560
Views
34
CrossRef citations to date
0
Altmetric
Review

Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature

, ORCID Icon & ORCID Icon
Pages 8673-8696 | Published online: 06 Nov 2020

References

  • Santos HA, Bimbo LM, Herranz B, Shahbazi MA, Hirvonen J, Salonen J. Nanostructured porous silicon in preclinical imaging: moving from bench to bedside. J Mater Res. 2013;28(2):152–164. doi:10.1557/jmr.2012.271
  • Prasad D, Chauhan H. Key targeting approaches for pharmaceutical drug delivery. Am Pharm Rev. 2013;16(6).
  • Maeda H. Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting. Proc Jpn Acad Ser B Phys Biol Sci. 2012;88(3):53–71. doi:10.2183/pjab.88.53
  • Yuan F, Dellian M, Fukumura D, et al. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res. 1995;55(17):3752–3756.7641188
  • Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 1986;46(12Part 1):6387–6392.2946403
  • Fang J, Sawa T, Maeda H. Factors and mechanism of “EPR” effect and the enhanced antitumor effects of macromolecular drugs including SMANCS. In: Maeda H., Kabanov A., Kataoka K., Okano T. editors, Advances in Experimental Medicine and Biology. Vol. 519. 2004:29–49. doi:10.1007/0-306-47932-x_2
  • Anselmo AC, Mitragotri S. Nanoparticles in the clinic. Bioeng Transl Med. 2016;1(1):10–29. doi:10.1002/btm2.1000329313004
  • Anselmo AC, Mitragotri S. Nanoparticles in the clinic: an update. Bioeng Transl Med. 2019;4(3):e10143. doi:10.1002/btm2.1014331572799
  • Borgå O, Lilienberg E, Bjermo H, Hansson F, Heldring N, Dediu R. Pharmacokinetics of total and unbound paclitaxel after administration of paclitaxel micellar or nab-paclitaxel: an open, randomized, cross-over, explorative study in breast cancer patients. Adv Ther. 2019;36(10):2825–2837. doi:10.1007/s12325-019-01058-631432461
  • Fujiwara Y, Mukai H, Saeki T, et al. A multi-national, randomised, open-label, parallel, Phase III non-inferiority study comparing NK105 and paclitaxel in metastatic or recurrent breast cancer patients. Br J Cancer. 2019;120(5):475–480. doi:10.1038/s41416-019-0391-z30745582
  • Weiss C, Carriere M, Fusco L, et al. Toward nanotechnology-enabled approaches against the COVID-19 pandemic. ACS Nano. 2020;14(6):6383–6406. doi:10.1021/acsnano.0c0369732519842
  • Florindo HF, Kleiner R, Vaskovich-Koubi D, et al. Immune-mediated approaches against COVID-19. Nat Nanotechnol. 2020;15(8):630–645. doi:10.1038/s41565-020-0732-332661375
  • Keech C, Albert G, Cho I, et al. Phase 1–2 Trial of a SARS-CoV-2 recombinant spike protein nanoparticle vaccine. N Engl J Med. 2020:NEJMoa2026920. doi:10.1056/NEJMoa2026920.
  • Lee DE, Koo H, Sun IC, Ryu JH, Kim K, Kwon IC. Multifunctional nanoparticles for multimodal imaging and theragnosis. Chem Soc Rev. 2012;41(7):2656–2672. doi:10.1039/c2cs15261d22189429
  • Kothamasu P, Kanumur H, Ravur N, Maddu C, Parasuramrajam R, Thangavel S. Nanocapsules: the weapons for novel drug delivery systems. BioImpacts. 2012;2(2):71–81. doi:10.5681/bi.2012.01123678444
  • Couvreur P, Barratt G, Fattal E, Legrand P, Vauthier C. Nanocapsule technology: a review. Crit Rev Ther Drug Carrier Syst. 2002;19(2):99–134. doi:10.1615/CritRevTherDrugCarrierSyst.v19.i2.1012197610
  • Deng S, Gigliobianco MR, Censi R, Di Martino P. Polymeric nanocapsules as nanotechnological alternative for drug delivery system: current status, challenges and opportunities. Nanomaterials. 2020;10(5):847. doi:10.3390/nano10050847
  • Benita S. Microparticulate drug delivery systems: release kinetic models. Microspheres Microcapsules Liposomes. 1998;2:155–181.
  • Mora-Huertas CE, Fessi H, Elaissari A. Polymer-based nanocapsules for drug delivery. Int J Pharm. 2010;385(1–2):113–142. doi:10.1016/j.ijpharm.2009.10.01819825408
  • Ottenbrite RM, Kim SW. Polymeric Drugs and Drug Delivery Systems. CRC Press; 2019. doi:10.1201/9780429136405
  • Rostamizadeh K, Torchilin VP. Polymeric nanomicelles as versatile tool for multidrug delivery in chemotherapy. In: Ranjita Shegokar editor, Nanopharmaceuticals. Zimmern: Elsevier; 2020:45–72. doi:10.1016/b978-0-12-817778-5.00003-8
  • Pattni BS, Chupin VV, Torchilin VP. New developments in liposomal drug delivery. Chem Rev. 2015;115(19):10938–10966. doi:10.1021/acs.chemrev.5b0004626010257
  • Rahnfeld L, Luciani P. Injectable lipid-based depot formulations: where do we stand? Pharmaceutics. 2020;12(6):567. doi:10.3390/PHARMACEUTICS12060567
  • Pinto Reis C, Neufeld RJ, Ribeiro AJ, Veiga F. Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles. Nanomedicine. 2006;2(1):8–21. doi:10.1016/j.nano.2005.12.00317292111
  • Kumari A, Singla R, Guliani A, Yadav SK. Nanoencapsulation for drug delivery. EXCLI J. 2014;13:265–286. doi:10.17877/DE290R-1559226417260
  • Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release. 2001;70(1–2):1–20. doi:10.1016/S0168-3659(00)00339-411166403
  • Sun M, Hu H, Sun L, Fan Z. The application of biomacromolecules to improve oral absorption by enhanced intestinal permeability: A mini-review. Chin Chem Lett. 2020;31(7):1729–1736. doi:10.1016/j.cclet.2020.02.035
  • Fu D, Liu D, Zhang L, Sun L. Self-assembled fluorescent tripeptide nanoparticles for bioimaging and drug delivery applications. Chin Chem Lett. 2020. doi:10.1016/j.cclet.2020.07.011
  • Fan Z, Chang Y, Cui C, et al. Near infrared fluorescent peptide nanoparticles for enhancing esophageal cancer therapeutic efficacy. Nat Commun. 2018;9(1):1–11. doi:10.1038/s41467-018-04763-y29317637
  • Khoee S, Yaghoobian M. An investigation into the role of surfactants in controlling particle size of polymeric nanocapsules containing penicillin-G in double emulsion. Eur J Med Chem. 2009;44(6):2392–2399. doi:10.1016/j.ejmech.2008.09.04519010570
  • Torchilin VP. Multifunctional nanocarriers. Adv Drug Deliv Rev. 2006;58(14):1532–1555. doi:10.1016/j.addr.2006.09.00917092599
  • Singh R, Lillard JW. Nanoparticle-based targeted drug delivery. Exp Mol Pathol. 2009;86(3):215–223. doi:10.1016/j.yexmp.2008.12.00419186176
  • Decher G, Hong JD, Schmitt J. Buildup of ultrathin multilayer films by a self-assembly process: III. Consecutively alternating adsorption of anionic and cationic polyelectrolytes on charged surfaces. Thin Solid Films. 1992;210–211(PART 2):831–835. doi:10.1016/0040-6090(92)90417-A
  • Decher G. Fuzzy nanoassemblies: toward layered polymeric multicomposites. Science. 1997;277(5330):1232–1237. doi:10.1126/science.277.5330.1232
  • Iler RK. Multilayers of colloidal particles. J Colloid Interface Sci. 1966;21(6):569–594. doi:10.1016/0095-8522(66)90018-3
  • Sukhorukov GB, Donath E, Lichtenfeld H, et al. Layer-by-layer self assembly of polyelectrolytes on colloidal particles. Colloids Surf a Physicochem Eng Asp. 1998;137(1–3):253–266. doi:10.1016/S0927-7757(98)00213-1
  • Szczepanowicz K, Bazylińska U, Pietkiewicz J, Szyk-Warszyńska L, Wilk KA, Warszyński P. Biocompatible long-sustained release oil-core polyelectrolyte nanocarriers: from controlling physical state and stability to biological impact. Adv Colloid Interface Sci. 2015;222:678–691. doi:10.1016/j.cis.2014.10.00525453660
  • Szczepanowicz K, Dronka-Góra D, Para G, Warszyński P. Encapsulation of liquid cores by layer-by-layer adsorption of polyelectrolytes. J Microencapsul. 2010;27(3):198–204. doi:10.3109/0265204090305206919545219
  • Shchukin DG, Sukhorukov GB. Nanoparticle synthesis in engineered organic nanoscale reactors. Adv Mater. 2004;16(8):671–682. doi:10.1002/adma.200306466
  • Katagiri K, Caruso F. Monodisperse polyelectrolyte-supported asymmetric lipid-bilayer vesicles. Adv Mater. 2005;17(6):738–743. doi:10.1002/adma.200401441
  • Angelatos AS, Katagiri K, Caruso F. Bioinspired colloidal systems via layer-by-layer assembly. Soft Matter. 2006;2(1):18–23. doi:10.1039/b511930h32646088
  • Torchilin VP, Trubetskoy VS. Which polymers can make nanoparticulate drug carriers long-circulating? Adv Drug Deliv Rev. 1995;16(2–3):141–155. doi:10.1016/0169-409X(95)00022-Y
  • Moghimi SM, Hunter AC, Murray JC. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev. 2011;53(2):283–318.
  • Kingshott P, Griesser HJ. Surfaces that resist bioadhesion. Curr Opin Solid State Mater Sci. 1999;4(4):403–412. doi:10.1016/S1359-0286(99)00018-2
  • Maeda H, Greish K, Fang J. The EPR effect and polymeric drugs: A paradigm shift for cancer chemotherapy in the 21st century. Adv Polym Sci. 2006;193(1):103–121. doi:10.1007/12_026
  • Torchilin VP. Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery. Nat Rev Drug Discov. 2014;13(11):813–827. doi:10.1038/nrd433325287120
  • Polyak B, Friedman G. Magnetic targeting for site-specific drug delivery: applications and clinical potential. Expert Opin Drug Deliv. 2009;6(1):53–70. doi:10.1517/1742524080266279519236208
  • Torchilin VP. Drug targeting. Eur J Pharm Sci. 2000;11(SUPPL. 2):S81–S91. doi:10.1016/S0928-0987(00)00166-411033430
  • Häfeli U, Schütt W, Teller J, Zborowski M. Scientific and Clinical Applications of Magnetic Carriers. Springer Science & Business Media; 1997.
  • Pankhurst QA, Connolly J, Jones SK, Dobson J. Applications of magnetic nanoparticles in biomedicine. J Phys D Appl Phys. 2003;36(13):R167. doi:10.1088/0022-3727/49/50/501002
  • Reimer P, Weissleder R. Development and experimental use of receptor-specific MR contrast media. Radiologe. 1996;36(2):153–163. doi:10.1007/s0011700500538867433
  • Arbab AS, Bashaw LA, Miller BR, et al. Characterization of biophysical and metabolic properties of cells labeled with superparamagnetic iron oxide nanoparticles and transfection agent for cellular MR imaging. Radiology. 2003;229(3):838–846. doi:10.1148/radiol.229302121514657318
  • Gupta AK, Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials. 2005;26(18):3995–4021. doi:10.1016/j.biomaterials.2004.10.01215626447
  • Chen S, Weissleder R. Polymer-Coated Iron Oxide Nanoparticles for Medical Imaging. Massachusetts Institute of Technology; 2010.
  • Vilela C, Figueiredo ARP, Silvestre AJD, Freire CSR. Multilayered materials based on biopolymers as drug delivery systems. Expert Opin Drug Deliv. 2017;14(2):189–200. doi:10.1080/17425247.2016.121456827488175
  • Correa S, Dreaden EC, Gu L, Hammond PT. Engineering nanolayered particles for modular drug delivery. J Control Release. 2016;240:364–386. doi:10.1016/j.jconrel.2016.01.04026809005
  • Picart C, Caruso F, Voegel J. Layer-By-Layer Films for Biomedical Applications. John Wiley & Sons; 2015.
  • Johnston APR, Cortez C, Angelatos AS, Caruso F. Layer-by-layer engineered capsules and their applications. Curr Opin Colloid Interface Sci. 2006;11(4):203–209. doi:10.1016/j.cocis.2006.05.001
  • Fessi H, Puisieux F, Devissaguet J Process for preparing a colloidal and disperse system in the shape of nanocapsules; 1988.
  • Schubert S, Delaney, Jr JT, Schubert US. Nanoprecipitation and nanoformulation of polymers: from history to powerful possibilities beyond poly(lactic acid). Soft Matter. 2011;7(5):1581–1588. doi:10.1039/c0sm00862a
  • Gericke M, Schulze P, Heinze T. Nanoparticles based on hydrophobic polysaccharide derivatives—formation principles, characterization techniques, and biomedical applications. Macromol Biosci. 2020;20(4):1900415. doi:10.1002/mabi.201900415
  • Galindo-Rodriguez S, Allémann E, Fessi H, Doelker E. Physicochemical parameters associated with nanoparticle formation in the salting-out, emulsification-diffusion, and nanoprecipitation methods. Pharm Res. 2004;21(8):1428–1439. doi:10.1023/B:PHAM.0000036917.75634.be15359578
  • Hornig S, Heinze T, Becer CR, Schubert US. Synthetic polymeric nanoparticles by nanoprecipitation. J Mater Chem. 2009;19(23):3838–3840. doi:10.1039/b906556n
  • Fessi H, Puisieux F, Devissaguet JP, Ammoury N, Benita S. Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int J Pharm. 1989;55(1):R1–R4. doi:10.1016/0378-5173(89)90281-0
  • Che Marzuki NH, Wahab RA, Abdul Hamid M. An overview of nanoemulsion: concepts of development and cosmeceutical applications. Biotechnol Biotechnol Equip. 2019;33(1):779–797. doi:10.1080/13102818.2019.1620124
  • Gupta A, Eral HB, Hatton TA, Doyle PS. Nanoemulsions: formation, properties and applications. Soft Matter. 2016;12(11):2826–2841. doi:10.1039/c5sm02958a26924445
  • Tiarks F, Landfester K, Antonietti M. Preparation of polymeric nanocapsules by miniemulsion polymerization. Langmuir. 2001;17(3):908–918. doi:10.1021/la001276n
  • Landfester K. Encapsulation through (Mini)Emulsion polymerization. In: Swapan Kumar Ghosh editor, Functional Coatings, Weinheim:John Wiley and Sons; 2006;29–66. doi:10.1002/3527608478.ch2
  • Khan I, Saeed K, Khan I. Nanoparticles: properties, applications and toxicities. Arab J Chem. 2019;12(7):908–931. doi:10.1016/j.arabjc.2017.05.011
  • Grigoriev DO, Miller R. Mono- and multilayer covered drops as carriers. Curr Opin Colloid Interface Sci. 2009;14(1):48–59. doi:10.1016/j.cocis.2008.03.003
  • Dos Santos DS, Dos Santos Goldenberg RC. Doxorubicin-induced cardiotoxicity: from mechanisms to development of efficient therapy. In: Wenyong Tan editor. Cardiotoxicity. London: InTech; 2018;3–24. doi:10.5772/intechopen.79588
  • Wang Z, Zhang Y, Cao B, et al. Explosible nanocapsules excited by pulsed microwaves for efficient thermoacoustic-chemo combination therapy. Nanoscale. 2019;11(4):1710–1719. doi:10.1039/c8nr08498j30623943
  • Zhang Y, He P, Liu X, et al. A PEGylated alternating copolymer with oxidation-sensitive phenylboronic ester pendants for anticancer drug delivery. Biomater Sci. 2019;7(9):3898–3905. doi:10.1039/c9bm00884e31317137
  • Harter P, Sehouli J, Kimmig R, et al. Addition of vandetanib to pegylated liposomal doxorubicin (PLD) in patients with recurrent ovarian cancer. A randomized phase I/II study of the AGO study group (AGO-OVAR 2.13). Invest New Drugs. 2013;31(6):1499–1504. doi:10.1007/s10637-013-0011-324005613
  • Zhou Z, Jafari M, Sriram V, et al. Delayed sequential co-delivery of gefitinib and doxorubicin for targeted combination chemotherapy. Mol Pharm. 2017;14(12):4551–4559. doi:10.1021/acs.molpharmaceut.7b0066929077410
  • Dong Y, Liao H, Yu J, et al. Incorporation of drug efflux inhibitor and chemotherapeutic agent into an inorganic/organic platform for the effective treatment of multidrug resistant breast cancer. J Nanobiotechnology. 2019;17(1):125. doi:10.1186/s12951-019-0559-y31870362
  • Wang F, Li Y, Shen Y, Wang A, Wang S, Xie T. The functions and applications of RGD in tumor therapy and tissue engineering. Int J Mol Sci. 2013;14(7):13447–13462. doi:10.3390/ijms14071344723807504
  • Gupta B, Pathak S, Poudel BK, et al. Folate receptor-targeted hybrid lipid-core nanocapsules for sequential delivery of doxorubicin and tanespimycin. Colloids Surf B Biointerfaces. 2017;155:83–92. doi:10.1016/j.colsurfb.2017.04.01028410515
  • Chen J, Li X, Sun Y, et al. Synthesis of size-tunable hollow polypyrrole nanostructures and their assembly into folate-targeting and pH-responsive anticancer drug-delivery agents. Chem Eur J. 2017;23(68):17279–17289. doi:10.1002/chem.20170294528913948
  • Jeong Y, Kim ST, Jiang Y, et al. Nanoparticle-dendrimer hybrid nanocapsules for therapeutic delivery. Nanomedicine. 2016;11(12):1571–1578. doi:10.2217/nnm-2016-003427175480
  • Al-Jamal KT, Bai J, Wang JTW, et al. Magnetic Drug targeting: preclinical in vivo studies, mathematical modeling, and extrapolation to humans. Nano Lett. 2016;16(9):5652–5660. doi:10.1021/acs.nanolett.6b0226127541372
  • Bai J, Wang JTW, Rubio N, et al. Triple-modal imaging of magnetically-targeted nanocapsules in solid tumours in vivo. Theranostics. 2016;6(3):342–356. doi:10.7150/thno.1191826909110
  • Schlegel I, Renz P, Simon J, et al. Highly Loaded semipermeable nanocapsules for magnetic resonance imaging. Macromol Biosci. 2018;18(4):e1700387. doi:10.1002/mabi.20170038729392837
  • Calcagno V, Vecchione R, Quagliariello V, et al. Oil core-PEG shell nanocarriers for in vivo MRI imaging. Adv Healthcare Mater. 2019;8(3):1801313. doi:10.1002/adhm.201801313
  • Xu L, Du J, Wan CF, et al. Ultrasound molecular imaging of breast cancer in MCF-7 orthotopic mice using gold nanoshelled poly(lactic-co-glycolic acid) nanocapsules: A novel dual-targeted ultrasound contrast agent. Int J Nanomedicine. 2018;13:1791–1807. doi:10.2147/IJN.S15399329606871
  • Achmad A, Yamaguchi A, Hanaoka H, Tsushima Y. Thin-shelled PEGylated perfluorooctyl bromide nanocapsules for tumor-targeted ultrasound contrast agent. Contrast Media Mol Imaging. 2018;2018:1725323. doi:10.1155/2018/172532330515065
  • Chen L, Fu C, Deng Y, Wu W, Fu A. A pH-sensitive nanocarrier for tumor targeting: delivery of ruthenium complex for tumor theranostic by pH-sensitive nanocapsule. Pharm Res. 2016;33(12):2989–2998. doi:10.1007/s11095-016-2021-227590630
  • You Y, Wang Z, Ran H, et al. Nanoparticle-enhanced synergistic HIFU ablation and transarterial chemoembolization for efficient cancer therapy. Nanoscale. 2016;8(7):4324–4339. doi:10.1039/c5nr08292g26837265
  • Wang Z, Ju Y, Ali Z, et al. Near-infrared light and tumor microenvironment dual responsive size-switchable nanocapsules for multimodal tumor theranostics. Nat Commun. 2019;10(1):1–12. doi:10.1038/s41467-019-12142-430602773
  • Wang H, Chao Y, Liu J, et al. Photosensitizer-crosslinked in-situ polymerization on catalase for tumor hypoxia modulation & enhanced photodynamic therapy. Biomaterials. 2018;181:310–317. doi:10.1016/j.biomaterials.2018.08.01130096565
  • Wu X, Wu Y, Wang Z, et al. A cascade-targeting nanocapsule for enhanced photothermal tumor therapy with aid of autophagy inhibition. Adv Healthcare Mater. 2018;7(11):1800121. doi:10.1002/adhm.201800121
  • Sun L, Li Q, Zhang L, et al. Stimuli responsive PEGylated bismuth selenide hollow nanocapsules for fluorescence/CT imaging and light-driven multimodal tumor therapy. Biomater Sci. 2019;7(7):3025–3040. doi:10.1039/c9bm00351g31115395
  • Wu J, Bremner DH, Niu S, et al. Chemodrug-gated biodegradable hollow mesoporous organosilica nanotheranostics for multimodal imaging-guided low-temperature photothermal therapy/chemotherapy of cancer. ACS Appl Mater Interfaces. 2018;10(49):42115–42126. doi:10.1021/acsami.8b1644830462492
  • Alqaraghuli HGJ, Kashanian S, Rafipour RA. Review on targeting nanoparticles for breast cancer. Curr Pharm Biotechnol. 2019;20(13):1087–1107. doi:10.2174/138920102066619073113000131364513
  • Lee H, Hoang B, Fonge H, Reilly RM, Allen C. In vivo distribution of polymeric nanoparticles at the whole-body, tumor, and cellular levels. Pharm Res. 2010;27(11):2343–2355. doi:10.1007/s11095-010-0068-z20195708
  • Prabhakar U, Maeda H, Jain RK, et al. Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology. Cancer Res. 2013;73(8):2412–2417. doi:10.1158/0008-5472.CAN-12-456123423979
  • Nakamura Y, Mochida A, Choyke PL, Kobayashi H. Nanodrug delivery: is the enhanced permeability and retention effect sufficient for curing cancer? Bioconjug Chem. 2016;27(10):2225–2238. doi:10.1021/acs.bioconjchem.6b0043727547843
  • Neesse A, Michl P, Frese KK, et al. Stromal biology and therapy in pancreatic cancer. Gut. 2011;60(6):861–868. doi:10.1136/gut.2010.22609220966025
  • Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012;366(10):883–892. doi:10.1056/NEJMoa111320522397650
  • Cutler DM. Early returns from the era of precision medicine. JAMA. 2020;323(2):109–110. doi:10.1001/jama.2019.2065931935015
  • Kim H, Niu L, Larson P, et al. Polymeric nanoparticles encapsulating novel TLR7/8 agonists as immunostimulatory adjuvants for enhanced cancer immunotherapy. Biomaterials. 2018;164:38–53. doi:10.1016/j.biomaterials.2018.02.03429482062
  • Wang Y, Lin YX, Qiao SL, et al. Polymeric nanoparticles enable reversing macrophage in tumor microenvironment for immunotherapy. Biomaterials. 2017;112:153–163. doi:10.1016/j.biomaterials.2016.09.03427768970
  • Zheng C, Wang Q, Wang Y, et al. In situ modification of the tumor cell surface with immunomodulating nanoparticles for effective suppression of tumor growth in mice. Adv Mater. 2019;31(32):1902542. doi:10.1002/adma.201902542
  • Bachmann MF, Jennings GT. Vaccine delivery: A matter of size, geometry, kinetics and molecular patterns. Nat Rev Immunol. 2010;10(11):787–796. doi:10.1038/nri286820948547
  • Peleteiro M, Presas E, González-Aramundiz JV, et al. Polymeric nanocapsules for vaccine delivery: influence of the polymeric shell on the interaction with the immune system. Front Immunol. 2018;9:791. doi:10.3389/fimmu.2018.0079129725329
  • Crecente-Campo J, Lorenzo-Abalde S, Mora A, et al. Bilayer polymeric nanocapsules: a formulation approach for a thermostable and adjuvanted E. coli antigen vaccine. J Control Release. 2018;286:20–32. doi:10.1016/j.jconrel.2018.07.01830017722
  • Correia-Pinto JF, Peleteiro M, Csaba N, González-Fernández Á, Alonso MJ. Multi-enveloping of particulated antigens with biopolymers and immunostimulant polynucleotides. J Drug Deliv Sci Technol. 2015;30:424–434. doi:10.1016/j.jddst.2015.08.010
  • Vicente S, Peleteiro M, Díaz-Freitas B, Sanchez A, González-Fernández Á, Alonso MJ. Co-delivery of viral proteins and a TLR7 agonist from polysaccharide nanocapsules: A needle-free vaccination strategy. J Control Release. 2013;172(3):773–781. doi:10.1016/j.jconrel.2013.09.01224076340
  • Fichter M, Piradashvili K, Pietrzak-Nguyen A, et al. Polymeric hepatitis C virus non-structural protein 5A nanocapsules induce intrahepatic antigen-specific immune responses. Biomaterials. 2016;108:1–12. doi:10.1016/j.biomaterials.2016.08.04627614817
  • Smarr CB, Yap WT, Neef TP, et al. Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre- and postsensitization. Proc Natl Acad Sci U S A. 2016;113(18):5059–5064. doi:10.1073/pnas.150578211327091976
  • Cardoso AM, de Oliveira EG, Coradini K, et al. Chitosan hydrogels containing nanoencapsulated phenytoin for cutaneous use: skin permeation/penetration and efficacy in wound healing. Mater Sci Eng C. 2019;96:205–217. doi:10.1016/j.msec.2018.11.013
  • Muniz BV, Baratelli D, Di Carla S, et al. Hybrid hydrogel composed of polymeric nanocapsules co-loading lidocaine and prilocaine for topical intraoral anesthesia. Sci Rep. 2018;8(1):1–12. doi:10.1038/s41598-018-36382-429311619
  • Shoba E, Lakra R, Kiran MS, Korrapati PS. Fabrication of core-shell nanofibers for controlled delivery of bromelain and salvianolic acid B for skin regeneration in wound therapeutics. Biomed Mater. 2017;12(3). doi:10.1088/1748-605X/aa6684
  • Tian H, Du J, Wen J, et al. Growth-factor nanocapsules that enable tunable controlled release for bone regeneration. ACS Nano. 2016;10(8):7362–7369. doi:10.1021/acsnano.5b0795027227573
  • Kann B, Spengler C, Coradini K, et al. Intracellular delivery of poorly soluble polyphenols: elucidating the interplay of self-assembling nanocarriers and human chondrocytes. Anal Chem. 2016;88(14):7014–7022. doi:10.1021/acs.analchem.6b0019927329347
  • Coradini K, Friedrich RB, Fonseca FN, et al. A novel approach to arthritis treatment based on resveratrol and curcumin co-encapsulated in lipid-core nanocapsules: in vivo studies. Eur J Pharm Sci. 2015;78:163–170. doi:10.1016/j.ejps.2015.07.01226206297
  • Sezlev Bilecen D, Uludag H, Hasirci V. Development of PEI-RANK siRNA complex loaded PLGA nanocapsules for the treatment of osteoporosis. Tissue Eng Part A. 2019;25(1–2):34–43. doi:10.1089/ten.TEA.2017.047629652606
  • Chiang CS, Chen JY, Chiang MY, et al. Using the interplay of magnetic guidance and controlled TGF-β release from protein-based nanocapsules to stimulate chondrogenesis. Int J Nanomedicine. 2018;13:3177–3188. doi:10.2147/IJN.S15628429922054
  • Reimondez-Troitiño S, Alcalde I, Csaba N, et al. Polymeric nanocapsules: a potential new therapy for corneal wound healing. Drug Deliv Transl Res. 2016;6(6):708–721. doi:10.1007/s13346-016-0312-027392604
  • Lee JH, Sahu A, Choi W Il, Lee JY, Tae G. ZOT-derived peptide and chitosan functionalized nanocarrier for oral delivery of protein drug. Biomaterials. 2016;103:160–169. doi:10.1016/j.biomaterials.2016.06.05927380442
  • Wang WL, Lu RL, DiPierro MR, Fasano A. Zonula occludin toxin, a microtubule binding protein. World J Gastroenterol. 2000;6(3):330–334. doi:10.3748/wjg.v6.i3.33011819591
  • Sun L, Liu Z, Tian H, et al. Scalable manufacturing of enteric encapsulation systems for site-specific oral insulin delivery. Biomacromolecules. 2019;20(1):528–538. doi:10.1021/acs.biomac.8b0153030537806
  • Sallam MA, Helal HM, Mortada SM. Rationally designed nanocarriers for intranasal therapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition. Int J Nanomedicine. 2016;11:2345–2357. doi:10.2147/IJN.S9854727307734
  • Chen G, Abdeen AA, Wang Y, et al. A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing. Nat Nanotechnol. 2019;14(10):974–980. doi:10.1038/s41565-019-0539-231501532
  • Wu D, Qin M, Xu D, et al. A bioinspired platform for effective delivery of protein therapeutics to the central nervous system. Adv Mater. 2019;31(18):1807557. doi:10.1002/adma.201807557
  • Xu D, Wu D, Qin M, et al. Efficient delivery of nerve growth factors to the central nervous system for neural regeneration. Adv Mater. 2019;31(33):1900727. doi:10.1002/adma.201900727
  • da Silveira EF, Ferreira LM, Gehrcke M, et al. 2-(2-Methoxyphenyl)-3-((Piperidin-1-yl)ethyl)thiazolidin-4-one-loaded polymeric nanocapsules: in vitro antiglioma activity and in vivo toxicity evaluation. Cell Mol Neurobiol. 2019;39(6):783–797. doi:10.1007/s10571-019-00678-431115733
  • Ferreira LM, Azambuja JH, da Silveira EF, et al. Antitumor action of diphenyl diselenide nanocapsules: in vitro assessments and preclinical evidence in an animal model of glioblastoma multiforme. J Trace Elem Med Biol. 2019;55:180–189. doi:10.1016/j.jtemb.2019.06.01031345356
  • Pramanik SK, Sreedharan S, Singh H, et al. Mitochondria targeting non-isocyanate-based polyurethane nanocapsules for enzyme-triggered drug release. Bioconjug Chem. 2018;29(11):3532–3543. doi:10.1021/acs.bioconjchem.8b0046030036048
  • Zhao T, Wang P, Li Q, et al. Near-infrared triggered decomposition of nanocapsules with high tumor accumulation and stimuli responsive fast elimination. Angew Chem Int Ed. 2018;57(10):2611–2615. doi:10.1002/anie.201711354
  • Lollo G, Gonzalez-Paredes A, Garcia-Fuentes M, Calvo P, Torres D, Alonso MJ. Polyarginine nanocapsules as a potential oral peptide delivery carrier. J Pharm Sci. 2017;106(2):611–618. doi:10.1016/j.xphs.2016.09.02927855960
  • Kim J, Ramasamy T, Choi JY, et al. PEGylated polypeptide lipid nanocapsules to enhance the anticancer efficacy of erlotinib in non-small cell lung cancer. Colloids Surf B Biointerfaces. 2017;150:393–401. doi:10.1016/j.colsurfb.2016.11.00227825759
  • Yin X, Han L, Mu S, et al. Preparation and evaluation of etoposide-loaded lipid-based nanosuspensions for high-dose treatment of lymphoma. Nanomedicine. 2019;14(11):1403–1427. doi:10.2217/nnm-2018-050231180263
  • Drewes CC, Fiel LA, Bexiga CG, et al. Novel therapeutic mechanisms determine the effectiveness of lipid-core nanocapsules on melanoma models. Int J Nanomedicine. 2016;11:1261–1279. doi:10.2147/IJN.S10154327099491
  • Gaudin A, Song E, King AR, et al. PEGylated squalenoyl-gemcitabine nanoparticles for the treatment of glioblastoma. Biomaterials. 2016;105:136–144. doi:10.1016/j.biomaterials.2016.07.03727521616
  • Ingallina C, Costa PM, Ghirga F, et al. Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy. Nanomedicine. 2017;12(7):711–728. doi:10.2217/nnm-2016-038828322108
  • Pereira NRC, Loiola RA, Rodrigues SF, et al. Mechanisms of the effectiveness of poly(ε-caprolactone) lipid-core nanocapsules loaded with methotrexate on glioblastoma multiforme treatment. Int J Nanomedicine. 2018;13:4563–4573. doi:10.2147/IJN.S16840030154652
  • Yin J, Xiang C, Song X. Nanoencapsulation of psoralidin via chitosan and Eudragit S100 for enhancement of oral bioavailability. Int J Pharm. 2016;510(1):203–209. doi:10.1016/j.ijpharm.2016.05.00727154253
  • Carletto B, Berton J, Ferreira TN, et al. Resveratrol-loaded nanocapsules inhibit murine melanoma tumor growth. Colloids Surf B Biointerfaces. 2016;144:65–72. doi:10.1016/j.colsurfb.2016.04.00127070053
  • Ravikumara NR, Bharadwaj M, Madhusudhan B. Tamoxifen citrate-loaded poly(d,l) lactic acid nanoparticles: evaluation for their anticancer activity in vitro and in vivo. J Biomater Appl. 2016;31(5):755–772. doi:10.1177/088532821667056127664187
  • Ran J, Wang C, Zhang J, et al. New insight into Polydopamine@ZIF-8 Nanohybrids: a zinc-releasing container for potential anticancer activity. Polymers. 2018;10(5):476. doi:10.3390/polym10050476
  • Khan I, Joshi G, Nakhate KT, Kumar R, Gupta U. Nano-co-delivery of berberine and anticancer drug using PLGA nanoparticles: exploration of better anticancer activity and in vivo kinetics. Pharm Res. 2019;36(10):149. doi:10.1007/s11095-019-2677-531420752
  • Ganassin R, Horst FH, Camargo NS, et al. Selol nanocapsules with a poly(methyl vinyl ether-co-maleic anhydride) shell conjugated to doxorubicin for combinatorial chemotherapy against murine breast adenocarcinoma in vivo. Artif Cells Nanomed Biotechnol. 2018;46(sup2):1046–1052. doi:10.1080/21691401.2018.147842329842818
  • Xu Y, Hu B, Xu J, Wu J, Ye B. Preparation of biodegradable polymeric nanocapsules for treatment of malignant tumor using coaxial capillary microfluidic device. Cancer Biother Radiopharm. 2020. doi:10.1089/cbr.2019.3412
  • Gao J, Fan K, Jin Y, et al. PEGylated lipid bilayer coated mesoporous silica nanoparticles co-delivery of paclitaxel and curcumin leads to increased tumor site drug accumulation and reduced tumor burden. Eur J Pharm Sci. 2019;140:105070. doi:10.1016/j.ejps.2019.10507031518679
  • Boissenot T, Fattal E, Bordat A, et al. Paclitaxel-loaded PEGylated nanocapsules of perfluorooctyl bromide as theranostic agents. Eur J Pharm Biopharm. 2016;108:136–144. doi:10.1016/j.ejpb.2016.08.01727594209
  • Boissenot T, Bordat A, Larrat B, et al. Ultrasound-induced mild hyperthermia improves the anticancer efficacy of both Taxol® and paclitaxel-loaded nanocapsules. J Control Release. 2017;264:219–227. doi:10.1016/j.jconrel.2017.08.04128867377
  • Abouhussein DMN, Bahaa El Din Mahmoud D, Mohammad FE. Design of a liquid nano-sized drug delivery system with enhanced solubility of rivaroxaban for venous thromboembolism management in paediatric patients and emergency cases. J Liposome Res. 2019;29(4):399–412. doi:10.1080/08982104.2019.157673230720378
  • Rani R, Dahiya S, Dhingra D, et al. Antidiabetic activity enhancement in streptozotocin + nicotinamide-induced diabetic rats through combinational polymeric nanoformulation. Int J Nanomedicine. 2019;14:4383–4395. doi:10.2147/IJN.S20531931354267
  • Geroge JK, Verma PRP, Venkatesan J, et al. Studies on core-shell nanocapsules of felodipine: in vitro-in vivo evaluations. AAPS PharmSciTech. 2017;18(8):2871–2888. doi:10.1208/s12249-017-0770-928424979
  • Liu Y, Liu Q, Liu Y, Ju F, Ma Q, He Q. In vivo evaluation of enhanced drug carrier efficiency and cardiac anti-hypertrophy therapeutic potential of nano-curcumin encapsulated photo-plasmonic nanoparticles combined polymerized nano-vesicles: A novel strategy. J Photochem Photobiol B. 2019;199:111619. doi:10.1016/j.jphotobiol.2019.11161931622787
  • Gomes MLS, da Silva Nascimento N, Borsato DM, et al. Long-lasting anti-platelet activity of cilostazol from poly(ε-caprolactone)-poly(ethylene glycol) blend nanocapsules. Mater Sci Eng C. 2019;94:694–702. doi:10.1016/j.msec.2018.10.029
  • Qelliny MR, Aly UF, Elgarhy OH, Khaled KA. Budesonide-loaded Eudragit S 100 nanocapsules for the treatment of acetic acid-induced colitis in animal model. AAPS PharmSciTech. 2019;20(6):237. doi:10.1208/s12249-019-1453-531243601
  • Sadeghi Ghadi Z, Ebrahimnejad P. Curcumin entrapped hyaluronan containing niosomes: preparation, characterisation and in vitro/in vivo evaluation. J Microencapsul. 2019;36(2):169–179. doi:10.1080/02652048.2019.161736031104531
  • Marto J, Ruivo E, Lucas SD, et al. Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance. Eur J Pharm Biopharm. 2018;127:1–11. doi:10.1016/j.ejpb.2018.01.01129409864
  • Barros Silva Soares de Souza EP, Trindade GDGG, Lins Dantas Gomes MV, et al. Anti-inflammatory effect of nano-encapsulated nerolidol on zymosan-induced arthritis in mice. Food Chem Toxicol. 2020;135:110958. doi:10.1016/j.fct.2019.11095831715307
  • de Oliveira MTP, de Sa Coutinho D, de Souza ÉT, et al. Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways. Int J Nanomedicine. 2019;14:5215–5228. doi:10.2147/IJN.S20066631371957
  • Nishihira VSK, Fontana BD, Ianiski FR, et al. PEGylated meloxicam-loaded nanocapsules reverse in vitro damage on caspase activity and do not induce toxicity in cultured human lymphocytes and mice. Biomed Pharmacother. 2018;107:1259–1267. doi:10.1016/j.biopha.2018.08.12030257340
  • Marcondes Sari MH, Zborowski VA, Ferreira LM, et al. Enhanced pharmacological actions of p,p’-methoxyl-diphenyl diselenide-loaded polymeric nanocapsules in a mouse model of neuropathic pain: behavioral and molecular insights. J Trace Elem Med Biol. 2018;46:17–25. doi:10.1016/j.jtemb.2017.11.00229413106
  • Vieira SM, Michels LR, Roversi K, et al. A surface modification of clozapine-loaded nanocapsules improves their efficacy: a study of formulation development and biological assessment. Colloids Surf B Biointerfaces. 2016;145:748–756. doi:10.1016/j.colsurfb.2016.05.06527295491
  • Carradori D, Saulnier P, Préat V, Des Rieux A, Eyer J. NFL-lipid nanocapsules for brain neural stem cell targeting in vitro and in vivo. J Control Release. 2016;238:253–262. doi:10.1016/j.jconrel.2016.08.00627503706
  • Ghosh S, Sarkar S, Choudhury ST, Ghosh T, Das N. Triphenyl phosphonium coated nano-quercetin for oral delivery: neuroprotective effects in attenuating age related global moderate cerebral ischemia reperfusion injury in rats. Nanomedicine. 2017;13(8):2439–2450. doi:10.1016/j.nano.2017.08.00228822845
  • Clementino A, Batger M, Garrastazu G, et al. The nasal delivery of nanoencapsulated statins – an approach for brain delivery. Int J Nanomedicine. 2016;11:6575–6590. doi:10.2147/IJN.S11903327994459
  • Jaguezeski AM, Souza CF, Perin G, et al. Effect of free and nano-encapsulated curcumin on treatment and energetic metabolism of gerbils infected by Listeria monocytogenes. Microb Pathog. 2019;134:103564. doi:10.1016/j.micpath.2019.10356431163248
  • Vidal-Romero G, Zambrano-Zaragoza ML, Martínez-Acevedo L, Leyva-Gómez G, Mendoza-Elvira SE, Quintanar-Guerrero D. Design and evaluation of pH-dependent nanosystems based on cellulose acetate phthalate, nanoparticles loaded with chlorhexidine for periodontal treatment. Pharmaceutics. 2019;11(11):604. doi:10.3390/pharmaceutics11110604
  • Lucena PA, Nascimento TL, Gaeti MPN, et al. In vivo vaginal fungal load reduction after treatment with itraconazole-loaded polycaprolactone-nanoparticles. J Biomed Nanotechnol. 2018;14(7):1347–1358. doi:10.1166/jbn.2018.257429944108
  • Branquinho RT, De Mello CGC, Oliveira MT, et al. Lychnopholide in poly(D,L-lactide)-block-polyethylene glycol nanocapsules cures infection with a drug-resistant Trypanosoma cruzi strain at acute and chronic phases. Antimicrob Agents Chemother. 2020;64(4). doi:10.1128/AAC.01937-19
  • Branquinho RT, Pound-Lana G, Marques Milagre M, et al. Increased body exposure to new anti-trypanosomal through nanoencapsulation. Sci Rep. 2017;7(1). doi:10.1038/s41598-017-08469-x
  • Branquinho RT, Roy J, Farah C, et al. Biodegradable polymeric nanocapsules prevent cardiotoxicity of anti-trypanosomal lychnopholide. Sci Rep. 2017;7. doi:10.1038/srep44998
  • De Mello CGC, Branquinho RT, Oliveira MT, et al. Efficacy of lychnopholide polymeric nanocapsules after oral and intravenous administration in murine experimental Chagas disease. Antimicrob Agents Chemother. 2016;60(9):5215–5222. doi:10.1128/AAC.00178-1627324760
  • Sousa-Batista AJ, Poletto FS, Philipon CIMS, Guterres SS, Pohlmann AR, Rossi-Bergmann B. Lipid-core nanocapsules increase the oral efficacy of quercetin in cutaneous leishmaniasis. Parasitology. 2017;144(13):1769–1774. doi:10.1017/S003118201700097X28653597
  • Michels LR, Maciel TR, Nakama KA, et al. Effects of surface characteristics of polymeric nanocapsules on the pharmacokinetics and efficacy of antimalarial quinine. Int J Nanomedicine. 2019;14:10165–10178. doi:10.2147/IJN.S22791432021159
  • Ismail M, Du Y, Ling L, Li X. Artesunate-heparin conjugate based nanocapsules with improved pharmacokinetics to combat malaria. Int J Pharm. 2019;562:162–171. doi:10.1016/j.ijpharm.2019.03.03130902709
  • Velasques K, Maciel TR, de Castro Dal Forno AH, et al. Co-nanoencapsulation of antimalarial drugs increases their in vitro efficacy against Plasmodium falciparum and decreases their toxicity to Caenorhabditis elegans. Eur J Pharm Sci. 2018;118:1–12. doi:10.1016/j.ejps.2018.03.01429550283
  • Gomes GS, Maciel TR, Piegas EM, et al. Optimization of curcuma oil/quinine-loaded nanocapsules for malaria treatment. AAPS PharmSciTech. 2018;19(2):551–564. doi:10.1208/s12249-017-0854-628875471
  • Souza ACM, Mosqueira VCF, Silveira APA, et al. Reduced cardiotoxicity and increased oral efficacy of artemether polymeric nanocapsules in Plasmodium berghei-infected mice. Parasitology. 2018;145(8):1075–1083. doi:10.1017/S003118201700220729223181