Mechanism Investigation of Hyaluronidase-Combined Multistage Nanoparticles for Solid Tumor Penetration and Antitumor Effect

References

• Niu Y, Zhu J, Li Y, et al. Size shrinkable drug delivery nanosystems and priming the tumor microenvironment for deep intratumoral penetration of nanoparticles. J Control Release. 2018;277:35–47. doi:10.1016/j.jconrel.2018.03.01229545106
   PubMed Web of Science ®Google Scholar
• Cao J, Chen Z, Chi J, et al. Recent progress in synergistic chemotherapy and phototherapy by targeted drug delivery systems for cancer treatment. Artif Cells Nanomed Biotechnol. 2018;46(sup1):817–830. doi:10.1080/21691401.2018.1436553
   PubMed Web of Science ®Google Scholar
• Kratz F, Warnecke A. Finding the optimal balance: challenges of improving conventional cancer chemotherapy using suitable combinations with nano-sized drug delivery systems. J Control Release. 2012;164(2):221–235. doi:10.1016/j.jconrel.2012.05.04522705248
   PubMed Web of Science ®Google Scholar
• Chen J, Ding J, Wang Y, et al. Sequentially responsive shell-stacked nanoparticles for deep penetration into solid tumors. Adv Mater. 2017;29(32):1701170. doi:10.1002/adma.201701170
   Web of Science ®Google Scholar
• Cui T, Yan Z, Qin H, et al. A sequential target-responsive nanocarrier with enhanced tumor penetration and neighboring effect in vivo. Small. 2019;15(42):e1903323. doi:10.1002/smll.20190332331468717
   PubMed Web of Science ®Google Scholar
• Han M, Huang-Fu MY, Guo WW, et al. MMP-2-sensitive HA end-conjugated poly(amidoamine) dendrimers via click reaction to enhance drug penetration into solid tumor. ACS Appl Mater Interfaces. 2017;9(49):42459–42470. doi:10.1021/acsami.7b1009829143522
   PubMed Web of Science ®Google Scholar
• Li HJ, Du JZ, Du XJ, et al. Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy. Proc Natl Acad Sci U S A. 2016;113(15):4164–4169. doi:10.1073/pnas.152208011327035960
   PubMed Web of Science ®Google Scholar
• Ruan S, Cao X, Cun X, et al. Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release. Biomaterials. 2015;60:100–110. doi:10.1016/j.biomaterials.2015.05.00625988725
   PubMed Web of Science ®Google Scholar
• Ostergaard L, Tietze A, Nielsen T, et al. The relationship between tumor blood flow, angiogenesis, tumor hypoxia, and aerobic glycolysis. Cancer Res. 2013;73(18):5618–5624. doi:10.1158/0008-5472.CAN-13-096423764543
   PubMed Web of Science ®Google Scholar
• Xiao W, Ruan S, Yu W, et al. Normalizing tumor vessels to increase the enzyme-induced retention and targeting of gold nanoparticle for breast cancer imaging and treatment. Mol Pharm. 2017;14(10):3489–3498. doi:10.1021/acs.molpharmaceut.7b0047528845990
   PubMedGoogle Scholar
• Khawar IA, Kim JH, Kuh HJ. Improving drug delivery to solid tumors: priming the tumor microenvironment. J Control Release. 2015;201:78–89. doi:10.1016/j.jconrel.2014.12.01825526702
   PubMed Web of Science ®Google Scholar
• Zhang YR, Lin R, Li HJ, et al. Strategies to improve tumor penetration of nanomedicines through nanoparticle design. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019;11(1):e1519. doi:10.1002/wnan.151929659166
   PubMed Web of Science ®Google Scholar
• Eikenes L, Tufto I, Schnell EA, et al. Effect of collagenase and hyaluronidase on free and anomalous diffusion in multicellular spheroids and xenografts. Anticancer Res. 2010;30(2):359–368.20332440
   PubMed Web of Science ®Google Scholar
• Whatcott CJ, Han H, Posner RG, et al. Targeting the tumor microenvironment in cancer: why hyaluronidase deserves a second look. Cancer Discov. 2011;1(4):291–296. doi:10.1158/2159-8290.CD-11-013622053288
   PubMed Web of Science ®Google Scholar
• Sironen RK, Tammi M, Tammi R, et al. Hyaluronan in human malignancies. Exp Cell Res. 2011;317(4):383–391. doi:10.1016/j.yexcr.2010.11.01721134368
   PubMed Web of Science ®Google Scholar
• Itano N, Zhuo L, Kimata K. Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and progression. Cancer Sci. 2008;99(9):1720–1725. doi:10.1111/j.1349-7006.2008.00885.x18564137
   PubMed Web of Science ®Google Scholar
• Camenisch TD, Spicer AP, Brehm-Gibson T, et al. Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. J Clin Invest. 2000;106(3):349–360. doi:10.1172/JCI1027210930438
   PubMed Web of Science ®Google Scholar
• Chanmee T, Ontong P, Itano N. Hyaluronan: a modulator of the tumor microenvironment. Cancer Lett. 2016;375(1):20–30. doi:10.1016/j.canlet.2016.02.03126921785
   PubMed Web of Science ®Google Scholar
• Toole BP, Hascall VC. Hyaluronan and tumor growth. Am J Pathol. 2002;161(3):745–747. doi:10.1016/S0002-9440(10)64232-012213700
   PubMed Web of Science ®Google Scholar
• Ropponen K, Tammi M, Parkkinen J, et al. Tumor cell-associated hyaluronan as an unfavorable prognostic factor in colorectal cancer. Cancer Res. 1998;58(2):342–347.9443415
   PubMed Web of Science ®Google Scholar
• Knudson W. Tumor-associated hyaluronan. Providing an extracellular matrix that facilitates invasion. Am J Pathol. 1996;148(6):1721–1726.8669457
   PubMed Web of Science ®Google Scholar
• Eikenes L, Tari M, Tufto I, et al. Hyaluronidase induces a transcapillary pressure gradient and improves the distribution and uptake of liposomal doxorubicin (Caelyx) in human osteosarcoma xenografts. Br J Cancer. 2005;93(1):81–88. doi:10.1038/sj.bjc.660262615942637
   PubMed Web of Science ®Google Scholar
• Platt VM, Szoka FC Jr. Anticancer therapeutics: targeting macromolecules and nanocarriers to hyaluronan or CD44, a hyaluronan receptor. Mol Pharm. 2008;5(4):474–486. doi:10.1021/mp800024g18547053
   PubMedGoogle Scholar
• Dai J, Han S, Ju F, et al. Preparation and evaluation of tumour microenvironment response multistage nanoparticles for epirubicin delivery and deep tumour penetration. Artif Cells Nanomed Biotechnol. 2018;46(sup2):860–873. doi:10.1080/21691401.2018.147052829771149
   PubMed Web of Science ®Google Scholar
• Glasgow MD, Chougule MB. Recent developments in active tumor targeted multifunctional nanoparticles for combination chemotherapy in cancer treatment and imaging. J Biomed Nanotechnol. 2015;11(11):1859–1898. doi:10.1166/jbn.2015.214526554150
   PubMed Web of Science ®Google Scholar
• Mao C, Xie X, Liu X, et al. The controlled drug release by pH-sensitive molecularly imprinted nanospheres for enhanced antibacterial activity. Mater Sci Eng C Mater Biol Appl. 2017;77:84–91. doi:10.1016/j.msec.2017.03.25928532100
   PubMed Web of Science ®Google Scholar
• Jiang L, Liang Y, Huo Q, et al. Viral capsids mimicking based on pH-sensitive biodegradable polymeric micelles for efficient anticancer drug delivery. J Biomed Nanotechnol. 2018;14(8):1409–1419. doi:10.1166/jbn.2018.258729903056
   PubMedGoogle Scholar
• Huo Q, Liang Y, Lu W, et al. Integrated metalloproteinase, pH and glutathione responsive prodrug-based nanomedicine for efficient target chemotherapy. J Biomed Nanotechnol. 2019;15(8):1673–1687. doi:10.1166/jbn.2019.280131219020
   PubMed Web of Science ®Google Scholar
• Zhu Y, Zhang J, Meng F, et al. cRGD/TAT dual-ligand reversibly cross-linked micelles loaded with docetaxel penetrate deeply into tumor tissue and show high antitumor efficacy in vivo. ACS Appl Mater Interfaces. 2017;9(41):35651–35663. doi:10.1021/acsami.7b1243928952305
   PubMed Web of Science ®Google Scholar
• Zhou H, Fan Z, Deng J, et al. Hyaluronidase embedded in nanocarrier PEG shell for enhanced tumor penetration and highly efficient antitumor efficacy. Nano Lett. 2016;16(5):3268–3277. doi:10.1021/acs.nanolett.6b0082027057591
   PubMed Web of Science ®Google Scholar
• Ge R, Cao J, Chi J, et al. <p>NIR-guided dendritic nanoplatform for improving antitumor efficacy by combining chemo-phototherapy. Int J Nanomedicine. 2019;14:4931–4947. doi:10.2147/IJN.S20317131371941
   PubMed Web of Science ®Google Scholar
• Deng C, Jia M, Wei G, et al. Inducing optimal antitumor immune response through coadministering iRGD with pirarubicin loaded nanostructured lipid carriers for breast cancer therapy. Mol Pharm. 2017;14(1):296–309. doi:10.1021/acs.molpharmaceut.6b0093227936775
   PubMedGoogle Scholar
• Balaji A, Jaganathan SK, Ismail AF, et al. Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and Carica papaya extract for the management of burn injuries. Int J Nanomedicine. 2016;11:4339–4355. doi:10.2147/IJN.S11226527621626
   PubMed Web of Science ®Google Scholar
• Joo KI, Lei Y, Lee CL, et al. Site-specific labeling of enveloped viruses with quantum dots for single virus tracking. ACS Nano. 2008;2(8):1553–1562. doi:10.1021/nn800213619079775
   PubMed Web of Science ®Google Scholar
• Sahay G, Alakhova DY, Kabanov AV. Endocytosis of nanomedicines. J Control Release. 2010;145(3):182–195. doi:10.1016/j.jconrel.2010.01.03620226220
   PubMed Web of Science ®Google Scholar
• Goodman TT, Ng CP, Pun SH. 3-D tissue culture systems for the evaluation and optimization of nanoparticle-based drug carriers. Bioconjug Chem. 2008;19(10):1951–1959. doi:10.1021/bc800233a18788773
   PubMed Web of Science ®Google Scholar
• Hu G, Zhang H, Zhang L, et al. Integrin-mediated active tumor targeting and tumor microenvironment response dendrimer-gelatin nanoparticles for drug delivery and tumor treatment. Int J Pharm. 2015;496(2):1057–1068. doi:10.1016/j.ijpharm.2015.11.02526598487
   PubMedGoogle Scholar
• Brekken C, de Lange Davies C. Hyaluronidase reduces the interstitial fluid pressure in solid tumours in a non-linear concentration-dependent manner. Cancer Lett. 1998;131(1):65–70. doi:10.1016/S0304-3835(98)00202-X9839621
   PubMed Web of Science ®Google Scholar
• Pan A, Wang Z, Chen B, et al. Localized co-delivery of collagenase and trastuzumab by thermosensitive hydrogels for enhanced antitumor efficacy in human breast xenograft. Drug Deliv. 2018;25(1):1495–1503. doi:10.1080/10717544.2018.147497129943651
   PubMed Web of Science ®Google Scholar
• Pankova D, Chen Y, Terajima M, et al. Cancer-associated fibroblasts induce a collagen cross-link switch in tumor stroma. Mol Cancer Res. 2016;14(3):287–295. doi:10.1158/1541-7786.MCR-15-030726631572
   PubMed Web of Science ®Google Scholar
• Zhang J, Miao L, Guo S, et al. Synergistic anti-tumor effects of combined gemcitabine and cisplatin nanoparticles in a stroma-rich bladder carcinoma model. J Control Release. 2014;182:90–96. doi:10.1016/j.jconrel.2014.03.01624637468
   PubMed Web of Science ®Google Scholar
• Pang N, Li J, Sun A, et al. Prior anti-CAFs break down the CAFs barrier and improve accumulation of docetaxel micelles in tumor. Int J Nanomedicine. 2018;13:5971–5990. doi:10.2147/IJN.S17122430323586
   PubMed Web of Science ®Google Scholar
• Henriksson R, Grankvist K. Protective effect of iron chelators on epirubicin-induced fibroblast toxicity. Cancer Lett. 1988;43(3):179–183. doi:10.1016/0304-3835(88)90168-13144433
   PubMed Web of Science ®Google Scholar
• Gong H, Chao Y, Xiang J, et al. Hyaluronidase to enhance nanoparticle-based photodynamic tumor therapy. Nano Lett. 2016;16(4):2512–2521. doi:10.1021/acs.nanolett.6b0006827022664
   PubMed Web of Science ®Google Scholar
• Kee N, Sivalingam S, Boonstra R, et al. The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis. J Neurosci Methods. 2002;115(1):97–105. doi:10.1016/S0165-0270(02)00007-911897369
   PubMed Web of Science ®Google Scholar