Overcoming Multiple Absorption Barrier for Insulin Oral Delivery Using Multifunctional Nanoparticles Based on Chitosan Derivatives and Hyaluronic Acid

References

• Maher S, Mrsny RJ, Brayden DJ. Intestinal permeation enhancers for oral peptide delivery. Adv Drug Deliv Rev. 2016;106(Pt B):277–319. doi:10.1016/j.addr.2016.06.00527320643
   PubMed Web of Science ®Google Scholar
• Malhaire H, Gimel JC, Roger E, et al. How to design the surface of peptide-loaded nanoparticles for efficient oral bioavailability? Adv Drug Deliv Rev. 2016;106(Pt B):320–336. doi:10.1016/j.addr.2016.03.01127058155
   PubMedGoogle Scholar
• Sosnik A, Augustine R. Challenges in oral drug delivery of antiretrovirals and the innovative strategies to overcome them. Adv Drug Deliv Rev. 2016;103:105–120. doi:10.1016/j.addr.2015.12.02226772138
   PubMed Web of Science ®Google Scholar
• Presas E, McCartney F, Sultan E, et al. Physicochemical, pharmacokinetic and pharmacodynamic analyses of amphiphilic cyclodextrin-based nanoparticles designed to enhance intestinal delivery of insulin. J Controlled Release. 2018;286:402–414. doi:10.1016/j.jconrel.2018.07.045
   PubMed Web of Science ®Google Scholar
• Sheng J, Han L, Qin J, et al. N-trimethyl chitosan chloride-coated PLGA nanoparticles overcoming multiple barriers to oral insulin absorption. ACS Appl Mater Interfaces. 2015;7(28):30–41. doi:10.1021/acsami.5b03555
   Web of Science ®Google Scholar
• Brayden DJ, Alonso MJ. Oral delivery of peptides: opportunities and issues for translation. Adv Drug Deliv Rev. 2016;106(Pt B):193–195. doi:10.1016/j.addr.2016.10.00527865345
   PubMedGoogle Scholar
• Dhuria SV, Hanson LR, Frey WH, et al. Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci. 2010;99.
   Web of Science ®Google Scholar
• Laffleur F, Hintzen F, Shahnaz G, et al. Development and in vitro evaluation of slippery nanoparticles for enhanced diffusion through native mucus. Nanomedicine. 2014;9(3):387–396. doi:10.2217/nnm.13.2623611618
   PubMed Web of Science ®Google Scholar
• Li X, Qi J, Xie Y, et al. Nanoemulsions coated with alginate/chitosan as oral insulin delivery systems: preparation, characterization, and hypoglycemic effect in rats. Int J Nanomed. 2013;8:23–32. doi:10.2147/IJN.S38507
   PubMed Web of Science ®Google Scholar
• Niu Z, Conejos-Sánchez I, Griffin B, et al. Lipid-based nanocarriers for oral peptide delivery. Adv Drug Deliv Rev. 2016;106(Pt B):337–354. doi:10.1016/j.addr.2016.04.00127080735
   PubMedGoogle Scholar
• Yu M, Yang Y;, Zhu C, et al. Advances in the transepithelial transport of nanoparticles. Drug Discov Today. 2016;21(7):1155–1161. doi:10.1016/j.drudis.2016.05.00727196527
   PubMed Web of Science ®Google Scholar
• Ensign LM, Schneider C, Suk JS, et al. Mucus penetrating nanoparticles: biophysical tool and method of drug and gene delivery. Adv Mater. 2012;24(28):87–94. doi:10.1002/adma.201201800
   Web of Science ®Google Scholar
• Li L, Jiang GH, Yu WJ, et al. Preparation of chitosan-based multifunctional nanocarriers overcoming multiple barriers for oral delivery of insulin. Mater Sci Eng C. 2017;70:278–286. doi:10.1016/j.msec.2016.08.083
   PubMed Web of Science ®Google Scholar
• Banerjee A, Ibsen K;, Brown T, et al. Ionic liquids for oral insulin delivery. Proc Nat Acad Sci. 2018;115(28):7296–7301. doi:10.1073/pnas.172233811529941553
   PubMed Web of Science ®Google Scholar
• Fan WW, Xia DN, Zhu QL, et al. Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery. Biomaterials. 2018;151:13–23. doi:10.1016/j.biomaterials.2017.10.02229055774
   PubMed Web of Science ®Google Scholar
• Sultankulov B, Berillo D, Sultankulova K, et al. Progress in the development of chitosan-based biomaterials for tissue engineering and regenerative medicine. Biomolecules. 2019;9(9):470. doi:10.3390/biom9090470
   PubMed Web of Science ®Google Scholar
• Liou JS, Liu BR, Martin AL, et al. Protein transduction in human cells is enhanced by cell-penetrating peptides fused with an endosomolytic HA2 sequence. Peptides. 2012;37(2):273–284. doi:10.1016/j.peptides.2012.07.01922898256
   PubMed Web of Science ®Google Scholar
• Deng J, Zhang Z, Liu C, et al. The studies of N-Octyl-N-Arginine-Chitosan coated liposome as an oral delivery system of Cyclosporine A. J Pharm Pharmacol. 2015;67(10):1363–1370. doi:10.1111/jphp.1244826105005
   PubMed Web of Science ®Google Scholar
• Chen CH, Lin YS, Wu SY, et al. Mutlifunctional nanoparticles prepared from arginine-modified chitosan and thiolated fucoidan for oral delivery of hydrophobic and hydrophilic drugs. Carbohydr Polym. 2018;193:163–172. doi:10.1016/j.carbpol.2018.03.08029773368
   PubMed Web of Science ®Google Scholar
• Ali RM, Zeenat S, Muhammad A, et al. Self-assembled nanoparticles based on amphiphilic chitosan derivative and arginine for oral curcumin delivery. Int J Nanomed. 2016;11:4397–4412. doi:10.2147/IJN.S106116
   PubMed Web of Science ®Google Scholar
• Khalil ES, Saad B, Negim E-SM, et al. Novel water-soluble chitosan derivative prepared by graft polymerization of dicyandiamide: synthesis, characterisation, and its antibacterial property. J Polymer Res. 2015;22(6):116. doi:10.1007/s10965-015-0756-9
   Web of Science ®Google Scholar
• Sarmento B, Ribeiro A, Veiga F, et al. Alginate/chitosan nanoparticles are effective for oral insulin delivery. Pharm Res. 2007;24(12):198–206. doi:10.1007/s11095-007-9367-4
   Web of Science ®Google Scholar
• Garrido AA, Molina-Bolvar JA, Galvez-Ruiz MJ, et al. Mucoadhesive properties of liquid lipid nanocapsules enhanced by hyaluronic acid. J Mol Liq. 2019;302–317.
   Web of Science ®Google Scholar
• Liu M, Zhang J, Zhu X, et al. Efficient mucus permeation and tight junction opening by dissociable “mucus-inert” agent coated trimethyl chitosan nanoparticles for oral insulin delivery. J Controlled Release. 2016;222:67–77. doi:10.1016/j.jconrel.2015.12.008
   PubMed Web of Science ®Google Scholar
• Angela MW, Margaret PG, Nicholas AP. Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery. Acta Pharm Sin B. 2018;8(2):147–164. doi:10.1016/j.apsb.2018.01.01329719776
   PubMed Web of Science ®Google Scholar
• Lai SK, Wang YY, Hanes J. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev. 2009;61(2):158–171. doi:10.1016/j.addr.2008.11.00219133304
   PubMed Web of Science ®Google Scholar
• Khafagy El S, Morishita M. Oral biodrug delivery using cell-penetrating peptide. Adv Drug Deliv Rev. 2012;64(6):531–539. doi:10.1016/j.addr.2011.12.01422245080
   PubMed Web of Science ®Google Scholar
• Rehmani S, Dixon JE. Oral delivery of anti-diabetes therapeutics using cell penetrating and transcytosing peptide strategies. Peptides. 2018;100:24–35. doi:10.1016/j.peptides.2017.12.01429412825
   PubMed Web of Science ®Google Scholar
• Xu B, Jiang G, Yu W, et al. Preparation of poly (lactic-co-glycolic acid) and chitosan composite nanocarriers via electrostatic self assembly for oral delivery of insulin. Mater Sci Eng C Mater Biol Appl. 2017;78:420–428. doi:10.1016/j.msec.2017.04.11328576004
   PubMed Web of Science ®Google Scholar
• Shan S, Yao J, Xu L, et al. Preparation of Icaritin-loaded mPEG-PLA micelles and evaluation on ischemic brain injury. J Biomed Nanotechnol. 2019;15(4):674–685. doi:10.1166/jbn.2019.272130841962
   PubMed Web of Science ®Google Scholar
• Shan W, Zhu X, Liu M, et al. Overcoming the diffusion barrier of mucus and absorption barrier of epithelium by self-assembled nanoparticles for oral delivery of insulin. ACS Nano. 2015;9(3):45–56. doi:10.1021/acsnano.5b00028
   Web of Science ®Google Scholar
• Greenfield NJ. Using circular dichroism spectra to estimate protein secondary structure. Nat Protoc. 2006;1(6):2876–2890. doi:10.1038/nprot.2006.20217406547
   PubMed Web of Science ®Google Scholar
• Liu J, Cao J, Cao J, et al. Mechanistic insight into the interaction of gastrointestinal mucus with oral diblock copolymers synthesized via ATRP method. Int J Nanomed. 2018;13:2839–2856. doi:10.2147/IJN.S160651
   PubMed Web of Science ®Google Scholar
• Ge R, Cao J, Chi J, et al. NIR-guided dendritic nanoplatform for improving antitumor efficacy by combining chemo-phototherapy. Int J Nanomed. 2019;14:4931–4947. doi:10.2147/IJN.S203171
   PubMed Web of Science ®Google Scholar
• Lopes M, Shrestha N, Correia A, et al. Dual chitosan/albumin-coated alginate/dextran sulfate nanoparticles for enhanced oral delivery of insulin. J Controlled Release. 2016;232:29–41. doi:10.1016/j.jconrel.2016.04.012
   PubMed Web of Science ®Google Scholar
• Yao B, He J, Yin X, et al. The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-kappaB dependent mechanism in Caco-2 cells. Toxicol Lett. 2019;316:109–118. doi:10.1016/j.toxlet.2019.08.02431472180
   PubMed Web of Science ®Google Scholar
• Ranaldi G, Consalvo R, Sambuy Y, et al. Permeability characteristics of parental and clonal human intestinal Caco-2 cell lines differentiated in Serum-supplemented and serum-free media. Toxicology in Vitro. 2003;17:761–767. doi:10.1016/S0887-2333(03)00095-X14599474
   PubMed Web of Science ®Google Scholar
• Cheol-Hee C, Joon-Ho K, Sang-H K, et al. Reversal of P-glycoprotein-mediated MDR by 5,7,3ʹ,4ʹ,5ʹ-pentamethoxyflavone and SAR. Biochem Biophys Res Commun. 2004;320(3):672. doi:10.1016/j.bbrc.2004.06.02015240100
   PubMed Web of Science ®Google Scholar
• Artursson P, Palm K, Luthman K, et al. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv Drug Deliv Rev. 2012;64(12):280–289. doi:10.1016/j.addr.2012.09.005
   Google Scholar
• Xu Y, Zheng Y, Wu L, et al. Novel solid lipid nanoparticle with endosomal escape function for oral delivery of insulin. ACS Appl Mater Interfaces. 2018;10(11):9315–9324. doi:10.1021/acsami.8b0050729484890
   PubMed Web of Science ®Google Scholar
• He Z, Santos JL, Tian H, et al. Scalable fabrication of size-controlled chitosan nanoparticles for oral delivery of insulin. Biomaterials. 2017;130:28–41. doi:10.1016/j.biomaterials.2017.03.02828359018
   PubMed Web of Science ®Google Scholar
• Xia D, He H, Wang Y, et al. Ultrafast glucose-responsive, high loading capacity erythrocyte to self-regulate the release of insulin. Acta Biomater. 2018;69:301–312. doi:10.1016/j.actbio.2018.01.02929421303
   PubMed Web of Science ®Google Scholar
• Bai X, Kong M, Xia G, et al. Systematic investigation of fabrication conditions of nanocarrier based on carboxymethyl chitosan for sustained release of insulin. Int J Biol Macromol. 2017;102:468–474. doi:10.1016/j.ijbiomac.2017.03.18128366858
   PubMed Web of Science ®Google Scholar
• Barbari GR, Dorkoosh FA, Amini M, et al. A novel nanoemulsion-based method to produce ultrasmall, water-dispersible nanoparticles from chitosan, surface modified with cell-penetrating peptide for oral delivery of proteins and peptides. Int J Nanomed. 2017;12:3471–3483. doi:10.2147/IJN.S116063
   PubMed Web of Science ®Google Scholar
• Heni W, Vonna L, Haidara H. Experimental characterization of the nanoparticle size effect on the mechanical stability of nanoparticle-based coatings. Nano Lett. 2015;15(1):442–449. doi:10.1021/nl503768r25495006
   PubMed Web of Science ®Google Scholar
• Xia Y, Guo M, Xu T, et al. siRNA-loaded selenium nanoparticle modified with hyaluronic acid for enhanced hepatocellular carcinoma therapy. Int J Nanomed. 2018;13:1539–1552. doi:10.2147/IJN.S157519
   PubMed Web of Science ®Google Scholar
• Maisel K, Ensign L, Reddy M, et al. Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse. J Controlled Release. 2015;197:48–57. doi:10.1016/j.jconrel.2014.10.026
   PubMed Web of Science ®Google Scholar
• Zheng Y, Wu J, Shan W, et al. Correction to multifunctional nanoparticles enable efficient oral delivery of biomacromolecules via improving payload stability and regulating the transcytosis pathway. ACS Appl Mater Interfaces. 2019;11(19):48–52.
   Web of Science ®Google Scholar
• Jin Y, Song Y, Zhu X, et al. Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport. Biomaterials. 2012;33(5):1573–1582. doi:10.1016/j.biomaterials.2011.10.07522093292
   PubMed Web of Science ®Google Scholar
• Sung HW, Sonaje K, Liao ZX, et al. pH-responsive nanoparticles shelled with chitosan for oral delivery of insulin: from mechanism to therapeutic applications. Acc Chem Res. 2012;45(4):619–629. doi:10.1021/ar200234q22236133
   PubMed Web of Science ®Google Scholar
• Sonaje K, Lin KJ, Tseng MT, et al. Effects of chitosan-nanoparticle-mediated tight junction opening on the oral absorption of endotoxins. Biomaterials. 2011;32(33):8712–8721. doi:10.1016/j.biomaterials.2011.07.08621862121
   PubMed Web of Science ®Google Scholar
• Aguirre TA, Teijeiro-Osorio D, Rosa M, et al. Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials. Adv Drug Deliv Rev. 2016;106(Pt B):223–241. doi:10.1016/j.addr.2016.02.00426921819
   PubMed Web of Science ®Google Scholar
• Matteucci E, Giampietro O, Covolan V, et al. Insulin administration: present strategies and future directions for a noninvasive (possibly more physiological) delivery. Drug Des Devel Ther. 2015;9:3109–3118. doi:10.2147/DDDT.S79322
   PubMed Web of Science ®Google Scholar
• Jin X, Asghar S, Zhang M, et al. N-acetylcysteine modified hyaluronic acid-paclitaxel conjugate for efficient oral chemotherapy through mucosal bioadhesion ability. Colloids Surf B Biointerfaces. 2018;172:655–664. doi:10.1016/j.colsurfb.2018.09.02530243219
   PubMed Web of Science ®Google Scholar