L, Gan LC, Guo XQ, et al. Trans-resveratrol loaded chitosan nanoparticles modified with biotin and avidin to target hepatic carcinoma. Int J Pharm. 2013;452(1–2):355–362. doi:10.1016/j.ijpharm.2013.05.00723685116
   PubMedGoogle Scholar
• Samrot AV, Burman U, Philip SA, Shobana N, Chandrasekaran K. Synthesis of curcumin loaded polymeric nanoparticles from crab shell derived chitosan for drug delivery. Inf Med Unlocked. 2018;10:159–182. doi:10.1016/j.imu.2017.12.010
   Google Scholar
• Esfanjani AF, Jafari SM. Biopolymer nano-particles and natural nano-carriers for nano-encapsulation of phenolic compounds. Colloids Surf B Biointerfaces. 2016;146:532–543. doi:10.1016/j.colsurfb.2016.06.05327419648
   PubMed Web of Science ®Google Scholar
• Khan N, Bharali DJ, Adhami VM, et al. Oral administration of naturally occurring chitosan-based nanoformulated green tea polyphenol EGCG effectively inhibits prostate cancer cell growth in a xenograft model. Carcinogenesis. 2014;35:415–423. doi:10.1093/carcin/bgt32124072771
   PubMed Web of Science ®Google Scholar
• Loch-Neckel G, Santos-Bubniak L, Mazzarino L, et al. Orally administered chitosan-coated polycaprolactone nanoparticles containing curcumin attenuate metastatic melanoma in the lungs. J Pharm Sci. 2015;104:3524–3534. doi:10.1002/jps.2454826085173
   PubMed Web of Science ®Google Scholar
• Karri VV, Kuppusamy G, Talluri SV, et al. Curcumin loaded chitosan nanoparticles impregnated into collagen-alginate scaffolds for diabetic wound healing. Int J Biol Macromol. 2016;93:1519–1529. doi:10.1016/j.ijbiomac.2016.05.03827180291
   PubMed Web of Science ®Google Scholar
• Feng B, Ashraf MA, Peng L. Characterization of particle shape, zeta potential, loading efficiency and outdoor stability for chitosan-ricinoleic acid loaded with rotenone. Open Life Sci. 2016;11(1):380–386. doi:10.1515/biol-2016-0050
   Web of Science ®Google Scholar
• Suksaeree J, Monton C, Madaka F, et al. Formulation, physicochemical characterization, and in vitro study of chitosan/HPMC blends-based herbal blended patches. AAPS PharmSciTech. 2015;16(1):171–181. doi:10.1208/s12249-014-0216-625233803
   PubMed Web of Science ®Google Scholar
• Zhao F, Yao D, Guo R, Deng L, Dong A, Zhang J. Composites of polymer hydrogels and nanoparticulate systems for biomedical and pharmaceutical applications. Nanomaterials. 2015;5(4):2054–2130. doi:10.3390/nano504205428347111
   PubMed Web of Science ®Google Scholar
• Dimatteo R, Darling NJ, Segura T. In situ forming injectable hydrogels for drug delivery and wound repair. Adv Drug Deliv Rev. 2018;127:167–184. doi:10.1016/j.addr.2018.03.00729567395
   PubMed Web of Science ®Google Scholar
• Atta S, Khaliq S, Islam A, et al. Injectable biopolymer based hydrogels for drug delivery applications. Int J Biol Macromol. 2015;80:240–245. doi:10.1016/j.ijbiomac.2015.06.04426118484
   PubMed Web of Science ®Google Scholar
• Córdoba AL, Deladino L, Martino M. Effect of starch filler on calcium alginate hydrogels loaded with yerba mate antioxidants. Carbohydr Polym. 2013;95:315–323. doi:10.1016/j.carbpol.2013.03.01923618275
   PubMed Web of Science ®Google Scholar
• Mun S, Kim YR, McClements DJ. Control of β-carotene bioaccessibility using starch-based filled hydrogels. Food Chem. 2015;173:454–461. doi:10.1016/j.foodchem.2014.10.05325466045
   PubMed Web of Science ®Google Scholar
• Balestrin LA, Bidone J, Bortolin RC, Moresco K, Moreira JC, Teixeira HF. Protective effect of a hydrogel containing Achyrocline satureioides extract loaded nanoemulsion against UV-induced skin damage. J Photochem Photobiol B. 2016;163:269–276. doi:10.1016/j.jphotobiol.2016.08.03927599114
   PubMed Web of Science ®Google Scholar
• Lustosa AK, de Jesus Oliveira AC, Quelemes PV, et al. In situ synthesis of silver nanoparticles in a hydrogel of carboxymethyl cellulose with phthalated-cashew gum as a promising antibacterial and healing agent. Int J Mol Sci. 2017;18(11):2399–2413. doi:10.3390/ijms18112399
   PubMed Web of Science ®Google Scholar
• Qureshi MA, Khatoon F, Rizvi MA, Zafaryab M. Ethyl acetate Salix alba leaves extract-loaded chitosan-based hydrogel film for wound dressing applications. J Biomater Sci Polym Ed. 2015;26(18):1452–1464. doi:10.1080/09205063.2015.110084326525493
   PubMed Web of Science ®Google Scholar
• Muhsin MD, George G, Beagley K, Ferro V, Armitage C, Islam N. Synthesis and toxicological evaluation of a chitosan-L-leucine conjugate for pulmonary drug delivery applications. Biomacromolecules. 2014;15(10):3596–3607. doi:10.1021/bm500863525191851
   PubMed Web of Science ®Google Scholar
• Available from: https://www.labsexplorer.com/service/polymer-drug-conjugation-service_525. Accessed 125, 2019.
   Google Scholar
• Shohani S, Mondanizadeh M, Abdoli A, et al. Trimethyl chitosan improves anti-HIV effects of atripla as a new nanoformulated drug. Curr HIV Res. 2017;15(1):56–65. doi:10.2174/1570162X1466616121614280627993121
   PubMed Web of Science ®Google Scholar
• Du C, Qian J, Zhou L, Su Y, Zhang R, Dong CM. Biopolymer–drug conjugate nanotheranostics for multimodal imaging-guided synergistic cancer photothermal–chemotherapy. J Ocul Pharmacol Ther. 2017;9(37):31576–31588. doi:10.1021/acsami.7b10163
   Google Scholar
• Yi J, Liu Y, Zhang Y, Gao L. Fabrication of resveratrol-loaded whey protein–dextran colloidal complex for the stabilization and delivery of β-carotene emulsions. J Agric Food Chem. 2018;66(36):9481–9489. doi:10.1021/acs.jafc.8b0297330125505
   PubMed Web of Science ®Google Scholar
• Singh A, Dutta PK, Kumar H, Kureel AK, Rai AK. Synthesis of chitin-glucan-aldehyde-quercetin conjugate and evaluation of anticancer and antioxidant activities. Carbohydr Polym. 2018;193:99–107. doi:10.1016/j.carbpol.2018.03.09229773403
   PubMed Web of Science ®Google Scholar
• Singh A, Kureel AK, Dutta PK, Kumar S, Rai AK. Curcumin loaded chitin-glucan quercetin conjugate: synthesis, characterization, antioxidant, in vitro release study, and anticancer activity. Int J Biol Macromol. 2018;110:234–244. doi:10.1016/j.ijbiomac.2017.11.00229128588
   PubMed Web of Science ®Google Scholar
• Chen J, Qin X, Zhong S, Chen S, Su W, Liu Y. Characterization of curcumin/cyclodextrin polymer inclusion complex and investigation on its antioxidant and antiproliferative activities. Molecules. 2018;23(5):1179–1191. doi:10.3390/molecules23051179
   PubMed Web of Science ®Google Scholar
• Zhang H, Xu W, Omari-Siaw E, et al. Redox-responsive PEGylated self-assembled prodrug-nanoparticles formed by single disulfide bond bridge periplocymarin-vitamin E conjugate for liver cancer chemotherapy. Drug Deliv. 2017;24(1):1170–1178. doi:10.1080/10717544.2017.136539328835137
   PubMed Web of Science ®Google Scholar
• Kang C, Sun Y, Wang M, Cheng X. Nanosized camptothecin conjugates for single and combined drug delivery. Eur J BioMed Res. 2016;2:8–14. doi:10.18088/ejbmr.2.1.2016.pp8-14
   Google Scholar
• Luna Nanotech. Gold Nanoparticles - Citrate. Available from: https://www.lunanano.com/product-page/gold-nanoparticles-citrate-coated. Accessed 125, 2019.
   Google Scholar
• Poudel BK, Soe ZC, Ruttala HB, et al. In situ fabrication of mesoporous silica-coated silver-gold hollow nanoshell for remotely controllable chemo-photothermal therapy via phase-change molecule as gatekeepers. Int J Pharm. 2018;548(1):92–103. doi:10.1016/j.ijpharm.2018.06.05629959089
   PubMed Web of Science ®Google Scholar
• Vio V, Jose Marchant M, Araya E, Kogan JM. Metal nanoparticles for the treatment and diagnosis of neurodegenerative brain diseases. Curr Pharm Des. 2017;23(13):1916–1926. doi:10.2174/138161282366617010515294828056734
   PubMed Web of Science ®Google Scholar
• Vodyanoy V, Daniels Y, Pustovyy O, MacCrehan WA, Muramoto S, Stan G. Engineered metal nanoparticles in the sub-nanomolar levels kill cancer cells. Int J Nanomed. 2016;11:1567–1576. doi:10.2147/IJN
   PubMed Web of Science ®Google Scholar
• Vijayakumar V, Samal SK, Mohanty S, Nayak SK. Recent advancements in biopolymer and metal nanoparticle-based materials in diabetic wound healing management. Int J Biol Macromol. 2018;122:137–148. doi:10.1016/j.ijbiomac.2018.10.12030342131
   PubMed Web of Science ®Google Scholar
• Sun YW, Wang LH, Meng DL, Che X. A green and facile preparation approach, licochalcone A capped on hollow gold nanoparticles, for improving the solubility and dissolution of anticancer natural product. Oncotarget. 2017;8(62):105673–105681. doi:10.18632/oncotarget.2238729285282
   PubMedGoogle Scholar
• Azeez L, Lateef A, Adebisi SA. Silver nanoparticles (AgNPs) biosynthesized using pod extract of Cola nitida enhances antioxidant activity and phytochemical composition of Amaranthus caudatus Linn. Appl Nanosci. 2017;7(1–2):59–66. doi:10.1007/s13204-017-0546-2
   Web of Science ®Google Scholar
• Namvar F, Rahman HS, Mohamad R, et al. Cytotoxic effects of biosynthesized zinc oxide nanoparticles on murine cell lines. Evid Based Complement Altern Med. 2015;2015:1–11. doi:10.1155/2015/593014
   Web of Science ®Google Scholar
• Danafar H, Sharafi A, Kheiri S. Co-delivery of sulforaphane and curcumin with PEGylated iron oxide-gold core shell nanoparticles for delivery to breast cancer cell line. Iran J Pharm Res. 2018;17(2):480–494.29881406
   PubMed Web of Science ®Google Scholar
• Azizi S, Shahri MM, Rahman HS, Rahim RA, Rasedee A, Mohamad R. Green synthesis palladium nanoparticles mediated by white tea (Camellia sinensis) extract with antioxidant, antibacterial, and antiproliferative activities toward the human leukemia (MOLT-4) cell line. Int J Nanomed. 2017;12:8841–8853. doi:10.2147/IJN.S149371
   PubMed Web of Science ®Google Scholar
• Poonia N, Lather V, Pandita D. Mesoporous silica nanoparticles: a smart nanosystem for management of breast cancer. Drug Discov Today. 2017;23(2):315–332. doi:10.1016/j.drudis.2017.10.02229128658
   PubMed Web of Science ®Google Scholar
• Al-Asmar A, Giosafatto CV, Sabbah M, Sanchez A, Villalonga Santana R, Mariniello L. Effect of Mesoporous Silica Nanoparticles on The Physicochemical Properties of Pectin Packaging Material for Strawberry Wrapping. Nanomaterials. 2020;10(1):52–70.
   Google Scholar
• Zhou Y, Quan G, Wu Q, et al. Mesoporous silica nanoparticles for drug and gene delivery. Acta Pharm Sin B. 2018;8(2):165–177. doi:10.1016/j.apsb.2018.01.00729719777
   PubMed Web of Science ®Google Scholar
• Desai D, Zhang J, Sandholm J, et al. Lipid bilayer-gated mesoporous silica nanocarriers for tumor-targeted delivery of zoledronic acid in vivo. Mol Pharmacol. 2017;14(9):3218–3227. doi:10.1021/acs.molpharmaceut.7b00519
   PubMedGoogle Scholar
• Cao X, Deng WW, Fu M, et al. In vitro release and in vitro–in vivo correlation for silybin meglumine incorporated into hollow-type mesoporous silica nanoparticles. Int J Nanomed. 2012;7:753–762. doi:10.2147/IJN.S28348
   PubMed Web of Science ®Google Scholar
• AbouAitah K, Swiderska-Sroda A, Farghali AA, et al. Folic acid–conjugated mesoporous silica particles as nanocarriers of natural prodrugs for cancer targeting and antioxidant action. Oncotarget. 2018;9(41):26466–26490. doi:10.18632/oncotarget.2547029899871
   PubMedGoogle Scholar
• Lin J, Cai Q, Tang Y, et al. PEGylated lipid bilayer coated mesoporous silica nanoparticles for co-delivery of paclitaxel and curcumin: design, characterization and its cytotoxic effect. Int J Pharm. 2018;536(1):272–282. doi:10.1016/j.ijpharm.2017.10.04329079221
   PubMedGoogle Scholar
• Li T, Chen X, Liu Y, et al. pH-sensitive mesoporous silica nanoparticles anticancer prodrugs for sustained release of ursolic acid and the enhanced anti-cancer efficacy for hepatocellular carcinoma cancer. Eur J Pharm Sci. 2017;96:456–463. doi:10.1016/j.ejps.2016.10.01927771513
   PubMed Web of Science ®Google Scholar
• Kumar B, Kulanthaivel S, Mondal A, et al. Mesoporous silica nanoparticle based enzyme responsive system for colon specific drug delivery through guar gum capping. Colloids Surf B Biointerfaces. 2017;150:352–361. doi:10.1016/j.colsurfb.2016.10.04927847225
   PubMed Web of Science ®Google Scholar
• Choi JY, Ramasamy T, Kim SY, et al. PEGylated lipid bilayer-supported mesoporous silica nanoparticle composite for synergistic co-delivery of axitinib and celastrol in multi-targeted cancer therapy. Acta Biomater. 2016;39:94–105. doi:10.1016/j.actbio.2016.05.01227163403
   PubMed Web of Science ®Google Scholar
• Souza AC, Amaral AC. Antifungal therapy for systemic mycosis and the nanobiotechnology era: improving efficacy, biodistribution and toxicity. Front Microbiol. 2017;8(336):1–13. doi:10.3389/fmicb.2017.0033628197127
   PubMedGoogle Scholar
• García Rubia G, Peigneux A, Jabalera Y, et al. pH-dependent adsorption release of doxorubicin on mamc-biomimetic magnetite nanoparticles. Langmuir. 2018;34(45):13713–13724. doi:10.1021/acs.langmuir.8b0310930394747
   PubMed Web of Science ®Google Scholar
• Lungu II, Radulescu M, Mogosanu GD, Grumezescu AM. pH sensitive core-shell magnetic nanoparticles for targeted drug delivery in cancer therapy. Rom J Morphol Embryol. 2016;57(1):23–32.27151685
   PubMed Web of Science ®Google Scholar
• Wang C, Zhang H, Chen Y, Shi F, Chen B. Gambogic acid-loaded magnetic Fe3O4 nanoparticles inhibit panc-1 pancreatic cancer cell proliferation and migration by inactivating transcription factor ETS1. Int J Nanomed. 2012;7:781–787. doi:10.2147/IJN.S28509
   PubMed Web of Science ®Google Scholar
• Rayegan A, Allafchian A, Sarsari IA, Kameli P. Synthesis and characterization of basil seed mucilage coated Fe3O4 magnetic nanoparticles as a drug carrier for the controlled delivery of cephalexin. Int J Biol Macromol. 2018;113:317–328. doi:10.1016/j.ijbiomac.2018.02.13429481957
   PubMed Web of Science ®Google Scholar
• Arokiyaraj S, Saravanan M, Prakash NU, Arasu MV, Vijayakumar B, Vincent S. Enhanced antibacterial activity of iron oxide magnetic nanoparticles treated with Argemone mexicana L. leaf extract: an in vitro study. Mater Res Bull. 2013;48(9):3323–3327. doi:10.1016/j.materresbull.2013.05.059
   Web of Science ®Google Scholar
• Namvar F, Rahman HS, Mohamad R, et al. Cytotoxic effect of magnetic iron oxide nanoparticles synthesized via seaweed aqueous extract. Int J Nanomed. 2014;9:2479–2488. doi:10.2147/IJN.S59661
   PubMed Web of Science ®Google Scholar
• Allafchian A, Jalali SA, Hosseini F, Massoud M. Ocimum basilicum mucilage as a new green polymer support for silver in magnetic nanocomposites: production and characterization. J Environ Chem Eng. 2017;5(6):5912–5920. doi:10.1016/j.jece.2017.11.023
   Web of Science ®Google Scholar
• Dorniani D, Hussein MZ, Kura AU, Fakurazi S, Shaari AH, Ahmad Z. Preparation of Fe3O4 magnetic nanoparticles coated with gallic acid for drug delivery. Int J Nanomed. 2012;7:5745–5756. doi:10.2147/IJN.S35746
   PubMed Web of Science ®Google Scholar
• Wang C, Liu X, Chen S, Hu FQ, Sun J, Yuan H. Facile preparation of phospholipid-amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration. Chem Commun. 2018;54(93):13080–13083. doi:10.1039/C8CC07694D
   PubMed Web of Science ®Google Scholar
• Zhao L, Zhang Y, Miao Y, Nie L. Controlled synthesis, characterization and application of hydrophobic calcium carbonate nanoparticles in PVC. Powder Technol. 2016;288:184–190. doi:10.1016/j.powtec.2015.11.001
   Web of Science ®Google Scholar
• Näkki S, Wang JT, Wu J, et al. Designed inorganic porous nanovector with controlled release and MRI features for safe administration of doxorubicin. Int J Pharm. 2019;554:327–336. doi:10.1016/j.ijpharm.2018.10.07430391665
   PubMedGoogle Scholar
• Hammadi NI, Abba Y, Hezmee MNM, et al. Formulation of a sustained release docetaxel loaded cockle shell-derived calcium carbonate nanoparticles against breast cancer. Pharm Res. 2017;34:1193–1203. doi:10.1007/s11095-017-2135-128382563
   PubMed Web of Science ®Google Scholar
• Shi H, Li L, Zhang L, et al. Designed preparation of polyacrylic acid/calcium carbonate nanoparticles with high doxorubicin payload for liver cancer chemotherapy. Cryst Eng Comm. 2015;17:4768–4773. doi:10.1039/C5CE00708A
   Google Scholar
• Tully J, Fakhrullin R, Lvov Y. Halloysite clay nanotube composites with sustained release of chemicals In: Nanomaterials and Nanoarchitectures. Springer, Dordrecht; 2015:87–118.
   Google Scholar
• Lazzara G, Cavallaro G, Panchal A, et al. An assembly of organic-inorganic composites using halloysite clay nanotubes. Curr Opin Colloid Interface Sci. 2018;35:42–50. doi:10.1016/j.cocis.2018.01.002
   Web of Science ®Google Scholar
• Tully J, Yendluri R, Lvov Y. Halloysite clay nanotubes for enzyme immobilization. Biomacromolecules. 2016;17(2):615–621. doi:10.1021/acs.biomac.5b0154226699154
   PubMed Web of Science ®Google Scholar
• Vergaro V, Lvov YM, Leporatti S. Halloysite clay nanotubes for resveratrol delivery to cancer cells. Macromol Biosci. 2012;12(9):1265–1271. doi:10.1002/mabi.v12.922887783
   PubMed Web of Science ®Google Scholar
• Lee MH, Seo HS, Park HJ. Thyme oil encapsulated in halloysite nanotubes for antimicrobial packaging system. J Food Sci. 2017;82(4):922–932. doi:10.1111/1750-3841.1367528272803
   PubMed Web of Science ®Google Scholar
• Cavallaro G, Lazzara G, Massaro M, et al. Biocompatible poly (N-isopropylacrylamide)-halloysite nanotubes for thermo responsive curcumin release. J Phys Chem C. 2015;119(16):8944–8951. doi:10.1021/acs.jpcc.5b00991
   Web of Science ®Google Scholar
• Massaro M, Piana S, Colletti CG, et al. Multicavity halloysite–amphiphilic cyclodextrin hybrids for co-delivery of natural drugs into thyroid cancer cells. J Mater Chem B. 2015;3(19):4074–4081. doi:10.1039/C5TB00564G32262629
   PubMed Web of Science ®Google Scholar
• Biddeci G, Cavallaro G, Di Blasi F, et al. Halloysite nanotubes loaded with peppermint essential oil as filler for functional biopolymer film. Carbohydr Polym. 2016;152:548–557. doi:10.1016/j.carbpol.2016.07.04127516303
   PubMed Web of Science ®Google Scholar
• Gorrasi G. Dispersion of halloysite loaded with natural antimicrobials into pectins: characterization and controlled release analysis. Carbohydr Polym. 2015;127:47–53. doi:10.1016/j.carbpol.2015.03.05025965455
   PubMed Web of Science ®Google Scholar
• Chamorro-Garcia A, Merkoçi A. Nanobiosensors in diagnostics. Nanobiomedicine. 2016;3:1849543516663574. doi:10.1177/184954351666357429942385
   PubMedGoogle Scholar
• Iannazzo D, Piperno A, Pistone A, Grassi G, Galvagno S. Recent advances in carbon nanotubes as delivery systems for anticancer drugs. Curr Med Chem. 2013;20(11):1333–1354. doi:10.2174/092986731132011000123432581
   PubMed Web of Science ®Google Scholar
• Ng CM, Loh H-S, Muthoosamy K, Sridewi N, Manickam S. Conjugation of insulin onto the sidewalls of single-walled carbon nanotubes through functionalization and diimide-activated amidation. Int J Nanomed. 2016;11:1607–1614. doi:10.2147/IJN.S98726
   PubMed Web of Science ®Google Scholar
• Floyd EL, Sapag K, Oh J, Lungu CT. Photothermal desorption of single-walled carbon nanotubes and coconut shell-activated carbons using a continuous light source for application in air sampling. Ann Occup Hyg. 2014;58(7):877–888. doi:10.1093/annhyg/meu04325016598
   PubMedGoogle Scholar
• Jha PK, Jha RK, Rout D, Gnanasekar S, Rana SV, Hossain M. Potential targetability of multi-walled carbon nanotube loaded with silver nanoparticles photosynthesized from Ocimum tenuiflorum (tulsi extract) in fertility diagnosis. J Drug Target. 2017;25(7):616–625. doi:10.1080/1061186X.2017.130653428294638
   PubMed Web of Science ®Google Scholar
• Azandaryani AH, Kashanian S, Derakhshandeh K. Folate Conjugated hybrid nanocarrier for targeted letrozole delivery in breast cancer treatment. Pharm Res. 2017;34(12):2798–2808. doi:10.1007/s11095-017-2260-x29110284
   PubMed Web of Science ®Google Scholar
• Date T, Nimbalkar V, Kamat J, Mittal A, Mahato RI, Chitkara D. Lipid-polymer hybrid nanocarriers for delivering cancer therapeutics. J Control Release. 2017;271:60–73. doi:10.1016/j.jconrel.2017.12.01629273320
   PubMed Web of Science ®Google Scholar
• Sedki M, Khalil IA, El-Sherbiny IM. Hybrid nanocarrier system for guiding and augmenting simvastatin cytotoxic activity against prostate cancer. Artif Cells Nanomed Biotechnol. 2018;46:1–10.
   Web of Science ®Google Scholar
• Lim WQ, Phua SZ, Xu HV, Sreejith S, Zhao Y. Recent advances in multifunctional silica-based hybrid nanocarriers for bioimaging and cancer therapy. Nanoscale. 2016;8(25):12510–12519. doi:10.1039/C5NR07853A26750573
   PubMed Web of Science ®Google Scholar
• Zhang J, Han X, Li X, et al. Core-shell hybrid liposomal vesicles loaded with panax notoginsenoside: preparation, characterization and protective effects on global cerebral ischemia/reperfusion injury and acute myocardial ischemia in rats. Int J Nanomed. 2012;7:4299–4310. doi:10.2147/IJN.S32385
   PubMed Web of Science ®Google Scholar
• Stanley S. Biological nanoparticles and their influence on organisms. Curr Opin Biotechnol. 2014;28:69–74. doi:10.1016/j.copbio.2013.11.01424832077
   PubMed Web of Science ®Google Scholar
• Loredo-Tovias M, Duran-Meza AL, Villagrana-Escareño MV, et al. Encapsidated ultrasmall nanolipospheres as novel nanocarriers for highly hydrophobic anticancer drugs. Nanoscale. 2017;9(32):11625–11631. doi:10.1039/C7NR02118F28770909
   PubMed Web of Science ®Google Scholar
• Singh P, Kim YJ, Zhang D, Yang DC. Biological synthesis of nanoparticles from plants and microorganisms. Trends Biotechnol. 2016;34(7):588–599. doi:10.1016/j.tibtech.2016.02.00626944794
   PubMed Web of Science ®Google Scholar
• Gregory AE, Titball R, Williamson D. Vaccine delivery using nanoparticles. Front Cell Infect Microbiol. 2013;3(13):1–13.23355975
   PubMedGoogle Scholar
• Shukla S, Wen AM, Ayat NR, et al. Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice. Nanomedicine. 2014;9(2):221–235. doi:10.2217/nnm.13.7523834501
   PubMed Web of Science ®Google Scholar
• Wen AM, Lee KL, Yildiz I, Bruckman MA, Shukla S, Steinmetz NF. Viral nanoparticles for in vivo tumor imaging. J Vis Exp. 2012;69:1–12.
   Google Scholar
• Leong HS, Steinmetz NF, Ablack A, et al. Intravital imaging of embryonic and tumor neovasculature using viral nanoparticles. Nat Protoc. 2010;5(8):1406–1417. doi:10.1038/nprot.2010.10320671724
   PubMed Web of Science ®Google Scholar
• Lee KL, Murray AA, Le DH, et al. Combination of plant virus nanoparticle-based in situ vaccination with chemotherapy potentiates antitumor response. Nano Lett. 2017;17(7):4019–4028. doi:10.1021/acs.nanolett.7b0010728650644
   PubMed Web of Science ®Google Scholar
• Badri Narayanan K, Soo Han S. Genetic modifications of icosahedral plant virus-based nanoparticles for vaccine and immunotherapy applications. Curr Protein Pept Sci. 2017;18(11):1141–1151. doi:10.2174/138920371866617042415310928440187
   PubMed Web of Science ®Google Scholar
• Qi J, Zhuang J, Wu W, et al. Enhanced effect and mechanism of water-in-oil microemulsion as an oral delivery system of hydroxysafflor yellow A. Int J Nanomed. 2011;6:985–991. doi:10.2147/IJN.S18821
   PubMed Web of Science ®Google Scholar
• Bhargava K, Conti DS, da Rocha SR, Zhang Y. Application of an oregano oil nanoemulsion to the control of food-borne bacteria on fresh lettuce. Food Microbiol. 2015;47:69–73. doi:10.1016/j.fm.2014.11.00725583339
   PubMed Web of Science ®Google Scholar
• Sercombe L, Veerati T, Moheimani F, Wu SY, Sood AK, Hua S. Advances and challenges of liposome assisted drug delivery. Front. Pharmacol. 2015;6:286. doi:10.3389/fphar.2015.0028626648870
   PubMed Web of Science ®Google Scholar
• Hsu CY, Wang PW, Alalaiwe A, Lin ZC, Fang JY, Use of lipid Nanocarriers to improve Oral delivery of vitamins. Nutrients 2019;11(1):68–97.
   PubMed Web of Science ®Google Scholar
• Agnihotri N, Soni GC, Chanchal DK, Tiwari S, Fang JY, A Scientific Review On Nanoemulsion For Targeting Drug Delivery System. Int J Life Sci Rev. 2019;5(2):16–29.
   Google Scholar
• Hérault N, Wagner J, Abram SL, et al. Silver-Containing Titanium Dioxide Nanocapsules for Combating Multidrug-Resistant Bacteria. Int J Nanomed. 2020;15:1267–1281.
   PubMed Web of Science ®Google Scholar
• Dou XQ, Wang H, Zhang J, Aptamer–drug conjugate: targeted delivery of doxorubicin in a HER3 aptamer-functionalized liposomal delivery system reduces cardiotoxicity. Int J Nanomed. 2018;13:763–776.
   PubMed Web of Science ®Google Scholar
• Kevadiya BD, Chen L, Zhang L, Thomas MB, Davé RN, et al. Fenofibrate Nanocrystal Composite Microparticles for Intestine-Specific Oral Drug Delivery System. Pharmaceuticals. 2019;12(3):109–124.
   Web of Science ®Google Scholar
• Quan G, Niu B, Singh V, et al. Supersaturable solid self-microemulsifying drug delivery system: precipitation inhibition and bioavailability enhancement. Int J Nanomed. 2017;12:8801–8811.
   PubMed Web of Science ®Google Scholar
• Lee JW, Lee HY, Park SH, et al. Preparation and evaluation of dexamethasone-loaded electrospun nanofiber sheets as a sustained drug delivery system. Materials. 2016;9(3):175–186.
   PubMed Web of Science ®Google Scholar
• Jin X, Zhang ZH, Sun E, et al. Enhanced oral absorption of 20 (S)-protopanaxadiol by self-assembled liquid crystalline nanoparticles containing piperine: in vitro and in vivo studies. Int J Nanomed. 2013;8:641–652.
   PubMed Web of Science ®Google Scholar
• Safer AM, Leporatti S, Jose J, Soliman MS, et al. Conjugation Of EGCG And Chitosan NPs As A Novel Nano-Drug Delivery System. Int J Nanomed. 2019;14:8033–8046.
   PubMed Web of Science ®Google Scholar
• Muhammad Mailafiya M, Abubakar K, Danmaigoro A, et al. Cockle Shell-Derived Calcium Carbonate (Aragonite) Nanoparticles: A Dynamite to Nanomedicine. Appl Sci. 2019;9(14):2897–2922.
   Google Scholar
• Kamal N, Kochkodan V, Zekri A, Ahzi S et al. Polysulfone Membranes Embedded with Halloysites Nanotubes: Preparation and Properties. Membranes 2020;10(1):2–29.
   Google Scholar