^99mTc Radiolabeled HA/TPGS-Based Curcumin-Loaded Nanoparticle for Breast Cancer Synergistic Theranostics: Design, in vitro and in vivo Evaluation

References

• Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.2149230207593
   PubMed Web of Science ®Google Scholar
• Salehi B, Stojanovic-Radic Z, Matejic J, et al. The therapeutic potential of curcumin: a review of clinical trials. Eur J Med Chem. 2019;163:527–545. doi:10.1016/j.ejmech.2018.12.01630553144
   PubMed Web of Science ®Google Scholar
• Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA. The Essential medicinal chemistry of curcumin. J Med Chem. 2017;60(5):1620–1637. doi:10.1021/acs.jmedchem.6b0097528074653
   PubMed Web of Science ®Google Scholar
• Batra H, Pawar S, Bahl D. Curcumin in combination with anti-cancer drugs: a nanomedicine review. Pharmacol Res. 2019;139:91–105. doi:10.1016/j.phrs.2018.11.00530408575
   PubMed Web of Science ®Google Scholar
• Barati N, Momtazi-Borojeni AA, Majeed M, Sahebkar A. Potential therapeutic effects of curcumin in gastric cancer. J Cell Physiol. 2019;234(3):2317–2328. doi:10.1002/jcp.2722930191991
   PubMed Web of Science ®Google Scholar
• Hesari A, Azizian M, Sheikhi A, et al. Chemopreventive and therapeutic potential of curcumin in esophageal cancer: current and future status. Int J Cancer. 2019;144(6):1215–1226. doi:10.1002/ijc.3194730362511
   PubMed Web of Science ®Google Scholar
• Anand P, Kunnumakkara A, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4(6):807–818. doi:10.1021/mp700113r17999464
   PubMed Web of Science ®Google Scholar
• Feng T, Wei Y, Lee RJ, Zhao L. Liposomal curcumin and its application in cancer. Int J Nanomedicine. 2017;12:6027–6044. doi:10.2147/IJN.S13243428860764
   PubMed Web of Science ®Google Scholar
• Liu Y, Huang P, Hou X, et al. Hybrid curcumin-phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer. Int J Nanomedicine. 2019;14:3311–3330. doi:10.2147/IJN.S20084731190795
   PubMed Web of Science ®Google Scholar
• Ramasamy T, Ruttala HB, Gupta B, et al. Smart chemistry-based nanosized drug delivery systems for systemic applications: a comprehensive review. J Control Release. 2017;258:226–253. doi:10.1016/j.jconrel.2017.04.04328472638
   PubMed Web of Science ®Google Scholar
• Pattni BS, Chupin VV, Torchilin VP. New developments in liposomal drug delivery. Chem Rev. 2015;115(19):10938–10966. doi:10.1021/acs.chemrev.5b0004626010257
   PubMed Web of Science ®Google Scholar
• Silva CO, Pinho JO, Lopes JM, Almeida AJ, Gaspar MM, Reis C. Current trends in cancer nanotheranostics: metallic, polymeric, and lipid-based systems. Pharmaceutics. 2019;11(1):22. doi:10.3390/pharmaceutics11010022
   PubMed Web of Science ®Google Scholar
• Liu Y, Bhattarai P, Dai Z, Chen X. Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer. Chem Soc Rev. 2019;48(7):2053–2108.30259015
   PubMed Web of Science ®Google Scholar
• Vankayala R, Hwang KC. Near-infrared-light-activatable nanomaterial-mediated phototheranostic nanomedicines: an emerging paradigm for cancer treatment. Adv Mater. 2018;30(23):e1706320. doi:10.1002/adma.20170632029577458
   PubMed Web of Science ®Google Scholar
• Zhou Y, Peng Z, Seven ES, Leblanc RM. Crossing the blood-brain barrier with nanoparticles. J Control Release. 2018;270:290–303. doi:10.1016/j.jconrel.2017.12.01529269142
   PubMed Web of Science ®Google Scholar
• Gai S, Yang G, Yang P, et al. Recent advances in functional nanomaterials for light–triggered cancer therapy. Nano Today. 2018;19:146–187. doi:10.1016/j.nantod.2018.02.010
   Web of Science ®Google Scholar
• Kamel AE, Fadel M, Louis D. Curcumin-loaded nanostructured lipid carriers prepared using peceol and olive oil in photodynamic therapy: development and application in breast cancer cell line. Int J Nanomedicine. 2019;14:5073–5085. doi:10.2147/IJN.S21048431371948
   PubMed Web of Science ®Google Scholar
• Zhao S, Ma L, Cao C, Yu Q, Chen L, Liu J. Curcumin-loaded redox response of self-assembled micelles for enhanced antitumor and anti-inflammation efficacy. Int J Nanomedicine. 2017;12:2489–2504. doi:10.2147/IJN.S12319028408820
   PubMed Web of Science ®Google Scholar
• Mura S, Nicolas J, Couvreur P. Stimuli-responsive nanocarriers for drug delivery. Nat Mater. 2013;12(11):991–1003. doi:10.1038/nmat377624150417
   PubMed Web of Science ®Google Scholar
• Ekladious I, Colson YL, Grinstaff MW. Polymer-drug conjugate therapeutics: advances, insights and prospects. Nat Rev Drug Discov. 2019;18(4):273–294.30542076
   PubMed Web of Science ®Google Scholar
• Gao S, Tang G, Hua D, et al. Stimuli-responsive bio-based polymeric systems and their applications. J Mater Chem B. 2019;7(5):709–729. doi:10.1039/C8TB02491J32254845
   PubMed Web of Science ®Google Scholar
• Hu YW, Du YZ, Liu N, et al. Selective redox-responsive drug release in tumor cells mediated by chitosan-based glycolipid-like nanocarrier. J Control Release. 2015;206:91–100. doi:10.1016/j.jconrel.2015.03.01825796347
   PubMed Web of Science ®Google Scholar
• Huang G, Huang H. Hyaluronic acid-based biopharmaceutical delivery and tumor-targeted drug delivery system. J Control Release. 2018;278:122–126. doi:10.1016/j.jconrel.2018.04.01529649528
   PubMed Web of Science ®Google Scholar
• Chen C, Zhao S, Karnad A, Freeman JW. The biology and role of CD44 in cancer progression: therapeutic implications. J Hematol Oncol. 2018;11(1):64. doi:10.1186/s13045-018-0605-529747682
   PubMed Web of Science ®Google Scholar
• Misra S, Heldin P, Hascall VC, et al. Hyaluronan-CD44 interactions as potential targets for cancer therapy. FEBS J. 2011;278(9):1429–1443. doi:10.1111/j.1742-4658.2011.08071.x21362138
   PubMed Web of Science ®Google Scholar
• Dosio F, Arpicco S, Stella B, Fattal E. Hyaluronic acid for anticancer drug and nucleic acid delivery. Adv Drug Deliv Rev. 2016;97:204–236. doi:10.1016/j.addr.2015.11.01126592477
   PubMed Web of Science ®Google Scholar
• Xi Y, Jiang T, Yu Y, et al. Dual targeting curcumin loaded alendronate-hyaluronan- octadecanoic acid micelles for improving osteosarcoma therapy. Int J Nanomedicine. 2019;14:6425–6437. doi:10.2147/IJN.S21198131496695
   PubMed Web of Science ®Google Scholar
• Su Z, Liu D, Chen L, et al. CD44-targeted magnetic nanoparticles kill head and neck squamous cell carcinoma stem cells in an alternating magnetic field. Int J Nanomedicine. 2019;14:7549–7560. doi:10.2147/IJN.S21508731571863
   PubMed Web of Science ®Google Scholar
• Hang C, Zou Y, Zhong Y, Zhong Z, Meng F. NIR and UV-responsive degradable hyaluronic acid nanogels for CD44-targeted and remotely triggered intracellular doxorubicin delivery. Colloids Surf B Biointerfaces. 2017;158:547–555. doi:10.1016/j.colsurfb.2017.07.04128743090
   PubMed Web of Science ®Google Scholar
• Yang Z, Sun N, Cheng R, Zhao C, Liu J, Tian Z. Hybrid nanoparticles coated with hyaluronic acid lipoid for targeted co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells. J Mater Chem B. 2017;5(33):6762–6775. doi:10.1039/C7TB01510K32264326
   PubMed Web of Science ®Google Scholar
• Jeannot V, Gauche C, Mazzaferro S, et al. Anti-tumor efficacy of hyaluronan-based nanoparticles for the co-delivery of drugs in lung cancer. J Control Release. 2018;275:117–128. doi:10.1016/j.jconrel.2018.02.02429474960
   PubMed Web of Science ®Google Scholar
• Gu Z, Wang X, Cheng R, Cheng L, Zhong Z. Hyaluronic acid shell and disulfide-crosslinked core micelles for in vivo targeted delivery of bortezomib for the treatment of multiple myeloma. Acta Biomater. 2018;80:288–295. doi:10.1016/j.actbio.2018.09.02230240956
   PubMed Web of Science ®Google Scholar
• Zhang Z, Tan S, Feng SS. Vitamin E TPGS as a molecular biomaterial for drug delivery. Biomaterials. 2012;33(19):4889–4906. doi:10.1016/j.biomaterials.2012.03.04622498300
   PubMed Web of Science ®Google Scholar
• Yang C, Wu T, Qi Y, Zhang Z. Recent advances in the application of vitamin E TPGS for drug delivery. Theranostics. 2018;8(2):464–485. doi:10.7150/thno.2271129290821
   PubMed Web of Science ®Google Scholar
• Gorain B, Choudhury H, Pandey M, Kesharwani P. Paclitaxel loaded vitamin E-TPGS nanoparticles for cancer therapy. Mater Sci Eng C Mater Biol Appl. 2018;91:868–880. doi:10.1016/j.msec.2018.05.05430033322
   PubMed Web of Science ®Google Scholar
• Kutty R, Tay C, Lim C, Feng S, Leong D. Anti-migratory and increased cytotoxic effects of novel dual drug-loaded complex hybrid micelles in triple negative breast cancer cells. Nano Res. 2015;8:2533–2547. doi:10.1007/s12274-015-0760-8
   Web of Science ®Google Scholar
• Kutty R, Chia S, Setyawati M, Muthu M, Feng S, Leong D. In vivo and ex vivo proofs of concept that cetuximab conjugated vitamin E TPGS micelles increases efficacy of delivered docetaxel against triple negative breast cancer. Biomaterials. 2015;63:58–69. doi:10.1016/j.biomaterials.2015.06.00526081868
   PubMed Web of Science ®Google Scholar
• Tan G, Feng S, Leong D. The reduction of anti-cancer drug antagonism by the spatial protection of drugs with PLA-TPGS nanoparticles. Biomaterials. 2014;35:3044–3051. doi:10.1016/j.biomaterials.2013.12.03324439415
   PubMed Web of Science ®Google Scholar
• Boros E, Packard AB. Radioactive transition metals for imaging and therapy. Chem Rev. 2019;119(2):870–901. doi:10.1021/acs.chemrev.8b0028130299088
   PubMed Web of Science ®Google Scholar
• Banerjee S, Pillai MR, Ramamoorthy N. Evolution of Tc-99m in diagnostic radiopharmaceuticals. Semin Nucl Med. 2001;4:260–277. doi:10.1053/snuc.2001.26205
   Google Scholar
• Laznicek M, Laznickova A, Cozikva D, Velebny V. Preclinical pharmacokinetics of radiolabelled hyaluronan. Pharmacol Rep. 2012;64:428–437. doi:10.1016/S1734-1140(12)70784-322661195
   PubMed Web of Science ®Google Scholar
• Polyak A, Hajdu I, Bodnar M, et al. (99m) Tc-labelled nanosystem as tumour imaging agent for SPECT and SPECT/CT modalities. Int J Pharm. 2013;449(1–2):10–17. doi:10.1016/j.ijpharm.2013.03.04923562750
   PubMedGoogle Scholar
• Song S, Qi H, Xu J, et al. Hyaluronan-based nanocarriers with CD44-overexpressed cancer cell targeting. Pharm Res. 2014;31(11):2988–3005. doi:10.1007/s11095-014-1393-424842660
   PubMed Web of Science ®Google Scholar
• Qhattal HSS, Hye T, Alali A, Liu X. Hyaluronan polymer length, grafting density, and surface poly (ethylene glycol) coating influence in vivo circulation and tumor targeting of hyaluronan grafted liposomes. ACS Nano. 2014;8:5423–5440. doi:10.1021/nn405839n24806526
   PubMed Web of Science ®Google Scholar
• Hafez IM, Cullis PR. Cholesteryl hemisuccinate exhibits pH sensitive polymorphic phase behavior. Biochim Biophys Acta. 2000;1463:107–114. doi:10.1016/S0005-2736(99)00186-810631299
   PubMed Web of Science ®Google Scholar
• Carafa M, Di Marzio L, Marianecci C, et al. Designing novel pH-sensitive non-phospholipid vesicle: characterization and cell interaction. Eur J Pharm Sci. 2006;28:385–393.16797946
   PubMed Web of Science ®Google Scholar
• Tesan FC, Portillo MG, Moretton MA, et al. Radiolabeling and biological Characterization of TPGS-based nanomicelles by means of small animal imaging. Nucl Med Biol. 2017;44:62–68. doi:10.1016/j.nucmedbio.2016.09.00627821346
   PubMed Web of Science ®Google Scholar
• Melendez-Alafort L, Nadali A, Zangoni E, et al. Biokinetic and dosimetric studies of 188Re-hyaluronic acid: a new radiopharmaceutical for treatment of hepatocellular carcinoma. Nucl Med Biol. 2009;36(6):693–701. doi:10.1016/j.nucmedbio.2009.04.00619647176
   PubMed Web of Science ®Google Scholar
• Lepareur N, Lacoeuille F, Bouvry C, et al. Rhenium-188 labeled radiopharmaceuticals: current clinical applications in oncology and promising perspectives. Front Med (Lausanne). 2019;6:132. doi:10.3389/fmed.2019.0013231259173
   PubMed Web of Science ®Google Scholar
• Hasanzadeh L, Kazemi Oskuee R, Sadri K, et al. Green synthesis of labeled CeO2 nanoparticles with 99mTc and its biodistribution evaluation in mice. Life Sci. 2018;212:233–240. doi:10.1016/j.lfs.2018.10.01030304691
   PubMed Web of Science ®Google Scholar
• Mirkovic M, Radovic M, Stankovic D, et al. (99m) Tc-bisphosphonate-coated magnetic nanoparticles as potential theranostic nanoagent. Mater Sci Eng C Mater Biol Appl. 2019;102:124–133. doi:10.1016/j.msec.2019.04.03431146983
   PubMed Web of Science ®Google Scholar
• Wang J, Zhang L, Peng F, Shi X, Leong D. Targeting endothelial cell junctions with negatively charged gold nanoparticles. Chem Mater. 2018;30:3759–3767.
   Web of Science ®Google Scholar
• Peng F, Tee J, Seyawati M, et al. Inorganic nanomaterials as highly efficient inhibitors of cellular hepatic fibrosis. ACS Appl Mater Interfaces. 2018;10(38):31938–31946. doi:10.1021/acsami.8b1052730156820
   PubMed Web of Science ®Google Scholar
• Tay C, Setyawati M, Leong D. Nanoparticle density: a critical biophysical regulator of endothelial permeability. ACS Nano. 2017;11(3):2764–2772. doi:10.1021/acsnano.6b0780628287706
   PubMed Web of Science ®Google Scholar
• Setyawati M, Tay C, Bay B, Leong D. Gold nanoparticles induced endothelial leakiness depends on particle size and endothelial cell origin. ACS Nano. 2017;11(5):5020–5030. doi:10.1021/acsnano.7b0174428422481
   PubMed Web of Science ®Google Scholar
• Setyawati M, Tay C, Chia S, et al. Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the hemophilic interaction of VE–cadherin. Nat Commun. 2013;4:1673. doi:10.1038/ncomms265523575677
   PubMed Web of Science ®Google Scholar
• Peng F, Setyawati M, Tee J, et al. Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness. Nat Nanotechnol. 2019;14(3):279–286. doi:10.1038/s41565-018-0356-z30692675
   PubMed Web of Science ®Google Scholar
• Setyawati M, Mochalin V, Leong D. Tuning endothelial permeability with functionalized nanodiamonds. ACS Nano. 2016;10(1):1170–1181. doi:10.1021/acsnano.5b0648726643115
   PubMed Web of Science ®Google Scholar
• Tee J, Setyawati MI, Peng F, et al. Angiopoietin-1 accelerates restoration of endothelial cell barrier integrity from nanoparticle-induced leakiness. Nanotoxicology. 2019;13(5):682–700. doi:10.1080/17435390.2019.157164630776942
   PubMed Web of Science ®Google Scholar
• Jin H, Pi J, Zhao Y, et al. EGFR-targeting PLGA-PEG nanoparticles as a curcumin delivery system for breast cancer therapy. Nanoscale. 2017;9(42):16365–16374. doi:10.1039/C7NR06898K29052674
   PubMed Web of Science ®Google Scholar
• Wang G, de Kruijff RM, Abou D, et al. Pharmacokinetics of polymersomes composed of poly (butadiene-ethylene oxide); healthy versus tumor-bearing mice. J Biomed Nanotechnol. 2016;12(2):320–328. doi:10.1166/jbn.2016.217827305765
   PubMed Web of Science ®Google Scholar
• Cao J, Wei Y, Zhang Y, Wang G, Ji X, Zhong Z. Iodine-rich polymersomes enable versatile SPECT/CT imaging and potent radioisotope therapy for tumor in vivo. ACS Appl Mater Interfaces. 2019;11(21):18953–18959. doi:10.1021/acsami.9b0429431062589
   PubMed Web of Science ®Google Scholar
• Zhang H, Liu G, Zeng X, et al. Fabrication of genistein-loaded biodegradable TPGS-b-PCL nanoparticles for improved therapeutic effects in cervical cancer cells. Int J Nanomedicine. 2015;10:2461–2473. doi:10.2147/IJN.S7898825848264
   PubMed Web of Science ®Google Scholar
• Cheng X, Zeng X, Li D, et al. TPGS-grafted and acid-responsive soy protein nanogels for efficient intracellular drug release, accumulation, penetration in 3D tumor spheroids of drug-resistant cancer cells. Mater Sci Eng C Mater Biol Appl. 2019;102:863–875. doi:10.1016/j.msec.2019.05.01731147058
   PubMed Web of Science ®Google Scholar
• Collnot EM, Baldes C, Schaefer UF, Edgar KJ, Wempe MF, Lehr CM. Vitamin E TPGS P-Glycoprotein inhibition mechanism: influence on conformational flexibility, intracellular ATP levels, and role of time and site of access. Mol Pharm. 2010;7(3):642–651. doi:10.1021/mp900191s20205474
   PubMed Web of Science ®Google Scholar