A Three-Dimensional Printed Polycaprolactone Scaffold Combined with Co-Axially Electrospun Vancomycin/Ceftazidime/Bone Morphological Protein-2 Sheath-Core Nanofibers for the Repair of Segmental Bone Defects During the Masquelet Procedure

References

• Oh CW, Apivatthakakul T, Oh JK, et al. Bone transport with an external fixator and a locking plate for segmental tibial defects. Bone Joint J. 2013;95-B(12):1667–1672. doi:10.1302/0301-620X.95B12.3150724293598
   PubMed Web of Science ®Google Scholar
• Rigal S, Merloz P, Nen DL, Mathevon H, Masquelet AC. French Society of Orthopaedic Surgery and Traumatology. Bone transport techniques in posttraumatic bone defects. Orthop Traumatol Surg Res. 2012;98(1):103–108. doi:10.1016/j.otsr.2011.11.00222257763
   PubMedGoogle Scholar
• Demiralp B, Ege T, Kose O, Yurttas Y, Basbozkurt M. Reconstruction of intercalary bone defects following bone tumor resection with segmental bone transport using an Ilizarov circular external fixator. J Orthop Sci. 2014;19(6):1004–1011. doi:10.1007/s00776-014-0632-125146001
   PubMed Web of Science ®Google Scholar
• Bumbasirevic M, Stevanovic M, Bumbasirevic V, Lesic A, Atkinson HDE. Free vascularised fibular grafts in orthopaedics. Int Orthop. 2014;38(6):1277–1282. doi:10.1007/s00264-014-2281-624562850
   PubMed Web of Science ®Google Scholar
• Molina CS, Stinner DJ, Obremskey WT. Treatment of traumatic segmental long-bone defects. A critical analysis review. J Bone Joint Surg Rev. 2014;2(4).
   Google Scholar
• Morelli I, Drago L, George DA, Galazzi E, Scarponi S, Romano CL. Masquelet technique: myth or reality? A systematic review and meta-analysis. Injury. 2016;47 Supple 6:S68–S76. doi:10.1016/S0020-1383(16)30842-728040090
   PubMed Web of Science ®Google Scholar
• El-Alfy BS, Ali AM. Management of segmental skeletal defects by the induced membrane technique. Indian J Orthop. 2015;49(6):643–648. doi:10.4103/0019-5413.16875726806972
   PubMed Web of Science ®Google Scholar
• Gupta G, Ahmad S, Mohd Z, Khan AH, Sherwani MK, Khan AQ. Management of traumatic tibial diaphyseal bone defect by “induced-membrane technique”. Indian J Orthop. 2016;50(3):290–296. doi:10.4103/0019-5413.18178027293290
   PubMed Web of Science ®Google Scholar
• Uhthoff HK, Poitras P, Backman DS. Internal plate fixation of fractures: short history and recent developments. J Orthop Sci. 2006;11(2):118–126. doi:10.1007/s00776-005-0984-716568382
   PubMed Web of Science ®Google Scholar
• Tseng YY, Liao JY, Chen WA, Kao YC, Liu SJ. Biodegradable poly([D,L]-lactide-co-glycolide) nanofibers for the sustainable delivery of lidocaine into the epidural space after laminectomy. Nanomedicine (Lond). 2014;9(1):77–87. doi:10.2217/nnm.13.4223799985
   PubMed Web of Science ®Google Scholar
• Hsu YH, Chen DW, Tai CD, et al. Biodegradable drug-eluting nanofiber-enveloped implants for sustained release of high bactericidal concentrations of vancomycin and ceftazidime: in vitro and in vivo studies. Int J Nanomed. 2014;9:4347–4355. doi:10.2147/IJN.S66526
   PubMed Web of Science ®Google Scholar
• Casagrande S, Tiribuzi R, Cassetti E, et al. Biodegradable composite porous poly(dl-lactide-co-glycolide) scaffold supports mesenchymal stem cell differentiation and calcium phosphate deposition. Artif Cells Nanomed Biotechnol. 2018;46(sup1):219–229. doi:10.1080/21691401.2017.141786629265950
   PubMed Web of Science ®Google Scholar
• Dwivedi C, Pandey H, Pandey AC, et al. In vivo biocompatibility of electrospun biodegradable dual carrier (antibiotic + growth factor) in a mouse model-implications for rapid wound healing. Pharmaceutics. 2019;11(4):E180. doi:10.3390/pharmaceutics1104018031013995
   PubMed Web of Science ®Google Scholar
• Kim J, Lima E, Silva R, et al. Anisotropic poly(lactic-co-glycolic acid) microparticles enable sustained release of a peptide for long-term inhibition of ocular neovascularization. Acta Biomater. 2019;97:451–460. doi:10.1016/j.actbio.2019.07.05431374338
   PubMed Web of Science ®Google Scholar
• Arabpour Z, Baradaran-Rafii A, Bakhshaiesh NL, et al. Design and characterization of biodegradable multi layered electrospun nanofibers for corneal tissue engineering applications. J Biomed Mater Res A. 2019;107(10):2340–2349. doi:10.1002/jbm.a.3674231161710
   PubMed Web of Science ®Google Scholar
• Pan S, Qi Z, Li Q, et al. Graphene oxide-PLGA hybrid nanofibres for the local delivery of IGF-1 and BDNF in spinal cord repair. Artif Cells Nanomed Biotechnol. 2019;47(1):651–664. doi:10.1080/21691401.2019.157584330829545
   PubMed Web of Science ®Google Scholar
• Zolfaghari D, Tebyanian H, Soufdoost RS, et al. Modified PLGA nanofibers as a nerve regenerator with Schwann cells. Cell Mol Biol (Noisy-Le-Grand). 2018;64(14):66–71. doi:10.14715/cmb/2018.64.14.11
   PubMed Web of Science ®Google Scholar
• Kumbar SG, Nukavarapu SP, James R, Nair LS, Laurencin CT. Electrospun poly(lactic acid-co-glycolic acid) scaffolds for skin tissue engineering. Biomaterials. 2008;29(30):4100–4107. doi:10.1016/j.biomaterials.2008.06.02818639927
   PubMed Web of Science ®Google Scholar
• Hsu YH, Lin CT, Yu YH, Chou YC, Liu SJ, Chan EC. Dual delivery of active anti-bactericidal agents and bone morphogenetic protein at sustainable high concentrations using biodegradable sheath-core-structured drug-eluting nanofibers. Int J Nanomed. 2016;11:3927–3937. doi:10.2147/IJN.S107250
   PubMed Web of Science ®Google Scholar
• Chou YC, Lee D, Chang TM, et al. Development of a three-dimensional (3D) printed biodegradable cage to convert morselized corticocancellous bone chips into a structured cortical bone graft. Int J Mol Sci. 2016;17(4):E595. doi:10.3390/ijms1704059527104525
   PubMed Web of Science ®Google Scholar
• Yu YH, Wu RC, Lee D, et al. Artificial membrane induced by novel biodegradable nanofibers in the Masquelet procedure for treatment of segmental bone defects. J Nanomater. 2018;2018:8246571. doi:10.1155/2018/8246571
   Web of Science ®Google Scholar
• Yan Q, Dong H, Su J, et al. A review of 3D printing technology for medical applications. Engineering. 2018;4:729–742. doi:10.1016/j.eng.2018.07.021
   Web of Science ®Google Scholar
• Khaf A, Madihally SV. Recent advances in multiaxial electrospinning for drug delivery. Euro J Pharm Biopharm. 2017;112:1–17. doi:10.1016/j.ejpb.2016.11.010
   PubMed Web of Science ®Google Scholar
• McClellan P, Landis WJ. Recent applications of coaxial and emulsion electrospinning methods in the field of tissue engineering. Biores Open Access. 2016;5(1):212–227. doi:10.1089/biores.2016.002227610268
   PubMed Web of Science ®Google Scholar
• Masquelet AC, Fitoussi F, Begue T, Muller GP. Reconstruction of the long bones by the induced membrane and spongy autograft. Ann Chir Plast Esthet. 2000;45(3):346–353.10929461
   PubMedGoogle Scholar
• Apard T, Bigorre N, Cronier P, Duteille F, Bizot P, Massin PP. Two-stage reconstruction of post-traumatic segmental tibia bone loss with nailing. Orthop Traumatol Surg Res. 2010;96(5):):549–553. doi:10.1016/j.otsr.2010.02.01020605548
   PubMed Web of Science ®Google Scholar
• Donegan DJ, Scolaro J, Matuszewski P, Mehta SES. Staged bone grafting following placement of an antibiotic spacer block for the management of segmental long bone defects. Orthopedics. 2011;34(11):e730–e735. doi:10.3928/01477447-20110922-1622049954
   PubMed Web of Science ®Google Scholar
• Stafford PR, Norris BL. Reamer-irrigator-aspirator bone graft and bi Masquelet technique for segmental bone defect nonunions: a review of 25 cases. Injury. 2010;41(Supple 2):S72–S77. doi:10.1016/S0020-1383(10)70014-021144933
   PubMedGoogle Scholar
• Giannoudis PV, Harwood PJ, Tosounidis T, Kanakaris NK. Restoration of long bone defects treated with the induced membrane technique: protocol and outcomes. Injury. 2016;47(Supple 6):S53–S61. doi:10.1016/S0020-1383(16)30840-328040088
   PubMedGoogle Scholar
• Ma CH, Chiu YC, Tsai KL, Tu YK, Yen CY, Wu CH. Masquelet technique with external locking plate for recalcitrant distal tibial nonunion. Injury. 2017;48(12):2847–2852. doi:10.1016/j.injury.2017.10.03729122282
   PubMed Web of Science ®Google Scholar
• Cho JW, Kim J, Cho WT, et al. Circumferential bone grafting around an absorbable gelatin sponge core reduced the amount of grafted bone in the induced membrane technique for critical-size defects of long bones. Injury. 2017;48(10):2292–2305.28802745
   PubMed Web of Science ®Google Scholar
• Sasaki G, Watanabe Y, Miyamoto W, et al. Induced membrane technique using beta-tricalcium phosphate for reconstruction of femoral and tibial segmental bone loss due to infection: technical tips and preliminary clinical results. Int Orthop. 2018;42(1):17–24. doi:10.1007/s00264-017-3503-528536801
   PubMed Web of Science ®Google Scholar
• Masquelet AC. Induced membrane technique: pearls and pitfalls. J Orthop Trauma. 2017;31(Supple5):S36–S38. doi:10.1097/BOT.0000000000000979
   PubMedGoogle Scholar
• Giotikas D, Tarazi N, Spalding L, Nabergoj M, Krkovic M. Results of the induced membrane technique in the management of traumatic bone loss in the lower limb: a cohort study. J Orthop Trauma. 2019;33(3):131–136. doi:10.1097/BOT.000000000000138430562247
   PubMed Web of Science ®Google Scholar
• Stella M, Santolini E, Autuori A, Felli L, Santolini F. Masquelet technique to treat a septic nonunion after nailing of a femoral open fracture. Injury. 2018;49(Supple4):S29–S33. doi:10.1016/j.injury.2018.11.017
   PubMedGoogle Scholar
• Morris R, Hossain M, Evans A, Pallister I. Induced membrane technique for treating tibial defects gives mixed results. Bone Joint J. 2017;99-B(5):680–685. doi:10.1302/0301-620X.99B5.BJJ-2016-0694.R228455479
   PubMed Web of Science ®Google Scholar
• Chan YS, Ueng SW, Wang CJ, Lee SS, Chao EK, Shin CH. Management of small infected tibial defects with antibiotic-impregnated autogenic cancellous bone grafting. J Trauma. 1998;45(4):758–764. doi:10.1097/00005373-199810000-000239783617
   PubMedGoogle Scholar
• Shiels SM, Raut VP, Patterson PB, Barnes BR, Wenke JC. Antibiotic-loaded bone graft for reduction of surgical site infection in spinal fusion. Spine J. 2017;17(12):1917–1925. doi:10.1016/j.spinee.2017.06.03928684346
   PubMed Web of Science ®Google Scholar
• Kanakeshwar RB, Jayaramaraju D, Agraharam D, Rajasekaran S. Management of resistant distal femur non-unions with allograft strut and autografts combined with osteosynthesis in a series of 22 patients. Injury. 2017;48(Suppl2):S14–S17. doi:10.1016/S0020-1383(17)30488-628802414
   PubMedGoogle Scholar
• Nau C, Seebach C, Trumm A, et al. Alteration of Masquelet’s induced membrane characteristics by different kinds of antibiotic enriched bone cement in a critical size defect model in the rat’s femur. Injury. 2016;47(2):325–334. doi:10.1016/j.injury.2015.10.07926652225
   PubMed Web of Science ®Google Scholar
• Shah SR, Smith BT, Tatara AM, et al. Effects of local antibiotic delivery from porous space maintainers on infection clearance and induction of an osteogenic membrane in an infected bone defect. Tissue Eng Part A. 2017;23(3–4):91–100. doi:10.1089/ten.tea.2016.038927998243
   PubMed Web of Science ®Google Scholar
• Luangphakdy V, Elizabeth Pluhar G, Piuzzi NS, et al. The effect of surgical technique and spacer texture on bone regeneration: a caprine study using the Masquelet technique. Clin Orthop Relat Res. 2017;475(10):2575–2585. doi:10.1007/s11999-017-5420-828634897
   PubMed Web of Science ®Google Scholar
• Dimitriou R, Mataliotakis GI, Angoules AG, Kanakaris NK, Giannoudis PV. Complications following autologous bone graft harvesting from the iliac crest and using the RIA: a systematic review. Injury. 2011;42(Suppl2):S3–S15. doi:10.1016/j.injury.2011.06.015
   PubMedGoogle Scholar