References
- VézinaCKudelskiASehgalSNRapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principleJ Antibiot (Tokyo)1975287217261102508
- SehgalSNRapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progressionClin Biochem1998313353409721431
- SimamoraPAlvarezJMYalkowskySHSolubilization of rapamycinInt J Pharm2001213252911165091
- RoufMABilensoyEVuralİHincalAADetermination of stability of rapamycin following exposure to different conditionsEuro J Pharm Sci2007321 Suppl 1S46
- RoufMABilensoyEVuralİHincalAAInclusion complexation of rapamycin with beta-cyclodextrin to improve solubility and stability of the drugThe 2nd BBBB Conference on Pharmaceutical SciencesSeptember 13–15, 2007Tallinn-Tartu, Estonia
- BuechGBertelmannEPleyerUSiebenbrodtIBorchertHHFormulation of sirolimus eye drops and corneal permeation studiesJ Ocul Pharmacol Ther20072329230317593014
- AlemdarAYSadleDMcAlisterVCMendezILiposomal formulations of tacrolimus and rapamycin increase graft survival and fiber outgrowth of dopaminergic graftsCell Transplant20041326327115191164
- RosenHAbribatTThe rise and rise of drug deliveryNat Rev Drug Discov2005438138515864267
- JunghannsJUMullerRHNanocrystal technology, drug delivery and clinical applicationsInt J Nanomed20083295310
- PreethamACSatishCSFormulation of a poorly water-soluble drug sirolimus in solid dispersions to improve dissolutionJ Disp Sci Technol201132778783
- VasconcelosTSarmentoBCostaPSolid dispersions as strategy to improve oral bioavailability of poor water soluble drugsDrug Discov Today2007121068107518061887
- LeunerCDressmanJImproving drug solubility for oral delivery using solid dispersionsEuro J Pharm Biopharm2000504760
- SrinarongPde WaardHFrijlinkHWHinrichsWLJImproved dissolution behavior of lipophilic drugs by solid dispersions: the production process as starting point for formulation considerationsExpert Opin Drug Deliv201181121114021722000
- SerajuddinATMSolid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughsJ Pharm Sci1999881058106610514356
- JanssensSVan den MooterGReview: physical chemistry of solid dispersionsJ Pharm Pharmacol2009611571158619958579
- CraigDQThe mechanisms of drug release from solid dispersions in water-soluble polymersInt J Pharm200223113114411755266
- KaravasEGeorgarakisESigalasMPAvgoustakisKBikiarisDInvestigation of the release mechanism of a sparingly water-soluble drug from solid dispersions in hydrophilic carriers based on physical state of drug, particle size distribution and drug-polymer interactionsEuro J Pharm Biopharm200766334347
- WonDHKimMSLeeSParkJSHwangSJImproved physicochemical characteristics of felodipine solid dispersion particles by supercritical anti-solvent precipitation processInt J Pharm200530119920816024189
- JunSWKimMSJoGHCefuroxime axetil solid dispersions prepared using solution enhanced dispersion by supercritical fluidsJ Pharm Pharmacol2005571529153716354397
- JunSWKimMSKimJSPreparation and characterization of simvastatin/hydroxypropyl-beta-cyclodextrin inclusion complex using supercritical antisolvent (SAS) processEur J Pharm Biopharm20076641342117240129
- KalaniMYunusRApplication of supercritical antisolvent method in drug encapsulation: a reviewInt J Nanomed2011614291442
- FagesJLochardHLetourneauJJSauceauMRodierEParticle generation for pharmaceutical applications using supercritical fluid technologyPowder Technol2004141219226
- PasqualiIBettiniRGiordanoFSolid-state chemistry and particle engineering with supercritical fluids in pharmaceuticsEuro J Pharm Sci200627299310
- RicciutelliMDi MartinoPBarboniLMartelliSEvaluation of rapamycin chemical stability in volatile-organic solvents by HPLCJ Pharm Biomed Anal2006411070107416545930
- WangXVenkatramanSSBoeyFYLooJSCTanLPControlled release of sirolimus from a multilayered PLGA stent matrixBiomaterials2006275588559516879865
- PaineMFLeungLYLimHKIdentification of a novel route of extraction of sirolimus in human small intestine: roles of metabolism and secretionJ Pharmacol Exp Ther200230117418611907172
- KimMSJinSJKimJSPreparation, characterization and in vivo evaluation of amorphous atorvastatin calcium nanoparticles using supercritical antisolvent (SAS) processEur J Pharm Biopharm20086945446518359211
- StreitFChristiansUSchiebelUMMeyerASewingKFStructural identification of three metabolites and a degradation product of the macrolide immunosuppressant sirolimus (rapamycin) by electrospray-MS/MS after incubation with human liver microsomesDrug Metab Dispos199624127212788937863
- MalekiSGravesSBeckerSTherapeutic monitoring of sirolimus in human whole-blood samples by high-performance liquid chromatographyClin Ther200022Suppl BB25B2710823371
- WacherVJSilvermanJAWongSSirolimus oral absorption in rats is increased by ketoconazole but is not affected by D-alpha-tocopheryl poly(ethylene glycol 1000) succinateJ Pharmacol Exp Ther200230330831312235265
- JuppoAMBoissierCKhooCEvaluation of solid dispersion particles prepared with SEDSInt J Pharm200325038540112527165
- KimMSKimJSHwangSJEnhancement of wettability and dissolution properties of cilostazol using the supercritical antisolvent process: effect of various additivesChem Pharm Bull20105823023320118585
- AlonzoDEGaoYZhouDMoHZhangGGZTaylorLSDissolution and precipitation behavior of amorphous solid dispersionsJ Pharm Sci20111003316333121607951
- KonnoHHandaTAlonzoDETaylorLSEffect of polymer type on the dissolution profile of amorphous solid dispersions containing felodipineEur J Pharm Biopharm20087049349918577451
- LampenAZhangYHackbarthIBenetLZSewingKFChristiansUMetabolism and transport of the macrolide immunosuppressant sirolimus in the small intestineJ Pharmacol Exp Ther1998285110411129618413
- PaineMFLeungLYWatkinsPBNew insights into drug absorption: studies with sirolimusTher Drug Monit20042646346715385826
- CumminsCLJacobsenWChristiansUBenetLZCYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolamJ Pharmacol Exp Ther200430814315514569063
- Abu-DiakOAJonesDSAndrewsGPAn investigation into the dissolution properties of celecoxib melt extrudates: understanding the role of polymer type and concentration in stabilizing supersaturated drug concentrationsMol Pharm201181362137121696180