p66shc siRNA Nanoparticles Ameliorate Chondrocytic Mitochondrial Dysfunction in Osteoarthritis

References

• Ziskoven C, Jager M, Zilkens C, Bloch W, Brixius K, Krauspe R. Oxidative stress in secondary osteoarthritis: from cartilage destruction to clinical presentation? Orthop Rev (Pavia). 2010;2(2):e23. doi:10.4081/or.2010.e2321808712
   PubMedGoogle Scholar
• Lee CM, Kisiday JD, McIlwraith CW, Grodzinsky AJ, Frisbie DD. Synoviocytes protect cartilage from the effects of injury in vitro. BMC Musculoskelet Disord. 2013;14:54. doi:10.1186/1471-2474-14-5423374282
   PubMed Web of Science ®Google Scholar
• Sandell LJ, Aigner T. Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res. 2001;3(2):107–113. doi:10.1186/ar14811178118
   PubMedGoogle Scholar
• Khan IM, Palmer EA, Archer CW. Fibroblast growth factor-2 induced chondrocyte cluster formation in experimentally wounded articular cartilage is blocked by soluble Jagged-1. Osteoarthritis Cartilage. 2010;18(2):208–219. doi:10.1016/j.joca.2009.08.01119748609
   PubMed Web of Science ®Google Scholar
• Hoshiyama Y, Otsuki S, Oda S, et al. Chondrocyte clusters adjacent to sites of cartilage degeneration have characteristics of progenitor cells. J Orthop Res. 2015;33(4):548–555. doi:10.1002/jor.v33.425691232
   PubMed Web of Science ®Google Scholar
• Del Carlo M Jr., Loeser RF. Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species. Arthritis Rheum. 2002;46(2):394–403.11840442
   PubMedGoogle Scholar
• Horton WE Jr., Feng L, Adams C. Chondrocyte apoptosis in development, aging and disease. Matrix Biol. 1998;17(2):107–115. doi:10.1016/S0945-053X(98)90024-59694591
   PubMed Web of Science ®Google Scholar
• Soto-Hermida A, Fernandez-Moreno M, Pertega-Diaz S, et al. Mitochondrial DNA haplogroups modulate the radiographic progression of Spanish patients with osteoarthritis. Rheumatol Int. 2015;35(2):337–344. doi:10.1007/s00296-014-3104-125086630
   PubMed Web of Science ®Google Scholar
• Liu JT, Guo X, Ma WJ, et al. Mitochondrial function is altered in articular chondrocytes of an endemic osteoarthritis, Kashin-Beck disease. Osteoarthritis Cartilage. 2010;18(9):1218–1226. doi:10.1016/j.joca.2010.07.00320650322
   PubMed Web of Science ®Google Scholar
• Fernandez-Moreno M, Soto-Hermida A, Pertega S, et al. Mitochondrial DNA (mtDNA) haplogroups and serum levels of anti-oxidant enzymes in patients with osteoarthritis. BMC Musculoskelet Disord. 2011;12:264. doi:10.1186/1471-2474-12-26422108257
   PubMed Web of Science ®Google Scholar
• Lee SW, Song YS, Shin SH, et al. Cilostazol protects rat chondrocytes against nitric oxide-induced apoptosis in vitro and prevents cartilage destruction in a rat model of osteoarthritis. Arthritis Rheum. 2008;58(3):790–800.18311796
   PubMedGoogle Scholar
• Lebiedzinska M, Karkucinska-Wieckowska A, Giorgi C, et al. Oxidative stress-dependent p66Shc phosphorylation in skin fibroblasts of children with mitochondrial disorders. Biochim Biophys Acta. 2010;1797(6):952–960. doi:10.1016/j.bbabio.2010.03.00520226758
   PubMed Web of Science ®Google Scholar
• Galimov ER. The role of p66shc in oxidative stress and apoptosis. Acta Naturae. 2010;2(4):44–51. doi:10.32607/20758251-2010-2-4-44-5122649663
   PubMed Web of Science ®Google Scholar
• Bhat SS, Anand D, Khanday FA. p66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosis. Mol Cancer. 2015;14.25623255
   PubMed Web of Science ®Google Scholar
• Khanday FA, Yamamori T, Mattagajasingh I, et al. Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress. Mol Biol Cell. 2006;17(1):122–129. doi:10.1091/mbc.e05-06-057016251354
   PubMed Web of Science ®Google Scholar
• Menini S, Iacobini C, Ricci C, et al. Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation. Diabetologia. 2007;50(9):1997–2007. doi:10.1007/s00125-007-0728-717611735
   PubMed Web of Science ®Google Scholar
• Nagar H, Jung SB, Kwon SK, et al. CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation. PLoS One. 2014;9(6):e98670. doi:10.1371/journal.pone.009867024906005
   PubMed Web of Science ®Google Scholar
• Yang M, Stowe DF, Udoh KB, Heisner JS, Camara AK. Reversible blockade of complex I or inhibition of PKCbeta reduces activation and mitochondria translocation of p66Shc to preserve cardiac function after ischemia. PLoS One. 2014;9(12):e113534. doi:10.1371/journal.pone.011353425436907
   PubMed Web of Science ®Google Scholar
• Ziolkowski W, Flis DJ, Halon M, et al. Prolonged swimming promotes cellular oxidative stress and p66Shc phosphorylation, but does not induce oxidative stress in mitochondria in the rat heart. Free Radic Res. 2015;49(1):7–16. doi:10.3109/10715762.2014.96814725287525
   PubMed Web of Science ®Google Scholar
• Blanco FJ, Lopez-Armada MJ, Maneiro E. Mitochondrial dysfunction in osteoarthritis. Mitochondrion. 2004;4(5–6):715–728. doi:10.1016/j.mito.2004.07.02216120427
   PubMed Web of Science ®Google Scholar
• Malik A, Gupta M, Mani R, Bhatnagar R. Single-dose Ag85B-ESAT6-loaded poly(lactic-co-glycolic acid) nanoparticles confer protective immunity against tuberculosis. Int J Nanomedicine. 2019;14:3129–3143. doi:10.2147/IJN.S17239131118627
   PubMed Web of Science ®Google Scholar
• Te Boekhorst BC, Jensen LB, Colombo S, et al. MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model. J Control Release. 2012;161(3):772–780. doi:10.1016/j.jconrel.2012.05.004.22580113
   PubMed Web of Science ®Google Scholar
• Maji R, Dey NS, Satapathy BS, Mukherjee B, Mondal S. Preparation and characterization of Tamoxifen citrate loaded nanoparticles for breast cancer therapy. Int J Nanomedicine. 2014;9:3107–3118. doi:10.2147/IJN.S6353525028549
   PubMed Web of Science ®Google Scholar
• Ben David-Naim M, Grad E, Aizik G, et al. Polymeric nanoparticles of siRNA prepared by a double-emulsion solvent-diffusion technique: physicochemical properties, toxicity, biodistribution and efficacy in a mammary carcinoma mice model. Biomaterials. 2017;145:154–167. doi:10.1016/j.biomaterials.2017.08.03628863309
   PubMed Web of Science ®Google Scholar
• Ramot Y, Rotkopf S, Gabai RM, et al. Preclinical safety evaluation in rats of a polymeric matrix containing an siRNA drug used as a local and prolonged delivery system for pancreatic cancer therapy. Toxicol Pathol. 2016;44(6):856–865. doi:10.1177/019262331664586027147553
   PubMed Web of Science ®Google Scholar
• Kapoor DN, Bhatia A, Kaur R, Sharma R, Kaur G, Dhawan S. PLGA: a unique polymer for drug delivery. Ther Deliv. 2015;6(1):41–58. doi:10.4155/tde.14.9125565440
   PubMed Web of Science ®Google Scholar
• Sadat Tabatabaei Mirakabad F, Nejati-Koshki K, Akbarzadeh A, et al. PLGA-based nanoparticles as cancer drug delivery systems. Asian Pac J Cancer Prev. 2014;15(2):517–535. doi:10.7314/APJCP.2014.15.2.517.24568455
   PubMedGoogle Scholar
• Johnson RH, Hu H, Haworth ST, Cho PS, Dawson CA, Linehan JH. Feldkamp and circle-and-line cone-beam reconstruction for 3D micro-CT of vascular networks. Phys Med Biol. 1998;43(4):929–940. doi:10.1088/0031-9155/43/4/0209572516
   PubMed Web of Science ®Google Scholar
• Bakker B, Eijkel GB, Heeren RM, Karperien M, Post JN, Cillero-Pastor B. Oxygen regulates lipid profiles in human primary chondrocyte cultures. Osteoarthr Cartil. 2016;24:S456–S457. doi:10.1016/j.joca.2016.01.833
   Web of Science ®Google Scholar
• Roh DH, Kim HW, Yoon SY, et al. Intrathecal injection of the sigma(1) receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain. Anesthesiology. 2008;109(5):879–889. doi:10.1097/ALN.0b013e3181895a8318946301
   PubMed Web of Science ®Google Scholar
• Zhang E, Yi MH, Shin N, et al. Endoplasmic reticulum stress impairment in the spinal dorsal horn of a neuropathic pain model. Sci Rep. 2015;5:11555. doi:10.1038/srep1155526109318
   PubMed Web of Science ®Google Scholar
• Shin J, Yin Y, Park H, et al. p38 siRNA-encapsulated PLGA nanoparticles alleviate neuropathic pain behavior in rats by inhibiting microglia activation. Nanomedicine (Lond). 2018;13(13):1607–1621. doi:10.2217/nnm-2018-005430028250
   PubMed Web of Science ®Google Scholar
• Peltonen L, Aitta J, Hyvonen S, Karjalainen M, Hirvonen J. Improved entrapment efficiency of hydrophilic drug substance during nanoprecipitation of poly(l)lactide nanoparticles. AAPS PharmSciTech. 2004;5:1.
   PubMed Web of Science ®Google Scholar
• Karim A, Amin AK, Hall AC. The clustering and morphology of chondrocytes in normal and mildly degenerate human femoral head cartilage studied by confocal laser scanning microscopy. J Anat. 2018;232(4):686–698. doi:10.1111/joa.2018.232.issue-429283191
   PubMed Web of Science ®Google Scholar
• Jiang LP, Li LJ, Geng CY, et al. Monosodium iodoacetate induces apoptosis via the mitochondrial pathway involving ROS production and caspase activation in rat chondrocytes in vitro. J Orthop Res. 2013;31(3):364–369. doi:10.1002/jor.v31.323124986
   PubMed Web of Science ®Google Scholar
• Pitcher T, Sousa-Valente J, Malcangio M. The monoiodoacetate model of osteoarthritis pain in the mouse. J Vis Exp. 2016;111.
   Google Scholar
• Maneiro E, Lopez-Armada MJ, de Andres MC, et al. Effect of nitric oxide on mitochondrial respiratory activity of human articular chondrocytes. Ann Rheum Dis. 2005;64(3):388–395. doi:10.1136/ard.2004.02215215708893
   PubMed Web of Science ®Google Scholar
• Chernyak BV, Izyumov DS, Lyamzaev KG, et al. Production of reactive oxygen species in mitochondria of HeLa cells under oxidative stress. Biochim Biophys Acta. 2006;1757(5):525–534. doi:10.1016/j.bbabio.2006.02.01916678116
   PubMed Web of Science ®Google Scholar
• Menon JU, Kuriakose A, Iyer R, et al. Dual-drug containing core-shell nanoparticles for lung cancer therapy. Sci Rep. 2017;7(1):13249. doi:10.1038/s41598-017-13320-429038584
   PubMed Web of Science ®Google Scholar
• Moilanen LJ, Hamalainen M, Nummenmaa E, et al. Mia-induced inflammation and joint pain are reduced in Trpa1 deficient mice - potential role for Trpa1 in osteoarthritis. Osteoarthr Cartil. 2015;23:A259–A259. doi:10.1016/j.joca.2015.02.472
   Web of Science ®Google Scholar
• Lunghi B, De Cunto G, Cavarra E, et al. Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema. PLoS One. 2015;10(3):e0119797. doi:10.1371/journal.pone.011979725790295
   PubMed Web of Science ®Google Scholar
• Giorgio M, Migliaccio E, Orsini F, et al. Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell. 2005;122(2):221–233. doi:10.1016/j.cell.2005.05.01116051147
   PubMed Web of Science ®Google Scholar
• Oshikawa J, Kim SJ, Furuta E, et al. Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells. Am J Physiol Heart Circ Physiol. 2012;302(3):H724–732. doi:10.1152/ajpheart.00739.201122101521
   PubMed Web of Science ®Google Scholar
• Onnis A, Cianfanelli V, Cassioli C, et al. The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II. Autophagy. 2018;14(12):2117–2138. doi:10.1080/15548627.2018.150515330109811
   PubMed Web of Science ®Google Scholar
• De Marchi E, Baldassari F, Bononi A, Wieckowski MR, Pinton P. Oxidative stress in cardiovascular diseases and obesity: role of p66Shc and protein kinase C. Oxid Med Cell Longev. 2013;2013:564961. doi:10.1155/2013/56496123606925
   PubMed Web of Science ®Google Scholar
• Ma W, Li J, Hu J, et al. miR214-regulated p53-NOX4/p66shc pathway plays a crucial role in the protective effect of Ginkgolide B against cisplatin-induced cytotoxicity in HEI-OC1 cells. Chem Biol Interact. 2016;245:72–81.26768586
   PubMed Web of Science ®Google Scholar
• Tomilov AA, Bicocca V, Schoenfeld RA, et al. Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem. 2010;285(2):1153–1165. doi:10.1074/jbc.M109.01749119892704
   PubMed Web of Science ®Google Scholar
• Rafiei P, Haddadi A. Docetaxel-loaded PLGA and PLGA-PEG nanoparticles for intravenous application: pharmacokinetics and biodistribution profile. Int J Nanomedicine. 2017;12:935–947. doi:10.2147/IJN.S12188128184163
   PubMed Web of Science ®Google Scholar