Folate and Pegylated Aliphatic Polyester Nanoparticles for Targeted Anticancer Drug Delivery

References

• Ghoncheh M, Pournamdar Z, Salehiniya H. Incidence and mortality and epidemiology of breast cancer in the world. Asian Pac J Cancer Prev. 2016;17(S3):43–46. doi:10.7314/APJCP.2016.17.S3.43
   PubMedGoogle Scholar
• Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69–90. doi:10.3322/caac.2010721296855
   PubMed Web of Science ®Google Scholar
• Kitagawa R, Katsumata N, Shibata T, et al. Paclitaxel plus carboplatin versus paclitaxel plus cisplatin in metastatic or recurrent cervical cancer: the open-label randomized phase III trial JCOG0505. J Clin Oncol. 2015;33(19):2129–2135. doi:10.1200/JCO.2014.58.439125732161
   PubMed Web of Science ®Google Scholar
• Singla AK, Garg A, Aggarwal D. Paclitaxel and its formulations. Int J Pharm. 2002;235(1–2):179–192. doi:10.1016/S0378-5173(01)00986-311879753
   PubMed Web of Science ®Google Scholar
• Spencer CM, Paclitaxel FD. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer. Drugs. 1994;48(5):794–847. doi:10.2165/00003495-199448050-000097530632
   PubMed Web of Science ®Google Scholar
• Sofias AM, Dunne M, Storm G, Allen C. The battle of “nano” paclitaxel. Adv Drug Deliv Rev. 2017;122:20–30. doi:10.1016/j.addr.2017.02.00328257998
   PubMed Web of Science ®Google Scholar
• Siafaka P, Betsiou M, Tsolou A, et al. Synthesis of folate-pegylated polyester nanoparticles encapsulating ixabepilone for targeting folate receptor overexpressing breast cancer cells. J Mater Sci Mater Med. 2015;26(12):275. doi:10.1007/s10856-015-5609-x26543021
   PubMed Web of Science ®Google Scholar
• Torchilin V. Multifunctional and stimuli-sensitive pharmaceutical nanocarriers. Eur J Pharm Biopharm. 2009;71(3):431–444. doi:10.1016/j.ejpb.2008.09.02618977297
   PubMed Web of Science ®Google Scholar
• Siafaka PI, Ustundag Okur N, Karavas E, Bikiaris DN. Surface modified multifunctional and stimuli responsive nanoparticles for drug targeting: current status and uses. Int J Mol Sci. 2016;17(9):1440. doi:10.3390/ijms17091440
   PubMed Web of Science ®Google Scholar
• Yang T, Choi MK, Cui FD, et al. Preparation and evaluation of paclitaxel-loaded PEGylated immunoliposome. J Control Release. 2007;120(3):169–177. doi:10.1016/j.jconrel.2007.05.01117586082
   PubMed Web of Science ®Google Scholar
• Liggins RT, Burt HM. Paclitaxel-loaded poly(L-lactic acid) microspheres 3: blending low and high molecular weight polymers to control morphology and drug release. Int J Pharm. 2004;282(1–2):61–71. doi:10.1016/j.ijpharm.2004.05.02615336382
   PubMedGoogle Scholar
• Zhang Z, Feng SS. The drug encapsulation efficiency, in vitro drug release, cellular uptake and cytotoxicity of paclitaxel-loaded poly(lactide)-tocopheryl polyethylene glycol succinate nanoparticles. Biomaterials. 2006;27(21):4025–4033. doi:10.1016/j.biomaterials.2006.03.00616564085
   PubMed Web of Science ®Google Scholar
• Huh KM, Min HS, Lee SC, Lee HJ, Kim S, Park K. A new hydrotropic block copolymer micelle system for aqueous solubilization of paclitaxel. J Control Release. 2008;126(2):122–129. doi:10.1016/j.jconrel.2007.11.00818155795
   PubMed Web of Science ®Google Scholar
• Parveen S, Misra R, Sahoo SK. Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging. Nanomedicine. 2012;8(2):147–166. doi:10.1016/j.nano.2011.05.01621703993
   PubMed Web of Science ®Google Scholar
• Karimi M, Ghasemi A, Sahandi Zangabad P, et al. Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems. Chem Soc Rev. 2016;45(5):1457–1501.26776487
   PubMed Web of Science ®Google Scholar
• Bikiaris D, Karavelidis V, Karavas E. Effectiveness of various drug carriers in controlled release formulations of raloxifene HCl prepared by melt mixing. Curr Drug Deliv. 2009;6(5):425–436. doi:10.2174/15672010978994163219751201
   PubMedGoogle Scholar
• Bikiaris D, Karavelidis V, Karavas E. Novel biodegradable polyesters. Synthesis and application as drug carriers for the preparation of raloxifene HCl loaded nanoparticles. Molecules. 2009;14(7):2410–2430. doi:10.3390/molecules1407241019633613
   PubMed Web of Science ®Google Scholar
• Bikiaris D, Papageorgiou G, Achilias D. Synthesis and comparative biodegradability studies of three poly(alkylene succinate)s. Polym Degrad Stabil. 2006;91(1):31–43.
   Web of Science ®Google Scholar
• Papageorgiou G, Bikiaris D. Crystallization and melting behavior of three biodegradable poly(alkylene succinates). A comparative study. Polym. 2005;46(26):12081–92.
   Web of Science ®Google Scholar
• Chan P, Kurisawa M, Chung JE, Yang YY. Synthesis and characterization of chitosan-g-poly(ethylene glycol)-folate as a non-viral carrier for tumor-targeted gene delivery. Biomaterials. 2007;28(3):540–549. doi:10.1016/j.biomaterials.2006.08.04616999995
   PubMed Web of Science ®Google Scholar
• Couvreur P, Vauthier C. Nanotechnology: intelligent design to treat complex disease. Pharm Res. 2006;23(7):1417–1450. doi:10.1007/s11095-006-0284-816779701
   PubMed Web of Science ®Google Scholar
• Duncan R. Polymer conjugates as anticancer nanomedicines. Nat Rev Cancer. 2006;6(9):688–701. doi:10.1038/nrc195816900224
   PubMed Web of Science ®Google Scholar
• Chan P, Kurisawa M, Eun Chung J, Yang Y-Y. Synthesis and characterization of chitosan-g-poly(ethylene glycol)-folate as a non-viral carrier for tumor-targeted gene delivery. Biomaterials. 2007;28(3):540–9.16999995
   PubMed Web of Science ®Google Scholar
• Kyriakopoulou S, Matthaiolampakis G, Papadimitriou S, Karavas E, Bikiaris D, Avgoustaκis K. Ppsu-PEG copolymers and their application in the preparation of cisplatin-loaded nanoparticles. Curr Nanosci. 2011;7(4):503–9.
   Web of Science ®Google Scholar
• Tong R, Cheng J. Anticancer polymeric nanomedicines. Polym Rev. 2007;47(3):345–381. doi:10.1080/15583720701455079
   Web of Science ®Google Scholar
• Vassiliou AA, Papadimitriou SA, Bikiaris DN, Mattheolabakis G, Avgoustakis K. Facile synthesis of polyester-PEG triblock copolymers and preparation of amphiphilic nanoparticles as drug carriers. J Control Release. 2010;148(3):388–395. doi:10.1016/j.jconrel.2010.09.01720869413
   PubMed Web of Science ®Google Scholar
• van Vlerken LE, Amiji MM. Multi-functional polymeric nanoparticles for tumour-targeted drug delivery. Expert Opin Drug Deliv. 2006;3(2):205–216. doi:10.1517/17425247.3.2.20516506948
   PubMedGoogle Scholar
• Choi CH, Alabi CA, Webster P, Davis ME. Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles. Proc Natl Acad Sci U S A. 2010;107(3):1235–1240. doi:10.1073/pnas.091414010720080552
   PubMed Web of Science ®Google Scholar
• Hu X, Yan L, Xiao H, Li X, Jing X. Application of microwave-assisted click chemistry in the preparation of functionalized copolymers for drug conjugation. J Appl Polym Sci. 2013;127(5):3365–3373. doi:10.1002/app.37662
   Web of Science ®Google Scholar
• Karavelidis V, Bikiaris D, Avgoustakis K. New thermosensitive nanoparticles prepared by biocompatible pegylated aliphatic polyester block copolymers for local cancer treatment. J Pharm Pharmacol. 2015;67(2):215–230. doi:10.1111/jphp.1233725616209
   PubMed Web of Science ®Google Scholar
• Gryparis EC, Mattheolabakis G, Bikiaris D, Avgoustakis K. Effect of conditions of preparation on the size and encapsulation properties of PLGA-mPEG nanoparticles of cisplatin. Drug Deliv. 2007;14(6):371–380. doi:10.1080/1071754070120293717701526
   PubMed Web of Science ®Google Scholar
• Tsolou A, Nelson G, Trachana V, et al. The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult. IUBMB Life. 2012;64(5):432–442. doi:10.1002/iub.101822473755
   PubMed Web of Science ®Google Scholar
• Anderson KE, Stevenson BR, Rogers JA. Folic acid-PEO-labeled liposomes to improve gastrointestinal absorption of encapsulated agents. J Control Release. 1999;60(2–3):189–198. doi:10.1016/S0168-3659(99)00072-310425325
   PubMed Web of Science ®Google Scholar
• Karavelidis V, Karavas E, Giliopoulos D, Papadimitriou S, Bikiaris D. Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior. Int J Nanomedicine. 2011;6:3021–3032. doi:10.2147/IJN.S2601622162659
   PubMed Web of Science ®Google Scholar
• Filippousi M, Papadimitriou SA, Bikiaris DN, et al. Novel core-shell magnetic nanoparticles for Taxol encapsulation in biodegradable and biocompatible block copolymers: preparation, characterization and release properties. Int J Pharm. 2013;448(1):221–230. doi:10.1016/j.ijpharm.2013.03.02523524084
   PubMedGoogle Scholar
• Brazel CS, Huang X. The cost of optimal drug delivery: reducing and preventing the burst effect in matrix systems In: Carrier-Based Drug Delivery. Vol. 879 American Chemical Society; 2004:267–282.
   Google Scholar
• Ke N, Wang X, xu X, Abassi Y. The xCELLigence System for Real-Time and Label-Free Monitoring of Cell Viability. Vol. 7402011.
   Google Scholar
• Abassi YA, Xi B, Zhang W, et al. Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects. Chem Biol. 2009;16(7):712–723. doi:10.1016/j.chembiol.2009.05.01119635408
   PubMed Web of Science ®Google Scholar
• Lacroix M, Leclercq G. Relevance of breast cancer cell lines as models for breast tumours: an update. Breast Cancer Res Treat. 2004;83(3):249–289.14758095
   PubMed Web of Science ®Google Scholar
• Holliday DL, Speirs V. Choosing the right cell line for breast cancer research. Breast Cancer Res. 2011;13(4):215. doi:10.1186/bcr288921884641
   PubMed Web of Science ®Google Scholar
• Wang S, Luo Y, Zeng S, et al. Dodecanol-poly(D,L-lactic acid)-b-poly (ethylene glycol)-folate (Dol-PLA-PEG-FA) nanoparticles: evaluation of cell cytotoxicity and selecting capability in vitro. Colloids Surf B Biointerfaces. 2013;102:130–135. doi:10.1016/j.colsurfb.2012.07.03023000678
   PubMed Web of Science ®Google Scholar
• Swietach P, Vaughan-Jones RD, Harris AL, Hulikova A. The chemistry, physiology and pathology of pH in cancer. Philos Trans R Soc Lond B Biol Sci. 2014;369(1638):20130099. doi:10.1098/rstb.2013.009924493747
   PubMed Web of Science ®Google Scholar
• Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer. 2004;4(11):891–899. doi:10.1038/nrc147815516961
   PubMed Web of Science ®Google Scholar
• Holm J, Hansen SI, Hoier-Madsen M. Ionic charge, hydrophobicity and tryptophan fluorescence of the folate binding protein isolated from cow’s milk. Biosci Rep. 2001;21(3):305–313. doi:10.1023/A:101323423196011892997
   PubMed Web of Science ®Google Scholar
• Holm J, Lawaetz AJ, Hansen SI. Ligand binding induces a sharp decrease in hydrophobicity of folate binding protein assessed by 1-anilinonaphthalene-8-sulphonate which suppresses self-association of the hydrophobic apo-protein. Biochem Biophys Res Commun. 2012;425(1):19–24. doi:10.1016/j.bbrc.2012.07.03622814109
   PubMed Web of Science ®Google Scholar
• Kaarsholm NC, Kolstrup AM, Danielsen SE, Holm J, Hansen SI. Ligand-induced conformation change in folate-binding protein. Biochem J. 1993;292(Pt 3):921–925. doi:10.1042/bj29209218318019
   PubMedGoogle Scholar
• Kamen BA, Wang MT, Streckfuss AJ, Peryea X, Anderson RG. Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles. J Biol Chem. 1988;263(27):13602–13609.3417674
   PubMed Web of Science ®Google Scholar
• Rothberg KG, Ying YS, Kolhouse JF, Kamen BA, Anderson RG. The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathway. J Cell Biol. 1990;110(3):637–649. doi:10.1083/jcb.110.3.6371968465
   PubMed Web of Science ®Google Scholar
• Lewis CM, Smith AK, Kamen BA. Receptor-mediated folate uptake is positively regulated by disruption of the actin cytoskeleton. Cancer Res. 1998;58(14):2952–2956.9679952
   PubMed Web of Science ®Google Scholar
• Sabharanjak S, Mayor S. Folate receptor endocytosis and trafficking. Adv Drug Deliv Rev. 2004;56(8):1099–1109. doi:10.1016/j.addr.2004.01.01015094209
   PubMed Web of Science ®Google Scholar
• Campbell IG, Jones TA, Foulkes WD, Trowsdale J. Folate-binding protein is a marker for ovarian cancer. Cancer Res. 1991;51(19):5329–5338.1717147
   PubMed Web of Science ®Google Scholar
• Knutson KL, Krco CJ, Erskine CL, et al. T-cell immunity to the folate receptor alpha is prevalent in women with breast or ovarian cancer. J Clin Oncol. 2006;24(26):4254–4261. doi:10.1200/JCO.2006.05.931116908932
   PubMed Web of Science ®Google Scholar
• Kelemen LE. The role of folate receptor alpha in cancer development, progression and treatment: cause, consequence or innocent bystander? Int J Cancer. 2006;119(2):243–250. doi:10.1002/ijc.2171216453285
   PubMed Web of Science ®Google Scholar
• Jhaveri MS, Rait AS, Chung KN, Trepel JB, Chang EH. Antisense oligonucleotides targeted to the human alpha folate receptor inhibit breast cancer cell growth and sensitize the cells to doxorubicin treatment. Mol Cancer Ther. 2004;3(12):1505–1512.15634643
   PubMed Web of Science ®Google Scholar
• Brooks SC, Locke ER, Soule HD. Estrogen receptor in a human cell line (MCF-7) from breast carcinoma. J Biol Chem. 1973;248(17):6251–6253.4353636
   PubMed Web of Science ®Google Scholar
• Masters JR. HeLa cells 50 years on: the good, the bad and the ugly. Nat Rev Cancer. 2002;2(4):315–319. doi:10.1038/nrc77512001993
   PubMed Web of Science ®Google Scholar
• Meier R, Henning TD, Boddington S, et al. Breast cancers: MR imaging of folate-receptor expression with the folate-specific nanoparticle P1133. Radiology. 2010;255(2):527–535. doi:10.1148/radiol.1009005020413763
   PubMed Web of Science ®Google Scholar
• Matherly LH, Gangjee A. Discovery of novel antifolate inhibitors of de novo purine nucleotide biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry In: Jackman ALC, editor. Targeted Drug Strategies for Cancer and Inflammation. Boston, MA: Springer; 2011:119–134.
   Google Scholar
• Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, Kirchhausen T. Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell. 2006;10(6):839–850. doi:10.1016/j.devcel.2006.04.00216740485
   PubMed Web of Science ®Google Scholar
• Fretz M, Jin J, Conibere R, et al. Effects of Na+/H+ exchanger inhibitors on subcellular localisation of endocytic organelles and intracellular dynamics of protein transduction domains HIV-TAT peptide and octaarginine. J Control Release. 2006;116(2):247–254. doi:10.1016/j.jconrel.2006.07.00916971016
   PubMed Web of Science ®Google Scholar
• Langston Suen WL, Chau Y. Size-dependent internalisation of folate-decorated nanoparticles via the pathways of clathrin and caveolae-mediated endocytosis in ARPE-19 cells. J Pharm Pharmacol. 2014;66(4):564–573. doi:10.1111/jphp.1213424635558
   PubMed Web of Science ®Google Scholar